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1-(Bromomethyl)-2-Chloro-4-Fluorobenzene

1-(Bromomethyl)-2-Chloro-4-Fluorobenzene

Hongda Chemical

Specifications

HS Code

322893

Chemical Formula C7H5BrClF
Molecular Weight 223.47
Appearance Typically a colorless to light - yellow liquid
Boiling Point Data depends on purity, around 200 - 220°C under normal pressure
Density Approximately 1.7 - 1.8 g/cm³
Solubility Soluble in organic solvents like dichloromethane, chloroform, insoluble in water
Vapor Pressure Low vapor pressure at room temperature
Flash Point Caution, may be flammable, flash point needs experimental determination
Stability Stable under normal storage conditions, but reactive to strong bases and nucleophiles

As an accredited 1-(Bromomethyl)-2-Chloro-4-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 1-(bromomethyl)-2 - chloro - 4 - fluorobenzene in a sealed glass bottle.
Storage 1-(Bromomethyl)-2-chloro-4-fluorobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly sealed container to prevent leakage and exposure to air and moisture, which could potentially lead to decomposition or reaction. Label the storage container clearly for easy identification and safety.
Shipping 1-(Bromomethyl)-2-chloro-4-fluorobenzene is shipped in well - sealed containers, compliant with chemical transport regulations. Special care is taken to prevent leakage during transit due to its potentially hazardous nature.
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1-(Bromomethyl)-2-Chloro-4-Fluorobenzene 1-(Bromomethyl)-2-Chloro-4-Fluorobenzene
General Information
Historical Development
1- (Bromomethyl) -2-Chloro-4-Fluorobenzene, organic compounds are also. The evolution of chemistry, the study of such substances, has undergone years of continuous improvement.
Ancient chemistry, mostly limited by the inspection of ordinary substances, has not been as fine as this category. In modern times, chemical technology has become new, and instruments have gradually refined, so researchers have to look at it in detail. At first, only a little knowledge of its basic composition, after countless experiments, its structure has been analyzed and its properties have been explored.
The synthesis method in the past was complicated and inefficient, and the yield was meager. However, chemists are determined to study and improve the process unremitting, so that the synthesis process is gradually smoother and the yield can be improved. Today, 1- (Bromomethyl) -2-Chloro-4-Fluorobenzene in medicine, materials and other fields, all have important uses, it is due to the efforts of researchers of the past generations, in order to have the current achievements of this material research, its historical evolution, and the brilliant track of chemical development.
Product Overview
1- (Bromomethyl) -2-Chloro-4-Fluorobenzene, an organic compound. It may be a colorless liquid with a special odor. This compound contains halogen elements such as bromine, chlorine, and fluorine, and has a wide range of uses in the field of organic synthesis.
Its preparation method, Chang Wai's specific chemical reaction, connects the atoms according to a specific structure through ingenious steps. Because of its halogenation characteristics, it can participate in many nucleophilic substitution reactions and is an important intermediate for the construction of complex organic molecules.
In the chemical industry, or used in the preparation of pharmaceuticals, pesticides, and fine chemicals. With its unique chemical properties, it can endow the product with specific functions and activities. However, when preparing and using, it is necessary to pay attention to its safety, because it contains halogen elements, or it may be toxic and corrosive to a certain extent, and the operation should follow strict procedures.
Physical & Chemical Properties
1- (Bromomethyl) -2-Chloro-4-Fluorobenzene is an organic compound. In terms of physical properties, it is a solid state at room temperature. Due to the halogen atom, the intermolecular force is relatively large. The appearance may be a white crystalline solid with a certain luster.
From the chemical properties, bromomethyl in this compound is active and can undergo nucleophilic substitution. Chlorine and fluorine atoms change the electron cloud density of the benzene ring, which affects the activity of the electrophilic substitution reaction of the benzene ring. In the case of nucleophilic reagents, bromine atoms on bromomethyl are easily replaced to form new derivatives. This property is widely used in the field of organic synthesis and can be used to prepare complex organic molecules. Its physicochemical properties determine its important position in organic synthesis and related research fields.
Technical Specifications & Labeling
Today there is a product, named 1- (Bromomethyl) -2-Chloro-4-Fluorobenzene. In addition, the technical specifications and identification (product parameters) of the product should be carefully reviewed by our generation.
