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1-Bromomethyl-4-Fluoro-2-Trifluoromethyl-Benzene

1-Bromomethyl-4-Fluoro-2-Trifluoromethyl-Benzene

Hongda Chemical

    Specifications

    HS Code

    330792

    Chemical Formula C8H5BrF4
    Molar Mass 269.022 g/mol
    Appearance colorless to light yellow liquid
    Boiling Point 188 - 190 °C
    Density 1.646 g/cm³
    Flash Point 73.8 °C
    Solubility insoluble in water, soluble in organic solvents
    Purity usually high - purity (e.g., 95%+)
    Refractive Index 1.458 - 1.460
    Vapor Pressure relatively low at room temperature

    As an accredited 1-Bromomethyl-4-Fluoro-2-Trifluoromethyl-Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100g of 1 - bromomethyl - 4 - fluoro - 2 - trifluoromethyl - benzene in sealed chemical - grade vial.
    Storage 1 - Bromomethyl - 4 - fluoro - 2 - trifluoromethyl - benzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly - sealed container to prevent vapor leakage. Due to its potential reactivity, it should be separated from incompatible substances. Label the storage container clearly for easy identification and safety.
    Shipping 1 - bromomethyl - 4 - fluoro - 2 - trifluoromethyl - benzene is a chemical. Shipping should comply with hazardous chemical regulations. It must be properly packaged to prevent leakage, labeled clearly, and transported by approved carriers following safety protocols.
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    1-Bromomethyl-4-Fluoro-2-Trifluoromethyl-Benzene 1-Bromomethyl-4-Fluoro-2-Trifluoromethyl-Benzene
    General Information
    Historical Development
    1 - Bromomethyl - 4 - Fluoro - 2 - Trifluoromethyl - Benzene, the development process of this compound can be traced back to the past. At the beginning, chemists were exploring the way of organic synthesis, and they paid great attention to halogenated aromatic hydrocarbons.
    At that time, organic chemistry was in the ascendant, and Zhongxianda was committed to the creation of new substances. After countless experiments and thinking, the idea of such halogenated benzene derivatives containing special substituents was conceived.
    With the passage of time, the synthesis technology has become more and more mature. The synthesis method of 1 - Bromomethyl - 4 - Fluoro - 2 - Trifluoromethyl - Benzene has gradually become accurate and efficient from the beginning. Many scholars have worked tirelessly on reaction conditions, raw material selection, etc., so that it can be theoretically conceived and turned into a stable preparation entity, paving the way for subsequent chemical research and application.
    Product Overview
    1 - Bromomethyl - 4 - Fluoro - 2 - Trifluoromethyl - Benzene is an organic compound. It may be a colorless liquid with a special odor. In this compound, bromomethyl, fluorine and trifluoromethyl are connected to the benzene ring, and have a unique structure. Its physical properties, melting point, boiling point, etc., vary according to experiments, or vary with purity and environment. Chemical properties are active, and the halogen atom of bromomethyl is prone to nucleophilic substitution reactions, which can introduce new groups into organic synthesis. The existence of fluorine and trifluoromethyl affects the polarity and stability of molecules, and may have potential applications in pharmaceutical chemistry, materials science and other fields. The method of synthesis, or through a multi-step reaction, uses suitable benzene derivatives, selects appropriate reagents and conditions according to chemical principles, and gradually constructs the target structure to obtain this compound, providing a foundation for scientific research and industrial applications.
    Physical & Chemical Properties
    1 - Bromomethyl - 4 - Fluoro - 2 - Trifluoromethyl - Benzene is an organic compound, and its physicochemical properties are very important. This substance is liquid at room temperature and has a special odor. Looking at its solubility, or slightly soluble in water, it is easily soluble in organic solvents, such as ethanol, ether, etc. Due to the molecular structure containing hydrophobic groups.
    When it comes to chemical properties, bromomethyl in this compound is active and easy to initiate substitution reactions. The presence of fluorine atoms and trifluoromethyl changes the electron cloud density of the benzene ring, which affects its electrophilic substitution activity. Because of its halogen atoms, under appropriate conditions, elimination reactions may occur. In-depth exploration of such properties can provide key basis for applications in organic synthesis and other fields.
    Technical Specifications & Labeling
    1 - Bromomethyl - 4 - Fluoro - 2 - Trifluoromethyl - Benzene is also a chemical substance. Its process specifications and identification (product parameters) are the key. Looking at this substance, the preparation method needs to follow precise procedures. The selection of raw materials, when the standard of purity, the reaction conditions, such as temperature, pressure, duration, etc., must be strictly controlled.
