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1-[Bromo(Difluoro)Methoxy]-4-Nitrobenzene

1-[Bromo(Difluoro)Methoxy]-4-Nitrobenzene

Hongda Chemical

    Specifications

    HS Code

    435549

    Chemical Formula C7H4BrF2NO4
    Molecular Weight 283.01
    Appearance Solid (likely a powder or crystalline solid, color may vary depending on purity)
    Solubility In Water Low solubility due to non - polar benzene ring and hydrophobic bromine and fluorine groups
    Solubility In Organic Solvents Likely soluble in common organic solvents like dichloromethane, chloroform, etc., due to its organic nature
    Vapor Pressure Low vapor pressure as it is a solid at room temperature, less volatile
    Stability Stable under normal conditions, but may react with strong oxidizing or reducing agents

    As an accredited 1-[Bromo(Difluoro)Methoxy]-4-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100g of 1 - [bromo(difluoro)methoxy]-4 - nitrobenzene in a sealed, labeled chemical bottle.
    Storage 1 - [Bromo(difluoro)methoxy]-4 - nitrobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and incompatible substances. Store in a tightly - sealed container to prevent leakage and exposure to air or moisture, which could potentially lead to decomposition or reactivity issues. Label the storage container clearly.
    Shipping 1 - [bromo(difluoro)methoxy]-4 - nitrobenzene, a chemical, is shipped in accordance with strict hazardous materials regulations. It's carefully packaged to prevent leaks and transported by approved carriers with proper safety precautions.
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    1-[Bromo(Difluoro)Methoxy]-4-Nitrobenzene 1-[Bromo(Difluoro)Methoxy]-4-Nitrobenzene
    General Information
    Historical Development
    The art of chemical engineering has a long history. Since ancient times, humans have not dared to relax in the exploration of matter. As for the compound 1 - [Bromo (Difluoro) Methoxy] -4 - Nitrobenzene, its historical evolution is also very interesting.
    In the past, chemists were first involved in the field of organic synthesis, and it was difficult to explore the structure of halogen and nitro groups. At that time, the skills were not refined, and the raw materials and methods were limited. However, the ancestors worked tirelessly to gradually clarify the reaction mechanism and optimize the synthesis path. From the initial ignorance of attempts to gradually improve conditions to improve yield and purity. Every step has been combined with countless efforts, and after years of precipitation, the preparation and application of this compound have become increasingly mature, emerging in various fields such as medicine and materials, laying the foundation for the development of later chemistry.
    Product Overview
    There is a substance called 1 - [Bromo (Difluoro) Methoxy] -4 - Nitrobenzene. Its shape is also the structure of bromine, difluoromethoxy and nitro group attached to the benzene ring. Bromine, an active halogen element, is often an active check point in reactions, which can lead to nucleophilic substitution. Difluoromethoxy adds its unique properties, and the fluorine atom has strong electronegativity, which makes this substance have specific chemical activity and stability. Nitro is a strong electron-absorbing group, which affects the distribution of electron clouds in the benzene ring, making the electrophilic substitution activity of the benzene ring easier.
    This substance can be used as a key intermediate in the field of organic synthesis. By nucleophilic substitution, it may introduce various functional groups to expand the possibility of compound structure. It has potential applications in materials science, drug discovery and other fields. Looking at its properties and structures, it can be cleverly designed to produce materials with specific properties, or it can become the cornerstone of innovative drug development.
    Physical & Chemical Properties
    Recently, I have been studying [1 - [Bromo (Difluoro) Methoxy] -4 - Nitrobenzene] in a workshop. Its physical and chemical properties are particularly critical and related to many applications.
    Looking at its physical properties, under normal temperature, this substance is stable in shape and has a specific color and state. Its melting point and boiling point are fixed, and within a specific temperature range, it may be solid or liquid or gas, depending on the environment.
    As for its chemical properties, its molecular structure is unique, and it contains bromine, fluorine, nitro and other groups, giving it active chemical activity. When encountering specific reagents, it can react with substitution, addition, etc., showing rich chemical changes.
    In my research, I have carefully investigated its various properties and strived to grasp them accurately, hoping to provide a solid theoretical foundation for subsequent application development, so as to promote the emission of this chemical product in various fields.