This substance has its unique structure due to the sequence and combination of bromomethyl, chlorine and fluorine. The technical specifications need to clarify its purity geometry and the limit of impurities, which is fundamental to quality. In the identification, its physical properties, such as color, taste, state, and chemical properties, should be recorded in detail, so that users can know its characteristics to avoid harm.
In addition, product parameters should not be ignored. Data such as melting point, boiling point, density, etc. can be accurately marked to provide convenience for the application. In this way, this material can be properly used in the field of chemical engineering, and its effective use can be exerted to meet the purpose of our generation's research and development pursuit.
Preparation Method
This 1- (Bromomethyl) -2-Chloro-4-Fluorobenzene this substance, the method is as follows: First take the raw material, in an appropriate ratio, the compound containing bromine, chlorine and fluorine, according to a specific chemical process, step by step. First, the method of bromination, the introduction of bromomethyl, control its conditions, so that the reaction is smooth. Then, temperature control, control, accompanied by a catalyst, chlorine and fluorine groups are precisely bound to the benzene ring. During the reaction steps, careful operation, in sequence, so that each step of the reaction is sufficient. In the catalytic mechanism, the appropriate catalyst is selected to increase the reaction rate and improve the purity of the product. Thus, to obtain 1- (Bromomethyl) -2-Chloro-4-Fluorobenzene, which is prepared raw materials and production processes, reaction steps, catalytic mechanisms are detailed herein, follow this may be.
Chemical Reactions & Modifications
1- (Bromomethyl) -2-Chloro-4-Fluorobenzene is a key raw material for organic synthesis, and its chemical reaction and modification are of great significance.
Looking at the synthesis reaction in the past, although the initial method can be obtained, the yield is not high and there are many impurities. Due to the harsh reaction conditions, many side reactions occur.
After unremitting research, the reaction path is improved. Under the new reaction conditions, with the help of a specific catalyst, the proportion of reactants is optimized, and the reaction selectivity is greatly increased. The yield can be significantly improved, and the product purity is also greatly improved.
After this compound is modified, the application field is broader. In pharmaceutical chemistry, it can be the key structure of specific drugs; in materials science, its modified products show unique properties, providing possibility for the development of new materials. Through this chemical reaction and modification, 1- (Bromomethyl) -2-Chloro-4-Fluorobenzene potential is full, and the future application prospect is promising.
Synonyms & Product Names
1- (Bromomethyl) -2-Chloro-4-Fluorobenzene is an important chemical substance. There are many synonyms, and different fields and researchers may have different names according to their habits and cognition. In the industry, there are also different trade names.
The synonyms of this compound are the key to accurately describe its chemical structure and properties. From the perspective of chemical structure, each synonym reflects its unique atomic composition and connection. And the trade name, more consideration is given to marketing activities and application scenarios.
Knowing its synonyms and trade names is of great significance in chemical research, production and application. Researchers can use this to communicate accurately and avoid misunderstandings due to title differences. Producers can also use well-known trade names to enhance product recognition during marketing activities.
The chemical world is complex, but they all point to the essence of matter. Clarity 1- (Bromomethyl) -2-Chloro-4-Fluorobenzene synonyms and trade names is the cornerstone of exploring its mysteries.
Safety & Operational Standards
1- (Bromomethyl) -2-Chloro-4-Fluorobenzene is a chemical commonly used in organic synthesis. It is crucial to its safety and operating practices.
In terms of safety, this substance is toxic and irritating. The presence of bromomethyl, chlorine and fluorine atoms makes it harmful to many parts of the human body. If accidentally touched with the skin, it can cause redness, pain and even burns. Once in contact with the eyes, it is more likely to cause serious damage to the eye tissue and affect vision. If inhaled its volatile aerosol, it will irritate the respiratory tract, cause cough, asthma, long-term or heavy inhalation, and even endanger lung function.
In terms of operating specifications, the experimental field needs to be well ventilated, equipped with effective ventilation equipment, and timely discharge of volatile aerosol to reduce the concentration of harmful substances in the air. Operators must wear complete protective equipment, such as protective clothing, protective gloves and protective glasses, to prevent skin-eye contact. When using this substance, it should be carefully handled in a fume hood to avoid the spread of its volatiles. During weighing and transferring, the action should be precise and gentle to prevent spillage. If spillage occurs, correct cleaning measures should be taken immediately. According to its chemical properties, suitable adsorption materials should be selected for collection, and then properly disposed of. After the experiment, the remaining substances should be stored in a specific container according to regulations, indicating the composition, date and other information. For the waste generated by the experiment, it should also be collected in accordance with the regulations on chemical waste disposal, and handed over to professional institutions for disposal. It must not be discarded at will.
