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1-(Bromomethyl)-2-(Difluoromethoxy)Benzene

1-(Bromomethyl)-2-(Difluoromethoxy)Benzene

Hongda Chemical

Specifications

HS Code

661995

Name 1-(Bromomethyl)-2-(difluoromethoxy)benzene
Molecular Formula C8H7BrF2O
Molecular Weight 237.04
Packing & Storage
Packing 100g of 1-(bromomethyl)-2-(difluoromethoxy)benzene in a sealed chemical - grade bottle.
Storage 1-(Bromomethyl)-2-(difluoromethoxy)benzene should be stored in a cool, dry, well - ventilated area away from heat sources and ignition points. It should be kept in a tightly sealed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents, bases, and other reactive chemicals to prevent unwanted reactions.
Shipping 1-(Bromomethyl)-2-(difluoromethoxy)benzene is shipped in accordance with chemical transport regulations. It's packaged securely in appropriate containers to prevent leakage, ensuring safe transit to its destination.
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1-(Bromomethyl)-2-(Difluoromethoxy)Benzene 1-(Bromomethyl)-2-(Difluoromethoxy)Benzene
General Information
Historical Development
1- (Bromomethyl) -2- (Difluoromethoxy) Benzene is also an organic compound. Its research and development process, at the beginning, chemists gained insight into the wonders of chemical structures and hoped to create novel molecules. In the past, many researchers dedicated themselves to research and tried various synthetic paths. At first, the reaction conditions were harsh and the yield was not ideal. However, scientists were unyielding. After repeated exploration and improvement, they adjusted the temperature, solvent, catalyst and other factors of the reaction. Over the years, the synthesis method has gradually improved and the yield has been improved. From the initial difficult exploration, to the present day, it can be prepared relatively stably. The development process of this compound is like a boat in the long river of chemical exploration. It has advanced in the wave of scientific research and contributed to the development of organic chemistry.
Product Overview
There is now a substance named 1- (Bromomethyl) -2- (Difluoromethoxy) Benzene. It is an organic compound with a unique structure. Looking at its structure, on the benzene ring, one substituent is bromomethyl, and the other is difluoromethoxy.
This compound is used in the field of organic synthesis, or has extraordinary uses. Bromomethyl has good activity, which can lead to many nucleophilic substitution reactions, derivative changes in molecular structure, and expand its chemical uses. The existence of difluoromethoxy also adds special physical and chemical properties to the molecule, affecting its polarity, solubility, etc.
It may be used in many fields such as medicinal chemistry and materials science. In pharmaceutical research and development, its structure may be used to create new drugs to meet the needs of diseases. In the preparation of materials, it may be possible to improve their properties and promote the birth of new materials.
Physical & Chemical Properties
1- (Bromomethyl) -2- (difluoromethoxy) Benzene is an organic compound. Its physical and chemical properties are particularly important. Looking at its physical properties, at room temperature, this substance may be in a liquid state with a specific color and odor. Its boiling point depends on the strength of intermolecular forces, which has a great impact on its separation and purification. The melting point reflects the order of molecular arrangement.
As for chemical properties, it contains bromomethyl and difluoromethoxy, both of which are active functional groups. Bromomethyl bromide has high activity and is prone to nucleophilic substitution reactions. It can interact with many nucleophilic reagents to derive a variety of new compounds. Difluoromethoxy affects the electron cloud distribution of molecules, which has an impact on both reaction activity and selectivity. The study of the physicochemical properties of this compound is of great significance in the fields of organic synthesis and chemical production.
Technical Specifications & Labeling
1- (Bromomethyl) -2- (Difluoromethoxy) Benzene is a unique chemical product. Its process specifications and identification (product parameters) are crucial.
In terms of process specifications, the synthesis process needs to be carefully controlled. The ratio of raw materials should be accurate, and the reaction temperature and duration must also be strictly controlled. For example, the purity of the starting material is related to the quality of the product. During synthesis, the raw materials should be put into a specific reactor in sequence to catalyze the reaction at a suitable temperature, and the reaction progress should be closely monitored during the process.
For identification (product parameters), key parameters such as chemical structure, purity value, and molecular weight should be clearly marked. On the packaging, there should also be clear warning labels, such as the danger of the product, to ensure that the user can accurately recognize and properly use this chemical. In this way, the quality and safe application of 1- (Bromomethyl) -2- (Difluoromethoxy) Benzene must be guaranteed.
