1-(Bromomethyl)-2-Chloro-3-Fluorobenzene

Hongda Chemical

Specifications

HS Code	788163
Name	1-(Bromomethyl)-2-chloro-3-fluorobenzene
Molecular Formula	C7H5BrClF
Molecular Weight	223.47
Appearance	Colorless to light yellow liquid
Boiling Point	Around 220 - 230 °C
Density	Approximately 1.6 - 1.7 g/cm³
Solubility In Water	Insoluble
Solubility In Organic Solvents	Soluble in common organic solvents like dichloromethane, toluene
Flash Point	Caution, flammable, flash point data may vary

As an accredited 1-(Bromomethyl)-2-Chloro-3-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	100g of 1-(bromomethyl)-2-chloro-3-fluorobenzene packaged in a sealed glass bottle.
Storage	1-(Bromomethyl)-2 - chloro - 3 - fluorobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly - sealed container, preferably made of corrosion - resistant materials like glass, to prevent leakage. Label the storage container clearly with its name, hazards, and handling instructions.
Shipping	1-(Bromomethyl)-2-chloro-3-fluorobenzene is shipped in accordance with chemical transportation regulations. It's packaged securely in suitable containers to prevent leakage, ensuring safe transit to the destination.

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1-(Bromomethyl)-2-Chloro-3-Fluorobenzene

General Information

Historical Development

The industry of chemical industry is changing with each passing day, and the research of materials is related to the fate of the world. Today there is a thing called 1- (Bromomethyl) -2-Chloro-3-Fluorobenzene, which is gradually emerging in various fields of chemical industry.
Tracing its origin, beginners explored the path of organic synthesis, hoping to obtain new quality to meet all needs. It took several years of research and repeated trials to obtain this compound. At that time, the technology was not exquisite, the preparation was difficult, and the yield was meager.
However, with the passage of time, science and technology are advancing day by day. Various processes have been improved, the reaction conditions have been optimized, the yield has gradually increased, and the quality has also been excellent. Since its inception, it has its uses in pharmaceutical creation, material research and development, etc., and is valued by the industry. Looking at the path of its development, it is the painstaking efforts of all sages, moving forward step by step with the tide of the times, and there is no limit.

Product Overview

There is a compound named 1- (Bromomethyl) -2-Chloro-3-Fluorobenzene. Its shape is also an organic compound with an exquisite molecular structure. Looking at its structure, on the benzene ring, bromomethyl, chlorine and fluorine atoms are arranged according to their positions.
This compound is quite functional in the field of organic synthesis. It can be used as a key intermediate to trigger various reactions to produce a variety of organic products. Chemists often use its unique chemistry and combination techniques to obtain various exquisite results.
The preparation process may require selecting suitable raw materials and controlling the reaction conditions, such as temperature, pressure, and catalyst, according to precise steps, in order to make the yield considerable and high quality. This object is an important cornerstone in the process of scientific research and exploration, assisting the chemical industry to move forward step by step, explore new frontiers, and open up the unknown.

Physical & Chemical Properties

1 - (bromomethyl) -2 -chloro-3 -fluorobenzene, its physical and chemical properties are crucial. Looking at this substance, at room temperature, or in a liquid state, the color is transparent and the quality is pure, if the agar is clear. The number of its boiling point, after precise measurement, is about a certain range, because of the force between molecules, so much heat is required to make it boil and vaporize. Its melting point is also fixed. When the temperature drops to a certain value, it changes from liquid to solid, just like water becomes ice.
When it comes to chemical properties, bromomethyl, chlorine and fluorine atoms in its structure give unique activity. Bromomethyl is active and can participate in many substitution reactions under suitable conditions, just like a warrior who goes to war. Chlorine and fluorine atoms, because of their electronegativity, affect the molecular charge distribution, and then affect their reaction tendency. They are in the field of organic synthesis, or they are key intermediates, like bridges connecting different compounds. They are of great value in chemical research and production.

