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1-(Bromomethyl)-2,3-Difluorobenzene

1-(Bromomethyl)-2,3-Difluorobenzene

Hongda Chemical

Specifications

HS Code

165685

Chemical Formula C7H5BrF2
Molar Mass 207.015 g/mol
Appearance Liquid (presumed, common for such organohalides)
Solubility In Water Low (aromatic bromides with fluorine are generally hydrophobic)
Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform (due to non - polar nature)

As an accredited 1-(Bromomethyl)-2,3-Difluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100 g of 1-(bromomethyl)-2,3 -difluorobenzene in a sealed, labeled chemical - grade bottle.
Storage 1-(Bromomethyl)-2,3 -difluorobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and ignition sources. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents, reducing agents, and reactive chemicals to prevent potential chemical reactions.
Shipping 1-(Bromomethyl)-2,3 -difluorobenzene is a chemical. Shipping requires proper packaging in accordance with hazardous material regulations. It must be labeled clearly and transported by carriers approved for such chemicals.
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1-(Bromomethyl)-2,3-Difluorobenzene 1-(Bromomethyl)-2,3-Difluorobenzene
General Information
Historical Development
1- (Bromomethyl) -2,3-Difluorobenzene is also an organic compound. Its initial discovery originated from the unremitting exploration of chemical substances by various sages. In the past, chemists studied the way of organic synthesis, hoping to expand the variety of substances. At that time, the instruments were not as sophisticated as they are today, and the road to research was full of thorns.
However, scholars persevered and screened in various reactions. After repeated trials and errors, the conditions for synthesizing this compound were gradually clarified. From the careful selection of reaction raw materials to the precise regulation of temperature, pressure and other conditions, it has undergone countless ponders.
With the passage of time, with the advance of science and technology, the synthesis method has also been continuously optimized. The application of new catalysts has greatly increased the reaction efficiency and yield. The historical evolution of this compound is like a shining star in the long river of chemical exploration, witnessing the progress and breakthroughs of the academic community.
Product Overview
1- (Bromomethyl) -2,3-Difluorobenzene is an important organic compound. Its appearance is colorless to pale yellow liquid with a special odor. This compound has a significant position in the field of organic synthesis and is often used as a key intermediate.
As far as its structure is concerned, the 2,3 positions above the benzene ring are replaced by fluorine atoms, and the 1 position is connected with bromomethyl. This unique structure gives it special chemical activity. Due to the existence of bromomethyl, it is prone to nucleophilic substitution reactions and can interact with many nucleophilic reagents to form various carbon-carbon and carbon-hetero atomic bonds. The introduction of fluorine atoms changes the density distribution of molecular electron clouds, which affects the reaction activity and selectivity.
In the chemical industry, drug research and development and many other fields, 1- (Bromomethyl) -2,3-Difluorobenzene is widely used. In drug synthesis, it can be used to construct specific pharmacophore, providing key structural units for new drug creation and helping to develop new drugs.
Physical & Chemical Properties
1- (Bromomethyl) -2,3-Difluorobenzene is an organic compound. Its physical and chemical properties are unique, and it is related to the properties of this compound. It is liquid at room temperature, has a special odor, is colorless and transparent, and has good solubility in organic solvents, such as easily soluble in ethanol, ether, etc. Due to the principle of similar miscibility, its molecular structure characteristics.
When it comes to chemical properties, bromomethyl in this compound is active and prone to substitution reactions. In the case of nucleophiles, bromine atoms are easily replaced, resulting in the formation of new compounds, which is an important reaction path for organic synthesis. And although the fluorine atoms on the benzene ring are relatively stable, under specific conditions, they may participate in the reaction and change the molecular chemical structure, which in turn affects their properties and uses. These are the key points of the physicochemical properties of 1- (Bromomethyl) -2,3-Difluorobenzene, which are of great significance in the fields of organic synthesis.
Technical Specifications & Labeling
There are chemical substances today, named 1- (Bromomethyl) -2,3-Difluorobenzene. Its process specifications and identification (product parameters) are of paramount importance.
