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1-(Bromomethyl)-3-Fluorobenzene

1-(Bromomethyl)-3-Fluorobenzene

Hongda Chemical

Specifications

HS Code

384202

Chemical Formula C7H6BrF
Molar Mass 191.024 g/mol
Appearance Colorless to light yellow liquid
Boiling Point Around 190 - 195 °C
Density Approx. 1.60 - 1.70 g/cm³
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, ethyl acetate
Flash Point Caution, flammable, flash point around 70 - 80 °C
Vapor Pressure Low vapor pressure at room temperature

As an accredited 1-(Bromomethyl)-3-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 1-(bromomethyl)-3-fluorobenzene packaged in a sealed, chemical - resistant bottle.
Storage 1-(Bromomethyl)-3-fluorobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly - sealed container to prevent vapor leakage. As it is a hazardous chemical, ensure storage is in a dedicated chemical storage facility, following all safety regulations to avoid potential fire, explosion, or harmful exposure risks.
Shipping 1-(Bromomethyl)-3-fluorobenzene is shipped in specialized, well - sealed containers. These containers are designed to prevent leakage, following strict chemical shipping regulations to ensure safe transport of this potentially hazardous chemical.
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1-(Bromomethyl)-3-Fluorobenzene 1-(Bromomethyl)-3-Fluorobenzene
General Information
Historical Development
Wenfu 1- (Bromomethyl) -3-Fluorobenzene This thing, its birth process, is a chapter in the evolution of chemistry. In the past, the sages of chemistry worked hard to explore the change of matter. At the beginning, the understanding of this thing was still shallow, but everyone worked tirelessly to study it. After countless experiments, observe the synthesis and decomposition of matter, and observe the influence of conditions. Therefore, gradually understand the method of its synthesis. From the early ignorant attempts to the later days of refined technology, countless intelligent people have devoted themselves to it. Or improve the raw materials, or optimize the process, so that this thing is obscure and unknown, and finally appear in the world, adding a treasure to the field of chemistry. Its development path also witnesses the prosperity of chemistry, and the work of predecessors cannot be forgotten.
Product Overview
1- (Bromomethyl) -3-Fluorobenzene is also an organic compound. Its color is clear and transparent, and it has a special odor. The structure of this compound is above the benzene ring, with bromomethyl at one place and fluorine atom at three places.
The preparation method is often obtained by a specific organic reaction. In the reaction process, it is necessary to fine-tune the reaction conditions, such as temperature, pressure, and the proportion of reactants, to obtain this product.
1- (Bromomethyl) -3-Fluorobenzene has a wide range of uses. In the field of organic synthesis, it is often an important intermediate for constructing more complex organic molecular structures. Due to the presence of bromomethyl and fluorine atoms, the activities of these two can lead to a variety of chemical reactions, which can assist in the preparation of various organic compounds. In the field of medicinal chemistry, it may also have potential application value, providing possible raw materials for the development of new drugs.
Physical & Chemical Properties
1- (Bromomethyl) -3-Fluorobenzene is also an organic compound. Its physical and chemical properties are quite important. Looking at its physical properties, at room temperature, this substance may be in a liquid state, with a specific color and taste. Its boiling point and melting point are related to changes in the state of matter, which have a great impact on its preservation and application. In terms of its chemical properties, due to the presence of bromomethyl and fluorine atoms, the reactivity is considerable. Bromomethyl is prone to nucleophilic substitution reactions, and fluorine atoms affect the distribution of electron clouds in molecules, making the compound unique in many chemical reactions. The physical and chemical properties of this compound are widely used in organic synthesis and other fields, and are of great importance to chemical researchers. Exploring its properties can help the development of related fields.
Technical Specifications & Labeling
1- (Bromomethyl) -3-Fluorobenzene is a key raw material for organic synthesis. Its preparation process requires strict technical specifications and standards. When the raw materials are well selected, the reaction conditions must be precisely controlled. Parameters such as temperature, pressure, and reaction time are all related to the purity and yield of the product.
In terms of technical specifications, the reaction device needs to be clean and airtight to prevent impurities from mixing in. The reaction process must be monitored in real time, and the conditions should be flexibly adjusted according to the feedback. The separation and purification steps should also be carefully operated to remove impurities and improve the quality of the product.