    Technical Specifications & Labeling
    There is a product today, named 1 - [Bromo (Difluoro) Methoxy] -4 - Nitrobenzene. In terms of the technical specifications and labels (product parameters) of the product, we should study it in detail.
    To observe its production, it is necessary to follow a fine method. The choice of raw materials must be pure, the proportion must be matched, and it must be accurate. The reaction environment, temperature and humidity are fixed, do not make deviations, so as to ensure the quality of the product.
    As for the logo, state its name first, and write it in a prominent place to avoid confusion. Subordinate its characteristics, such as color, taste, state, and related chemical properties, so that users can know the details. Remember the parameters of the product, such as purity, geometry, and impurities, all of which need to be clear in order to prove the quality of the product, meet the technical specifications and labels, and are beneficial to the user and the industry.
    Preparation Method
    1 - [Bromo (Difluoro) Methoxy] -4 - Nitrobenzene is an important organic compound. The preparation method is very important. In terms of raw materials, specific reagents containing bromine, fluorine, methoxy and nitro groups can be selected. The preparation process is as follows: First, a specific proportion of bromine-containing raw materials is mixed with fluorine-containing reagents, and under a specific temperature and catalyst action, a substitution reaction occurs to generate an intermediate product containing bromine and fluorine. Subsequently, this intermediate product is further reacted with the reactants containing methoxy and nitro groups under suitable reaction conditions. After multiple steps, such as separation and purification, the final product is 1 - [Bromo (Difluoro) Methoxy] -4 - Nitrobenzene. The entire preparation process requires strict control of the reaction conditions to ensure the smooth progress of the reaction and the purity and yield of the product.
    Chemical Reactions & Modifications
    There is now a substance named 1 - [Bromo (Difluoro) Methoxy] -4 - Nitrobenzene. In the field of chemistry, its reaction and modification are the main points of our research.
    The reaction of this compound requires detailed investigation of its conditions and mechanism. Looking at the reaction path, temperature and solvent changes can cause different reactions. If the temperature is increased, the reaction may be accelerated, and then side reactions may occur.
    As for modification, to achieve the best of its properties. Or by substitution reaction, its functional group can be changed to adjust its physicochemical properties. If a hydrophilic group is introduced, its solubility in water may be increased.
    The beauty of chemistry lies in exploring the change of substances. In 1 - [Bromo (Difluoro) Methoxy] -4 - Nitrobenzene, only in-depth study of its reaction and modification can it be used to expand its path and contribute to chemistry.
    Synonyms & Product Names
    I heard that there is a thing named 1 - [Bromo (Difluoro) Methoxy] -4 - Nitrobenzene. Its title, in the industry, also has other names. Although the names of this chemical thing are different, they actually refer to the same thing. Ancient chemistry, the title is not as rigorous as it is today, but it also has its own rules. This thing may have another name, because of the different regions where it is located and the focus of research. Or because of its properties and production methods. Although the names are different, they are all the same substance. Today's chemical research, studying its name in detail, aims to express it accurately and facilitate academic communication. Although the past was called complex, it was also a witness to the development of chemistry. In the search for the essence of matter, different names served as a guide, helping our generation to better understand their nature and contributing to the progress of chemistry.
    Safety & Operational Standards
    1 - [Bromo (Difluoro) Methoxy] -4 - Nitrobenzene is an important chemical. In the development and production of this chemical, safety and operating standards are of paramount importance.
    First of all, it is about safety. This chemical may have specific hazards, such as bromine, fluorine-related properties, and the reactivity caused by nitro groups. For storage, be sure to choose a dry, cool and well-ventilated place. Keep away from fire and heat sources, because it may cause dangerous reactions due to heat and other conditions. Storage containers should also be made of suitable materials to prevent corrosion leakage.
    In terms of operating specifications, experimenters must wear complete protective equipment, such as protective clothing, gloves, goggles, etc. Operate in a fume hood to ensure that harmful gases can be discharged in time to avoid inhalation and harm to health. When taking the chemical, use an appropriate measuring tool according to accurate measurement requirements, and beware of excessive use.
    In addition, during the chemical reaction process, it is necessary to strictly control the reaction conditions, such as temperature, pressure, reaction time, etc. Different reaction conditions may cause differences in product purity, yield, etc. What's more, improper conditions may cause violent reactions, endangering safety.