Only by strictly following the above safety and operation specifications can we ensure the safety of personnel and the environment during the use of 1- (Bromomethyl) -2-Chloro-4-Fluorobenzene, and ensure the smooth progress of experiments and production activities.
Application Area
1- (Bromomethyl) -2-Chloro-4-Fluorobenzene is an important organic compound. Its application field is quite wide. In the field of medicinal chemistry, it can be used as a key intermediate to synthesize drug molecules with specific biological activities, and help develop new therapeutic drugs to deal with various diseases. In the field of materials science, with its unique chemical structure, it can participate in the preparation of functional materials, such as optoelectronic materials, and contribute to the improvement of material properties. In organic synthetic chemistry, this compound can act as a starting material to construct complex organic molecular structures through various reaction pathways and promote the development of organic synthesis methodologies. Therefore, 1- (Bromomethyl) -2-Chloro-4-Fluorobenzene has shown important application value in many fields and is of great significance to scientific research and industrial production development.
Research & Development
Yu devoted himself to researching this (1 - (Bromomethyl) -2 - Chloro - 4 - Fluorobenzene) for a long time. This product has unique properties and has great potential in the field of organic synthesis. At the beginning, I explored its structure to understand the location of bromine, chlorine and fluorine atoms, and knew the beauty of its spatial arrangement. This is the basis for research.
Then I observed its reaction characteristics, and after many attempts, I promoted it with different reagents and conditions. In a mild environment, when I encountered nucleophiles, I got a novel product with a unique structure, or it could be used to create new drugs.
Although the road of research and development was full of thorns, every achievement was inexplicable. Now that I have a little understanding of its nature, I hope to make good use of it in the future. In the fields of medicine and materials, I will create a new situation, adding new achievements to the academic and industrial circles, so that its potential can be fully developed, and it will benefit everyone.
Toxicity Research
Today, there is a substance, named 1- (Bromomethyl) -2-Chloro-4-Fluorobenzene, in our chemical research, its toxicity research is the key. We study the characteristics of this substance in detail and explore its toxicity in different environments.
After many experiments, observe its effect on various organisms. Or apply it to plants and trees to observe the change of their growth situation; or use it to insects to observe the transformation of their life activities. When this substance is in high concentrations, it has a significant inhibition on the growth of plants and trees, the branches and leaves turn yellow, and the vitality is gradually lost. For insects, it can also cause their movement to be slow, and even die.
It can be seen that 1- (Bromomethyl) -2-Chloro-4-Fluorobenzene is quite toxic. We should treat it with caution. When it is produced, used and disposed of, we must strictly abide by the procedures to prevent it from escaping and endangering life and the environment. In the future, we still need to delve deeper into the mechanism of its toxicity and find ways to prevent and resolve it, so as to ensure the well-being of all things in the world.
Future Prospects
I tasted 1- (Bromomethyl) -2-Chloro-4-Fluorobenzene this compound, and felt that its future was promising. Looking at the structure of this compound, bromine, chlorine, and fluorine atoms are combined with benzene rings and bromomethyl groups, and this unique structure endows it with specific chemical properties.
In terms of self-reactive activity, bromomethyl groups are active and can lead to various nucleophilic substitution reactions. In the field of organic synthesis, they can be used as key intermediates to expand the creation path of new compounds. From an application perspective, because of its halogen-containing atoms, it may find opportunities in medical chemistry or develop special drugs. And in the field of materials science, reasonable modification may improve the properties of materials.
I believe that with time and in-depth investigation, 1- (Bromomethyl) -2-Chloro-4-Fluorobenzene will shine, adding to the development of various fields of chemistry and developing infinite possibilities in the future.
Where to Buy 1-(Bromomethyl)-2-Chloro-4-Fluorobenzene in China?
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Frequently Asked Questions

As a leading 1-(Bromomethyl)-2-Chloro-4-Fluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What is the main use of 1- (Bromomethyl) -2-Chloro-4-Fluorobenzene?
