1-(Bromomethyl)-4-(Difluoromethyl)Benzene

Hongda Chemical

Specifications

HS Code	912780
Chemical Formula	C8H7BrF2
Molecular Weight	221.04
Appearance	Typically a colorless to light - colored liquid
Boiling Point	Data may vary depending on purity, generally in a certain range related to its molecular structure
Density	A value specific to this compound, related to mass and volume
Solubility In Water	Poorly soluble in water due to its non - polar nature
Solubility In Organic Solvents	Soluble in common organic solvents like dichloromethane, toluene
Flash Point	A characteristic value indicating flammability risk
Vapor Pressure	A value that reflects the tendency of the compound to vaporize

As an accredited 1-(Bromomethyl)-4-(Difluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	100g of 1-(bromomethyl)-4-(difluoromethyl)benzene in a sealed chemical - grade bottle.
Storage	1-(Bromomethyl)-4-(difluoromethyl)benzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. It should be kept in a tightly sealed container to prevent leakage and exposure to air or moisture. Store it separately from oxidizing agents and incompatible substances to avoid potential chemical reactions.
Shipping	1-(Bromomethyl)-4-(difluoromethyl)benzene is shipped in accordance with chemical regulations. Packed in suitable containers, it's transported by approved carriers, ensuring safety during transit to prevent any chemical - related risks.

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1-(Bromomethyl)-4-(Difluoromethyl)Benzene

General Information

Historical Development

1- (bromomethyl) -4- (difluoromethyl) benzene, the development process of this compound has also been traced throughout the ages. In the past, chemical research was just emerging, and all the wise men dedicated themselves to the field of organic synthesis. At that time, the knowledge of such compounds containing halogenated hydrocarbons and special substituents was still shallow.
With the passage of time, chemical technology has become more and more refined. Many scholars have gradually understood the synthesis method after repeated experiments and careful investigation. At the beginning, the synthesis steps were complicated and the yield was not abundant. However, the scientific researchers persevered and continuously improved the reaction conditions and optimized the synthesis path.
As of today, the synthesis process of 1- (bromomethyl) -4- (difluoromethyl) benzene has become mature, emerging in many fields such as medicine and materials, adding a strong touch to the development of chemistry. It is also expected to open up a wider application world in the future.

Product Overview

Today there is a substance called 1- (Bromomethyl) -4- (Difluoromethyl) Benzene. This is an organic compound with a unique molecular structure. Looking at its structure, on the benzene ring, one is attached to bromomethyl and the other is connected to difluoromethyl.
Bromomethyl has active properties and can initiate many nucleophilic substitution reactions, which add to organic synthesis. Difluoromethyl is also an extraordinary substance, which can significantly change the physical and chemical properties of compounds due to its special electronic effects.
This substance has a wide range of uses in the field of organic synthesis and can be used as a key intermediate to help create a variety of organic materials and drugs. Through ingenious reaction paths, many products with special properties can be derived, which are expected to shine in materials science and pharmaceutical research and development, and contribute to the progress of related fields.

Physical & Chemical Properties

1- (Bromomethyl) -4- (difluoromethyl) Benzene is an organic compound, and its physical and chemical properties are quite important. The properties of this compound, at room temperature or as a colorless to slightly yellow liquid, have certain volatility. Looking at its physical properties, the boiling point or due to the presence of bromine and difluoromethyl in the molecular structure, the intermolecular force changes, and the boiling point is in a specific range. In terms of solubility, it may exhibit good solubility in organic solvents. Due to the principle of similar miscibility, its organic structure makes it easily soluble in common organic solvents such as ethanol and ether.
In terms of chemical properties, bromine is active methyl, prone to nucleophilic substitution, and can react with many nucleophilic reagents to generate new compounds. Difluoromethyl gives it a unique electronic effect, which affects the distribution of electron clouds on the benzene ring, and then affects the related reactivity of the benzene ring. This compound may have a wide application prospect in the field of organic synthesis, and can be used as a key intermediate to participate in the preparation of many complex organic compounds.

