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1-(Bromomethyl)-3-(Trifluoromethyl)Benzene

1-(Bromomethyl)-3-(Trifluoromethyl)Benzene

Hongda Chemical

Specifications

HS Code

820967

Chemical Formula C8H6BrF3
Molecular Weight 239.03
Appearance Liquid (usually)
Boiling Point Data depends on purity, around a certain value related to its structure
Density Depends on conditions, but has a characteristic value for pure substance
Solubility In Water Low solubility in water
Solubility In Organic Solvents Soluble in many organic solvents like dichloromethane, toluene
Flash Point Related to its flammability, has a specific value
Vapor Pressure Varies with temperature, has a temperature - dependent value
Stability Stable under normal conditions, but can react with strong bases, nucleophiles
Packing & Storage
Packing 100g of 1-(bromomethyl)-3-(trifluoromethyl)benzene packaged in a sealed glass bottle.
Storage 1-(Bromomethyl)-3-(trifluoromethyl)benzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. It should be kept in a tightly sealed container, preferably made of corrosion - resistant materials. Due to its potential reactivity, store it separately from oxidizing agents, bases, and other incompatible substances to prevent hazardous reactions.
Shipping 1-(Bromomethyl)-3-(trifluoromethyl)benzene is shipped in specialized, sealed containers. It adheres to strict chemical shipping regulations to ensure safe transit due to its potentially hazardous nature.
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1-(Bromomethyl)-3-(Trifluoromethyl)Benzene 1-(Bromomethyl)-3-(Trifluoromethyl)Benzene
General Information
Historical Development
1- (Bromomethyl) -3- (Trifluoromethyl) Benzene is also an organic compound. At the beginning of the study of its product, everyone had not yet explored the wonders of organic synthesis. At that time, all kinds of technologies were still in their infancy, and it was difficult to make this product.
However, with the passage of time, the field of organic chemistry has advanced by thousands of miles. Chemists have made unremitting research, and they have made progress in reaction mechanism, raw material ratio, and condition control. Syntheses that were difficult to achieve in the past are now getting better.
Looking at its development path, it is like sailing against the current, and every step depends on the persistence and wisdom of researchers. From the beginnings of ignorance to the gradual maturation of the process, 1- (Bromomethyl) -3- (Trifluoromethyl) Benzene has gradually expanded its use in medicine, materials, and other industries, with promising prospects. It has also added luster to the brilliance of organic chemistry.
Product Overview
1- (Bromomethyl) -3- (Trifluoromethyl) Benzene, this substance is a useful reagent in organic synthesis. Its properties are colorless to light yellow liquid at room temperature, with a special odor and certain volatility. In its structure, above the benzene ring, bromomethyl and trifluoromethyl are in an intermediate position, which gives it unique chemical activity.
In the field of organic synthesis, it is often used as an alkylation reagent. With the activity of bromine atoms, it can be substituted with many nucleophilic reagents to introduce the benzyl structure containing trifluoromethyl, which is widely used in pharmaceutical chemistry, materials science and other fields. Because of its strong electron absorption, trifluoromethyl can significantly change the physicochemical properties and biological activities of molecules, providing an effective way to create novel compounds.
Physical & Chemical Properties
1- (Bromomethyl) -3- (trifluoromethyl) benzene is an organic compound with unique physical and chemical properties. Looking at its physical properties, it is mostly colorless to light yellow liquid at room temperature, with a special odor. Its boiling point, melting point and density are affected by the presence of bromomethyl and trifluoromethyl in the molecular structure. The boiling point or due to the change of intermolecular forces is in a specific range, and the density varies depending on the type and arrangement of atoms.
In terms of its chemical properties, bromomethyl is active and easily participates in nucleophilic substitution reactions, such as reacting with nucleophilic reagents such as alcohols and amines to form new compounds. Trifluoromethyl has strong electron-absorbing properties, which changes the electron cloud density of the benzene ring and affects the substitution activity and selectivity on the benzene ring. This compound is widely used in the field of organic synthesis and can be used as an intermediate to prepare medicines, pesticides and functional materials, etc., to promote the development of organic chemistry.
Technical Specifications & Labeling
1- (Bromomethyl) -3- (Trifluoromethyl) Benzene is an important organic compound. Its preparation process needs to be precisely controlled. The selection of raw materials should be of high purity, and the reaction conditions are also crucial. The temperature needs to be constant in a specific range, and the pressure must also meet the standard.
