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What are the chemical properties of 1- (Bromomethyl) -3- (4-Fluorophenoxy) Benzene?
1 - (bromomethyl) -3- (4 -fluorophenoxy) benzene, this is an organic compound. Looking at its structure, above the benzene ring, there is a bromomethyl group in one place and a 4-fluorophenoxy group in the other place.
In terms of its physical properties, it may be solid at room temperature, but it also varies depending on the specific environment. Its melting point and boiling point belong to the family of intermolecular forces. Intermolecular van der Waals forces are determined by their structure. The existence of bromomethyl and fluorophenoxy makes the intermolecular interaction unusual.
As for chemical properties, bromomethyl is quite active. The cover bromide atom has strong electronegativity, which makes the carbon-bromide bond polarity significant and vulnerable to attack by nucleophiles. In case of nucleophiles of alcohols, it can form ethers; in case of amines, it can be replaced by raw amines. In this substitution reaction, the nucleophile provides electron pairs to attack the carbon of bromomethyl, and the bromine ions leave to form new chemical bonds.
Furthermore, the presence of the benzene ring also gives it special chemical properties. The benzene ring has a conjugated system and is rich in electrons, which easily reacts with electrophilic reagents. Although 4-fluorophenoxy is connected to the benzene ring, the electron cloud distribution of the benzene ring is adjusted, but the overall electrophilic substitution activity of the benzene ring still exists. In case of electrophilic reagents such as halogenating agents and nitrifying agents, substitution can occur at specific positions of the benzene ring. In the
4 -fluorophenoxy group, the fluorine atom has a strong electron-absorbing induction effect, which can affect the electron cloud density distribution between the phenoxy group and the benzene ring, and then has an impact on the overall molecular reactivity and selectivity. In many reactions, this structural characteristic will cause different reaction check points and rates. In summary, the chemical properties of 1 - (bromomethyl) -3 - (4 -fluorophenoxy) benzene are determined by the synergistic structure of its various parts. In the field of organic synthesis, due to these characteristics, it can be used as a key intermediate and participate in the preparation of various complex organic compounds.
What are the common uses of 1- (Bromomethyl) -3- (4-Fluorophenoxy) Benzene?
1 - (bromomethyl) -3- (4 -fluorophenoxy) benzene, an important intermediate in organic synthesis, has a wide range of uses in many fields. Its common preparation routes are diverse, and are described in detail as follows:
First, halogenation is a common method. Using a compound containing the corresponding benzene ring structure as the starting material, bromomethyl can be introduced at a specific position through the action of halogenating reagents. For example, by selecting a suitable brominating reagent, such as N-bromosuccinimide (NBS), in the presence of an initiator, bromomethyl can be achieved in the side chain of the benzene ring, thereby introducing bromomethyl. This process requires fine control of reaction conditions, such as reaction temperature, reagent dosage, and reaction time. If the temperature is too high, it is easy to cause side reactions to occur and form polybrominated products; if the temperature is too low, the reaction rate will be slow and the yield will be poor.
Second, etherification reaction is also a common method. Fluorinated phenols and halogenated benzene derivatives are used as raw materials. Under basic conditions, ether bonds are formed through nucleophilic substitution reaction, and then the target molecular structure is constructed. In this reaction, the choice of base is crucial. Common bases such as potassium carbonate and sodium hydroxide, etc. The alkalinity and solubility of different bases have a significant impact on the reaction process. At the same time, the polarity of the solvent also affects the reaction rate and selectivity, so careful screening is required.
Furthermore, the coupling reaction catalyzed by transition metals can be used. Appropriate transition metal catalysts, such as palladium catalysts, are selected to couple benzene ring compounds containing specific functional groups to achieve the synthesis of the target product. Such reactions usually have the advantages of high efficiency and good selectivity, but the catalyst cost is higher, the reaction conditions are more harsh, and the reaction equipment and operation requirements are strict.
In the actual synthesis process, it is necessary to comprehensively consider the availability of raw materials, the difficulty of controlling the reaction conditions, production costs, yield and purity, and carefully select the most suitable synthesis method to achieve the efficient preparation of 1- (bromomethyl) -3- (4-fluorophenoxy) benzene.
What is the synthesis method of 1- (Bromomethyl) -3- (4-Fluorophenoxy) Benzene
To prepare 1 - (bromomethyl) - 3 - (4 - fluorophenoxy) benzene, the method is as follows:
Take 3 - hydroxybenzaldehyde first, and shield its aldehyde group with an appropriate protective group. The method of acetalization can be used to react it with diols, such as ethylene glycol, under acid catalysis to obtain the corresponding acetal, which can protect the aldehyde group from being affected in subsequent reactions. Then, 4-fluorobromobenzene is blended with a base, such as potassium carbonate, in an organic solvent, such as N, N-dimethylformamide (DMF), and heated to an appropriate temperature, such as 80-100 ° C. When stirring the reaction number, the bromine atom of 4-fluorobromobenzene is connected to the phenolic hydroxyl group of 3-hydroxybenzaldehyde through a nucleophilic substitution reaction to obtain an acetal derivative of 3- (4-fluorophenoxy) benzaldehyde.