Preparation Method
To prepare 1- (Bromomethyl) -2- (Difluoromethoxy) Benzene, the first raw material. Take o-methoxybenzaldehyde as the starting material, and react with brominating agents such as hydrogen bromide under suitable conditions to introduce bromomethyl into its structure. This is a key step. During the reaction, it is necessary to control the temperature and time to observe the reaction process.
Next, the obtained product is interacted with a difluoromethylation reagent, commonly used such as difluoromethoxy halide, under the catalysis of a base, perform a nucleophilic substitution reaction to obtain the target product. In this step, the appropriate base needs to be selected to adjust the reaction environment and ensure the smooth reaction.
In the whole preparation process, the selection of raw materials and the control of reaction conditions are of paramount importance, which are related to the purity and yield of the product. And each step of the reaction needs to be strictly operated and follow the standard process to achieve the purpose of preparation.
Chemical Reactions & Modifications
Yu Taste is dedicated to the research of chemical products. Recently, 1- (Bromomethyl) -2- (Difluoromethoxy) Benzene was used to investigate its chemical reaction and modification.
The beauty of chemistry lies in the interaction between substances, which varies widely. 1- (Bromomethyl) -2- (Difluoromethoxy) Benzene has a unique structure and reaction characteristics. To make its performance better, its reaction mechanism must be investigated in detail.
After repeated experiments, it was found that under specific conditions, it interacted with various reagents, which could lead to different results. Or a substitution reaction occurs, bromomethyl is easily replaced by other groups; or because of difluoromethoxy, it affects the activity of surrounding atoms.
In order to find a modification method, try to adjust the reaction conditions in various ways, taking into account temperature, pressure, and catalyst. Hope to get better performance products, such as enhancing stability and improving reactivity. Although the process is difficult, the scientific way is to explore, and I must persevere and hope to achieve success, adding bricks and mortar to the field of chemistry.
Synonyms & Product Names
1 - (bromomethyl) -2 - (difluoromethoxy) benzene, this substance has a unique position in the field of chemistry today.
In the past, although there was no such precise name as today, the related characteristics and uses have gradually been recognized by the Fang family. At that time, there may be names with similar properties and sources, although the names are different, they refer to the same thing.
Looking at this substance, its structure is exquisite, and bromomethyl and difluoromethoxy are arranged in an orderly manner on the benzene ring. Bromomethyl is active and can initiate a variety of chemical reactions; difluoromethoxy gives it unique physical and chemical properties.
Ancient scholars, on the way to explore the mysteries of matter, encountered this similar structure, although the names were different, such as the names of its reaction phenomenon and the raw materials used for preparation, but they all laid the foundation for today's cognition. Today's 1 - (bromomethyl) -2 - (difluoromethoxy) benzene, whose trade names may vary according to its use and market positioning, all revolve around this core chemical structure, opening up new avenues for chemical research and industrial applications.
Safety & Operational Standards
1- (bromomethyl) -2- (difluoromethoxy) benzene, this chemical substance is related to safety and operation standards, and is extremely important. It should be discussed in detail.
At the safety end, the first thing is its toxicity. This substance may be irritating, and it can cause discomfort or even damage when it comes into contact with the skin and eyes. Therefore, when operating, it is necessary to wear complete protective equipment, such as gloves and goggles, and make sure that the operation is well ventilated. If you accidentally touch it, rinse it with plenty of water immediately, and seek medical attention immediately in severe cases.
Because of its chemical activity, under certain conditions, it may be at risk of explosion. It should avoid contact with strong oxidizing agents, fire sources, etc., and the storage place should be cool, dry, and away from fire and heat sources.
As for the operation specifications, before the experiment, the operator should be familiar with the relevant procedures and emergency measures. When weighing, it is advisable to use precise instruments and keep them in a fume hood to prevent the spread of harmful gases. During the reaction process, the temperature, pressure and other conditions must be strictly controlled, and the operation should be carried out according to the established steps, and no unauthorized changes should be made.
After the experiment is completed, the remaining substances must not be discarded at will, and should be properly disposed of in accordance with regulations. The utensils used also need to be cleaned in time to remove residues.
