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1-(Bromomethyl)-4-(Difluoromethoxy)Benzene

1-(Bromomethyl)-4-(Difluoromethoxy)Benzene

Hongda Chemical

Specifications

HS Code

830641

Chemical Formula C8H7BrF2O
Molecular Weight 237.04
Appearance Typically a colorless to light - yellow liquid
Boiling Point Data may vary, but around 190 - 210 °C under normal pressure
Density Approx. 1.5 - 1.7 g/cm³
Solubility In Water Insoluble in water
Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform
Flash Point Caution, potentially flammable, flash point around 70 - 90 °C
Vapor Pressure Low vapor pressure at room temperature
Stability Stable under normal storage conditions, but reactive to strong bases and nucleophiles
Packing & Storage
Packing 500g of 1-(bromomethyl)-4-(difluoromethoxy)benzene in sealed, chemical - resistant containers.
Storage 1-(Bromomethyl)-4-(difluoromethoxy)benzene should be stored in a cool, dry, well - ventilated area away from heat sources and ignition sources. It should be kept in a tightly closed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents, bases, and reactive compounds to prevent potential chemical reactions.
Shipping 1-(Bromomethyl)-4-(difluoromethoxy)benzene is a chemical. Shipping requires proper packaging in accordance with hazardous material regulations, ensuring leak - proof containment and clear labeling for safe transport.
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1-(Bromomethyl)-4-(Difluoromethoxy)Benzene 1-(Bromomethyl)-4-(Difluoromethoxy)Benzene
General Information
Historical Development
The historical development of 1- (Bromomethyl) -4- (Difluoromethoxy) Benzene
Guanfu 1- (Bromomethyl) -4- (Difluoromethoxy) Benzene, in the field of chemistry, when it first emerged, its properties were not yet known. In the early days, many chemists dedicated themselves to the exploration of various compounds and searched for a long time in organic synthesis.
At that time, many scholars focused on the research of halogenated aromatics, hoping to expand their applications. With the improvement of experimental techniques and the completion of analytical methods, more and more researchers noticed the 1- (Bromomethyl) -4- (Difluoromethoxy) Benzene of this special structure. Everyone made unremitting efforts to deeply analyze its reaction characteristics. After repeated trials, it is clear that it can be used as a key intermediate in many organic reactions, and it shows potential value in the fields of medicine and material synthesis. Therefore, its research has become increasingly prosperous, and it has been continuously promoted to move forward steadily in the chemical development process, laying the foundation for subsequent wide application.
Product Overview
1- (Bromomethyl) -4- (Difluoromethoxy) Benzene is also an organic compound. Its shape may be a colorless liquid with a special odor. The structure of this compound is based on a phenyl ring, one-dibromomethyl on the ring, and four-difluoromethoxy. Because of its unique chemical structure, it has attracted much attention in the field of organic synthesis.
Its preparation method, or by multi-step reaction. This compound can be obtained by taking a suitable benzene derivative as the starting material and by various reaction steps such as halogenation and etherification. In organic synthesis, it is often used as a key intermediate and can participate in many reactions, such as nucleophilic substitution reactions, through which different functional groups are introduced to construct complex organic molecular structures. It has potential application value in the fields of medicine, pesticides and materials science, and is an important object of organic chemistry research.
Physical & Chemical Properties
1- (Bromomethyl) -4- (difluoromethoxy) Benzene is also an organic compound. Its physical and chemical properties are quite important to chemical researchers. Looking at its physical properties, at room temperature, or in a liquid state, it has a certain boiling point and melting point, which is related to the strength of its intermolecular forces. Its color or colorless and transparent, and its taste or special aroma. As for chemical properties, its activities are different due to the presence of bromomethyl and difluoromethoxy groups. Bromomethyl can participate in the nucleophilic substitution reaction, which is the main place for introducing other groups. Difluoromethoxy affects the electron cloud distribution of molecules, which is related to its stability and reaction tendency. In the field of organic synthesis, this compound can be used as a key raw material to produce a variety of products with special properties. Its physical and chemical properties are of great significance in chemical research and industrial production.