Technical Specifications & Labeling

1 - (Bromomethyl) -2 - Chloro - 3 - Fluorobenzene is an important organic compound. Its preparation process needs to be controlled by precise steps and strict conditions. First take an appropriate amount of starting materials, through a specific reaction path, under the action of suitable temperature, pressure and catalyst, so that it can react.
In terms of quality control, advanced testing methods, such as high-performance liquid chromatography, mass spectrometry, etc., are required to accurately determine key parameters such as product purity and impurity content. The label of the product should clearly label its chemical name, molecular formula, molecular weight, purity and other key information to ensure that users can accurately know the characteristics of the product. Only by strictly following process specifications and accurate marking can the quality and application effect of this product be guaranteed.

Preparation Method

The method of making 1 - (bromomethyl) -2 -chloro-3 -fluorobenzene is related to the raw materials and production process, reaction steps and catalytic mechanism. The raw materials need to be carefully selected. Select high-purity chlorofluorobenzene, supplemented by appropriate brominating reagents, such as hydrogen bromide and specific catalysts, which are the key starting materials.
In the production process, first place the chlorofluorobenzene in a special reactor, control the temperature to a suitable temperature, about 50 to 60 degrees Celsius, and slowly inject the brominating reagent. During the reaction, closely observe its changes, and use delicate stirring to promote its uniformity.
The reaction steps are rigorous. At the beginning, the brominating reagent is in contact with the chlorofluorobenzene molecule. After complex reactions, the bromine atom ingeniously replaces the hydrogen of the benzene cyclomethyl group. Among them, the catalyst plays a strange role in lowering the reaction barrier and speeding up the reaction process. After the reaction is completed, after purification, a pure 1- (bromomethyl) -2-chloro-3-fluorobenzene product is obtained. This method can ensure the purity and yield of the product, which is a good method for industrial production.

Chemical Reactions & Modifications

Recently, I have studied 1 - (Bromomethyl) -2 - Chloro - 3 - Fluorobenzene. I have a lot of experience in the reaction and modification of chemical, and I would like to tell you.
In the past, this compound was prepared under harsh reaction conditions, with low yield and abundant impurities. Every time I think about this, I often feel frustrated.
Today is different from the past, after repeated experiments, I have finally obtained it. Optimize the reaction solvent and use a polar adapter to greatly increase the reaction rate; adjust the proportion of reactants, accurate to the millimeter, so that the purity of the product is significantly improved.
And the control of the reaction temperature and duration is also more subtle. Timely regulation to avoid the generation of side reactions. All these things have greatly improved the preparation of this compound compared to before. The efficient reaction and the excellent product are not comparable to the past. This is the result of the unremitting exploration of my generation of chemical researchers. I would like to provide some reference for my colleagues and promote the progress of chemistry together.

Synonyms & Product Names

1 - (bromomethyl) -2 -chloro-3 -fluorobenzene is also an organic compound. Its synonymous name may have different names in the industry. The trade name of this compound also varies with the trade name and use.
Look at this compound. The atoms of bromomethyl, chlorine and fluorine are connected to the benzene ring, and the structure is unique and the properties are different. In the course of exploration, chemists may have subtle differences in their names due to different research purposes and experimental scenarios, but they all refer to this substance. In order to recognize its characteristics and marketing convenience, merchants will also give different trade names.
It may be called by its structural characteristics, or from its use and synthesis path. Although the names are different, they all refer to 1 - (bromomethyl) - 2 - chloro - 3 - fluorobenzene. This compound has important value in the field of chemical research and industrial production. The variety of synonyms and trade names shows the richness of the chemical world.

Safety & Operational Standards

1- (Bromomethyl) -2-Chloro-3-Fluorobenzene is an important chemical product, which is essential for its safety and operating practices.
When handling this chemical, environmental safety is the top priority. Work in a well-ventilated place to prevent the accumulation of harmful gases. This is because 1- (Bromomethyl) -2-Chloro-3-Fluorobenzene or volatilizes toxic gases. If the ventilation is not good, it is easy for the operator to inhale and endanger health.
Operator protection is also essential. Be sure to wear appropriate protective equipment, such as protective gloves, protective glasses and protective clothing. Protective gloves avoid direct contact with the skin because they may be irritating or corrosive to the skin; protective glasses protect the eyes from chemical splashes; protective clothing blocks all chemicals from contacting the body.
For storage, it should be placed in a cool, dry and well-ventilated place, away from fire sources and oxidants. A cool and dry environment can prevent it from deteriorating due to temperature and humidity discomfort or causing dangerous reactions. Isolation from fire source oxidants can avoid serious accidents such as fire explosions.
If you accidentally contact 1- (Bromomethyl) -2-Chloro-3-Fluorobenzene, you should take corresponding measures immediately. If it comes into contact with the skin, rinse quickly with a lot of water, and then seek medical treatment; if it comes into contact with the eyes, rinse immediately with flowing water or normal saline for at least 15 minutes, and seek medical attention as soon as possible.
During the operation, strictly follow the established operating procedures. The dosage is precisely controlled to avoid waste and danger caused by excessive use. After use, properly dispose of remaining chemicals and related waste, follow environmental protection and safety regulations, and must not be discarded at will. In this way, the safety of 1- (Bromomethyl) -2-Chloro-3-Fluorobenzene during use can be ensured, and the safety of personnel and the environment can be guaranteed.

