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1-(Bromomethyl)-3-(Trifluoromethoxy)Benzene

1-(Bromomethyl)-3-(Trifluoromethoxy)Benzene

Hongda Chemical

    Specifications

    HS Code

    281721

    Chemical Formula C8H6BrF3O
    Molecular Weight 255.03
    Appearance Typically a colorless to light - colored liquid
    Boiling Point Data may vary, around 180 - 200°C (estimated)
    Density Estimated to be relatively high due to bromine presence, around 1.6 - 1.8 g/cm³
    Solubility In Water Low solubility, as it is an organic compound with non - polar groups
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, toluene
    Flash Point Caution: likely flammable, flash point needs experimental determination
    Reactivity The bromomethyl group is reactive, can undergo substitution reactions

    As an accredited 1-(Bromomethyl)-3-(Trifluoromethoxy)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 500g of 1-(bromomethyl)-3-(trifluoromethoxy)benzene packaged in a sealed glass bottle.
    Storage 1-(Bromomethyl)-3-(trifluoromethoxy)benzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. Keep it in a tightly sealed container to prevent vapor leakage. Due to its reactivity, store it separately from oxidizing agents, reducing agents, and bases. Ensure storage areas comply with safety regulations to avoid potential hazards.
    Shipping 1-(Bromomethyl)-3-(trifluoromethoxy)benzene is shipped in sealed, corrosion - resistant containers. It follows strict hazardous chemical shipping regulations, ensuring proper labeling and secure handling during transit.
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    1-(Bromomethyl)-3-(Trifluoromethoxy)Benzene 1-(Bromomethyl)-3-(Trifluoromethoxy)Benzene
    General Information
    Historical Development
    1- (bromomethyl) -3- (trifluoromethoxy) benzene, the development of this substance, has its origins. In the past, chemical scholars studied and explored, with the aim of blazing a new trail in the field of organic synthesis. At the beginning, the relevant reaction mechanism was unknown, and the synthesis method was also difficult. However, the public has been diligent and tried countless times. Or carefully adapt the reaction conditions, or find another way in the selection of raw materials. After long-term accumulation, an effective synthesis method was finally found. Over time, the technology has been continuously refined, from the crude initial to the maturity of the synthesis process. The reaction efficiency has gradually increased, and the purity of the product has also increased. Its application in many fields such as medicine and materials is also becoming more and more extensive. This is the hard work of chemists of all ages, which has led to the development of 1- (bromomethyl) -3- (trifluoromethoxy) benzene today.
    Product Overview
    There is now a substance named 1- (bromomethyl) -3- (trifluoromethoxy) benzene. It is an organic compound with a unique chemical structure. Looking at its structure, one is connected to bromomethyl and the other is connected to trifluoromethoxy.
    This compound may be of important use in the field of organic synthesis. Bromomethyl has good activity and can participate in many nucleophilic substitution reactions, providing the possibility of constructing new carbon-carbon bonds or carbon-heterogeneous bonds. The introduction of trifluoromethoxy can significantly change the physical and chemical properties of molecules, such as improving their fat solubility and stability.
    Or in medicinal chemistry, it can be used as a key intermediate to assist the research and development of new drugs; it may also be used in the field of materials science to prepare functional materials with special properties. Its application prospects are worthy of our in-depth investigation and study.
    Physical & Chemical Properties
    Recently, a chemical substance has been developed, which is called 1- (Bromomethyl) -3- (Trifluoromethoxy) Benzene. Its properties are also related to physical and chemical characteristics, which is quite important to us.
    This compound may have a specific appearance, a colorless liquid, or a different color and shape. Regarding its melting point and boiling point, there is a fixed number. The geometry of the melting point and the geometry of the boiling point are the keys to physical characterization.
    As for chemical properties, under specific reaction conditions, its bromomethyl and trifluoromethoxy parts can initiate various reactions. In case of a certain type of reagent, bromomethyl can be substituted, and trifluoromethoxy can also participate in specific chemical transformations. In the field of organic synthesis, it can be used as a key raw material. With reasonable design and reaction paths, many valuable derivatives can be prepared. Such various physical and chemical properties are to be explored in detail by us to clarify their uses and expand their potential.