Technical Specifications & Labeling
1- (Bromomethyl) -4- (Difluoromethoxy) Benzene is also an organic compound. Its preparation is related to the delicacy of the chemical industry. To make this product, you must follow the precise method. The choice of raw materials and the accurate ratio are all important matters. The reaction environment, the control of temperature and humidity, should not be sparse.
The evaluation of its quality has various standards. Outside observation, it should have a specific color state. The measurement of purity, measured by precision, must reach the specified number. The inspection of impurities is meticulous and there should be no difference. In this way, only qualified products should be used for various purposes and meet the needs of industry and scientific research.
Preparation Method
1- (Bromomethyl) -4- (Difluoromethoxy) Benzene is an organic compound, and its preparation method is very important. In terms of raw material selection, when starting with p-hydroxyanisole and difluorobromomethane, both are readily available chemical reagents. The synthesis process is as follows: first dissolve p-hydroxyanisole in a suitable organic solvent, such as dichloromethane, and slowly add alkali under low temperature stirring to activate the phenolic hydroxyl group. Then add difluorobromomethane and heat up when the reaction number is refluxed. When the reaction is completed, the reaction solution is cooled, washed with dilute acid, and then extracted with an organic phase. After the extract is dried with anhydrous sodium sulfate, the solvent is removed by distillation under reduced pressure to obtain a crude product. In order to improve the purity, column chromatography is required, and the mixture of petroleum ether and ethyl acetate is used as the eluent to obtain pure 1- (Bromomethyl) -4- (Difluoromethoxy) Benzene. In this preparation process, precise control of the reaction conditions and the specification of each step are the keys to ensure the quality and yield of the product.
Chemical Reactions & Modifications
I try to study the chemical reaction and modification of this 1- (Bromomethyl) -4- (Difluoromethoxy) Benzene. Its material is also related to the chemical industry, and it is of great use in the synthesis process.
The initial reaction, the conditions may not be perfect, and the yield is not high. I thought deeply about it, and wanted to change it, but to adjust the temperature of the reaction, change the ratio of the reactants, and choose a suitable catalyst. After many tests, when the temperature is at a certain value and the ratio is appropriate, a good agent is added, and the reaction effect is gradually improved, and the yield is also improved.
The structure is also considered, and the method of chemical modification is considered to increase its performance. Or add groups, or change bonds, so that in specific scenes, can develop better properties. After this study, this compound is expected to have better performance in materials, medicine and other fields, contributing to the progress of chemistry.
Synonyms & Product Names
1 - (bromomethyl) -4- (difluoromethoxy) benzene, this substance is quite crucial in the study of chemistry. Its synonymous names and commodity names need to be explored in detail.
In the field of Guanfu chemistry, there are many names derived from one thing and many things, or due to different synthesis paths or different applications. 1 - (bromomethyl) -4- (difluoromethoxy) benzene also has other names. These synonymous names are like a list of stars, each of which contains bits and pieces of related research.
As for the name of the product, merchants recognize its characteristics, or give it a unique logo according to its use or process. Knowing its synonymous name and the name of the product is of great help in research, exchange and discussion, allowing us to accurately grasp this object and proceed unimpeded in the path of chemical research.
Safety & Operational Standards
1- (Bromomethyl) -4- (Difluoromethoxy) Benzene Safety and Operation Specifications
Husband 1- (Bromomethyl) -4- (Difluoromethoxy) Benzene is also a chemical product, and its safe operation is very important, so you can't be careless.
The first word is the way to store it. It should be placed in a place that is dry and well-connected, and it should be a source of fire and energy to avoid ignition and explosion. The device should be kept in good condition, and it should not be oxidized, oxidized, and other substances should be combined to prevent the disease of biochemical reactions.
The second time and the operation of it. The person who operates this product must be subject to it, knowing the importance of operation. During operation, the weasel must wear suitable anti-damage, such as anti-eye protection, which can protect the eyes from its damage; gas mask, which can block harmful damage; corrosion-resistant gloves and work clothes, to prevent the skin from connecting. Operating the place, the communication must be good, and if necessary, it can be arranged in a row to dissipate harmful steam.
Furthermore, if it is unfortunate that there is a leakage. That is, it is isolated, and it is forbidden for people to approach. Quickly cut the fire source to prevent damage from being large. A small amount of leakage can be absorbed by inert materials such as sand and vermiculite, and collected in a dense container for proper handling. If there is a large amount of leakage, it needs to be plugged. Use an explosion-proof pump to move it to the container and hand it over to the container.