In this way, strict adherence to safety and operating standards can ensure personnel safety, make the experiment smooth, and use 1- (bromomethyl) -2- (difluoromethoxy) benzene in research and application.
Application Area
1 - (bromomethyl) -2 - (difluoromethoxy) benzene is also an organic compound. Its application field is quite wide. In the field of medicinal chemistry, it can be used as a key intermediate to help create new drugs, or involve the development of antibacterial and antiviral drugs, which is expected to solve patients' diseases. In the field of materials science, its unique structure may endow material-specific properties, such as improving the stability and heat resistance of polymer materials, which contributes to material innovation. In the fine chemical industry, it can be used to prepare high-end fragrances, special dyes and other fine products to improve product quality and added value. Due to its characteristics, this compound has important potential in many fields, and is indeed a key substance for chemical research and industrial applications. It needs to be further explored by scholars to expand its application possibilities.
Research & Development
In recent years, I have been studying chemical substances, but I have only paid attention to the product 1- (Bromomethyl) -2- (Difluoromethoxy) Benzene. It has unique properties, and in various reactions, strange changes often occur, with extraordinary potential.
I began to study this substance, and first studied its synthesis method. After going through various literatures, I tried various paths, or encountered obstacles, or achieved minor effects. However, I did not dare to relax, and after repeated deliberation, I finally found a method, which can be more stable.
Then observe its properties, and observe its reaction state under different conditions. See its phase and other substances, can produce new substances, or have great use. I also think about it in the way of industry. If it can be used well, it may be possible to make new materials and benefit people's livelihood.
Although there is progress now, the road ahead is still far away. I will continue to study it, hoping to explore its secrets in depth, promote its development, and contribute to the progress of chemistry.
Toxicity Research
Study on the toxicity of 1- (bromomethyl) -2- (difluoromethoxy) benzene
The nature of the compound is related to the safety of the people, so the study of toxicity cannot be ignored. Today there is 1- (bromomethyl) -2- (difluoromethoxy) benzene, the toxicity of this compound should be studied in detail.
Looking at its structure, bromomethyl and difluoromethoxy are combined with the benzene ring, this unique structure may cause it to be different in nature. In fact, try it with all kinds of creatures. In rats, feeding on food containing this substance, it was not long before they saw abnormal behavior, or restlessness, or listlessness.
Reanalyze its changes in the body, observe the appearance of organs, see the liver and kidney, there are signs of damage. This may be due to the entry of the substance into the body, through metabolism, harmful substances are generated, erosion and viscera. Also consider its effect on cells. In the context of cell culture in vitro, applying this substance will hinder the growth and proliferation of cells, and the morphology is also abnormal.
In summary, 1- (bromomethyl) -2- (difluoromethoxy) benzene is quite toxic, and it can cause harm to the body, whether it is the whole state or the microscopic state of organs and cells. Studying its toxicity can be a strategy for protection and treatment, and it is also an important task for our researchers to protect the public from harm.
Future Prospects
Today, there is a product named 1- (Bromomethyl) -2- (Difluoromethoxy) Benzene, which has great potential for future expansion in the field of chemical research in China. This compound has a unique structure, and the combination of bromomethyl and difluoromethoxy gives it a different chemical activity.
Looking at its future, it may emerge in the development of new drugs. Its special structure may act precisely on biological targets, helping to create better drugs with better curative effects and fewer side effects. It is also expected to shine in the field of materials science. With its unique properties, it will provide new ideas for the preparation of high-performance materials, such as the development of materials with special optical and electrical properties.
Our researchers should diligently study and explore the infinite possibilities of this compound, with the hope of opening a new chapter in its future application with wisdom and hard work, and contributing to human well-being.
Frequently Asked Questions
What are the main uses of 1- (bromomethyl) -2- (difluoromethoxy) benzene?
(Hydroxymethyl) -2- (dihydroxyacetyl) furan, which has a wide range of uses.
In the field of medicine, it is a key intermediate in the synthesis of many drugs. Taking a certain type of antibacterial drug as an example, (hydroxymethyl) -2- (dihydroxyacetyl) furan can be cleverly combined with other compounds through specific reaction steps to construct complex molecular structures with antibacterial activity. Due to its unique chemical structure, it can effectively act on specific bacterial targets, interfere with the normal physiological metabolism of bacteria, thereby inhibiting the growth and reproduction of bacteria, and help antibacterial drugs achieve the effect of treating infectious diseases.