1 - (bromomethyl) -2 -chloro-4 -fluorobenzene, an organic compound, is widely used in the field of organic synthesis.
First, it is often used to construct carbon-carbon bonds. Through nucleophilic substitution, the bromine atom on bromomethyl is highly active and can react with many nucleophilic reagents, such as those containing carbon anions, thereby realizing the formation of carbon-carbon bonds. This is of great significance in the construction process of complex organic molecules, such as the synthesis of aromatic compounds with specific structures.
Second, it has made significant contributions to the field of medicinal chemistry. Due to the presence of halogen atoms in its structure, it can affect the physical and chemical properties of molecules, such as fat solubility and stability. Therefore, it is often used as a key intermediate in the design and synthesis of new drug molecules. For example, to develop drugs targeting specific targets, its structure can be modified to introduce other functional groups to enhance the affinity and biological activity of the drug and the target.
Third, it also has applications in materials science. It can participate in polymerization reactions to generate polymer materials with special properties. For example, polymerization with monomers containing specific functional groups can endow materials with unique optical and electrical properties, such as the preparation of optoelectronic materials that respond to specific wavelengths of light.
Fourth, it is used for the synthesis of various fine chemicals. Such as the synthesis of special structures of fragrances, additives, etc. Due to its unique structure, it can be converted into fine chemicals with specific functions and properties through a series of reactions, meeting the needs of different industries.
In short, the structural properties of 1- (bromomethyl) -2-chloro-4-fluorobenzene itself play a crucial role in many fields such as organic synthesis, pharmaceutical chemistry, materials science and fine chemical synthesis, providing key starting materials and synthesis pathways for the preparation and performance optimization of many compounds.
What are the physical properties of 1- (Bromomethyl) -2-Chloro-4-Fluorobenzene
1 - (bromomethyl) -2 -chloro-4 -fluorobenzene is also an organic compound. Its physical properties are particularly important and are related to many chemical applications.
Looking at its physical state, it is mostly liquid or solid at room temperature, but the exact state also varies depending on environmental conditions. Its color is often nearly colorless to light yellow, or slightly different due to the presence of impurities.
As for the melting point and boiling point, the melting point is about [X] ° C, and the boiling point is about [X] ° C. These two are very helpful for the separation, purification and identification of substances. The melting point is stable, which can prove its high purity; the value of the boiling point is related to the setting of conditions for operations such as distillation.
In terms of density, it is about [X] g/cm ³. This property can be used to distinguish and analyze mixed systems with other substances. If mixed with water, it may float on water or sink underwater due to its density, depending on the specific value.
Solubility is also an important physical property. 1 - (bromomethyl) -2 -chloro-4 -fluorobenzene has good solubility in organic solvents such as ethanol, ether, and dichloromethane. However, in water, the solubility is very small, due to the dominant role of hydrophobic groups in the molecular structure. In terms of
volatility, relatively speaking, it has a certain degree of volatility, which can cause poor ventilation or increase the concentration in the air. Therefore, when storing and using, pay attention to ventilation and ventilation to ensure safety.
Refractive index is also one of its physical properties, about [X]. This parameter is indispensable in the purity identification of substances and optical related studies.
In summary, many physical properties of 1- (bromomethyl) -2 -chloro-4 -fluorobenzene, such as physical state, color, melting boiling point, density, solubility, volatility and refractive index, are of great significance in chemical research, industrial production and other fields, laying the foundation for the manipulation, application and in-depth exploration of substances.
What are the synthesis methods of 1- (Bromomethyl) -2-Chloro-4-Fluorobenzene
1 - (bromomethyl) -2 - chloro - 4 - fluorobenzene synthesis methods are commonly used in the following ways.
First, bromomethyl can be introduced by the corresponding halogenated aromatic hydrocarbons through a specific reaction. First, take the benzene ring compound containing chlorine and fluorine, and carry out the bromomethylation reaction with a specific reagent under suitable reaction conditions. In this process, the reaction temperature, the proportion of reactants and the reaction time need to be carefully regulated. If the temperature is too high, it may cause side reactions, resulting in poor product purity; if the temperature is too low, the reaction rate will be delayed and the yield will be affected. The proportion of reactants is also critical, and accurate calculation must be made to make the reaction proceed in the direction of generating the
Second, it can be achieved from another type of starting material through a multi-step reaction. First, the raw material molecules are chlorinated and fluorinated to construct a benzene ring structure containing chlorine and fluorine. Then, bromomethyl is gradually introduced through the conversion reaction of specific functional groups. Although this path has many steps, the reaction conditions in each step are relatively mild, and the product is easy to control and purify.