If you accidentally pick up this product. If the skin is exposed, wash it with a large amount of flowing water immediately, and then wash it with soap. If there is any problem, it will be treated as soon as possible. When the eyes are connected, lift the eyes immediately and wash them with flowing water or physiological water, which also needs to be done. If you inhale its steam, quickly reach the air to be fresh and keep breathing. If you are sleepy, give oxygen. It is necessary to perform artificial respiration, and send it immediately.
Therefore, the safe operation of 1- (Bromomethyl) -4- (Difluoromethoxy) Benzene can be carried out with care and compliance, so as to ensure personal safety, avoid environmental harm, and make chemical research and life good.
Application Area
Today there is a product called 1- (Bromomethyl) -4- (Difluoromethoxy) Benzene. The application field of this compound is quite wide.
In the field of pharmaceutical research and development, it can be used as a key intermediate to help create new drugs to treat various diseases. Because of its unique chemical structure, it may interact with specific targets in organisms to exert pharmacological effects.
In the field of materials science, it also has its uses. It can be introduced into polymer systems through specific reactions to improve the properties of materials, such as improving the stability and weather resistance of materials.
Furthermore, in the field of fine chemicals, this compound can participate in the synthesis of a variety of high-value-added fine chemicals to meet the special needs of different industries. All of these show the important value of 1- (Bromomethyl) -4- (Difluoromethoxy) Benzene in many application fields.
Research & Development
In recent years, I have specialized in the field of chemistry, specializing in the study of a product named 1- (bromomethyl) -4- (difluoromethoxy) benzene. The properties of this product are related to organic synthesis and have a wide range of uses.
At the beginning, explore the method of its preparation, and the selection of raw materials and reaction conditions need to be considered. Temperature, pressure, and catalyst dosage are slightly different, and the results are very different. After repeated tests, a suitable path is finally obtained, and the yield is gradually improved.
Then, study its performance in different reaction systems. Interact with various reagents, observe the formation of products, and analyze the reaction mechanism. In this process, gain insight into the laws of its chemical activity, paving the way for subsequent applications.
Looking to the future, we hope to develop new synthetic routes and develop novel compounds based on this substance. In the fields of medicine, materials, etc., we will find its application, promote the development of the industry, and do our best for the progress of chemistry.
Toxicity Research
In the study of toxicology, bromomethyl-4- (difluoromethoxy) benzene is very important. Whether its sex is strong or not is related to the safety of all things.
Looking at past studies, such compounds may have different effects. Or disturb the metabolism of organisms and disrupt their physiological order; or invade the structure of cells and damage their normal ability.
Now in the world, the toxicity of this substance has not been fully studied. To know its nature in detail, we should follow the scientific method and devise exquisite tests. Select all kinds of objects to be tested, observe their exposure, observe changes in physiology and behavior.
Record the obtained numbers in detail, and analyze their inner laws. In this way, the true appearance of the toxicity of Fangdeming bromomethyl-4- (difluoromethoxy) benzene paves the way for future generations to use this product to protect the environment and personal safety, so as not to cause various disasters due to unknown harm.
Future Prospects
The Prospect of the Future, in the field of materials, 1- (Bromomethyl) -4- (Difluoromethoxy) Benzene This product has something to hope for. Its characteristics are special, or it can be used in new research to cure the world's diseases. The way to do it is to seek refinement. If this product can be used in it, it may be the foundation of a good prescription.
And in the field of materials, it is also expected to be a new environment. In this world, materials seek innovation and seeking new things. This product or material uses its characteristics to increase its performance, change its performance, and use it in general utensils to make life convenient.
It is also the way to synthesize, not refined. Start with this product, or you can explore new things and create more strange things. In the future, the research is unremitting, and it is hoped that the power of this product will be excavated, benefiting the world and achieving extraordinary achievements.
Frequently Asked Questions
What is the main use of 1- (Bromomethyl) -4- (Difluoromethoxy) Benzene?
1 - (bromomethyl) -4 - (difluoromethoxy) benzene, an organic compound, has a wide range of uses and plays a key role in the field of organic synthesis.