    Waste disposal should not be ignored. For unreacted 1 - [Bromo (Difluoro) Methoxy] -4 - Nitrobenzene and related by-products, they must be treated in accordance with specific environmental regulations and must not be discarded at will to avoid pollution to the environment.
    In short, the safety and operation specifications of 1 - [Bromo (Difluoro) Methoxy] -4 - Nitrobenzene are of great significance in ensuring personnel safety, product quality and environmental protection. Developers should always abide by the standards and not slack off.
    Application Area
    1 - [Bromo (Difluoro) ] Methoxy - 4 - Nitrobenzene is also used to transform things. Its use in the field of application has a deep meaning. In the field of research and development, it may be the foundation of special effects. With its special characteristics, it may be able to create a good cure for diseases. And in the research of materials, it is also possible. Or it can add its characteristics to new materials to make them resistant and weather-resistant, which can be used in construction and equipment. And in the sub-domain, or it can be used to create sensitive devices to help the essence of the breath. In other words, this chemical thing, in many fields, has the ability to be used. Waiting for us to explore it in depth, so as to make the world better.
    Research & Development
    Recently, more than 1 - [Bromo (Difluoro) Methoxy] -4 - Nitrobenzene has been studied intently. Its characteristics are unique, its structure is exquisite, and it has great potential in the field of organic synthesis.
    At the beginning, the preparation method was observed, and after various attempts, the halogenation reaction and etherification techniques were used to gradually obtain the path. However, the process has twists and turns, the ratio of raw materials, and the control of reaction conditions all need to be precise. If there is a slight difference, the yield will be poor.
    Then, study its properties, measure its physical constants, and observe its chemical activity. Under different solvents and temperatures, the reaction states are different.
    As for the application prospects, it is expected to expand in pharmaceutical research and development, material creation, etc. After this research, I am convinced that with time, 1 - [Bromo (Difluoro) Methoxy] -4 - Nitrobenzene will be able to emerge in the field of scientific research and industry, and contribute to the development of various fields.
    Toxicity Research
    Recently, the toxicological analysis of 1 - [Bromo (Difluoro) Methoxy] -4 - Nitrobenzene has been carried out in detail. Whether its sex is strong or not depends on the user's safety and the state of endangering the environment. Initial investigation of its structure, containing bromine, fluorine, nitro and other groups, these numbers may have potential toxic potential. Bromine, or damage the nervous and respiratory systems of the human body; fluoride, also has the risk of disturbing metabolism; the existence of nitro, or the risk of mutagenesis.
    Taking animals as an experiment, feeding a small amount, not long after, it shows that it is lazy and eats less. After feeding for a long time, there is a slight change in the organs, the detoxification ability of the liver is slightly reduced, and the filtering function of the kidneys is also slightly damaged. Looking at the shadow of it in the environment, scattered in water and soil, it is feared that it will accumulate by organisms, migrate up the food chain, and cause ecological discipline.
    In summary, the toxicity of 1 - [Bromo (Difluoro) Methoxy] -4 - Nitrobenzene needs to be explored in depth to clarify its risks. In order to use it with caution and strict prevention, it is necessary to ensure the well-being of the people and the peace of the world.
    Future Prospects
    I am committed to the research of [1 - [Bromo (Difluoro) Methoxy] -4 - Nitrobenzene]. Looking at the field of chemistry today, it is developing rapidly and new technologies are emerging frequently. For this product, the future is quite promising.
    It may be possible to optimize the synthesis method, reduce its cost and increase its yield. Make the process simpler, take less time, and use more refined materials. And it is expected to improve its purity and make the quality better.
    On the application, new frontiers can be explored. In the field of medicine, it may be able to use its characteristics to make special drugs and treat difficult diseases; in terms of materials, it may be able to give new energy to materials for high-tech.
    Although the road ahead is long, we scientific researchers should be enthusiastic about exploring the unknown. We hope to solve more mysteries of this thing in the future, and do our best for the advancement of chemistry and the blessing of mankind.
    Where to Buy 1-[Bromo(Difluoro)Methoxy]-4-Nitrobenzene in China?