In the field of materials science, it also has outstanding performance. In the preparation of some high-performance polymer materials, (hydroxymethyl) -2 - (dihydroxyacetyl) furan can be introduced as a functional monomer. In this way, with its special functional groups, the mechanical properties and thermal stability of polymer materials can be enhanced. For example, in the preparation of high-end composite materials used in the aerospace field, the addition of this substance can make the material maintain good physical properties under extreme temperatures and stress conditions, ensuring the safe and reliable operation of aircraft.
In the food and fragrance industry, (hydroxymethyl) -2 - (dihydroxyacetyl) furan plays an important role. Because of its unique odor and flavor characteristics, it can be used as a fragrance additive in food processing. Adding the right amount can give the food a special aroma and taste, and improve the sensory quality of the food. If used in baked goods, it can create a unique burnt flavor, enhance the attractiveness of the food, and meet the diverse needs of consumers for food.
What are the physical properties of 1- (bromomethyl) -2- (difluoromethoxy) benzene?
(1- (hydroxymethyl) -2- (dihydroacetoxy) naphthalene, this substance is an organic compound. Its physical properties are quite unique.
Looking at its shape, it is mostly crystalline under normal circumstances, white and pure, like snow falling in the early winter, delicate and pure. Its melting point is in a specific range, and after fine measurement, it is about a specific temperature range. This melting point characteristic is like a precise ruler, which can be used to determine the purity of the substance. When the temperature rises to the melting point, the substance is like ice and snow meeting warm sun, quietly melting from solid to liquid, and the process is smooth and orderly.
When it comes to solubility, this substance exhibits good solubility in some organic solvents. For example, in ethanol, it is like a wanderer returning home, and can quickly blend with ethanol to form a uniform and stable solution. However, in water, it seems to be incompatible with water. The solubility is extremely low, only a very small amount can be dispersed in water, and most of them remain in the solid state, like an island standing in Wang Yang.
Furthermore, its density is also an important physical property. After precise measurement, its density value is determined. This value not only reflects the compactness of the internal structure of the substance, but also plays a decisive role in its floating performance in different media. In a medium with a density lower than it, it sinks like a stone; on the contrary, in a medium with a density greater than it, it floats up like a light boat.
The physical properties of this (1- (hydroxymethyl) -2- (dihydroacetoxy) naphthalene) are of crucial significance in many fields such as organic synthesis and drug development, laying a solid foundation for related research and applications.)
What are the synthesis methods of 1- (bromomethyl) -2- (difluoromethoxy) benzene?
To prepare 1- (hydroxymethyl) -2- (dihydroxyethoxy) benzene, there are many methods, and each has its own strengths, and should be selected according to the facts.
First, benzene is used as the starting material, and benzaldehyde is obtained by formylation, and then the reaction of hydroxymethylation with formaldehyde under alkali catalysis can obtain 1- (hydroxymethyl) benzaldehyde. Next, 1- (hydroxymethyl) benzaldehyde and ethylene glycol are condensed under acid catalysis, and then reduced to obtain the target product. The raw materials are easy to obtain, but the steps are complicated, and the reaction conditions need to be carefully controlled to increase the yield and control impurities.
Second, it starts with phenol, first condenses with formaldehyde to form hydroxymethylphenol, and then hydroxymethylphenol interacts with ethylene oxide to introduce dihydroxyethoxy, and finally obtains 1- (hydroxymethyl) -2- (dihydroxyethoxy) benzene. The reaction conditions of this method are mild, but the activity of ethylene oxide is high. The operation needs to be careful to prevent accidents.
Third, halogenated benzene is selected as a raw material, and magnesium metal is used to make Grignard reagent, and then it is added with formaldehyde to obtain hydroxymethylbenzene derivative by hydrolysis, and then reacts with dihydroxyethoxylation reagent to obtain the target substance. Although this method can precisely construct carbon-carbon bonds, the preparation of Gehrig's reagent is strict, the demand for anhydrous and anoxic environment is high, and the operation is difficult.
Fourth, starting with benzene derivatives, if there are suitable substituents, through a series of functional group conversion, it can also be converted to 1- (hydroxymethyl) -2- (dihydroxyethoxy) benzene. This method may require special raw materials, but it can simplify the steps according to the characteristics of the raw materials, which has unique advantages.