To identify this product, strict Quality Standards must be followed. The appearance should be clear and colorless, and the purity test must be carried out with the help of high-end instruments to ensure that the impurity content is extremely low. The parameters are accurate and accurate to meet the specifications of the product. In this way, high-quality 1- (Bromomethyl) -3- (Trifluoromethyl) Benzene can be produced to meet the needs of all parties.
Preparation Method
To prepare 1- (Bromomethyl) -3- (Trifluoromethyl) Benzene, it is necessary to clarify its raw materials, production process, reaction steps and catalytic mechanism.
The preliminary raw material is 3- (Trifluoromethyl) toluene as the starting material, which is the key raw material. The reaction steps are as follows: Place 3- (Trifluoromethyl) toluene in a reactor, add an appropriate amount of bromine, and use benzoyl peroxide as the initiator. Under light or heating conditions, a free radical substitution reaction is initiated. The catalytic mechanism is that benzoyl peroxide is decomposed by heat or light to generate free radicals, which prompts the substitution of bromine with hydrogen atoms on the methyl group in 3- (Trifluoromethyl) toluene, and gradually generate the target product 1- (Bromomethyl) -3- (Trifluoromethyl) Benzene. During operation, it is necessary to pay attention to the reaction temperature and bromine dosage, and accurately control the yield and purity.
Chemical Reactions & Modifications
1- (Bromomethyl) -3- (Trifluoromethyl) Benzene is an important compound in organic synthesis. Looking at its chemical reactions, it often involves nucleophilic substitution and other reaction types. In the nucleophilic substitution reaction, bromomethyl is active and easy to be attacked by nucleophilic reagents, resulting in the formation of substitution products.
Discussing the chemical modification of this product, different functional groups can be introduced to change its physical and chemical properties. For example, connecting nitrogen-containing heterocycles may enhance its biological activity; adding conjugated structures may improve its optical properties. In this way, through exquisite design of chemical reactions, the structure of 1- (Bromomethyl) -3- (Trifluoromethyl) Benzene can be precisely regulated, so that it can meet a variety of application needs and bloom in the fields of medicine, materials and so on.
Synonyms & Product Names
1 - (bromomethyl) -3 - (trifluoromethyl) benzene, the synonym and trade name of this substance, there is much to be investigated. Its synonym is the name given by chemists according to its structure and properties, in order to facilitate academic communication and precise expression. The trade name is used by merchants in marketing activities, or it means commercial considerations and branding.
In the field of chemical research, scholars are used to a rigorous system of nomenclature, that is, 1 - (bromomethyl) -3 - (trifluoromethyl) benzene. This name accurately describes its molecular structure, so that colleagues in the academic community know its chemical composition. However, in industrial production and market transactions, there may be different trade names to increase their recognition, affinity, and promote their sales.
In this way, although synonyms and trade names refer to the same substance, they have different application scenarios and each has its own value, helping chemical substances to develop smoothly in the academic and commercial arenas.
Safety & Operational Standards
1- (bromomethyl) -3- (trifluoromethyl) benzene safety and operating specifications
Fu 1- (bromomethyl) -3- (trifluoromethyl) benzene is a chemical commonly used in organic synthesis. It has unique chemical properties and is used in many fields. However, it is also accompanied by safety risks. Therefore, its safety and operation specifications must be clearly understood to ensure the smooth operation of the experiment and the safety of personnel.
#1. Storage essentials
This chemical should be stored in a cool, dry and well ventilated place. Keep away from fire and heat sources to prevent accidents. Because it is sensitive to humidity and easy to deteriorate due to moisture, it is necessary to ensure that the storage environment is dry. And should be stored separately from oxidants, alkalis, etc., and should not be mixed. Due to its chemical activity, mixed storage with other substances can easily cause chemical reactions and cause danger.
#2. Rules of Operation
When operating, the operating procedures must be strictly followed. Experimenters wear appropriate protective equipment, such as protective clothing, gloves, and goggles, to prevent skin and eye contact. The operation should be carried out in a fume hood to disperse volatile harmful gases and ensure the safety of the experimental environment. When taking it, the action should be slow and careful to prevent spills. If it is accidentally spilled, immediately follow the emergency treatment procedures.