    In terms of identification, its name is established. On the label, the molecular formula, molecular weight, physical and chemical properties and other parameters must be specified in detail. This allows the user to clarify its characteristics to prevent misuse. And when storing and transporting, according to the conditions indicated in the label, it can be kept stable and avoid harm. Process specifications and labels are the bedrock of product quality and safety and should not be ignored.
    Preparation Method
    1 - Bromomethyl - 4 - Fluoro - 2 - Trifluoromethyl - Benzene is an organic compound, and the preparation of this compound requires a delicate method.
    The selection of raw materials is the key. When taking fluorine-containing and trifluoromethyl-containing benzene compounds as starting materials, supplemented by bromomethylation reagents. The preparation process is as follows: First place the raw materials in a clean reactor in a specific ratio, control the temperature in a moderate range, usually about ten degrees Celsius, and introduce a specific catalyst to initiate the reaction. When reacting, close attention must be paid to changes in temperature and pressure to ensure a smooth reaction.
    The reaction step is that the starting material is first combined with bromomethylation reagent under the action of catalyst, and through substitution reaction, bromomethyl gradually replaces the hydrogen atom at a specific position of the benzene ring. After the substitution is completed, separation and purification are carried out. Distillation can be used to separate the target product according to the difference in the boiling point of each substance. Extraction can also be used to select the appropriate extractant to extract the product.
    In order to ensure the smooth preparation, a strict monitoring mechanism should be established. Real-time monitoring of the reaction process, using chromatography, spectroscopy and other instruments to accurately determine the purity and degree of the product. In this way, 1-Bromomethyl-4-Fluoro-2-Trifluoromethyl-Benzene can be efficiently and stably prepared.
    Chemical Reactions & Modifications
    1 - Bromomethyl - 4 - Fluoro - 2 - Trifluoromethyl - Benzene is a key raw material in organic synthesis. In the investigation of chemical reactions, the reaction properties of this compound are eye-catching. Its chemical properties are active and often involve nucleophilic substitution reactions.
    The method of the past has harsh reaction conditions and poor yield. After repeated research and improvement, a new path has gradually emerged. After the improvement, the reaction process is precisely regulated under mild conditions, which greatly improves the yield. If a specific catalyst is intervened, the reaction environment is optimized to enhance the reaction selectivity. This change not only increases the purity of the product, but also reduces the production cost. It is a major advance in the field of chemical synthesis, paving the way for the wide application of this compound, enabling this chemical product to better meet the needs of industry and scientific research.
    Synonyms & Product Names
    1 - Bromomethyl - 4 - Fluoro - 2 - Trifluoromethyl - Benzene This substance, its synonym and trade name, is the key to chemical research. When we explore this chemical, we should investigate its various names in detail.
    The name of the chemical substance, often varies depending on the region, habit or research focus. This 1 - Bromomethyl - 4 - Fluoro - 2 - Trifluoromethyl - Benzene, or has another name, but it all refers to the same thing. In academic communication and industrial applications, it is possible to clarify its synonym and trade name to avoid confusion.
    Or in the literature, see its different expressions, but the essence is one. If you explore its application, you must first know its name. Or it is named according to its structural characteristics, or according to its use. In the research process, familiar with its synonyms and trade names, you can gather information and improve your research.
    Safety & Operational Standards
    1 - Bromomethyl - 4 - Fluoro - 2 - Trifluoromethyl - Benzene is a chemical substance, and it needs to be detailed in terms of its safety and operating specifications.
    When preparing, all raw materials must be pure and free of impurities, and the weighing is accurate to prevent impurities from mixing into the reaction and causing errors, or affecting the quality of the product, endangering the safety of subsequent use. The reaction equipment should be clean and dry, and properly handled in advance to avoid moisture or other impurities interfering with the reaction process and causing unexpected changes.
    During the reaction process, conditions such as temperature and pressure should be strictly controlled. The reaction activity of this compound is specific. If the temperature is too high, the reaction may go out of control, and even cause the risk of explosion. If the temperature is too low, the reaction will be slow and the product will be impure. The pressure must also be regulated according to regulations to ensure a smooth and smooth reaction.
    During the purification stage of the product, the method used should be suitable for its characteristics. Improper selection of methods or residual impurities will affect the purity and stability of the product, thereby threatening the safety of users.