Technical Specifications & Labeling

Today there is a product named 1 - (bromomethyl) -4- (difluoromethyl) benzene. To clarify its technical specifications and identification (product parameters), you should take a detailed examination of the school.
Its shape, color and taste must be carefully observed. Observing its color, distinguishing its taste, and examining its shape are the essentials of the first judgment. Its purity geometry and impurity geometry must be accurately determined. Analyze its composition and determine its content in a clever way, so that the data must be conclusive.
On the logo, the name must be correct, and the parameters must be detailed. The text noted must be clear and legible, so that the viewer can see it at a glance. In this way, the correct way to meet the technical specifications and labels can be used by those who use this item to know its details without the risk of misuse.

Preparation Method

The method of making 1- (bromomethyl) -4- (difluoromethyl) benzene is related to the raw materials and production process, reaction steps and catalytic mechanism. The selection of raw materials requires careful selection of suitable products to ensure the purity of the product. The production process needs to be carefully planned, and each step needs to be precisely controlled.
In the reaction step, the specific reactants need to be mixed in sequence, and they should be mixed under suitable temperature and pressure to make them respond slowly. In the meantime, pay close attention to the reaction process and fine-tune the conditions in a timely manner. As for the catalytic mechanism, choose a high-efficiency catalyst to accelerate the reaction and increase the yield. In this way, 1 - (bromomethyl) -4 - (difluoromethyl) benzene can be obtained through various fine operations to meet the needs of scientific research and production.

Chemical Reactions & Modifications

In modern times, chemical refinement has deepened in the research of various compounds. Today there is 1- (Bromomethyl) -4- (Difluoromethyl) Benzene, and its chemical reaction and modification are the needs of our research.
To understand its reaction, we must carefully consider various conditions. Temperature, pressure, and the genus of catalysts all affect its transformation. When the temperature and pressure are appropriate, a good catalyst may be used to promote its efficient transformation. However, the way of reaction often encounters obstacles, and the disturbance of impurities and the generation of side reactions need to be properly dealt with.
As for modification, it is designed to give it new substances. Or adjust its structure and increase its stability; or add its functional groups to expand its uses. It is up to us to explore the best method with ingenuity and practice. After repeated trials, we have found an exquisite way to make 1- (Bromomethyl) -4- (Difluoromethyl) Benzene in the field of chemistry, develop its extraordinary ability, and pave the way for various applications.

Synonyms & Product Names

1 - (bromomethyl) -4 - (difluoromethyl) benzene, this substance is very important in our chemical research. The exploration of its synonyms and trade names is one of the keys to scientific research.
Looking for its synonyms, such as [listing possible synonyms, it is difficult to list accurately because there is no actual background], are all different titles for expressing this substance. And trade names are on the market, or have different names due to differences in manufacturers and uses.
Knowing its synonyms and trade names is conducive to us to accurately locate relevant information during scientific research exchanges and literature access. When purchasing this chemical, we can also find suitable sources according to different trade names. In this way, we can conduct chemical research more efficiently and advance the progress of our scientific research.

Safety & Operational Standards

1- (Bromomethyl) -4- (Difluoromethyl) Benzene Safety and Operation Specifications
Husband 1- (Bromomethyl) -4- (Difluoromethyl) Benzene is also a chemical substance. If you want to do a good job, you must first understand the safety of its operation, so as to obtain its benefits and avoid its harm.
This compound has a certain degree of danger. Its bromomethyl Difluoromethyl, causing its sexual activity. When operating, you need to be careful. The first priority is the prevention of people. It is necessary to take appropriate anti-chemical clothing, including protective chemical clothing and gloves, which must be resistant to the invasion of this chemical product, and meet the requirements of secrecy, so as to separate the skin. It is also necessary to wear anti-steaming eyes, so that the eyes are protected from it, because if you are not careful to enter the eyes, it will cause serious damage. Don't ignore your mouth and nose. Wear a gas mask to prevent steaming and inhalation, so as not to harm the respiratory system.
Operating the environment, it is also necessary to do so. It is advisable to do it in a good way. The power of the device can be used to quickly discharge steaming and prevent it from accumulating. And it is necessary to prohibit open fires and flames. Because the compound or has flammable properties, in case of open flames and high temperatures, it may cause ignition and explosion.
The method of survival also has a fixed price. It is appropriate to place it in a place where it is dry and good. Oxidation, burning and other substances, because of their chemical properties, or strong reaction. The container must be sealed to prevent leakage. And it is clear that there is a danger of leakage, so that the operator knows the problem.
If it is unfortunate to leak, do not panic. Quickly evacuate people to a safe place, and those who are forbidden to do so are close. Those who are in a hurry must take measures to prevent leakage, and deal with it according to the method of. Small leaks can be sucked up by inert materials such as sand and vermiculite, collected and placed in a container, according to the law. If there is a large amount of leakage, it needs to be blocked by the embankment, and moved to the collector with an explosion-proof pump for proper handling.
Therefore, the safe operation of 1- (Bromomethyl) -4- (Difluoromethyl) Benzene must be clarified and guarded in order to ensure human safety, environmental safety and chemical research.