#3. Emergency measures
If the skin touches it, quickly rinse with a large amount of flowing water, and then seek medical treatment. If it splashes into the eye, immediately lift the eyelids and rinse with flowing water or normal saline, and also need immediate medical treatment. In case of fire, when using dry powder or carbon dioxide fire extinguishers to put out, do not use water, because it is insoluble in water, water will help the fire spread.
In short, although 1- (bromomethyl) -3- (trifluoromethyl) benzene is a beneficial chemical, when handling and using it, it is necessary to put safety first, strictly abide by the operating norms, and be familiar with emergency treatment. Only in this way can we save the danger and use it properly, which will contribute to scientific research and production.
Application Area
1- (Bromomethyl) -3- (Trifluoromethyl) Benzene is also an organic compound. Its application field is quite wide. In the field of pharmaceutical synthesis, it can be a key intermediary to help create special drugs to treat various diseases. In material science, it can be used as a modified raw material to give the material specific properties, such as enhancing its weather resistance and anti-corrosion ability. In the fine chemical industry, it is used to prepare high-end fine chemicals to increase the added value of the product. And because of its special structure, it has also emerged in the field of catalytic reactions, or it can be used as an efficient catalyst to improve the rate and selectivity of the reaction. All these show that 1- (Bromomethyl) -3- (Trifluoromethyl) Benzene has important value and broad prospects in various application fields.
Research & Development
In the field of organic chemistry, I have been focusing on exploring new compounds for a long time. The recently studied 1- (Bromomethyl) -3- (Trifluoromethyl) Benzene is of great value.
Its synthesis method has undergone many attempts and improvements. At first, it followed the conventional path, but the yield did not meet expectations. After analyzing the reaction mechanism in detail, adjusting the proportion of reactants and reaction conditions, and carefully studying the selection of temperature and catalyst. The final method can significantly improve the yield.
Looking forward to its development, this compound may have broad application prospects in the fields of medicine, materials and so on. In medicine, it can be used as a key intermediate to assist the development of new drugs; in the field of materials, its unique chemical structure may endow materials with special properties. I will continue to study and strive to expand its application scope and contribute to the development of chemistry.
Toxicity Research
The industry of chemical industry is related to people's livelihood, but the study of poisons is also an important matter. Today there is 1- (Bromomethyl) -3- (Trifluoromethyl) Benzene, and the study of its toxicity cannot be ignored.
Watching this thing, in the experimental environment, try it with all kinds of living beings. Seeing it against insects, when touched, it will stop chaos, and the vitality will gradually fade. Test it with mice, smell its qi, or eat food containing this thing, not long after, the spirit will wither, the body will tremble and stand upright, and the viscera will also have abnormal changes.
Investigating its toxicology, due to the different structure, entering the body will disrupt the follow of qi and blood, and disturb the ability of the viscera. Although this substance may be useful in industry, the danger of its toxicity cannot be ignored. Researchers should be cautious to ensure the safety of the living and not to let the harm of poisons flow into the world.
Future Prospects
Wuguanfu 1- (Bromomethyl) -3- (Trifluoromethyl) Benzene is unique and has extraordinary potential. In the future development, it is expected to shine in various fields.
Or used in fine chemicals, it is the key raw material for synthesizing novel materials, making the material properties excellent, and can make a name for itself in the electronics, medical and other industries. In the way of pharmaceutical research and development, it may be able to derive special drugs, overcome difficult diseases, and benefit all living beings.
Furthermore, in the field of catalysis, it may also lead to changes, improve reaction efficiency, and reduce energy consumption. The future, when the stars are bright, the prospects are vast, and it will definitely contribute to the advancement of science and technology and the benefit of people's livelihood.
Frequently Asked Questions
What are the main uses of 1- (Bromomethyl) -3- (Trifluoromethyl) Benzene?
1 - (bromomethyl) -3- (trifluoromethyl) benzene, its main use is quite extensive.
In the field of organic synthesis, this is a key intermediate. First, it can interact with many nucleophiles, such as alcohols, amines, and mercaptans, through nucleophilic substitution reactions. Taking the reaction with alcohols as an example, in the presence of suitable bases, bromine atoms can be replaced by alcoholoxy groups to form ether compounds, which are of great significance in the fields of pharmaceutical chemistry and materials science. Many drug molecules and functional materials contain ether bond structures. When reacted with amines, amino-substituted products are formed, which are either bioactive or used as ligands in the field of coordination chemistry, and play an important role in catalysis and material synthesis.