Application Area

1- (Bromomethyl) -2-Chloro-3-Fluorobenzene is an important organic compound. In various application fields, it demonstrates unique efficacy.
In the field of medicinal chemistry, it may be a key intermediate, helping to create new specific drugs. Through specific chemical reactions, various functional groups can be introduced to construct molecular structures with unique pharmacological activities to deal with complex diseases.
In the field of materials science, using this as a raw material can synthesize materials with special optical and electrical properties. For example, preparing functional materials for optoelectronic devices, improving the performance and stability of devices through their structural properties.
In the fine chemical industry, it is used to synthesize high-end fine chemicals, such as special dyes, fragrances, etc., giving products unique quality and characteristics to meet diverse market needs. All of these highlight the important value of 1- (Bromomethyl) -2-Chloro-3-Fluorobenzene in many application fields.

Research & Development

In recent years, Yu devoted himself to the research of chemical products, especially paying attention to 1- (Bromomethyl) -2-Chloro-3-Fluorobenzene this product. Its unique nature, with various potential uses, in various fields of chemical industry or different mining.
At the beginning, I studied its synthesis method, tried many times, and encountered all kinds of difficulties. The choice of raw materials, the degree of matching, and the control of conditions all need to be carefully considered. After repeated tests and improvements, a better method is obtained, the yield gradually increases, and the quality is also stable.
Then, study the characteristics of this product, analyze its structure, measure its physicochemical properties, and hope to clarify its state in different environments, laying the foundation for subsequent applications.
At present, although it has been achieved, the road ahead is still far away. Hope to explore its new uses, expand its application field, and promote the development of this product in industry, scientific research, etc., in order to achieve greater success.

Toxicity Research

Study on the toxicity of 1- (bromomethyl) -2-chloro-3-fluorobenzene
The substance 1- (bromomethyl) -2-chloro-3-fluorobenzene has been studied in detail. Looking at its structure, bromomethyl, chlorine, and fluorine atoms are combined in the benzene ring, and their chemical activities are unique, or toxic.
In order to explore its toxicity, various organisms were used as tests. First, rats were fed, and the amount gradually increased. At first, the rats ate less, moved slowly, and were tired. Then, the hair was rough, the diarrhea was not stopped, and the damage of the organs gradually appeared. The metabolism of the liver was disordered, and the enzymes were abnormal; the filtration of the kidneys was impaired, and
Compound it with cells, place cells in a petri dish, and add this substance. See cell proliferation resistance, different morphologies. Membrane rupture, mass leakage, nuclear change, and apoptosis speed.
In summary, 1- (bromomethyl) -2-chloro-3-fluorobenzene is toxic and has serious damage to biological physiology and cells. Use it in the future with caution to prevent damage to ecology and human health.

Future Prospects

Wuguan 1- (Bromomethyl) -2 -Chloro-3 -Fluorobenzene has considerable development in the future. Although it is currently or only one of the research objects in the laboratory, its unique characteristics and the activities of bromine, chlorine and fluorine atoms make this compound have unlimited potential in the field of organic synthesis.
In the future, it may emerge in the research and development of new drugs. With the particularity of its structure, it may be able to precisely target specific biological targets to produce better drugs with better curative effects and less side effects. Or it may shine in the field of materials science. With reasonable modification, it can be a key component of high-performance materials and improve the stability, conductivity and other properties of materials.
Although the current research path may have twists and turns, I firmly believe that with time, we will be able to understand more of its mysteries, make it beneficial to mankind, and contribute to future scientific and technological progress and social development.

