What are the main uses of 1- (Bromomethyl) -3- (Trifluoromethyl) Benzene?
1 - (bromomethyl) -3- (trifluoromethyl) benzene, its main use is quite extensive.
In the field of organic synthesis, this is a key intermediate. First, it can interact with many nucleophiles, such as alcohols, amines, and mercaptans, through nucleophilic substitution reactions. Taking the reaction with alcohols as an example, in the presence of suitable bases, bromine atoms can be replaced by alcoholoxy groups to form ether compounds, which are of great significance in the fields of pharmaceutical chemistry and materials science. Many drug molecules and functional materials contain ether bond structures. When reacted with amines, amino-substituted products are formed, which are either bioactive or used as ligands in the field of coordination chemistry, and play an important role in catalysis and material synthesis.
Second, in the reaction of building carbon-carbon bonds, 1- (bromomethyl) -3- (trifluoromethyl) benzene also plays a key role. For example, it can participate in palladium-catalyzed cross-coupling reactions, such as Suzuki coupling, Stille coupling, etc. In the Suzuki coupling reaction, combined with boron-containing reagents, diverse biphenyl derivatives can be efficiently constructed. Such derivatives are widely used in liquid crystal materials, organic Light Emitting Diode (OLED) and other fields, which can optimize the photoelectric properties of materials.
Third, the presence of trifluoromethyl in the molecule endows it with unique physical and chemical properties. Trifluoromethyl has strong electron absorption, which can change the electron cloud density and polarity of molecules, thereby affecting the solubility, stability and biological activity of compounds. In the field of drug development, the introduction of this structural unit may improve the metabolic stability, lipophilicity and binding ability of drugs to targets, helping to create new drugs with more efficient and low toxicity.
In addition, 1- (bromomethyl) -3- (trifluoromethyl) benzene is also used in material surface modification. It can be grafted to the surface of the material through chemical reaction, and the properties of trifluoromethyl can be used to improve the wettability and corrosion resistance of the material surface. It shows potential value in the modification treatment of coatings, plastics and other materials.
What are the physical properties of 1- (Bromomethyl) -3- (Trifluoromethyl) Benzene
1 - (bromomethyl) -3 - (trifluoromethyl) benzene is also an organic compound. Its physical properties are crucial and related to many practical applications.
This compound is mostly in a liquid state at room temperature, with specific fluidity and moderate viscosity. It can smoothly participate in reactions in many reaction systems, just like agile water flowing between ditches. Looking at its color, the pure one is often colorless and transparent, like a clear stream, with good visibility and easy observation and operation.
Its boiling point also has characteristics, about a certain temperature range, this temperature value is extremely important for the separation and purification of this compound. Just as the boiling of water is controlled by heat, the boiling point can be precisely grasped, and it can be cleverly separated from the mixture.
Melting point is also an important parameter. At a certain low temperature, it will gradually change from liquid to solid, such as river water freezing in cold. This property is quite meaningful for storage and specific reaction conditions.
Furthermore, in terms of solubility, it shows good solubility in common organic solvents, such as ethanol, ether, etc., just like salt dissolving in water, it can be evenly dispersed, which is conducive to the development of various chemical reactions in solution systems. However, the solubility in water is not good, just like the incompatibility of oil and water, and this property also affects its behavior in different environments. The density of
also has a fixed number, which is lighter or heavier than that of water. This property has a significant impact when it comes to operations such as stratification. If oil and water are stratified due to density differences, this compound will also exhibit a specific distribution in the relevant system according to its density.
The physical properties of 1 - (bromomethyl) -3 - (trifluoromethyl) benzene are diverse and unique, and each property is interrelated. It plays an important role in many fields such as chemical synthesis, separation and purification, storage and transportation, and needs to be carefully grasped and applied.
What are the synthesis methods of 1- (Bromomethyl) -3- (Trifluoromethyl) Benzene
1 - (bromomethyl) -3 - (trifluoromethyl) benzene, the synthesis method is as follows:
First, 3 - (trifluoromethyl) benzoic acid is used as the starting material. First, 3 - (trifluoromethyl) benzoic acid and methanol are esterified under the catalysis of concentrated sulfuric acid, which is the classic esterification path. Concentrated sulfuric acid as a catalyst can promote the reaction of benzoic acid and methanol to form 3 - (trifluoromethyl) benzoate methyl ester. The reaction needs to be carried out under heating conditions, and attention should be paid to controlling the temperature and reaction time to obtain a higher yield. Subsequently, 3 - (trifluoromethyl) benzyl alcohol was obtained by reducing methyl 3- (trifluoromethyl) benzoate with lithium aluminum hydride (LiAlH) as a reducing agent. LiAlHhas strong reducing properties, and the reaction needs to be operated under specific conditions such as anhydrous and low temperature to ensure safety and smooth reaction. Finally, 3 - (trifluoromethyl) benzyl alcohol is reacted with phosphorus tribromide (PBr 🥰). After this substitution reaction, the hydroxyl group is replaced by a bromine atom to obtain 1- (bromomethyl) -3- (trifluoromethyl) benzene. This reaction is relatively mild, but it is still necessary to pay attention to the control of reaction conditions, such as temperature, reactant ratio, etc.