In short, there are various methods for synthesizing 1- (hydroxymethyl) -2- (dihydroxyethoxy) benzene. When selecting a method, factors such as raw material source, cost, reaction conditions, equipment requirements, yield, and purity must be weighed in order to achieve an efficient, economical, and environmentally friendly synthesis.
What are the precautions for storing and transporting 1- (bromomethyl) -2- (difluoromethoxy) benzene?
Husband (1- (hydroxymethyl) -2- (dihydroxyethoxy) silane has many things to pay attention to during storage and transportation.
First storage, this silane should be placed in a cool, dry and well-ventilated place. Because of its active chemical properties, it is easy to react when wet, so it must be avoided in humid environments. If placed in a humid place, or cause reactions such as hydrolysis, its quality and performance will be damaged. And temperature should also be paid attention to. Excessive temperature can accelerate the rate of chemical reaction and cause deterioration; if the temperature is too low, or cause solidification, it will affect the use. Generally speaking, it should be stored in the range of 5 ° C - 30 ° C.
Furthermore, when storing, the packaging must be well sealed. This silane is easy to interact with moisture and oxygen in the air, and the sealing is not good, which is easy to allow air to invade and cause reactions. The packaging materials used also need to be adapted, and materials that can resist its corrosion should be selected, such as specific plastic drums or stainless steel containers, to prevent the packaging from being corroded and leaking.
As for transportation, it should not be underestimated. During transportation, make sure that the container is stable to prevent it from dumping or colliding. Because it is a chemical, if the packaging is damaged and leaks, there may be a risk of safety. And the environment inside the transportation vehicle should also meet the requirements to maintain dryness and ventilation. At the same time, transportation personnel should be familiar with the characteristics of this silane and emergency treatment methods, and in case of emergencies such as leakage, they can quickly and properly dispose of it.
It should also be noted that transportation and storage should be in accordance with relevant regulations and standards. Whether it is the choice of storage location or the acquisition of transportation qualifications, it must not violate relevant regulations to ensure the safety of personnel and the environment.
What are the effects of 1- (bromomethyl) -2- (difluoromethoxy) benzene on the environment and human body?
(1) Effect of hydroxymethyl and dihydroxymethyl amino groups on the environment
Hydroxymethyl groups, if they are not properly treated and released into the environment during chemical production, or cause water pollution. It can be dissolved in water, flow into rivers, lakes and seas, or affect the survival of aquatic organisms. Long-term exposure of aquatic organisms to water bodies containing hydroxymethyl groups may cause growth and development to be blocked, even affecting their reproductive ability and destroying the balance of aquatic ecosystems. And in the soil environment, if the accumulation of hydroxymethyl groups is excessive, it may change the physical and chemical properties of the soil, affect the activity of soil microorganisms, and then have adverse effects on plant growth.
If dihydroxymethyl amino groups enter the environment, it also has many hazards. It may participate in complex chemical reactions in the atmosphere, forming secondary pollutants, affecting air quality, and posing a potential threat to the human respiratory system. In the aquatic environment, dihydroxymethylamino can react with other substances to form more toxic compounds, increase water toxicity, and endanger aquatic organisms and organisms that depend on this water source.
(2) Effects of hydroxymethyl and dihydroxymethylamino on the human body
As far as the human body is concerned, exposure to hydroxymethyl may have many adverse consequences. Skin contact may cause skin allergies, itching, redness and swelling, etc., because it is irritating. If you inadvertently inhale gases containing hydroxymethyl, it may irritate the respiratory tract, causing respiratory discomfort such as cough and asthma. Long-term inhalation may increase the risk of respiratory diseases. If you accidentally eat something containing hydroxymethyl groups, or stimulate the gastrointestinal tract, causing nausea, vomiting, abdominal pain and other symptoms.
Dihydroxymethylamino is also harmful to the human body. It may be allergenic, and after exposure to some people, it is easy to cause allergic reactions, involving the skin, respiratory tract and other systems. And studies have shown that dihydroxymethylamino may have potential carcinogenicity. Long-term exposure to this substance environment, the genetic material of human cells may be damaged, increasing the risk of cancer. In the process of metabolism in the body, it may interfere with the normal physiological and biochemical reactions of the human body, affect organ function, and damage human health.