First, in the process of creating medicine, it can be used as an important intermediate. Because of its bromomethyl and difluoromethoxy groups in the structure, it has unique reactivity. For example, bromomethyl can be combined with many nucleophiles containing nitrogen and oxygen through nucleophilic substitution reactions to build a molecular structure with specific physiological activities. With such reactions, drugs for specific diseases, such as antiviral and anti-tumor drugs, can be prepared. The introduction of difluoromethoxy can adjust the lipid solubility and electron cloud distribution of molecules, enhance the affinity between drugs and targets, and improve drug efficacy.
Second, it is also indispensable in the research and development and manufacturing of pesticides. By structural modification and derivatization of it, high-efficiency, low-toxicity and environmentally friendly pesticides can be prepared. For example, after appropriate reaction, the compound can have high selective toxicity to specific pests, but has a slight impact on beneficial insects and the environment. Its structural properties can help the compound better adhere to the surface or enter the body of pests, interfere with the physiological metabolic process of pests, and achieve the purpose of pest control.
Third, in the field of materials science, 1- (bromomethyl) -4- (difluoromethoxy) benzene can be used to synthesize polymer materials with special functions. Bromomethyl can be used as the initiation point or cross-linking point of the polymerization reaction, which prompts the monomer to polymerize and build a polymer. The presence of difluoromethoxy can endow the material with unique properties, such as enhancing the weather resistance, chemical stability and low surface energy of the material. Such materials may be used in coatings, plastics and other industries to improve the quality and performance of products.
What are the physical properties of 1- (Bromomethyl) -4- (Difluoromethoxy) Benzene
1 - (bromomethyl) -4 - (difluoromethoxy) benzene, this is an organic compound. Looking at its structure, bromomethyl and difluoromethoxy are connected to the benzene ring. Its physical properties are unique, let me tell you one by one.
Discussing the properties, under normal circumstances, it may be a colorless to pale yellow liquid. This is because of its molecular structure, the conjugated system of the benzene ring interacts with the substituent group, resulting in its appearance. And due to the moderate polarity of the molecule, this form exists at room temperature and pressure.
is related to the boiling point, about a certain range. The introduction of bromomethyl and difluoromethoxy groups changes the intermolecular force. The bromine atom has a large atomic weight and a certain polarity, and the difluoromethoxy group also has polarity, which enhances the intermolecular force, so the boiling point is higher than that of benzene. However, the specific value still needs to be accurately determined according to the experiment. Generally, it is speculated that it is in a certain range due to different experimental conditions or slight differences.
As for the melting point, due to the relatively regular molecular structure and the arrangement or order between molecules, the melting point is also within a specific range. However, the steric resistance and electronic effect of the substituent group also affect the close accumulation of molecules, so the melting point is not very high.
In terms of solubility, since it is an organic compound, it can be soluble in common organic solvents such as ether and dichloromethane according to the principle of similar miscibility. The non-polar part of the benzene ring is compatible with the non-polar part of the organic solvent, while the bromomethyl group and the difluoromethoxy group have a certain polarity, but the whole still has good compatibility with the organic solvent. However, the solubility in water is not good, because the molecular polarity is not enough to overcome the hydrogen bonding of water, so it is difficult to dissolve in water.
1- (bromomethyl) -4- (difluoromethoxy) benzene has such physical properties because of its unique molecular structure. Each group affects each other to shape its physical properties.
What are the synthesis methods of 1- (Bromomethyl) -4- (Difluoromethoxy) Benzene
For the synthesis of 1 - (bromomethyl) -4 - (difluoromethoxy) benzene, please refer to the following methods.
First, start with 4-hydroxybenzaldehyde and react with difluoromethyl halide in an alkaline environment to obtain 4 - (difluoromethoxy) benzaldehyde. This reaction requires controlling the temperature and the ratio of reactants to achieve the best yield. After that, 4 - (difluoromethoxy) benzaldehyde is converted into 4 - (difluoromethoxy) benzyl alcohol by reduction reaction, such as sodium borohydride and other reducing agents. Then 4- (difluoromethoxy) benzyl alcohol is reacted with halogenated reagents such as hydrobromic acid or phosphorus bromide to obtain 1- (bromomethyl) -4- (difluoromethoxy) benzene.