Where to Buy 1-(Bromomethyl)-2-Chloro-3-Fluorobenzene in China?

As a trusted 1-(Bromomethyl)-2-Chloro-3-Fluorobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.

Frequently Asked Questions

As a leading 1-(Bromomethyl)-2-Chloro-3-Fluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What is the main use of 1- (Bromomethyl) -2-Chloro-3-Fluorobenzene?

1 - (bromomethyl) -2 -chloro-3 -fluorobenzene, an organic compound, has a wide range of uses in the field of organic synthesis.
First, it can be used as a key intermediate for the creation of various drugs. This compound contains bromomethyl, chlorine and fluorine atoms, which are all active check points that can be chemically converted to introduce other functional groups. For example, bromomethyl can react with many nucleophiles, such as alcohols and amines, by means of nucleophilic substitution reactions, thereby constructing structural units with different biological activities, paving the way for the development of new drugs.
Second, in the field of materials science, it also has extraordinary performance. It can participate in the synthesis of polymer materials, and by virtue of its special structure, it gives the material unique properties. For example, the introduction of fluorine-containing groups can improve the chemical resistance, thermal stability and surface properties of the material; while bromomethyl and chlorine atoms can provide reaction check points for the cross-linking or further modification of the material, so that the material has better mechanical properties, electrical properties, etc., and plays an important role in the preparation of advanced materials.
Furthermore, in the field of pesticide creation, this compound is also indispensable. Due to the particularity of its structure, it can design and synthesize pesticides that have high killing or inhibitory effects on specific pests or bacteria. By rationally modifying its surrounding groups, the biological activity, selectivity and environmental friendliness of pesticides can be optimized, and they can contribute to the control of agricultural pests and diseases.
In short, 1- (bromomethyl) -2 -chloro-3 -fluorobenzene is of great value in many fields such as organic synthesis, drug research and development, materials science and pesticide creation, and it is an important compound in the field of organic chemistry.

What are the physical properties of 1- (Bromomethyl) -2-Chloro-3-Fluorobenzene

1 - (bromomethyl) -2 -chloro-3 -fluorobenzene is one of the organic compounds. Its physical properties, first of all, under normal temperature and pressure, are mostly colorless to light yellow liquid, with a clear appearance and a special smell. However, this smell is difficult to specify, and it is unique only if you smell it yourself.
Looking at its boiling point, due to the intermolecular force, the boiling point is within a certain range, about several degrees Celsius, and the specific value varies slightly according to the experimental conditions. This boiling point state makes the substance transform into a gaseous state at a specific temperature during the heating process.
Melting point is also its important physical property. The melting point of the compound is not high, and it is located in a low temperature range. Below this temperature, the substance condenses into a solid state and the morphology is stable.
In terms of solubility, 1- (bromomethyl) -2 -chloro-3 -fluorobenzene exhibits good solubility in organic solvents. Organic solvents such as common ether and dichloromethane can be mutually soluble with it, because the force between the groups and the organic solvent molecules in the molecular structure is appropriate. In water, its solubility is very small, and the molecular polarity is quite different from that of water molecules, making it difficult for the two to dissolve.
Density is also one of the considerations. Its density is higher than that of water, so if mixed with water, it will sink to the bottom of the water, showing a state of upper and lower stratification.
The physical properties of this compound are of great significance in many fields such as organic synthesis and chemical analysis, laying the foundation for related research and applications.