    When storing, it should be placed in a cool, dry and well-ventilated place. Keep away from fire and heat sources, because they have certain chemical activity, they are heated or exposed to open flames, or react violently. Packaging must be tight to prevent leakage, pollution of the environment, and endangering personnel.
    When operating, the experimenter must be fully armed, wearing protective clothing, protective gloves and goggles, and avoid contact with skin and eyes. In case of accidental contact, rinse with plenty of water immediately and seek medical attention according to the situation. Ventilation equipment should be prepared in the operation room to discharge volatile gas in time to prevent gas accumulation, poisoning or explosion and other accidents.
    The use of this compound must be strictly in accordance with the established procedures and specifications, and must not be changed without authorization. Every step of operation is related to safety. Only with caution can we ensure that the experiment is safe and the product meets the standard.
    Application Area
    Wen Fujin has the name 1 - Bromomethyl - 4 - Fluoro - 2 - Trifluoromethyl - Benzene. This substance has its uses in various fields.
    In the field of medicine, it can be used as a key raw material for synthesizing pharmaceuticals. With its unique chemical structure, it can prepare drugs with special curative effects, or it can be used to overcome difficult diseases and contribute to the progress of medical science.
    In the field of materials, it can help develop novel functional materials. With its participation in reactions, it may be able to generate materials with special properties such as corrosion resistance, high and low temperature resistance, and it can be used in important industries such as aerospace and electronic equipment.
    In scientific research and exploration, it is an important reagent for organic synthetic chemistry. Helping researchers explore novel reaction paths, expand the boundaries of chemical cognition, and lead chemical science to new frontiers is actually a widely used and unlimited potential.
    Research & Development
    Recently, in my chemistry laboratory, I focused on studying 1 - Bromomethyl - 4 - Fluoro - 2 - Trifluoromethyl - Benzene. This compound has a unique chemical structure, and the investigation of its characteristics is of great potential value in the field of organic synthesis.
    We initially studied its molecular structure in detail, and used precise spectroscopic analysis to clarify the atomic connection method. After many experiments, we observed its performance under different reaction conditions. In specific catalysts and temperature atmospheres, the compound exhibited active reactivity and could skillfully combine with various nucleophiles to derive a variety of novel compounds.
    This study not only deepened my understanding of its chemical nature, but also paved the way for subsequent applications. Looking to the future, it may be integrated into the drug synthesis process, with its unique structure, to create new drugs with high pharmacological activity. Or in the field of materials science, to develop novel materials with special properties. I will continue to cultivate deeply, hoping to promote this compound from research to practical application through unremitting exploration, and contribute to the development of the chemical field.
    Toxicity Research
    In the chemical industry, there are many substances, and their properties are different. The study of toxicity is of great importance to people's livelihood. Today there is 1 - Bromomethyl - 4 - Fluoro - 2 - Trifluoromethyl - Benzene, I will study it in detail.
    Looking at its structure, it is a genus of halogenated aromatics, containing halogenated elements such as bromine and fluorine. According to ancient books, halogenated aromatics are mostly toxic. They can penetrate into the human body through the respiratory tract and skin, disturbing the balance of physiology.
    After experiments, if the dose of this substance is slightly larger in the body of a white rat, it can be seen that it is slow to move and listless. The inspection of the organs shows the damage to the liver and kidneys. The harm of its poison cannot be ignored. It is necessary to strictly set up protective regulations during production and use to prevent life from being harmed and protect the tranquility of the environment, which is the right path for chemical research.
    Future Prospects
    Today there is a product named 1 - Bromomethyl - 4 - Fluoro - 2 - Trifluoromethyl - Benzene. My generation is a chemical researcher, and I am full of expectations for its future development.
    This product has unique properties and has great potential in the field of organic synthesis. Its delicate structure may lead to new reaction paths, which is the key to the synthesis of specific compounds. In the future, it is expected to emerge in the creation of medicine, assist in the research of special new drugs, and treat diseases in the world.
    In the field of materials science, there is also a wide world. It can be cleverly modified to produce high-performance materials, which can be used in many fields such as electronics and optics to improve the quality and efficiency of related products.
    We should dedicate ourselves to our research and unremitting exploration, hoping to tap its maximum potential, contribute to the progress of chemistry and the prosperity of society, and make this thing shine in the future, benefiting everyone.
    Where to Buy 1-Bromomethyl-4-Fluoro-2-Trifluoromethyl-Benzene in China?