On the product label, the name, molecular formula, molecular weight, purity and other commodity parameters should be clearly marked. Ensure that the storage and transportation environment is suitable to avoid product deterioration due to improper environment. In this way, the quality and performance of 1- (Bromomethyl) -3-Fluorobenzene can be guaranteed.
Preparation Method
The preparation of 1- (Bromomethyl) -3-Fluorobenzene is related to the raw materials and production process, reaction steps and catalytic mechanism. The raw materials need to be carefully selected, based on benzene derivatives, supplemented by bromine and fluorine-containing reagents to ensure purity and suitability.
The production process first makes the benzene derivative meet the brominating agent and fluorinating agent in a suitable solvent, and is prepared according to a specific ratio. The reaction steps are rigorous, and temperature control, time control and pressure control are essential. In the initial stage, the reaction is initiated by slow heating, and the molecules are fully collided and combined until a moderate temperature is reached to maintain stability.
The catalytic mechanism is indispensable. A high-efficiency catalyst is selected to accelerate the reaction process and reduce the activation energy. The catalyst precisely acts on the reactants to promote chemical bond breaking and recombination. In this way, through a series of fine operations, 1- (Bromomethyl) -3-Fluorobenzene products can be obtained, and all links are closely interlocked to ensure product quality and yield.
Chemical Reactions & Modifications
I tried to study the chemical reaction and modification of 1- (Bromomethyl) -3-Fluorobenzene. This compound has unique properties and its reaction mechanism is worth studying. In common reactions, the structure of bromomethyl and fluorobenzene makes the reaction path different from others.
The method of the past, the reaction conditions are harsh, and the yield is not ideal. I think of an improved strategy to promote the reaction under mild conditions, hoping to increase the amount of product. Try a new catalyst, adjust the proportion of reactants, and observe its effect on the reaction.
After various experiments, it was found that a new catalyst can improve the reaction efficiency at milder temperatures and pressures, and the purity of the product also increases. This modification method may be a new way for the application of 1- (Bromomethyl) -3-Fluorobenzene to make it more effective in various fields of chemical industry.
Synonyms & Product Names
1- (Bromomethyl) -3-Fluorobenzene, this substance is also called m-fluorobenzene bromide. It is widely used in the field of organic synthesis. The name of m-fluorobenzene bromide is based on its chemical structure and is named after the system. And common names or trade names also exist.
In various chemical industries, m-fluorobenzene bromide is often used as an intermediate. Because of its active chemical properties, it can participate in multiple reactions to prepare a variety of organic compounds.
When our chemical researchers explore this substance, they need to study its properties and reaction mechanism in detail in order to achieve better utilization. We should also pay attention to the safety and environmental protection of its production and use to ensure that this chemical can be used safely and efficiently in various fields.
Safety & Operational Standards
The safe operation of 1- (Bromomethyl) -3-Fluorobenzene
1- (Bromomethyl) -3-Fluorobenzene is a compound often involved in chemical research. In the study and operation of this compound, it is very important to ensure safety, and specific operations need to be followed.
This compound has certain risk, its bromomethyl activity is high, and it is easy to lead to chemical reactions. Operation, the first thing to do is to prevent damage. Those who need to wear protective clothing, anti-wear gloves and eyes, etc., to prevent skin contact and entry into the eyes.
Furthermore, the operation environment is suitable for good communication, and it is best to operate in the middle of communication. This compound may be harmful. Good hygiene can effectively reduce the degree of harmful substances in the air and ensure the respiratory safety of those who do not breathe.
For storage, it is necessary to store 1- (Bromomethyl) -3-Fluorobenzene in the air, dry and dry, and the source of ignition and oxidation. Because of its chemical properties, it is easy to be dangerous if it is not stored.
If this compound is accidentally received, the skin should be washed with a large amount of water immediately, and it should be treated immediately; the eye should be washed with a large amount of water quickly, and it must not be rubbed, and it should be sent immediately.
Therefore, operation 1- (Bromomethyl) -3-Fluorobenzene, human prevention, operation environment, and emergency management all need to follow the safety standard in order to ensure the safety and profitability of research work.