Application Area

Modern chemistry has advanced, and all kinds of new substances have emerged. 1- (Bromomethyl) -4- (Difluoromethyl) Benzene is a compound that has shown its effectiveness in many fields. In the field of pharmaceutical research and development, it may be a key intermediate, which helps the creation of new drugs and is expected to cure all kinds of diseases. In the field of material science, it can be integrated into new materials through special reactions, so that the materials have specific properties, such as better stability and unique optical properties. And in the field of fine chemistry, based on this, a variety of fine chemicals can be derived to meet the needs of industry and life. In various application fields, it is like a shining star, with unlimited potential, waiting for us chemists to explore in depth, so as to show its greater function and benefit the world.

Research & Development

In recent years, I have been focusing on chemical substances, especially the study of 1- (Bromomethyl) -4- (Difluoromethyl) Benzene. This compound has a unique structure and great potential.
At the beginning, I studied its synthesis method. After many attempts, I adjusted the reaction conditions, such as temperature and the ratio of reagents, and strived for accuracy. During this time, I repeatedly encountered difficulties, and the yield did not meet expectations. However, I was not discouraged. After repeated research, I finally obtained a better way.
Then, explore its properties. Observe its physical properties, observe its chemical activity, and understand its changes in different environments. This research lays the foundation for its application.
As for development, the prospect is promising. It can be used to create new types of materials, which may contribute to the development of new drugs in the field of medicine. I will make unremitting efforts to expand its use and contribute to the progress of chemistry.

Toxicity Research

Toxicity of 1 - (bromomethyl) -4 - (difluoromethyl) benzene. This substance has a unique molecular structure, bromomethyl and difluoromethyl are connected to the benzene ring. Preliminary investigation of its chemical properties, or due to the characteristics of bromine and fluorine, it has a certain activity.
In terms of toxicity, bromomethyl is prone to initiate nucleophilic substitution reactions, in vivo, or with nucleophilic groups in cells, interfering with normal biochemical processes. Difluoromethyl also has an effect. Fluorine atoms have strong electronegativity, or change molecular polarity and lipid solubility, making it easier to penetrate biological membranes, thereby affecting cell function.
However, to determine its precise toxicity, multiple methods need to be applied. Cell experiments can be used to observe its effects on the growth and proliferation of different cell lines; animal experiments can also be conducted to explore its toxic effects on the whole organism, such as acute toxicity, sub-chronic toxicity, etc. After a series of studies, the complete picture of 1- (bromomethyl) -4- (difluoromethyl) benzene toxicity can be obtained, providing a solid basis for its safe use and protection.

Future Prospects

The future prospect concerns (1 - (Bromomethyl) -4- (Difluoromethyl) Benzene). I look at its properties, with extraordinary characteristics, and may be able to shine in various fields.
In the chemical industry, it can be a key raw material. After delicate synthesis, it can produce a variety of novel products, which seems to be the key to opening up new paths. In the field of medicine, due to its unique structure, it has the potential to become the cornerstone of innovative drugs, adding new power to the treatment of diseases and diseases. The field of materials is also expected to give rise to materials with specific properties, such as helping to develop high-sensitivity sensing materials and accurately understand environmental changes.
Although there may be thorns in the road ahead, with a heart of research and unremitting exploration, (1- (Bromomethyl) -4- (Difluoromethyl) Benzene) will surely shine, bring well-being to our lives, and open up a new world.

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Frequently Asked Questions

As a leading 1-(Bromomethyl)-4-(Difluoromethyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What is the main use of 1- (Bromomethyl) -4- (Difluoromethyl) Benzene?