Second, 3- (trifluoromethyl) toluene is used as the starting material. First, the bromination reaction of 3- (trifluoromethyl) toluene is carried out. N-bromosuccinimide (NBS) can be selected as the bromination reagent, and benzoyl peroxide (BPO) is used as the initiator to carry out the reaction under light conditions. NBS can provide bromine free radicals, and BPO decomposes under light to produce free radicals, initiating the replacement of hydrogen atoms on the methyl side chain of 3- (trifluoromethyl) toluene by bromine atoms to generate 1- (bromo methyl) -3- (trifluoromethyl) benzene. The reaction conditions are relatively easy to control and the lighting conditions are relatively easy to achieve, but attention should be paid to the purity of the reaction system and the monitoring of the reaction process to prevent side reactions, such as the formation of polybrominated products.
What are the precautions for 1- (Bromomethyl) -3- (Trifluoromethyl) Benzene in storage and transportation?
1 - (bromomethyl) -3 - (trifluoromethyl) benzene is also an organic compound. During storage and transportation, many matters must be observed.
First storage, this compound is active and sensitive to environmental factors, so it needs to be placed in a cool, dry and well ventilated place. Avoid open flames and hot topics to avoid the risk of fire and explosion. Because of its flammability and reactivity, it is easy to cause violent reactions when exposed to hot topics or open flames. And the warehouse temperature should be strictly controlled. Excessive temperature can cause the decomposition of compounds or accelerate reactions, damage their quality, or even cause dangerous accidents.
Furthermore, when storing, it must be stored separately with oxidizing agents, strong alkalis and other substances. 1 - (bromomethyl) -3 - (trifluoromethyl) benzene encounters such substances, which is prone to chemical reactions, or produces harmful gases, or causes combustion and explosion. Such as strong oxidizing agents, which can seize their electrons and cause violent oxidation reactions; strong bases can interact with active groups in compounds and cause unpredictable reactions.
As for transportation, caution is also required. Appropriate packaging materials should be selected to ensure that the packaging is complete and sealed. Special chemical packaging containers are often used to prevent leakage. During transportation, the vehicle must run smoothly to avoid bumps and vibrations, and avoid leakage caused by package damage.
And when transporting, it should not be mixed with contraband substances. Transportation personnel should be familiar with emergency treatment methods, and in case of leakage, they can take effective measures quickly to minimize the harm.
In summary, when storing and transporting 1- (bromomethyl) -3- (trifluoromethyl) benzene, it is necessary to pay attention to environmental conditions, isolate contraindicated substances, ensure that the packaging is intact, and enable relevant personnel to have emergency response capabilities, so as to ensure their safety and avoid accidents.
What is the approximate market price of 1- (Bromomethyl) -3- (Trifluoromethyl) Benzene?
For 1 - (bromomethyl) -3- (trifluoromethyl) benzene, its market value is roughly a few, and this is not enough. It is determined by its quality, and it is made by various reasons.
First, the raw materials are low. The production of this compound requires specific raw materials. If the raw materials are abundant and flat, the benzene is low or low; if the raw materials are dilute and difficult to find, it is high.
Second, the production method is high. The method of making, or complex or low. If the process requires multiple steps, and each step requires precise control of the components, the cost will also be high, and the market price will also increase accordingly.
Third, the supply and demand of the city. If the demand in the market is low, and the supply is limited, the supply is not low, and its price must be low; if the supply is low, the road is low, and the quick sale is low, the price may be low.
Fourth, the difference between the two families. Different companies, due to poor technology, good management, and different costs, the price is also different. Those with precise technology and proper management have controllable costs, or there may be low costs; no, low or high.
Therefore, in order to determine the market value of 1- (bromomethyl) -3- (trifluoromethyl) benzene, there are general factors to be considered. However, in general, in the chemical industry, its price per gram may be between 10 and 100 yuan, depending on the above factors.