Application Area
Today, there is a product named 1- (Bromomethyl) -3-Fluorobenzene, which has great potential in various application fields. In the field of pharmaceutical research and development, it can be used as a key intermediate to help synthesize specific drugs to cure various diseases and save patients from pain. In the context of material research and development, it can add its characteristics to new materials, make materials have better performance, or increase their durability, or add their flexibility. In the field of fine chemicals, it can be used to prepare unique chemicals, enrich chemical categories, and meet diverse needs. Therefore, 1- (Bromomethyl) -3-Fluorobenzene has great potential in the application field, just like a pearl hidden in a box, waiting for craftsmen to carve, shine, and benefit the world.
Research & Development
I am dedicated to the research and development of (1 - (Bromomethyl) -3 - Fluorobenzene). At first, I explored the method of its synthesis, and after many attempts, I used a specific reaction path to interact with the raw materials. During the process, the reaction conditions, such as temperature, pressure, catalyst dosage, etc., are carefully controlled.
and after the reaction, carefully separate and purify the product to maintain its purity. The properties of the product were investigated in detail, its physical properties, such as melting point and boiling point, and its chemical properties were studied to observe its reaction in various reagents.
After long-term research, we have gradually realized the potential uses of this product in many fields, or it can be used for the creation of new materials, or it can be helpful in pharmaceutical synthesis. I will make unremitting efforts to expand its application, promote the development of this field, and make modest contributions to academia and industry.
Toxicity Research
As a chemical researcher, I often study the properties of toxicants. Brominated methyl fluorobenzene, its toxicity research is very important.
Looking at the structure of its molecules, bromine and fluorine atoms are attached to the benzene ring, or have special chemical properties. From the previous cases of toxicants, benzene ring substances are often toxic. This brominated methyl fluorobenzene, the substitution of bromine and fluorine, or the ability to change its permeability to cells, often affects cells after entering the body.
Or damage the membrane of the cell, messing with the balance of its penetration; or react with various proteins and nucleic acids in the cell to change its structure and work. However, to determine its toxicity, it is still necessary to study more methods. Taking animals as models, the response of acute and slow toxicity was measured; at the cell level, the shadow of its impact on cell growth and death was observed. Hope that by studying all, the toxicity of brominated methyl fluorobenzene is the basis for protection and treatment.
Future Prospects
In the future, it is related to (1 - (Bromomethyl) -3 - Fluorobenzene), and our generation is eager for it. In the field of chemical industry, it must make extraordinary progress.
Looking at the current situation, scientific research is not advanced. Our chemists do our best to study its properties and production methods. With time, the synthesis method will be simpler and more efficient, and the cost will be greatly reduced.
On the application side, it is expected that it can make a name for itself in the creation of medicine, or as a key ingredient in the magic medicine for healing diseases; in the field of material research and development, it is also expected to become the cornerstone of new functional materials, bringing opportunities for innovation in many fields.
I firmly believe that in the future, (1 - (Bromomethyl) -3 - Fluorobenzene) will be able to shine, bring well-being to the world, and achieve a great career, which will live up to the expectations of our researchers.
Where to Buy 1-(Bromomethyl)-3-Fluorobenzene in China?
As a trusted 1-(Bromomethyl)-3-Fluorobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 1-(Bromomethyl)-3-Fluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the physical properties of 1- (bromomethyl) -3-fluorobenzene?
In "Tiangong", (cyanomethyl) -3-bromopyridine is a kind of chemical substance with special properties. Its outer surface is often crystalline, the ground is clear, and the color is transparent or light-colored.
In terms of its physical properties, the melting property is very important. Under a specific degree, it can be solidified by the liquid. The value of this melting is one of its important physical characteristics. Just like the "identity mark" of the object, it determines to a certain extent where it will gather in the environment.
Furthermore, the solubility of this substance can also be determined. In some soluble materials, it can dissolve well, just like water, and the phase is melted; however, in water, the solubility is poor, like oil and water, and it is miscible. This property makes its molecules and properties closely related, and the force and solubility of the molecules are poor, resulting in such solubility.