1 - (bromomethyl) -4 - (difluoromethyl) benzene, which is a commonly used raw material in the field of organic synthesis. Looking at its structure, bromomethyl and difluoromethyl are attached to the benzene ring, giving it unique chemical activity and can be used as key intermediates in many chemical reactions.
In the field of pharmaceutical chemistry, it is often an important building block for the synthesis of new drug molecules. By modifying and transforming its phenyl ring and substituents, chemists can construct compounds with specific pharmacological activities. For example, by means of nucleophilic substitution reactions, bromine atoms on bromomethyl are replaced by other functional groups, thereby introducing biologically active structural fragments, laying the foundation for the development of new drugs.
In the field of materials science, it also has certain uses. Due to its special structure, it can participate in polymerization reactions, etc., to prepare polymer materials with special properties. If copolymerized with other monomers, it can endow the material with unique physical and chemical properties, such as improving the solubility, thermal stability or optical properties of the material.
In addition, in the synthesis of fine chemical products, 1- (bromomethyl) -4- (difluoromethyl) benzene also plays an important role. It can be used to prepare fragrances, dyes and specialty chemicals. Through a series of chemical reactions, it can be structurally modified to meet the needs of different fine chemical products.
In conclusion, 1- (bromomethyl) -4- (difluoromethyl) benzene has important uses in many fields such as organic synthesis, medicinal chemistry, materials science, and fine chemistry. With its unique structure, it provides key starting materials and intermediates for research and production in various fields.

What are the physical properties of 1- (Bromomethyl) -4- (Difluoromethyl) Benzene

1 - (bromomethyl) -4 - (difluoromethyl) benzene is also an organic compound. It has unique physical properties, which are detailed as follows.
Looking at its physical state, under normal temperature and pressure, it is mostly colorless to light yellow liquid. This state makes it fully mixed and contacted with other substances in many reaction systems, and then participates in chemical reactions.
Smell it, it has a special smell. However, this smell is not a pungent and intolerable genus, but it is also enough to attract attention and can be used as one of the characteristics of preliminary identification.
When it comes to boiling point, it is about a certain temperature range. This temperature value is determined by its intermolecular forces, relative molecular mass and molecular structure. The characteristics of the boiling point are crucial in the process of separating and purifying this compound. By distillation, it can be effectively separated from the mixture according to its boiling point.
As for the melting point, there are also specific values. The level of the melting point is related to the transition conditions between the solid and liquid states of the compound, and is an important consideration in the storage, transportation and application scenarios of substances.
In terms of density, it is larger than water, so if it is mixed with water, it will sink to the bottom of the water. This density characteristic can be used as an important basis for operations involving liquid-liquid separation.
In terms of solubility, it exhibits good solubility in organic solvents such as ethanol, ether, dichloromethane, etc. Due to the principle of "similarity and miscibility", its molecular structure is similar to that of organic solvents, so it can be miscible with each other. However, the solubility in water is very small, and this difference can be well used in chemical experiments and industrial production extraction and separation processes to achieve efficient separation and purification of the compound.
In addition, the vapor pressure of 1- (bromomethyl) -4- (difluoromethyl) benzene also has a specific value, which is related to the equilibrium relationship between the gas phase and the liquid phase. It cannot be ignored in the research and application involving volatilization, diffusion and other processes.
To sum up, the physical properties of 1- (bromomethyl) -4- (difluoromethyl) benzene are interrelated and are of great significance in chemical research, industrial production and other fields, laying the foundation for in-depth understanding and rational use of this compound.

What are the chemical properties of 1- (Bromomethyl) -4- (Difluoromethyl) Benzene?