    Technical Specifications & Labeling
    1- (Bromomethyl) -3- (Trifluoromethoxy) Benzene is also a chemical product. Its technical quality is determined by the quality of the product. If the quality needs to be high, the content should be controlled in a small amount. Its physical quality, such as melting and boiling, also need to be determined and refined.

    In terms of quality, it is indicated by clear symbols and words. Contains the formula, Chinese name, and English name, so that the user can see at a glance. And it is clear about the dangerous characteristics to warn the user. In this way, the right way of the technical quality can ensure that this product is safe and effective in general applications.
    Preparation Method
    To prepare 1- (Bromomethyl) -3- (Trifluoromethoxy) Benzene, the raw materials and production process, reaction steps and catalytic mechanism are the key.
    The selection of raw materials, when selecting high-purity initial reactants, such as benzene compounds containing specific substituents, and impurities need to be strictly controlled to prevent side reactions. In the production process, the halogenation reaction is the basis, and the reaction conditions should be fine-tuned. The reaction step is to first react the benzene derivative with the brominating reagent at a specific temperature and catalyst in a suitable solvent. If a certain type of metal halide is used as the catalyst, the temperature is controlled at tens of degrees Celsius, so that the two can fully function and promote the introduction of bromomethyl.
    Catalytic mechanism, the catalyst can reduce the activation energy of the reaction and make the reaction proceed efficiently. Metal halide catalysts can complex with the reactants to change their electron cloud density and nucleophilic substitution of bromomethyl. In this way, high-purity 1- (Bromomethyl) -3- (Trifluoromethoxy) Benzene products are expected to be obtained through delicate regulation of raw materials, processes, steps and catalysis.
    Chemical Reactions & Modifications
    Today there is a chemical substance called 1- (Bromomethyl) -3- (Trifluoromethoxy) Benzene. In the way of chemical research, its reaction and modification are the key.
    Looking at this compound, its structure is unique, bromomethyl and trifluoromethoxy are combined in the benzene ring. To understand its reaction properties, it is necessary to investigate various conditions. At different temperatures and pressures, when encountering different reagents, the reaction paths are different.
    To change its properties, or increase its stability, or adjust its activity, it is necessary to use exquisite methods. Specific reactions, such as nucleophilic substitution, can be selected to change the groups on the benzene ring to achieve the purpose of modification.
    After repeated experiments, explorations, and insight into its reaction laws, a good strategy for its modification can be obtained, so that this compound can be used in the fields of chemical industry and medicine, and contribute to the progress of chemistry and the development of industry.
    Synonyms & Product Names
    1- (bromomethyl) -3- (trifluoromethoxy) benzene, which has attracted much attention in today's chemical research. Its nickname and trade name are also the ones we should investigate.
    In the past, the name of a chemical substance was often named according to its properties, preparation method or source. In 1- (bromomethyl) -3- (trifluoromethoxy) benzene, its name is determined according to its chemical structure. However, in the industry, there may also be those who are called by common names or trade names.
    Or because of its unique chemical properties, it has its uses in organic synthesis and other fields, so the industry has given many nicknames. Although these nicknames and trade names are different from scientific names, they can easily refer to this thing in specific contexts and industry exchanges, and help researchers and producers communicate.
    Therefore, exploring its synonyms and trade names is of great significance for in-depth understanding of the application and market circulation of this thing, so that we can have a clearer understanding of its role and status in the chemical world.
    Safety & Operational Standards
    Safety and Operation Specifications for 1- (Bromomethyl) -3- (Trifluoromethoxy) Benzene
    V 1- (Bromomethyl) -3- (Trifluoromethoxy) Benzene is an important substance in chemical research. During its experimental operation and research process, safety and operation standards are of paramount importance and cannot be ignored.
    In terms of safety, this substance is dangerous. Its bromomethyl structure is active and easy to react with other substances. In contact with water or moisture, or harmful gases, it endangers the safety of experimenters and the environment. Therefore, when storing, it must be placed in a dry, cool and well-ventilated place, away from water sources and fires. When taking it, the experimenter needs to wear professional protective equipment, such as protective gloves, goggles, experimental clothes, etc., to prevent substances from coming into contact with the skin and eyes and causing damage.
    As for the operation specifications, it is necessary to read the relevant materials carefully before the experiment to be familiar with its properties and reaction characteristics. Operate in the fume hood to ensure that harmful gases are discharged in time. Take an appropriate amount, do not waste excessively, and the operation process should be stable and accurate to avoid spilling. If it is accidentally spilled, it should be cleaned up immediately according to specific procedures to prevent the expansion of pollution. The reaction conditions also need to be precisely controlled. Temperature, pressure, reaction time, etc. are all related to the success or failure of the experiment and safety.