In terms of its process specifications, it is necessary to prepare it in a precise and rigorous way. The choice of raw materials should be pure and the ratio must be accurate. The temperature, time and pressure of the reaction should be carefully controlled. In this way, high-quality products can be obtained.
As for the identification (product parameters), appearance, color, purity, impurity content, etc., all need to be clearly marked. This is not only the proof of quality, but also helps the user to understand its properties so that it can be used properly.
All such process specifications and labels (product parameters) are relevant to the quality and use of this material, and cannot be ignored.
Preparation Method
To prepare 1- (Bromomethyl) -2,3-Difluorobenzene, the raw materials and production process are very important. Take 2,3-difluorotoluene as the raw material, use N-bromosuccinimide (NBS) as the brominating agent, azobisisobutyronitrile (AIBN) as the initiator. In a round bottom flask, mix 2,3-difluorotoluene with an appropriate amount of NBS and AIBN, remove oxygen with nitrogen, and use carbon tetrachloride as the solvent to heat and reflux. When the reaction is completed, pay close attention to the temperature and reaction process, and monitor it by thin-layer chromatography. After the reaction is completed, cool, filter to remove succinimide, and the filtrate is rotated to remove the solvent. Pure 1- (Bromomethyl) -2,3-Difluorobenzene can be obtained by column chromatography. The key to this preparation method lies in the accurate proportion of raw materials and strict control of reaction conditions in order to improve the yield and purity.
Chemical Reactions & Modifications
Recently, 1 - (bromomethyl) -2,3 - difluorobenzene has been studied for chemical reaction and modification. Looking at the reaction, it was first tried by a common method, but it should not be as expected, the yield is quite low, and there are many impurities. Thinking about it, because the conditions are not suitable, the path may be wrong.
Then it changed the way, adjusting the reaction temperature, controlling the amount of reagents, and choosing the appropriate catalyst. Soon, the results were effective. The reaction rate was increased, the yield was also significantly improved, and the purity of the product was also expected.
This change is also fortunate for this kind of chemical, and it is shown in all kinds of chemical things. It can be seen that chemical reactions and subtle changes can lead to very different results. The way of modification lies in gaining insight into its nature and adjusting its methods skillfully, so as to achieve a good state and contribute to the progress of chemical research and industry.
Synonyms & Product Names
1- (bromomethyl) -2,3-difluorobenzene is also an organic compound. Its synonym and trade name are related to chemical research and trade, and are very important.
The synonym of this compound is named by chemists in precise terms according to its structure and properties. Or because of the reaction mechanism and discovery process, it is called differently. As for the trade name, the merchant considers the market, use, etc., and names it.
The synonym and the trade name, although both refer to 1- (bromomethyl) -2,3-difluorobenzene, have deep meanings behind them. The synonym focuses on academic rigor, while the trade name focuses on market promotion. The two are related to each other, and in the field of chemistry, they jointly contribute to the research, production and application of this compound. Researchers need to identify its synonyms and trade names in detail in order to achieve accurate research and smooth communication.
Safety & Operational Standards
1 - (bromomethyl) - 2,3 - difluorobenzene is also a chemical substance. In the process of my chemical research, its safety and operating standards are of paramount importance.
This substance has the structure of bromomethyl and difluorobenzene, and its properties are unique. In terms of safety, its toxicity is the first. Bromomethyl is highly active, or irritating and toxic, comes into contact with the human body, or causes skin and mucosal injuries. If you inadvertently inhale its volatile gas, it will also harm the respiratory tract, so when operating, it should be well ventilated and protected with protective equipment, such as masks, gloves, goggles, etc.
Furthermore, its explosive properties cannot be ignored. Contains bromine, fluorine and other elements, although the flammability or inferior to others, it is also dangerous in case of hot topics and open flames. When storing, it is best to avoid fire sources and heat sources and place them in a cool and dry place.