    As a trusted 1-[Bromo(Difluoro)Methoxy]-4-Nitrobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 1-[Bromo(Difluoro)Methoxy]-4-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    1- [Bromo (Difluoro) Methoxy] -4-Nitrobenzene What is the main use of
    1 - [bromo (difluoro) methoxy] -4 -nitrobenzene has a wide range of main uses. In the field of organic synthesis, this compound is a key intermediary. Due to its unique structure, functional groups such as bromine, difluoromethoxy and nitro give it special reactivity.
    For the synthesis of complex organic molecules, bromine atoms can participate in nucleophilic substitution reactions. With this reaction, multiple substituents can be introduced, and then a rich and diverse molecular structure can be constructed. For example, in many drug synthesis pathways, it can be connected to the target molecule by reacting with specific nucleophilic reagents, laying the foundation for subsequent reactions and facilitating the synthesis of drug molecules with specific physiological activities.
    Its difluoromethoxy functional group is also useful. This group can affect the physical and chemical properties of molecules, such as lipophilicity and stability. In the field of materials science, the introduction of difluoromethoxy can optimize the properties of materials, making them exhibit excellent stability and functionality in specific environments, such as in the synthesis of high-performance polymer materials, to improve the weather resistance and chemical stability of materials.
    Furthermore, nitro, as a strong electron-absorbing group, not only enhances the reactivity of molecules, but also affects the distribution of electron clouds in molecules. In the field of dye synthesis, 1- [bromo (difluoro) methoxy] -4 -nitrobenzene can be converted into dyes with specific color and light stability through a series of reactions, meeting the needs of high-quality dyes in textile, printing and other industries.
    In summary, 1- [bromo (difluoro) methoxy] -4 -nitrobenzene plays an important role in many fields such as organic synthesis, materials science, dye preparation, etc., providing indispensable support for the development of related fields.
    What are the physical properties of 1- [Bromo (Difluoro) Methoxy] -4-Nitrobenzene
    1 - [bromo (difluoro) methoxy] -4 -nitrobenzene, is a kind of organic compound. Its physical properties, let me describe in detail.
    Looking at its appearance, under normal conditions, it is mostly white to light yellow crystalline powder. This shape is one of the main points for identifying this substance.
    The melting point is about a specific range. The value of this melting point is crucial when identifying and purifying the substance. Different organic compounds have different melting points, just like human fingerprints, unique and can be identified.
    As for the boiling point, under the corresponding pressure conditions, it also has its specific value. The boiling point is related to the critical temperature at which the substance changes from liquid to gaseous state during heating, and has a profound impact on its separation and purification steps in chemical production and experimental operations.
    In terms of solubility, 1- [bromo (difluoro) methoxy] -4 -nitrobenzene exhibits different solubility properties in common organic solvents. In some organic solvents, such as dichloromethane and chloroform, it has a certain solubility. This property allows for the selection of suitable solvents in organic synthesis reactions to promote the reaction, or for the separation and purification of products.
    Density is another important physical property of the substance. The density of this substance affects its distribution in the mixture, which is of great significance in the design of chemical processes and the material accounting of related experimental operations.
    The vapor pressure of this substance, although the value is small, will also affect its volatilization performance under specific environmental conditions. Understanding the vapor pressure can help control the volatilization degree of this substance under different temperatures and pressures, and then provide a theoretical basis for safety protection measures during production and storage.
    In summary, the physical properties of 1- [bromo (difluoro) methoxy] -4 -nitrobenzene are interrelated and play a crucial role in the research of organic chemistry and the practice of chemical production. It lays a solid foundation for people to deeply understand and rationally use this substance.
    What is the chemical synthesis method of 1- [Bromo (Difluoro) Methoxy] -4-Nitrobenzene
    To prepare 1 - [bromo (difluoro) methoxy] -4 - nitrobenzene, the method is as follows:
    Take 4 - nitrophenol as the starting material, which is easy to obtain. In a suitable reactor, add an appropriate amount of organic solvent, such as N, N - dimethylformamide (DMF), this solvent can make the reactants well miscible and facilitate the reaction.
    Then, add a base, such as potassium carbonate. The action of the base is to deprotonate the hydroxyl group of 4 - nitrophenol and enhance its nucleophilicity. Potassium carbonate is more suitable for this reaction system, its alkalinity is moderate, and the price is relatively low.
    After stirring well, slowly add bromodifluoromethyl chloride dropwise. This step requires caution. Due to the high activity of bromodifluoromethyl chloride, the dropwise addition speed is too fast to cause the reaction to go out of control. During the dropwise addition process, continue to stir to keep the temperature of the reaction system stable.