    Furthermore, experimental waste cannot be discarded at will. Waste containing this substance should be sorted and collected according to regulations and handed over to professional institutions for treatment to avoid polluting the environment.
    In short, in the research and application of 1- (bromomethyl) -3- (trifluoromethoxy) benzene, strict adherence to safety and operating standards can ensure the smooth operation of the experiment, the safety of personnel, and the cleanliness of the environment. This is the heavy responsibility of our chemical researchers and cannot be slack.
    Application Area
    1- (Bromomethyl) -3- (Trifluoromethoxy) Benzene is a special organic compound. Its application field is quite wide. In the field of pharmaceutical chemistry, it can be used as a key intermediate to help synthesize drug molecules with specific biological activities. With its unique chemical structure, it opens up new paths for drug research and development. In the field of materials science, it can be used to prepare functional materials, such as giving materials special optical, electrical or thermal properties. Because it contains bromine and trifluoromethoxy groups, it can be chemically modified to make materials have special uses. In organic synthesis chemistry, it is an important building block for the construction of complex organic molecules. Chemists use it to carry out various reactions, expand the structural diversity of organic compounds, and lay the foundation for exploring new substances and new properties.
    Research & Development
    In recent years, I have focused on the research of 1- (Bromomethyl) -3- (Trifluoromethoxy) Benzene. At the beginning, I explored the method of its synthesis. After various attempts, the raw materials were difficult to find, or the steps were complicated, and the results were not successful.
    However, I was not discouraged. I consulted countless books and visited Fang's house, and gradually obtained the essentials. Adjust the reaction conditions, choose the appropriate catalyst, and the synthesis road is gradually smoother.
    At the same time, consider the potential applications of this substance. In the field of medicine, it seems to have a unique activity, which is expected to contribute to the creation of new drugs; in terms of materials, it may be able to improve the performance and open up new frontiers.
    Although it has been achieved now, the road ahead is still long. I should make unremitting efforts to explore its potential, promote the development of this compound, and contribute to both academia and industry, living up to my original intention of research.
    Toxicity Research
    Recently, the monohalogenated aromatic hydrocarbon 1- (Bromomethyl) -3- (Trifluoromethoxy) Benzene has been studied, and its toxicity is of great significance. Examine this compound in detail, the haloalkyl group coexists with the fluoroalkoxy group, and the structure is different.
    For those who are toxic in ancient times, check the path of its entry into the body, either through the mouth, nose, or through the skin. This product has halogenated methyl groups, which are quite active, or can easily combine with biochemical molecules in the body, causing metabolic disorders. And the fluorine atom of the trifluoromethoxy group has high electronegativity, or changes the polarity and reactivity of the molecule, which impairs the normal function of cells.
    Although the toxicology of this product is not fully understood, according to the view of similar halofluoroaromatics, it may cause damage to the organs, especially the liver and kidneys. Or it may affect nerve conduction, making people in a trance and weak limbs. Therefore, the study of its toxicity is essential for protection and rational use.
    Future Prospects
    1- (Bromomethyl) -3- (Trifluoromethoxy) Benzene has gradually revealed its extraordinary properties in today's chemical research. Looking at its structure, bromomethyl and trifluoromethoxy are combined with benzene ring, this unique structure has infinite opportunities.
    Looking to the future, it may be able to emerge in the field of pharmaceutical creation. With its special groups, it can precisely target the source of diseases, help the birth of new drugs, and solve the diseases of the world. In the process of material research and development, it is also expected to shine. With its chemical activity, it may be able to generate novel functional materials for high-tech tools.
    Although the road ahead is uncertain, we chemical researchers should explore its mysteries with enthusiasm, hope to expand its use, develop its future grand vision, and contribute our efforts to the progress of the world.
    Where to Buy 1-(Bromomethyl)-3-(Trifluoromethoxy)Benzene in China?
    As a trusted 1-(Bromomethyl)-3-(Trifluoromethoxy)Benzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 1-(Bromomethyl)-3-(Trifluoromethoxy)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 1- (bromomethyl) -3- (trifluoromethoxy) benzene?