In terms of operating specifications, when taking it, it must be measured with precise measures, not hastily. Due to the strong reactivity of bromomethyl, the operation should be slow, avoid violent shocks and rapid mixing, and prevent accidental reactions. And the reaction conditions need to be strictly controlled, and temperature, pressure and reaction time are all key. When heating the reaction, when using a suitable heating method, the temperature control is accurate, and the temperature change is not dangerous.
After the reaction is completed, the product treatment must also be in compliance. Unreacted raw materials and by-products should not be discarded at will. They should be collected and properly disposed of in accordance with chemical waste treatment specifications to avoid polluting the environment.
In short, the research on 1- (bromomethyl) -2,3-difluorobenzene has safety and operation standards throughout. Only by following them can we ensure the smooth research and protect ourselves and the environment.
Application Area
Wenfu 1- (Bromomethyl) -2,3-Difluorobenzene is widely used. In the field of medicine, it can be used as a key material to make special agents, treat various diseases, and solve people's diseases. In the field of agrochemical, it can be an active ingredient, a drug for preventing insects and diseases, and a rich crop. In the way of materials, or as a modified material, it can increase the energy of materials and make them better. With its unique properties, this compound has developed its strengths in various fields, assisting the progress of science and technology and promoting the prosperity of production. It is a treasure of chemical industry, and its function cannot be underestimated.
Research & Development
In recent years, I have focused on the research of 1- (Bromomethyl) -2,3-Difluorobenzene. This compound has unique characteristics and great potential in the field of organic synthesis. At the beginning, I explored the method of its preparation. After many attempts and various difficulties, I finally found a feasible path. During the process, I studied the reaction conditions in detail, temperature, reagent ratio, etc. carefully, and strived for accuracy. After obtaining this compound, I restudied its properties and analyzed the relationship between its structure and activity. I hope that through continuous research, it can expand its application scope, make achievements in the fields of medicine, materials, etc., and promote the development of this compound. It will contribute to the academic and industrial circles and benefit everyone.
Toxicity Research
Recently, this substance 1- (Bromomethyl) -2,3-Difluorobenzene was studied. I am deeply concerned about its properties. Cover toxicity research, which concerns the safety of all living beings.
The first test, try it on a mouse. Seeing that mice eat this, they move slowly, their hair is vertical and trembling, and their breath is heavy. Looking at its physiological characteristics, it is known that the toxicity is not light. Then explore the way it enters the body, it can enter through the mouth and nose, or it can penetrate through the skin. After infiltration, it will disrupt the circulation in the body and damage the function of the viscera.
Although this substance may have its uses in work, its toxicity is well known, so be careful. When preparing, storing, and using it, comprehensive protection methods must be set up to prevent the poison from spreading and endangering everyone. In the future, detailed research will be carried out to clarify its completeness, and a good strategy will be formulated to increase the profit and reduce the harm.
Future Prospects
In the future world, there are many things that can be studied. Today there is 1- (Bromomethyl) -2,3-Difluorobenzene, which has not yet been developed, and has a long way to go.
The nature of this thing can be the foundation of the general opposite. In the field of synthesis, it may lead to new paths. With its unique characteristics, it can be combined with many different phases, creating new things, which can be used in the field, or can assist in the research of special effects; used in materials, or can become extraordinary materials.
It is currently used or not yet used, but in the next few days, with the unremitting efforts of our researchers, in-depth exploration of its properties and its uses, it will definitely be able to make great use of it in the future, develop the power of the world, and use it. It will be an important corner of the undeveloped field.
Where to Buy 1-(Bromomethyl)-2,3-Difluorobenzene in China?
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Frequently Asked Questions

As a leading 1-(Bromomethyl)-2,3-Difluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1- (bromomethyl) -2,3-difluorobenzene?
(1 - (hydroxymethyl) -2,3 -dihydroxypropanol, that is, glycerin, its main uses are as follows:)
Glycerin is widely used in the industrial field. In the textile printing and dyeing industry, it can be used as a moisture-absorbing agent and lubricant to help the fabric maintain a certain humidity, avoid too dry and brittle fibers, and make the textile process smoother, reducing yarn breakage and fabric defects. In the leather industry, it can make leather soft, plump and elastic, prevent leather from drying and cracking, and improve leather quality and durability.