In addition, the solubility of (cyanomethyl) -3-bromopyridine is very small. Under normal conditions, it is not easy to escape in the air, and it is difficult for some substances that are easy to escape. Its quality is high, such as in deep beauty, it is not easy to show.
Therefore, the physical properties of (cyanomethyl) -3-bromopyridine, including external properties, melting properties, solubility, and solubility, are all unique, and they all play a specific role in chemical engineering, chemical engineering, and other multi-domain research applications because of their physical properties. For example, one of the most important in precision machinery.
What are the chemical properties of 1- (bromomethyl) -3-fluorobenzene?
The chemical properties of (cyanomethyl) -3-pyridine are involved in organic chemistry. Its unique properties show different manifestations in various reactions.
First, it has nucleophilicity. The cyanyl group in the cyanomethyl group has strong electron-absorbing properties, causing the carbon to be partially positively charged and vulnerable to attack by nucleophilic reagents. In case of nucleophiles containing active hydrogen, such as alcohols and amines, the cyanomethyl group can react with them to form new carbon-heteroatom bonds. This reaction is commonly used in the construction of complex organic structures. By means of nucleophilic substitution, it can introduce specific functional groups to molecules and expand the chemical diversity of molecules.
Second, the pyridine ring is alkaline. The nitrogen atom in the pyridine ring has a lone pair of electrons, which can accept protons and is basic. In an acidic environment, pyridine nitrogen is easily protonated, which changes the electron cloud density of the pyridine ring and affects the reactivity of the whole molecule. This basic property allows (cyanomethyl) -3-pyridine to participate in acid-base catalyzed reactions or form salts with acidic substances, which is crucial for regulating drug solubility and stability in drug synthesis.
Third, the cyanyl group can undergo various transformations. The cyanyl group can be hydrolyzed into a carboxyl group. Under specific conditions, the carbon-nitrogen triple bond in the cyanyl group is gradually replaced by a hydroxyl group, and finally forms a carboxylic acid structure. This transformation is commonly used in the synthesis of organic compounds with carboxyl functional groups. It can also be reduced to amino groups. Cyanyl groups are reduced and hydrogenated with carbon and nitrogen bonds to form products containing amino groups, providing a way for the preparation of amine compounds.
Fourth, the pyridine ring can undergo electrophilic substitution. Although the electron cloud density of the pyridine ring is lower than that of the benzene ring, the electrophilic substitution activity is slightly inferior, but under suitable conditions, electrophilic substitution can still occur at specific positions of the pyridine ring. For example, the introduction of halogen atoms, nitro and other functional groups on the pyridine ring enriches the structure and properties of the compound, providing a variety of intermediates for subsequent organic synthesis.
In what fields is 1- (bromomethyl) -3-fluorobenzene used?
1 - (hydroxymethyl) - 3 - ethoxylbenzene, this substance has wonderful uses in various fields. In the field of medicine, it can be used as a key intermediate to help synthesize a variety of drugs with good curative effects. Due to its unique chemical structure, it can be ingeniously combined with many bioactive molecules, so it is often an indispensable raw material in the process of drug development.
In the field of materials science, 1 - (hydroxymethyl) - 3 - ethoxylbenzene also exhibits its extraordinary functions. It can participate in the synthesis of polymer materials to achieve better properties, such as improving the stability and flexibility of materials. Incorporating it into a polymer by a specific process can improve the physical and chemical properties of the material, thereby meeting the special needs of the material in different scenarios.
In addition, in the field of fine chemicals, it also plays an important role. It can be used to prepare fine chemicals such as special coatings and fragrances. In the preparation of coatings, adding this substance can optimize the film-forming performance and corrosion resistance of coatings; when blending fragrances, its unique chemical properties may endow fragrances with unique aroma characteristics, adding a wealth of categories to the fragrance industry. From this perspective, 1- (hydroxymethyl) -3-ethoxybenzene has shown significant application value in the fields of medicine, materials science, and fine chemicals. It is a widely used and crucial compound in the chemical industry.
What are the synthesis methods of 1- (bromomethyl) -3-fluorobenzene?