Second, in the reaction of building carbon-carbon bonds, 1- (bromomethyl) -3- (trifluoromethyl) benzene also plays a key role. For example, it can participate in palladium-catalyzed cross-coupling reactions, such as Suzuki coupling, Stille coupling, etc. In the Suzuki coupling reaction, combined with boron-containing reagents, diverse biphenyl derivatives can be efficiently constructed. Such derivatives are widely used in liquid crystal materials, organic Light Emitting Diode (OLED) and other fields, which can optimize the photoelectric properties of materials.
Third, the presence of trifluoromethyl in the molecule endows it with unique physical and chemical properties. Trifluoromethyl has strong electron absorption, which can change the electron cloud density and polarity of molecules, thereby affecting the solubility, stability and biological activity of compounds. In the field of drug development, the introduction of this structural unit may improve the metabolic stability, lipophilicity and binding ability of drugs to targets, helping to create new drugs with more efficient and low toxicity.
In addition, 1- (bromomethyl) -3- (trifluoromethyl) benzene is also used in material surface modification. It can be grafted to the surface of the material through chemical reaction, and the properties of trifluoromethyl can be used to improve the wettability and corrosion resistance of the material surface. It shows potential value in the modification treatment of coatings, plastics and other materials.
What are the physical properties of 1- (Bromomethyl) -3- (Trifluoromethyl) Benzene
1 - (bromomethyl) -3 - (trifluoromethyl) benzene is also an organic compound. Its physical properties are crucial and related to many practical applications.
This compound is mostly in a liquid state at room temperature, with specific fluidity and moderate viscosity. It can smoothly participate in reactions in many reaction systems, just like agile water flowing between ditches. Looking at its color, the pure one is often colorless and transparent, like a clear stream, with good visibility and easy observation and operation.
Its boiling point also has characteristics, about a certain temperature range, this temperature value is extremely important for the separation and purification of this compound. Just as the boiling of water is controlled by heat, the boiling point can be precisely grasped, and it can be cleverly separated from the mixture.
Melting point is also an important parameter. At a certain low temperature, it will gradually change from liquid to solid, such as river water freezing in cold. This property is quite meaningful for storage and specific reaction conditions.
Furthermore, in terms of solubility, it shows good solubility in common organic solvents, such as ethanol, ether, etc., just like salt dissolving in water, it can be evenly dispersed, which is conducive to the development of various chemical reactions in solution systems. However, the solubility in water is not good, just like the incompatibility of oil and water, and this property also affects its behavior in different environments. The density of
also has a fixed number, which is lighter or heavier than that of water. This property has a significant impact when it comes to operations such as stratification. If oil and water are stratified due to density differences, this compound will also exhibit a specific distribution in the relevant system according to its density.
The physical properties of 1 - (bromomethyl) -3 - (trifluoromethyl) benzene are diverse and unique, and each property is interrelated. It plays an important role in many fields such as chemical synthesis, separation and purification, storage and transportation, and needs to be carefully grasped and applied.
What are the synthesis methods of 1- (Bromomethyl) -3- (Trifluoromethyl) Benzene
1 - (bromomethyl) -3 - (trifluoromethyl) benzene, the synthesis method is as follows:
First, 3 - (trifluoromethyl) benzoic acid is used as the starting material. First, 3 - (trifluoromethyl) benzoic acid and methanol are esterified under the catalysis of concentrated sulfuric acid, which is the classic esterification path. Concentrated sulfuric acid as a catalyst can promote the reaction of benzoic acid and methanol to form 3 - (trifluoromethyl) benzoate methyl ester. The reaction needs to be carried out under heating conditions, and attention should be paid to controlling the temperature and reaction time to obtain a higher yield. Subsequently, 3 - (trifluoromethyl) benzyl alcohol was obtained by reducing methyl 3- (trifluoromethyl) benzoate with lithium aluminum hydride (LiAlH) as a reducing agent. LiAlHhas strong reducing properties, and the reaction needs to be operated under specific conditions such as anhydrous and low temperature to ensure safety and smooth reaction. Finally, 3 - (trifluoromethyl) benzyl alcohol is reacted with phosphorus tribromide (PBr 🥰). After this substitution reaction, the hydroxyl group is replaced by a bromine atom to obtain 1- (bromomethyl) -3- (trifluoromethyl) benzene. This reaction is relatively mild, but it is still necessary to pay attention to the control of reaction conditions, such as temperature, reactant ratio, etc.