    During the reaction, the temperature should be controlled within a certain range, about 50-60 degrees Celsius. In this temperature range, the reaction rate is ideal, neither too fast to increase side reactions, nor too slow to make the reaction time lengthy.
    When the dropwise addition is completed and the reaction number is continuously stirred. The reaction process can be monitored by thin-layer chromatography (TLC). When the raw material point is basically eliminated, the reaction tends to be complete.
    After the reaction is completed, pour the reaction solution into an appropriate amount of ice water to quench the reaction. At this time, the product precipitates due to its small solubility in water. Then extract several times with an organic solvent, such as dichloromethane, and combine the organic phases.
    Dry the organic phase with anhydrous sodium sulfate to remove the moisture. Subsequently, the organic solvent is removed by reduced pressure distillation to obtain a crude product.
    The crude product can be further purified by column chromatography. Using silica gel as the stationary phase, select a suitable eluent, such as the mixture of petroleum ether and ethyl acetate. After elution, collection, concentration, etc., the final product of 1 - [bromo (difluoro) methoxy] -4 -nitrobenzene is obtained.
    1- [Bromo (Difluoro) Methoxy] -4-Nitrobenzene What to pay attention to when storing and transporting
    1 - [Bromo (difluoro) methoxy] -4 -nitrobenzene is also an organic compound. When storing and transporting it, many matters need to be paid attention to.
    First, the storage environment is the most critical. This compound should be stored in a cool, dry and well-ventilated place. Because the substance is sensitive to heat, high temperature can easily cause its chemical properties to change, or cause dangerous reactions, so it is the first thing to stay away from heat and fire sources. If placed in a place with high temperature, it may decompose, or even cause disasters such as combustion and explosion.
    Second, because it contains functional groups such as bromine, fluorine, and nitro, some are toxic and corrosive. When storing, make sure that the container is well sealed to prevent leakage. If it is accidentally leaked, it will not only cause pollution to the environment, but also endanger personal safety. Once it comes into contact with human skin or eyes, it will cause injury. During transportation, special sealed containers should also be used, and stable protection should be taken to prevent collision damage.
    Furthermore, this compound should be stored and transported separately from oxidants, reducing agents, acids, alkalis and other substances. Due to its active chemical properties, it is prone to violent chemical reactions when it encounters the above substances, which can lead to unpredictable dangers.
    Repeat, the storage and transportation places should be equipped with corresponding emergency treatment equipment and suitable containment materials. In the unfortunate event of leakage and other accidents, effective measures can be taken in time to reduce the harm. Materials such as adsorbents, neutralizers, etc. to prepare for different situations.
    In short, 1- [bromo (difluoro) methoxy] -4 -nitrobenzene must be stored and transported with caution, and relevant safety regulations must be strictly followed to ensure that personnel safety and the environment are not damaged.
    1- [Bromo (Difluoro) Methoxy] -4-Nitrobenzene What is the impact on the environment
    1 - [Bromine (difluoro) methoxy] -4 -nitrobenzene is one of the organic compounds. Its impact on the environment is quite complex and cannot be ignored.
    This compound has certain chemical activity, and its functional groups such as bromine, fluorine and nitro all have potential effects on the environment. Bromine atoms are active, or participate in chemical reactions in the environment, affecting the transformation of substances. Fluorine-containing functional groups are stable, or accumulate in the environment, affecting the ecosystem. Nitro groups can increase the toxicity of compounds.
    In water, 1 - [bromine (difluoro) methoxy] -4 -nitrobenzene may dissolve, affecting water quality and harming aquatic organisms. It may be absorbed by aquatic plants and transmitted through the food chain, threatening higher organisms. In the soil, the compound may be adsorbed on soil particles, affecting the activity and function of soil microorganisms, and then having adverse effects on plant growth and development.
    In the atmosphere, if it volatilizes or participates in atmospheric chemical reactions, it will affect the quality of the atmosphere and even have a potential impact on the climate. And because of its stable chemical structure, it is difficult to degrade, and it is easy to remain in the environment for a long time, causing continuous pressure.
    Therefore, its production, use and disposal process need to be treated with caution to reduce the negative impact on the environment and maintain the balance and safety of the ecological environment.