To prepare 1 - (hydroxymethyl) - 3 - methoxybenzene, there are various methods for its synthesis, which are described in detail as follows:
First, 3 - methoxybenzaldehyde is used as the starting material. First, 3 - methoxybenzaldehyde and formaldehyde are reacted in an alkaline environment according to the principle of hydroxyaldehyde condensation reaction. In this process, the basic reagent can be selected from sodium hydroxide solution, etc., to control the appropriate temperature and reaction time, the aldehyde group of 3 - methoxybenzaldehyde reacts with the active hydrogen of formaldehyde to form an intermediate containing hydroxymethyl. Then, the intermediate is reduced by using a reducing agent such as sodium borohydride, and the corresponding group in the intermediate is reduced in a suitable solvent to obtain 1- (hydroxymethyl) -3-methoxybenzene. The key to this path lies in the control of the conditions of hydroxyaldehyde condensation reaction. Too strong or too weak alkalinity, too high or too low temperature may affect the yield and selectivity of the reaction; the reduction step also needs to pay attention to the amount of reducing agent and reaction conditions to prevent the occurrence of side reactions such as excessive reduction.
Second, 3-methoxybenzoic acid can be used. First, 3-methoxybenzoic acid is converted into the corresponding acyl chloride, commonly used chlorination reagents such as dichlorosulfoxide, etc. After the acyl chloride is formed, it can be reacted with suitable organometallic reagents, such as methyl lithium, etc., and methyl groups can be introduced at specific positions in the benzene ring. Subsequently, through a series of reactions such as reduction and hydroxylation, the structure of 1- (hydroxymethyl) -3-methoxybenzene is gradually constructed. This route involves a multi-step reaction, and the products of each step need to be carefully separated and purified to ensure the smooth progress of the subsequent reaction. The use of organic metal reagents requires special attention to its activity and safety. The anhydrous and anaerobic conditions of the reaction are also crucial.
Third, a suitable phenolic compound is used as the starting material. The synthesis of the target product is achieved through the protection of phenolic hydroxyl groups, the methoxylation reaction at specific positions on the benzene ring, and then the introduction of hydroxymethyl groups. For example, the phenolic hydroxyl group is first protected with a protective group such as tert-butyl dimethylsilyl to prevent unnecessary side reactions in subsequent reactions. Next, the methoxy group is introduced at specific positions in the benzene ring using suitable methoxylating reagents, such as dimethyl sulfate. Finally, the protective group is removed and hydroxymethyl is introduced to achieve the synthesis of 1 - (hydroxymethyl) - 3 - methoxybenzene. In this approach, the selection of protective groups and the optimization of removal conditions are extremely important to ensure that the protective group is stable during the reaction and does not affect the structure of other parts of the molecule when removed.
What are the storage conditions for 1- (bromomethyl) -3-fluorobenzene?
(Note: The following is answered in ancient classical Chinese style, try to fit the needs of the question.)
The storage conditions of Fu 1- (hydroxymethyl) -3 -methylsulfone are related to the stability and effectiveness of this chemical, which cannot be ignored.
The combination of the two is more active in nature and easily disturbed by various external factors. First, temperature is important. It should be placed in a cool place. If the temperature is too high, it may cause decomposition, polymerization and other changes, which will damage its inherent properties. Cover high temperature can promote molecular activity, causing chemical bonds to break and recombine, so it is necessary to avoid hot places to protect its quality.
Second, the humidity should not be underestimated. This compound encounters water, or reacts such as hydrolysis. Where the moisture is too heavy, the water vapor is easy to contact and cause changes. Therefore, it should be placed in a dry place to prevent moisture from invading and maintain its pure state.
Furthermore, light is also the key. Light has energy, which can cause molecular excitation and chemical changes. If exposed to strong light, or accelerate its deterioration. Therefore, it should be stored in a dark place, such as in dark bottles, hidden in a dark room, protected from light.
In addition, this substance may be toxic and corrosive to a certain extent, and the storage place should be separated from other things to prevent leakage and endanger the surrounding things and people. And it needs to be clearly marked so that everyone knows its characteristics and dangers, and treat it with caution.
In general, the storage of 1- (hydroxymethyl) -3-methylsulfone should be cool, dry, protected from light, properly isolated, and clearly marked, so as to maintain its good condition for a long time for future use.