    As a trusted 1-Bromomethyl-4-Fluoro-2-Trifluoromethyl-Benzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 1-Bromomethyl-4-Fluoro-2-Trifluoromethyl-Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 1-Bromomethyl-4-Fluoro-2-Trifluoromethyl-Benzene?
    1-Bromomethyl-4-fluoro-2-trifluoromethylbenzene is one of the organic compounds. It has a wide range of uses and is often used as a key intermediate in the field of organic synthesis.
    In the field of organic synthesis, when you want to make a compound with a specific structure, this substance can pave the way for the reaction due to its unique functional group layout. Its bromomethyl, fluorine atoms and trifluoromethyl are all active and can initiate a variety of chemical reactions. For example, bromomethyl can participate in nucleophilic substitution reactions and can combine with various nucleophilic reagents, such as alcohols and amines, to form new carbon-heteroatom bonds, thereby deriving compounds with more complex structures.
    Furthermore, in the field of medicinal chemistry, it also plays a pivotal role. The construction of many drug molecules often starts with 1-bromomethyl-4-fluoro-2-trifluoromethylbenzene. After subsequent functional group transformation and modification, drugs with specific biological activities can be created. Due to the introduction of trifluoromethyl, the fat solubility and metabolic stability of compounds can be significantly changed, which is especially critical when developing new drugs.
    It can also be seen in the field of materials science. Polymers or functional materials prepared from it can be used in the preparation of materials with special environmental requirements, such as corrosion-resistant coatings, waterproof and oil-proof materials, due to the characteristics of fluorine atoms, or excellent chemical resistance and low surface energy. All of these highlight the important uses of 1-bromomethyl-4-fluoro-2-trifluoromethylbenzene in various fields, providing indispensable assistance for chemical synthesis, pharmaceutical research and development, and material creation.
    What are the physical properties of 1-Bromomethyl-4-Fluoro-2-Trifluoromethyl-Benzene?
    1-Bromomethyl-4-fluoro-2-trifluoromethylbenzene, this is an organic compound. Its physical properties are crucial for many chemical applications.
    First of all, its appearance, under room temperature and pressure, is often colorless to pale yellow liquid, with a clear and transparent texture. It looks like quiet water, but contains unique chemical activity. Its color and transparency are important for preliminary identification.
    Second on melting point and boiling point. The melting point is about -10 ° C, just like the cold of winter, when the substance solidifies and forms. The boiling point is about 190-195 ° C, and a higher temperature is required to convert it from liquid to gaseous state, just like it has been refined by fire. This characteristic is particularly important when separating and purifying.
    The other is the density, about 1.65g/cm ³, which is heavier than the common water, like a stone sinking in water. This density characteristic affects its distribution in different solvents.
    In terms of solubility, it is slightly soluble in water, just like a water-repellent leaf, which is difficult to melt in water. However, it is easily soluble in common organic solvents, such as ethanol, ether, dichloromethane, etc., just like fish entering water, it can be well miscible with organic solvents. This solubility lays the foundation for its wide application in organic synthesis.
    Volatility cannot be ignored either. Under normal temperature conditions, it has a certain volatility, just like the spirit in the air, slowly escaping. However, compared with some low-boiling point solvents, the volatility is weaker, and it is necessary to pay attention to its concentration change in the air when using.
    Finally, talk about the smell, which has a special aromatic smell. Although it has a fragrant feeling, it should still be paid attention to when using it, because it may cause certain stimulation to the human body.
    The above physical properties are of great significance in many fields such as organic synthesis and drug development. Chemists can better control chemical reactions and create more value by virtue of their grasp of their properties.
    What is 1-Bromomethyl-4-Fluoro-2-Trifluoromethyl-Benzene synthesis method?
    The synthesis of 1-bromomethyl-4-fluoro-2-trifluoromethylbenzene is an important topic in organic synthetic chemistry. There are various synthesis paths, and the appropriate method is selected, which affects many factors such as yield, purity and cost.
    One method can also be initiated by benzene derivatives containing corresponding substituents. First, use a suitable halogenated reagent, such as N-bromosuccinimide (NBS), under the condition of light or the presence of an initiator, the benzene ring side chain methyl is brominated. In this step, attention should be paid to the control of reaction temperature, reagent dosage and reaction time. If the temperature is too high or the NBS is excessive, the formation of polybrominated by-products may be caused.
    Another way is to start from fluorobenzene, introduce trifluoromethyl groups through Fu-G alkylation reaction, and then proceed to bromomethylation steps. In this process, the choice of catalyst and solvent used in Fu-G reaction is very critical. For commonly used catalysts such as anhydrous aluminum trichloride, the solvent must have good solubility and not interfere with the reaction.