Furthermore, the reaction strategy of using transition metal catalysis can also be considered. Select a suitable transition metal catalyst, and in the presence of suitable ligands, promote a coupling reaction between the reactants to introduce bromomethyl. This method has the advantages of high efficiency and good selectivity, but it requires high reaction equipment and operation, and the cost of the catalyst may be a consideration.
In the actual synthesis, it is necessary to consider many factors such as raw material availability, cost, reaction conditions, product purity and yield, and carefully select an appropriate synthesis method to efficiently prepare 1- (bromomethyl) -2 -chloro-4 -fluorobenzene.
1- (Bromomethyl) -2-Chloro-4-Fluorobenzene What are the precautions in storage and transportation?
For 1 - (bromomethyl) -2 - chloro - 4 - fluorobenzene, many things should be paid attention to during storage and transportation.
This compound has certain chemical activity. When stored, the first environment is dry. Cover it in contact with water or moisture, it may cause chemical reactions and cause deterioration. The humidity in the warehouse should be controlled at a low level, and good moisture-proof facilities must be provided.
Temperature is also critical. It should be stored in a cool place away from high temperature environment. High temperature may cause the compound to decompose or accelerate its chemical reaction process, which will damage its quality and stability. In general, the suitable storage temperature is between 0 ° C and 25 ° C, depending on its characteristics and relevant instructions.
Furthermore, the storage place must be well ventilated. Because it may evaporate irritating or harmful gases, good ventilation can keep the air fresh and avoid safety accidents caused by gas accumulation.
As for transportation, the compound should be transported in accordance with the regulations of hazardous chemicals. The transportation container must be strong and well sealed to prevent leakage. The material of the container must be compatible with the compound and not react with it. During transportation, the temperature should also be controlled to avoid direct sunlight and violent vibration.
During loading and unloading, operators need to be cautious and wear appropriate protective equipment, such as protective gloves, goggles, etc., to prevent physical injury from contact.
All of these are 1- (bromomethyl) -2 -chloro-4 -fluorobenzene should be paid attention to during storage and transportation, so as to ensure its safety and quality.
1- (Bromomethyl) -2-Chloro-4-Fluorobenzene what are the associated security risks
1 - (bromomethyl) - 2 - chloro - 4 - fluorobenzene is a safety risk and cannot be ignored. This is an organic compound, and its properties of bromomethyl, chlorine and fluorine atoms make it potentially harmful.
Bear the brunt of it, it is irritating. If it comes into contact with the skin inadvertently, it may cause redness, pain, and even burns to the skin. The cover can react with the skin tissue due to its chemical activity. If it comes into contact with the eyes, it is particularly harmful, or damages the mucosa of the eye, causing blurred vision, pain, and in severe cases, permanent eye damage.
Furthermore, inhaling its volatile gas also poses a risk. In poorly ventilated spaces, its volatiles can irritate the respiratory tract, causing symptoms such as cough, asthma, and shortness of breath. Long-term or large-scale inhalation may damage lung function and cause lung diseases.
This compound is also flammable. Although it is not highly flammable, it can still burn in case of open flames and hot topics, and may produce toxic hydrogen bromide, hydrogen chloride, and hydrogen fluoride gases when burned. These gases are not only corrosive, but can seriously endanger human health and damage the respiratory tract, eyes, and other organs when inhaled.
In addition, the chemical activity of 1- (bromomethyl) -2 -chloro-4 -fluorobenzene makes it possible to participate in the reaction under certain conditions, or to form more dangerous products. During storage and use, if mixed with incompatible substances, or cause violent reactions, explosion and other serious consequences.
Therefore, when handling 1- (bromomethyl) -2 -chloro-4 -fluorobenzene, it is necessary to strictly follow safe operating procedures. Operators need to wear appropriate protective equipment, such as protective gloves, goggles, gas masks, etc. Storage should be in a cool and ventilated place, away from fire and heat sources, and stored separately from oxidants, acids, etc. Only in this way can safety risks be minimized and personal and environmental safety can be ensured.