Second, starting from p-cresol, difluoromethoxy is first introduced by difluoromethoxy. Then the methyl is oxidized, such as with an oxidizing agent such as potassium permanganate, to obtain 4- (difluoromethoxy) benzoic acid. Then 4- (difluoromethoxy) benzoic acid is reacted with a reducing agent such as lithium aluminum hydride to obtain 4- (difluoromethoxy) benzyl alcohol. Finally, 4 - (difluoromethoxy) benzyl alcohol is treated with a halogenating agent in the same method as before to obtain the target product.
Furthermore, using 4-bromoanisole as raw material, the methoxy group is first converted into difluoromethoxy group, which can be achieved through multi-step reaction. After methylation of the bromine atom ortho-site on the benzene ring, and then methyl bromide, 1- (bromomethyl) -4- (difluoromethoxy) benzene can also be obtained. In this process, the precise control of the reaction conditions at each step is very critical, such as the reaction temperature, reaction time, and the choice of catalyst, which all affect the purity and yield of the product. During synthesis, appropriate methods and conditions should be selected according to the actual situation to achieve the purpose of efficient synthesis.
What are the precautions for 1- (Bromomethyl) -4- (Difluoromethoxy) Benzene in storage and transportation?
1 - (bromomethyl) -4 - (difluoromethoxy) benzene is also an organic compound. During storage and transportation, many matters must be paid attention to.
Bear the brunt, when storing, choose a cool, dry and well-ventilated place. This compound is afraid of heat. If it is exposed to a high temperature environment, it may cause its chemical properties to be unstable or even cause danger. Therefore, the warehouse temperature should be controlled within a suitable range, and it is necessary to avoid open fires and hot topics to prevent accidents.
Furthermore, this material is toxic and corrosive, and contact can be harmful to the human body. During storage, the container must be well sealed to prevent leakage. In case of accidental leakage, the surrounding people should quickly leave the scene, go to a safe place, and strictly prohibit unrelated personnel from approaching. When handling leaks, professional protective equipment is required, and operations are carried out according to standardized procedures to avoid harming yourself.
During transportation, caution is also required. The transportation tools used should be clean, dry, and free of other substances that can react with them. The transportation vehicle should be equipped with corresponding fire protection equipment and leakage emergency treatment equipment for emergencies.
The escort personnel must be familiar with the characteristics of this object and emergency disposal methods. The transportation process must be stable to avoid bumps and vibrations to prevent leakage due to damaged packaging.
In short, the storage and transportation of 1- (bromomethyl) -4- (difluoromethoxy) benzene are all related to safety, and it is necessary to operate in strict accordance with regulations without any slack to ensure safety.
What is the market price of 1- (Bromomethyl) -4- (Difluoromethoxy) Benzene?
Today there is 1- (bromomethyl) -4- (difluoromethoxy) benzene, and its market price is difficult to determine. The price of this compound often varies for a variety of reasons.
First, the preparation process is simple and simple. If the preparation method is simple, the required raw materials are easily available and affordable, and no special equipment and harsh conditions are required, the cost may be low, and the market price may not be high. On the contrary, if the process is complicated, rare raw materials are required, and the energy consumption in the preparation process is quite large, and the equipment requirements are strict, the cost will rise and the price will be high.
Second, the state of market supply and demand is also the key. If there is strong demand for this product in the fields of medicine, chemical industry, etc., but the supply is limited, the merchant will raise the price because of its shortage. If the market demand is weak, but the production supply is sufficient, the price may be reduced for promotional sales.
Furthermore, the difference between manufacturers also leads to price differences. Large factories often have low prices due to scale effects, controllable costs, stable product quality, and competitive prices. If small factories have insufficient production technology, difficult to control costs, and high prices and poor quality products.
Again, regional factors cannot be ignored. Prices vary in different places due to differences in transportation costs, tax policies, and market environments. In places with convenient transportation and industrial agglomeration, the price may be relatively easy; in remote places, due to the superposition of transportation and other costs, the price may be high.
Therefore, in order to know the exact market price of 1- (bromomethyl) -4- (difluoromethoxy) benzene, the above factors must be carefully considered, and always pay attention to the dynamic situation of the chemical market.