After the reaction is completed, cool the reaction solution and treat it with an appropriate acid solution, such as dilute hydrochloric acid, hydrolyze the acetal, and restore the aldehyde group to obtain 3- (4-fluorophenoxy) benzaldehyde.
This aldehyde is then treated with a reducing agent, such as sodium borohydride, in an alcohol solvent, such as methanol, and reacted at room temperature to reduce the aldehyde group to hydroxymethyl to obtain 3- (4-fluorophenoxy) benzyl alcohol.
Finally, this alcohol is reacted with a brominating agent such as hydrobromic acid or phosphorus tribromide, and at an appropriate temperature, such as reflux temperature, the hydroxyl group of the alcohol is replaced by a bromine atom to obtain 1- (bromomethyl) -3- (4-fluorophenoxy) benzene. After the reaction is completed, the pure product can be obtained by separation and purification methods, such as column chromatography.
What are the precautions for storing 1- (Bromomethyl) -3- (4-Fluorophenoxy) Benzene?
1 - (bromomethyl) - 3 - (4 - fluorophenoxy) benzene, this is an organic compound. When storing it, many things need to be paid attention to.
Bear the brunt, temperature is very important. This compound is mostly sensitive to temperature changes. Under high temperature, it may cause chemical reactions or even decomposition and deterioration. Therefore, it should be stored in a cool place. Usually, the temperature should be controlled below 25 ° C, preferably between 15 and 20 ° C, so that its chemical properties can be kept stable.
Humidity should not be underestimated. Humid environment can easily make it absorb moisture, which in turn affects the quality. It needs to be stored in a dry place, and the humidity should be maintained at 40% - 60%. If conditions permit, a desiccant can be placed in the storage place to absorb excess water vapor.
Furthermore, light will also have an effect on it. The compound may be photosensitive, and long-term light exposure or photochemical reactions can cause structural changes. Therefore, it should be stored in a dark place or packaged in a dark container to block light intrusion.
In addition, this compound is toxic and corrosive to a certain extent. During storage, be sure to pack tightly to prevent leakage. If it comes into contact with the human body, or causes damage to the skin, eyes, etc.; once it leaks, it will also pollute the environment. When taking it, you should also strictly follow the operating procedures and take protective measures.
At the same time, the storage place should be kept away from fire sources, heat sources and strong oxidants. Because of its flammability, there is a risk of combustion and explosion in case of open flames and hot topics; contact with strong oxidants is also easy to cause violent reactions.
And it needs to be stored separately from other chemicals to avoid mixing with each other to cause reactions. The storage area should be clearly marked with its characteristics and precautions so that relevant personnel can know. Regularly check the storage to see if the packaging is in good condition and shows no signs of deterioration to ensure its safe storage.
What is the market price range for 1- (Bromomethyl) -3- (4-Fluorophenoxy) Benzene?
I have not yet obtained the cutting price of 1- (bromomethyl) -3- (4-fluorophenoxy) benzene in the market. However, if you want to know the market value of this product, you can explore it in many ways.
First, it is found on the chemical trading platform. Today, there are many chemical trading platforms on the Shanghai chemical trading platform, which list general chemical products and their prices. Log on to this platform, such as the German chemical industry, motorcycle, etc., under the name of 1- (bromomethyl) -3- (4-fluorophenoxy) benzene, or you can get different suppliers' prices, so you can find their prices.
Second, chemical products are supplied to commercial sites. Many chemical product suppliers list products and prices on their websites. You can search for well-known chemical product suppliers, such as Sigma-Aldrich, Alfa Aesar, etc., to search for this compound at their own stations and determine its value. However, different suppliers have different prices due to differences in product quality and packaging quality.
Third, chemical product suppliers or agents. They are familiar with the market conditions and can contact or send them to the market of 1- (bromomethyl) -3- (4-fluorophenoxy) benzene. They may report on the market price of 1- (bromomethyl) -3- (4-fluorophenoxy) benzene according to their own channels and sales.
Fourth, research and industry reports. Some research or industry analysis reports, or the market price of specific products. You can search for phase information in materials such as Web of Science, SciFinder, etc., or on industry reporting platforms.
In order to obtain 1- (bromomethyl) -3- (4-fluorophenoxy) benzene, it is advisable to use multiple methods. Only by considering the information obtained in each way can you obtain the phase information.