Second, 3- (trifluoromethyl) toluene is used as the starting material. First, the bromination reaction of 3- (trifluoromethyl) toluene is carried out. N-bromosuccinimide (NBS) can be selected as the bromination reagent, and benzoyl peroxide (BPO) is used as the initiator to carry out the reaction under light conditions. NBS can provide bromine free radicals, and BPO decomposes under light to produce free radicals, initiating the replacement of hydrogen atoms on the methyl side chain of 3- (trifluoromethyl) toluene by bromine atoms to generate 1- (bromo methyl) -3- (trifluoromethyl) benzene. The reaction conditions are relatively easy to control and the lighting conditions are relatively easy to achieve, but attention should be paid to the purity of the reaction system and the monitoring of the reaction process to prevent side reactions, such as the formation of polybrominated products.
What are the precautions for 1- (Bromomethyl) -3- (Trifluoromethyl) Benzene in storage and transportation?
1 - (bromomethyl) -3 - (trifluoromethyl) benzene is also an organic compound. During storage and transportation, many matters must be observed.
First storage, this compound is active and sensitive to environmental factors, so it needs to be placed in a cool, dry and well ventilated place. Avoid open flames and hot topics to avoid the risk of fire and explosion. Because of its flammability and reactivity, it is easy to cause violent reactions when exposed to hot topics or open flames. And the warehouse temperature should be strictly controlled. Excessive temperature can cause the decomposition of compounds or accelerate reactions, damage their quality, or even cause dangerous accidents.
Furthermore, when storing, it must be stored separately with oxidizing agents, strong alkalis and other substances. 1 - (bromomethyl) -3 - (trifluoromethyl) benzene encounters such substances, which is prone to chemical reactions, or produces harmful gases, or causes combustion and explosion. Such as strong oxidizing agents, which can seize their electrons and cause violent oxidation reactions; strong bases can interact with active groups in compounds and cause unpredictable reactions.
As for transportation, caution is also required. Appropriate packaging materials should be selected to ensure that the packaging is complete and sealed. Special chemical packaging containers are often used to prevent leakage. During transportation, the vehicle must run smoothly to avoid bumps and vibrations, and avoid leakage caused by package damage.
And when transporting, it should not be mixed with contraband substances. Transportation personnel should be familiar with emergency treatment methods, and in case of leakage, they can take effective measures quickly to minimize the harm.
In summary, when storing and transporting 1- (bromomethyl) -3- (trifluoromethyl) benzene, it is necessary to pay attention to environmental conditions, isolate contraindicated substances, ensure that the packaging is intact, and enable relevant personnel to have emergency response capabilities, so as to ensure their safety and avoid accidents.
What is the approximate market price of 1- (Bromomethyl) -3- (Trifluoromethyl) Benzene?
For 1 - (bromomethyl) -3- (trifluoromethyl) benzene, its market value is roughly a few, and this is not enough. It is determined by its quality, and it is made by various reasons.
First, the raw materials are low. The production of this compound requires specific raw materials. If the raw materials are abundant and flat, the benzene is low or low; if the raw materials are dilute and difficult to find, it is high.
Second, the production method is high. The method of making, or complex or low. If the process requires multiple steps, and each step requires precise control of the components, the cost will also be high, and the market price will also increase accordingly.
Third, the supply and demand of the city. If the demand in the market is low, and the supply is limited, the supply is not low, and its price must be low; if the supply is low, the road is low, and the quick sale is low, the price may be low.
Fourth, the difference between the two families. Different companies, due to poor technology, good management, and different costs, the price is also different. Those with precise technology and proper management have controllable costs, or there may be low costs; no, low or high.
Therefore, in order to determine the market value of 1- (bromomethyl) -3- (trifluoromethyl) benzene, there are general factors to be considered. However, in general, in the chemical industry, its price per gram may be between 10 and 100 yuan, depending on the above factors.