    (1) This substance is called 1- (hydroxymethyl) -3- (trifluoromethoxy) benzene, and it has a wide range of uses. In the field of medicinal chemistry, it is a key intermediate. Due to its specific chemical structure, it can participate in a variety of organic synthesis reactions and help build complex drug molecular structures.
    For example, when developing drugs for the treatment of certain neurological diseases, it can be connected to the main chain of drug molecules through specific chemical reactions. With its unique electronic effects and spatial resistance, it can optimize the binding ability of drugs to targets, improve the efficacy and specificity of drugs, and reduce the occurrence of adverse reactions.
    (2) In the field of materials science, 1- (hydroxymethyl) -3- (trifluoromethoxy) benzene also plays an important role. It can be used as a functional monomer to participate in the polymerization of polymer materials. After clever design and synthesis, the prepared polymer materials may have special physical and chemical properties.
    If the introduction of this substance can change the surface hydrophilicity, pore size and distribution of the membrane when preparing high-performance separation membrane materials, and then improve the selectivity and permeability of the membrane to specific substances, showing excellent application potential in gas separation, liquid purification and other fields.
    (3) In the field of organic synthesis chemistry, it provides a wealth of structural modification possibilities for organic synthesis chemists. Due to the unique reactivity of hydroxymethyl groups and trifluoromethoxy groups, many different reaction pathways can be derived.
    For example, hydroxymethyl groups can undergo reactions such as esterification and etherification, while trifluoromethoxy groups can affect the electron cloud density of molecules and the selectivity of reaction check points. With this, chemists can construct a library of rich and diverse organic compounds, providing a material basis and structural template for the development of new drugs and the creation of new materials.
    What are the physical properties of 1- (bromomethyl) -3- (trifluoromethoxy) benzene?
    (1- (hydroxymethyl) -3- (trifluoromethoxy) benzene, its physical properties are as follows:
    This substance is liquid at room temperature, and it is clear and transparent when viewed. If placed under light, it can be seen that its refractive property is good. The light penetrates into it and is refracted to a certain extent, just like a smart crystal flow. Its color is extremely light, almost colorless, pure like water, and there is no disturbance of variegated colors.
    Smell, it has a unique smell, not pungent and intolerable, but it is also different from fragrant and rich fragrance. This smell is unique and bright, which can be used as one of the help to distinguish it.
    When it comes to density, it is heavier than water. If it is co-placed with water in a device, it can be seen that it slowly sinks to the bottom of the water, just like a pearl falling on the abyss.
    In terms of solubility, it is quite compatible in organic solvents, such as ethanol and ether. When mixed, the two can form a uniform state, just like water and emulsion. However, in water, its solubility is not good, and the two meet. For example, oil floats in water, which is distinct and difficult to blend.
    Boiling point is also one of its important physical properties. When the external pressure reaches the standard, a specific temperature is required to make it boil and turn into a gaseous state. This temperature is not available at will, but is determined by rigorous measurement and experiment, which is its inherent characteristic. The melting point is also the same, under a specific low temperature, it gradually changes from liquid to solid, and the change of shape is rigorous and orderly, all according to its own physical properties.)
    Is 1- (bromomethyl) -3- (trifluoromethoxy) benzene chemically stable?
    1 - (benzyl) -3- (triethoxysilyl) benzene, the stability of its chemical properties is related to many aspects.
    The structure of this compound, benzyl, has a conjugated system of aromatic rings. The electron cloud distribution of aromatic rings is unique, and the delocalization of π electrons makes the benzyl part show a certain stability. And benzyl is connected to the benzene ring, which can affect the electron cloud density of the benzene ring by conjugation effect and induction effect. In chemical reactions, it can resist the attack of some electrophilic or nucleophilic reagents.
    Looking at triethoxysilyl, silicon atoms have empty d orbitals and can accept electron pairs. The ethoxy group is connected to the silicon atom to form a silicon-oxygen bond. This bond has a certain polarity, and the oxygen atom has strong electronegativity, which attracts the electron cloud of the silicon atom. However, the silicon-oxygen bond energy is quite high, about 452kJ/mol, and a higher energy is required to break it. Triethoxy silicon group is connected to the benzene ring, which can contribute to the overall stability of the compound through steric resistance and electronic effects.