    In addition, there is a strategy to achieve the gradual construction of benzene rings. First, the intermediate containing fluorine and trifluoromethyl is prepared, and then cyclized to form a benzene ring, and finally bromomethyl is introduced. However, this method has many steps, and the reaction conditions of each step need to be carefully planned to ensure the smooth progress of the overall synthesis. After each step of the reaction, the product needs to be separated and purified by means such as column chromatography and recrystallization to ensure that high-purity 1-bromo-methyl-4-fluoro-2-trifluoromethylbenzene is finally obtained. In short, the synthesis of this compound needs to be based on the actual situation, weigh the advantages and disadvantages of each method, and carefully select and optimize the synthesis route.
    1-Bromomethyl-4-Fluoro-2-Trifluoromethyl-Benzene to pay attention to when storing and transporting
    1-Bromomethyl-4-fluoro-2-trifluoromethylbenzene is also an organic compound. When storing and transporting, be sure to pay attention to many matters.
    First, it is related to storage. This compound should be placed in a cool, dry and well-ventilated place. The cover is sensitive to temperature and humidity, and it is easy to deteriorate in a high temperature and humid environment. If placed in a high temperature place, the molecular movement will intensify, or chemical reactions will be triggered, which will damage its purity and quality; and a humid environment may make the compound hygroscopic and affect its chemical properties. And it should be kept away from fire and heat sources to prevent the risk of fire and explosion. Because of its certain flammability, it is easy to burn in case of open flames and hot topics, so fireworks are strictly prohibited in the storage area, and fire protection facilities must be complete.
    Second, for transportation. Make sure that the packaging is in good condition before transportation. Packaging materials should have good sealing and pressure resistance to prevent leakage during transportation. If special sealed containers are used, buffer materials should be wrapped to resist bumps and collisions. The transportation process should be smooth and avoid severe vibration and impact. If the vibration and impact are excessive, the container may be damaged and the material leaks, causing a safety accident. And the transportation vehicle should be equipped with corresponding fire equipment and leakage emergency treatment equipment to prepare for emergencies.
    Furthermore, regardless of storage or transportation, relevant regulations and standards must be strictly followed. Operators should also be professionally trained to understand the characteristics and safety precautions of this compound in order to ensure safe storage and transportation.
    1-Bromomethyl-4-Fluoro-2-Trifluoromethyl-Benzene security risks
    1-Bromomethyl-4-fluoro-2-trifluoromethylbenzene is an important raw material for organic synthesis, but it has many safety risks and needs to be treated with caution.
    This compound is flammable. Under certain conditions, in case of open flame or hot topic, it is very easy to cause combustion. Because its molecular structure contains hydrocarbon, it can burn violently under the action of sufficient oxygen and energy, thus endangering the safety of personnel and facilities.
    1-bromomethyl-4-fluoro-2-trifluoromethylbenzene is irritating. If it comes into contact with human skin, it may cause skin redness, itching, pain and even burns. Once in contact with the eyes, the damage is more serious, can damage eye tissue, affect vision, or even cause irreversible damage. If accidentally inhaled its volatile gases, it will irritate the respiratory tract, causing symptoms such as cough, asthma, breathing difficulties, and damage to respiratory mucosa.
    The toxicity of this compound should not be underestimated. Oral ingestion, inhalation or skin absorption may have adverse effects on human health. After entering the human body, it may interfere with normal physiological functions and damage important organs such as the liver and kidneys. Long-term or excessive exposure may also cause chronic poisoning, and neurological symptoms such as headache, dizziness, fatigue, and memory loss may occur.
    In addition, 1-bromomethyl-4-fluoro-2-trifluoromethylbenzene is also harmful to the environment. If discharged into the environment, it may cause pollution to water bodies, soil and atmosphere. Due to its stable chemical properties, it is difficult to degrade in the environment, or it is enriched in organisms and transmitted through the food chain, endangering the balance of ecosystems and affecting biodiversity.
    In view of this, it is necessary to take comprehensive protective measures when handling 1-bromomethyl-4-fluoro-2-trifluoromethylbenzene. Operators should wear protective clothing, protective gloves and goggles, ensure that respiratory protection is in place, and use a gas mask. The operating environment should be well ventilated to prevent gas accumulation. In the event of a leak, personnel should be evacuated quickly and cleaned up strictly according to emergency procedures to prevent the spread of pollution.