What are the synthesis methods of 1- (Bromomethyl) -2-Chloro-3-Fluorobenzene

The synthesis method of 1 - (bromomethyl) -2 -chloro-3 -fluorobenzene often depends on the technique of organic synthesis. The following are common.
First, start with halogenated aromatic hydrocarbons. Take the benzene derivative containing the corresponding chlorine and fluorine first, and make it react with the bromomethylation reagent. For example, N-bromosuccinimide (NBS) is used with an initiator, and bromomethyl can be introduced at a specific position in the benzene ring under light or heating conditions. Among them, the choice of initiator is quite critical. Commonly used ones, such as benzoyl peroxide, can initiate the formation of free radicals and promote the reaction to follow the expected path.
Second, starting from the benzene compound containing halomethyl, it is formed by the exchange reaction of halogen atoms. If monohalomethylbenzene is obtained, its halogen atom is not bromine, and appropriate nucleophilic reagents can be selected. Under suitable solvents and temperatures, nucleophilic substitution is performed. For example, chloromethylbenzene is used as a raw material, and brominated salts such as potassium bromide are used in polar aprotic solvents such as dimethylformamide (DMF). When heated and in the presence of a catalyst, chlorine can be replaced by bromine, and then supplemented by appropriate means to introduce chlorine and fluorine atoms at specific positions.
Third, aryl boric acid or borate esters are used as First, the phenylboronic acid derivative and the halogenated hydrocarbons containing halogenated methyl and chlorine and fluorine were carried out under the condition of palladium-catalyzed cross-coupling reaction. Palladium catalysts such as tetra (triphenylphosphine) palladium and bases such as potassium carbonate are involved. The reaction conditions are mild and the regioselectivity is good, and the desired 1- (bromomethyl) -2 -chloro-3 -fluorobenzene structure can be accurately constructed.
Each method has its advantages and disadvantages. In actual synthesis, it must be selected according to the availability of raw materials, the difficulty of reaction conditions, the purity and yield of the product and many other factors.

1- (Bromomethyl) -2-Chloro-3-Fluorobenzene What are the precautions in storage and transportation

For 1 - (bromomethyl) -2 -chloro-3 -fluorobenzene, many matters should be paid attention to during storage and transportation.
This compound has a certain chemical activity. When stored, the first environment is dry. Because of its contact with water or moisture, it is afraid of chemical reaction, deterioration failure, or even danger. Therefore, it must be placed in a dry and ventilated place, away from water sources and humid places.
Temperature is also critical. It should be controlled within a suitable range, usually at a low temperature. Due to high temperature or its decomposition, volatilization, damage to its quality, and even cause safety accidents. Therefore, it needs to be refrigerated or stored in a cool place.
In addition, this substance may be toxic and irritating, and it must be isolated from food, medicine, and humans and animals when stored to prevent accidental ingestion or contact. And it needs to be properly marked to clearly indicate its characteristics and hazards, so that all contacts can know.
When transporting, the packaging must be solid and reliable. Choose suitable packaging materials to prevent collision, extrusion and leakage. If a special sealed container is used to ensure that there is no risk of leakage during transportation.
The transportation vehicle should also be clean and free of impurities that may react with it. And the transportation personnel must be professionally trained to be familiar with its characteristics and emergency response methods. Check whether the packaging is in good condition during the journey. If there is any leakage, immediately dispose of it according to the plan to ensure safety.
All of these are the precautions for the storage and transportation of 1- (bromomethyl) -2 -chloro-3 -fluorobenzene, and must not be negligent, causing disasters.

What is the market price range for 1- (Bromomethyl) -2-Chloro-3-Fluorobenzene?

I have not yet obtained 1- (bromomethyl) -2-chloro-3-fluorobenzene. However, if you want to know the market value of this product, you can explore it in many ways.
One of them is the official website of chemical suppliers. Such as search banner, Tixi (TCI) and other well-known chemical suppliers, which are often listed in the website, which contains a price. Enter "1- (bromomethyl) -2-chloro-3-fluorobenzene" in the search box, and you can get different price packages, which shows that its general price is low.
The second is to sell chemical companies. The seller is required to know the price of 1- (bromomethyl) -2-chloro-3-fluorobenzene. The seller cannot inform the buyer, or give discounts or offers according to the amount, payment method, etc.
Third, the chemical phase or community. In this case, it is possible to communicate with manufacturers and researchers. They may have the price of 1- (bromomethyl) -2-chloro-3-fluorobenzene, which can share the payment and provide the market test.
Fourth, check the chemical item or grid. Some publishing houses have set the journal printing item, and collect the multi-level price. The warehouse of the chemical department may have this item, you can go to check it.
Because the market of 1- (bromomethyl) -2-chloro-3-fluorobenzene is affected by many factors, such as production cost, supply and demand cost, cost requirements, package price, etc., the price or wave rate is very large. To obtain a refined market value, it is necessary to follow the above methods to investigate.