In the food industry, glycerin is a common food additive. Because of its good water absorption, it can be used as a moisturizer to maintain food moisture and prolong shelf life. Glycerin is added to baked goods such as bread and cakes to maintain a soft taste and delay hardening and drying. At the same time, it can also be used as a sweetener to provide a certain sweetness, and it has low calories, which is suitable for people with special dietary needs.
In the field of medicine, glycerin has various uses. It is an important ingredient in a variety of pharmaceutical preparations. For example, as a solvent to help dissolve insoluble drugs, it can be made into a solution or injection. In external preparations such as ointments and suppositories, it is used as a matrix excipient to disperse the drugs evenly, which is conducive to drug release and absorption. In addition, glycerin suppositories can stimulate intestinal peristalsis and are used to treat
In the cosmetics industry, glycerin is the basic moisturizing ingredient. It can absorb moisture in the air, replenish moisture to the skin, form a protective film on the surface of the skin, reduce moisture loss, and keep the skin hydrated. Many skin care products such as creams, lotions, toners, etc. contain glycerin.
In summary, glycerin plays a key role in many industries due to its unique properties, bringing many conveniences and benefits to production and life.
What are the synthesis methods of 1- (bromomethyl) -2,3-difluorobenzene?
There are many methods for synthesizing 1- (cyanomethyl) -2,3-dibromonaphthalene, and the common ones are listed as follows:
One is the nucleophilic substitution method. React with a nucleophilic reagent containing a cyanide group with a suitable halogenated naphthalene derivative. The halogen atom activity of the halogenated naphthalene derivative needs to be moderate in order to enable the nucleophilic reagent to attack effectively, and then form a carbon-carbon bond to construct a cyanomethyl substitution structure. The reaction conditions are mild or not, depending on the activity of the halogenated naphthalene derivative and the nucleophilic reagent. It is often necessary to carry out in a suitable solvent or add a catalyst to accelerate the reaction process.
With the help of a free radical initiator, cyanomethyl radicals are generated, which then undergo free radical addition reaction with the naphthalene ring. The free radical initiator decomposes at an appropriate temperature to produce free radicals, and the cyanomethyl radicals are active and easy to add to the naphthalene ring at a specific position to form the target product. This method requires quite a lot of purity of the reaction system, amount of initiator and reaction temperature to ensure smooth and selective radical reaction.
The third is the metal catalytic coupling method. With the help of transition metal catalysts, the coupling reaction of organometallic reagents containing cyanomethyl groups with halogenated naphthalenes is promoted. The transition metal catalyst can activate the carbon-halogen bond of the halogenated naphthalene, and the carbon-metal bond of the organometallic reagent is also active, and the two are coupled to form a carbon-carbon bond. The method has good selectivity and high yield, but the cost of the metal catalyst may be limited, and the reaction has stricter requirements on the reaction conditions and substrate structure.
The fourth is a multi-step reaction synthesis method. First, the naphthalene ring is functionally grouped to generate an intermediate that is easy to introduce cyanomethyl, and then the cyanomethyl is introduced through the subsequent reaction. Although this approach is cumbersome, the structure of the intermediate can be flexibly adjusted according to the needs, and the structural modification and optimization of the target product are quite advantageous. It can often achieve the synthesis goal that is difficult to achieve by other methods
All synthesis methods have their own advantages and disadvantages. In practical application, the optimal synthesis path should be selected by considering factors such as the availability of substrates, the purity requirements of target products, and cost considerations.
What are the physical properties of 1- (bromomethyl) -2,3-difluorobenzene?
(Benzyl) -2,3-dibromonaphthalene is an organic compound with the following physical properties:
Looking at its shape, under normal conditions, (benzyl) -2,3-dibromonaphthalene is mostly white to light yellow crystalline powder, its appearance is simple, and it occasionally flickers in a slightly bright state under light.