1 - (bromomethyl) -4 - (difluoromethyl) benzene is also an organic compound. It has unique chemical properties.
In this compound, bromomethyl and difluoromethyl are connected to the benzene ring, resulting in chemical activity different from that of benzene derivatives. Bromomethyl has high bromine atom activity and is prone to nucleophilic substitution. The capped bromine atom has good leaving properties and is often replaced by nucleophilic reagents. In case of alcohol nucleophilic reagents or ether compounds; in case of amines, it becomes an amine substitution product. This property is widely used in organic synthesis and can be used to construct various carbon-heteroatomic bonds by nucleophilic substitution.
The introduction of difluoromethyl makes the compound unique in its properties. Fluorine atoms are very electronegative, and difluoromethyl has a strong electron-withdrawing effect, which affects the electron cloud density distribution of the benzene ring, reducing the density of the adjacent and para-electron clouds of the benzene ring, and the electrophilic substitution reaction activity is different from that of traditional alkylbenzene. It may make the benzene ring more susceptible to nucleophilic attack, while the electrophilic substitution reaction is more difficult to occur in the benzene ring.
Furthermore, difluoromethyl affects the physical properties of molecules, such as boiling point and solubility. The presence of fluorine atoms increases the intermolecular forces, which affect the phase behavior and solubility of compounds in different solvents.
Overall, 1 - (bromomethyl) -4 - (difluoromethyl) benzene is a special substituent with rich chemical properties and may have potential application value in the fields of organic synthesis and materials science. It is an important intermediate for the synthesis of compounds with specific properties.

What is the preparation method of 1- (Bromomethyl) -4- (Difluoromethyl) Benzene?

The preparation method of 1- (bromomethyl) -4- (difluoromethyl) benzene is often the way of chemical synthesis. The preparation method is described in detail below.
First, 4- (difluoromethyl) benzoic acid can be started. First, 4- (difluoromethyl) benzoic acid is co-heated with thionyl chloride. This reaction is as said in the ancient method. "If the acid is co-heated with the agent of acid chloride, the acid will be converted to acid chloride" to obtain 4- (difluoromethyl) benzoyl chloride. After the reaction is completed, it is extracted with a suitable solvent such as dichloromethane and purified by distillation. Then, 4- (difluoromethyl) benzoyl chloride is reacted with lithium aluminum hydride in an ether solvent, and "when the acid chloride encounters lithium aluminum hydride, it is reduced to alcohol" to generate 4- (difluoromethyl) benzyl alcohol. After the reaction, it is processed by hydrolysis, extraction, drying and other steps. Finally, 4- (difluoromethyl) benzyl alcohol reacts with phosphorus tribromide, "when the alcohol encounters phosphorus tribromide, the hydroxyl group is replaced by bromine" to obtain 1- (bromomethyl) -4- (difluoromethyl) benzene. The product also needs to be purified by distillation and recrystallization.
Second, 4- (difluoromethyl) toluene is used as raw material. Under the presence of light or initiator, 4- (difluoromethyl) toluene is reacted with N-bromosuccinimide (NBS). This reaction "When light or initiator is present, the methyl group of toluene can be replaced by the bromine of NBS", and an appropriate amount of carbon tetrachloride is often added to the reaction system as a solvent. After the reaction is completed, 1- (bromomethyl) -4- (difluoromethyl) benzene can be obtained by separation, washing, drying, etc. The product is further purified by column chromatography.
Although the methods for preparing 1- (bromomethyl) -4- (difluoromethyl) benzene are different, it is necessary to pay attention to the control of reaction conditions and the purification of the product in order to obtain a pure target product.

What are the precautions for 1- (Bromomethyl) -4- (Difluoromethyl) Benzene in storage and transportation?

1 - (bromomethyl) -4 - (difluoromethyl) benzene is also an organic compound. During storage and transportation, many matters must be paid attention to.
First words storage, this compound should be placed in a cool, dry and well ventilated place. Because of its certain chemical activity, it is easy to react when heated or wet, which will damage its quality. The temperature should be controlled within a specific range to prevent decomposition and deterioration. And it should be kept away from fire and heat sources. Due to the risk of flammability, open flames or hot topics can cause danger. It must also be separated from oxidizing agents, strong bases and other substances, and it is easy to react violently when in contact with them.
As for transportation, it must be in accordance with relevant regulations and standards. The packaging must be tight and reliable to ensure that there is no leakage during the journey. Select suitable packaging materials to withstand vibration, collision and temperature changes. Transportation vehicles also need to have corresponding safety facilities, such as fire extinguishers, for emergencies. Transport personnel must be professionally trained to be familiar with the characteristics of this compound and emergency disposal methods. During transportation, always pay attention to environmental factors such as temperature and humidity to ensure that the transportation environment is suitable. Never mix with contraband substances to avoid accidents. In this way, the safety of 1 - (bromomethyl) -4 - (difluoromethyl) benzene during storage and transportation can be guaranteed.