    Under common chemical reaction environments, 1- (benzyl) -3- (triethoxysilyl) benzene is relatively stable without special reaction conditions, such as high temperature, strong acid, strong base or the presence of specific catalysts. However, when exposed to high temperatures, the bonds within the molecule can be impacted by thermal energy, and bond breaks and rearrangements may occur. Under strong acid and alkali environments, the silicon-oxygen bond or the bond between benzyl and benzene ring may undergo hydrolysis or other reactions due to the catalysis of acid and base, resulting in structural changes and loss of stability.
    In summary, the chemical properties of 1- (benzyl) -3- (triethoxysilyl) benzene are stable under conventional conditions, but under extreme or specific reaction conditions, its stability is challenged.
    What are the synthesis methods of 1- (bromomethyl) -3- (trifluoromethoxy) benzene?
    To prepare 1- (hydroxymethyl) -3- (trifluoromethoxy) benzene, the following ancient methods can be followed:
    First, benzene is used as the starting material. First, the benzene and the halogenated hydroxymethyl reagent are used in a suitable catalyst, such as anhydrous aluminum trichloride, etc., and the Fu-gram alkylation reaction is performed to obtain (halomethyl) benzene. Then treated with a basic reagent, the halogen atom is replaced by a hydroxyl group to obtain (hydroxymethyl) benzene. Then (hydroxymethyl) benzene is reacted with trifluoromethoxylation reagents, such as trifluoromethoxy halides, in the presence of bases and specific ligands, among which the base can be potassium carbonate and other ligands, such as nitrogen-containing heterocyclic ligands, through the process of nucleophilic substitution, the final result is 1- (hydroxymethyl) -3- (trifluoromethoxy) benzene.
    Second, starting from m-bromobenzyl alcohol. M-bromobenzyl alcohol reacts with trifluoromethoxylation reagents, such as trifluoromethoxy potassium, in polar aprotic solvents, such as N, N-dimethylformamide, under heating conditions, which is a nucleophilic substitution mechanism. The bromine atom is replaced by trifluoromethoxy to obtain the target product 1- (hydroxymethyl) -3- (trifluoromethoxy) benzene.
    Third, m-hydroxybenzyl alcohol is used as the raw material. First, the hydroxyl group of m-hydroxybenzyl alcohol is properly protected, such as with a silicon ether protecting group. Then the protected product is reacted with a trifluoromethoxylation reagent to introduce a trifluoromethoxy group. After the reaction is completed, the protecting group is removed, and the specific deprotection reagent is treated, such as removing the silicon ether protecting group under acidic conditions, and finally 1 - (hydroxymethyl) -3- (trifluoromethoxy) benzene is obtained.
    What should be paid attention to when storing and transporting 1- (bromomethyl) -3- (trifluoromethoxy) benzene?
    (1 - (hydroxymethyl) - 3 - (trichloroacetoxy) benzene needs to pay attention to many key points when storing and transporting.)
    First, storage is essential. This substance should be placed in a cool and dry place, away from heat sources and open flames. Due to its chemical properties, heat or exposure to open flames may cause violent reactions and cause dangerous conditions. If placed in direct sunlight or high temperature environment, it is easy to change the structure of the substance, or cause decomposition, damage its quality, and more likely to cause safety accidents. And the storage place should be well ventilated to prevent the accumulation of harmful gases. If the storage space is closed, once the substance volatilizes and produces harmful gases, the concentration rises, which is a great threat to human health and safety. Furthermore, it needs to be stored separately from oxidants, acids, etc. This substance has special chemical activity. Contact with these substances or chemical reactions, such as oxidation reactions or acid-base neutralization reactions, not only change the properties of the substance, but also cause serious consequences such as explosions and fires.
    Second, be careful when transporting. When transporting, be sure to ensure that the packaging is complete. Damaged packaging and material leakage not only pollute the environment, but also may harm contacts. Packaging materials should be selected that can resist certain external impact and chemical corrosion, such as strong plastic drums or special metal containers. Transportation vehicles should be selected with corresponding safety equipment, such as fire extinguishers, leakage emergency treatment tools, etc. In case of an accident during transportation, they can respond in time to reduce hazards. In addition, transport personnel should be professionally trained to be familiar with the characteristics of the substance and emergency treatment methods. In case of leakage, know how to properly protect themselves and what measures to take to prevent the leakage from expanding, such as adsorption with suitable adsorbents, to avoid more serious consequences caused by blind handling.