When it comes to the melting point, the melting point of this compound is quite specific, about [X] ° C. The melting point is the inherent characteristic of the substance, just like the human nature, stable and unique. At a specific temperature, the compound quietly changes from a solid state to a liquid state. This temperature is its melting point, which is like the "transformation" node of the substance.
Smell its taste, (benzyl) -2,3-dibromonaphthalene has a little special smell, but it is not pungent and intolerable, but it is also unique and recognizable. Its taste is light and different from common things, just like the field of smell draws a different color.
As for solubility, (benzyl) -2,3-dibromonaphthalene is insoluble in water, as if it is naturally repulsive with water, and the two are difficult to blend. However, in the context of organic solvents, such as ethanol, ether, etc., it can show good solubility, just like fish entering water, which can be dispersed and fused into one. This difference in solubility is due to the difference in its molecular structure and the forces between water molecules and organic solvent molecules.
In addition, its density is also an important physical property, weighing about [X] grams per cubic centimeter. This density data reflects the amount of substances contained in its unit volume. Compared with other substances, it can be seen that its light, heavy and dense state.
(benzyl) -2,3-dibromonaphthalene has unique physical properties and is of great significance in organic chemistry research and related application fields. It lays the foundation for its participation in various reactions and specific functions.
What are the precautions for 1- (bromomethyl) -2,3-difluorobenzene during storage and transportation?
(1) Storage Note
For ethylene oxide, it is a flammable and highly oxidizing gas, and its storage is especially important. It must be placed in a cool and well-ventilated place, away from fire and heat sources. Kuwen must not exceed 30 ° C, and appropriate equipment to prevent leakage should be prepared. And should not be mixed with easy (can) fuels, reducing agents, acids, edible chemicals, etc., to prevent accidental chemical reactions from causing danger.
(2) Transportation Note
When transporting, vehicles must be equipped with the corresponding variety and quantity of fire equipment and leakage emergency treatment equipment. Summer transportation should be selected in the morning and evening to avoid sun exposure. During transportation, make sure that the container does not leak, collapse, fall or damage. Speed should be slow, keep the distance between the vehicles, avoid sudden brakes and sharp turns, and avoid damage to the container due to collision and vibration. Transport vehicles should follow the designated route and do not stop in residential areas and densely populated places. When loading and unloading, be sure to pack and unload lightly to prevent damage to the packaging and containers.
Ethylene oxide needs to be careful throughout the storage and transportation process. All precautions are related to safety and must not be sloppy at all. In this way, disasters can be avoided and everything goes smoothly.
What is the market price of 1- (bromomethyl) -2,3-difluorobenzene?
In today's world, business conditions are treacherous and changeable, and it is not easy to know the market price of (hydroxymethyl) -2,3-dibromobutyraldehyde. However, it can be speculated in many ways.
Looking at the past, the ups and downs of market prices often depend on changes in supply and demand. If the demand for this product is ardent, and there are few suppliers, its price will rise; if the supply exceeds demand, the price may fall. This is the common sense of the market, both ancient and modern.
Furthermore, the price of raw materials is also the key. The production of (hydroxymethyl) -2,3-dibromobutyraldehyde depends on various raw materials. If the price of raw materials is high, the manufacturing cost will increase, and the market price will also rise; if the price of raw materials is low, the cost will drop, and the market price may drop.
And husband, the regulations of the decree and the adjustment of the tax will also have a great impact on the market price. If the decree is strict and the tax is heavy, the merchants will raise the price to ensure their profits; on the contrary, if the decree is wide and the tax is light, the price may stabilize, or even drop slightly.
And the progress of technology also affects the market price. If new technologies are introduced, the efficiency of production can be greatly increased, the cost is greatly reduced, and the supply in the market will increase, and the price may drop accordingly.
However, now I don't know the supply and demand situation, the price of raw materials, nor the status of government orders and technologies. It is difficult to determine the current market price of (hydroxymethyl) -2,3-dibromobutyraldehyde. Only willing to involve this business, diligently observe business conditions, and observe changes in time can we take advantage of market changes and gain opportunities and gain benefits.