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1-Bromo-5-Fluoro-2-Methyl-4-Nitro-Benzene

1-Bromo-5-Fluoro-2-Methyl-4-Nitro-Benzene

Hongda Chemical

Specifications

HS Code

658723

Chemical Formula C7H5BrFNO2
Molar Mass 236.02 g/mol
Appearance Solid (predicted from similar aromatic nitro - halide compounds)
Boiling Point No common data, but likely high due to aromatic and polar groups
Melting Point No common data, but melting points of similar aromatic halide - nitro compounds can range from 50 - 150°C
Density No common data, but for similar aromatic halide - nitrobenzenes, density is around 1.7 - 1.9 g/cm³
Solubility In Water Low solubility (aromatic and non - polar groups along with hydrophobic halides and nitro group)
Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform, toluene (due to its non - polar aromatic nature)
Pka No common data, but the nitro group can make the molecule slightly acidic in the presence of strong bases
Reactivity Reactive towards nucleophilic substitution reactions due to the presence of bromine and the electron - withdrawing nitro group

As an accredited 1-Bromo-5-Fluoro-2-Methyl-4-Nitro-Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 1 - bromo - 5 - fluoro - 2 - methyl - 4 - nitro - benzene in sealed chemical - grade packaging.
Storage 1 - Bromo - 5 - fluoro - 2 - methyl - 4 - nitro - benzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. Keep it in a tightly sealed container to prevent exposure to air and moisture. Store it separately from oxidizing agents, reducing agents, and bases to avoid potential chemical reactions.
Shipping 1 - bromo - 5 - fluoro - 2 - methyl - 4 - nitro - benzene is shipped in sealed, corrosion - resistant containers. Special care is taken to comply with hazardous chemical shipping regulations to prevent leakage and ensure safe transportation.
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1-Bromo-5-Fluoro-2-Methyl-4-Nitro-Benzene 1-Bromo-5-Fluoro-2-Methyl-4-Nitro-Benzene
General Information
Historical Development
All the things that have been tasted and heard of in chemistry have undergone years of research and development. Jin Yan 1 - Bromo - 5 - Fluoro - 2 - Methyl - 4 - Nitro - Benzene This product originated from the research of various sages. At the beginning, the academic community explored the field of organic synthesis and gradually deepened, and various compounds emerged one by one.
Everyone has been seeking new things through trial and error in the derivation of aromatics. After many experiments, or changing the conditions of the reaction, or more easily participating raw materials, this compound was obtained. Its birth is like a spark in the long night, adding new things to the library of organic chemistry. Since then, scholars' understanding of halogenated nitro aromatics has advanced to a new level, laying the foundation for subsequent related research and initiating a new journey in chemical creation.
Product Overview
1 - Bromo - 5 - Fluoro - 2 - Methyl - 4 - Nitro - Benzene, this is the chemical I recently studied. Its shape is crystalline, its color is nearly yellowish, and it is slightly faint under specific light.
This substance has a unique structure, with bromine, fluorine, methyl and nitro cleverly attached to the benzene ring. The introduction of bromine atoms gives it a certain nucleophilic substitution activity; fluorine atoms affect the electron cloud distribution of molecules due to their strong electronegativity, making their chemical properties more active; methyl groups have a subtle effect on their reactivity and spatial structure; the strong electron absorption of nitro groups greatly changes the electron density of benzene rings, resulting in the substance exhibiting different characteristics in many reactions.
After repeated experimental observations, it has good solubility in organic solvents. Under the action of specific temperatures and catalysts, it can participate in a series of important organic reactions, and is expected to emerge in the fields of fine chemicals and drug synthesis, contributing to the development of related industries.
Physical & Chemical Properties
1 - Bromo - 5 - Fluoro - 2 - Methyl - 4 - Nitro - Benzene is an important organic compound. Its physical properties are unique. It is a solid state at room temperature, has a yellowish color, and has a specific melting point and boiling point. The melting point is about [X] ° C, and the boiling point is around [X] ° C. This property is of great significance in the separation and purification process.
In terms of chemical properties, the functional groups of bromine, fluorine, methyl and nitro in its molecule endow it with various reactivity. The strong electron-absorbing properties of the nitro group reduce the electron cloud density of the benzene ring, increase the difficulty of electrophilic substitution reactions, and promote nucleophilic substitution reactions. Bromine atoms are relatively active and can participate in many nucleophilic substitution and elimination reactions, providing the possibility for the construction of new carbon-carbon or carbon-heteroatom bonds. Fluorine atoms have a significant impact on molecular stability and reaction selectivity due to their high electronegativity. Methyl groups can affect the spatial structure and electron cloud distribution of molecules and change their chemical activity. All kinds of physical and chemical properties lay the foundation for the in-depth study and application of this compound.
Technical Specifications & Labeling
1 - Bromo - 5 - Fluoro - 2 - Methyl - 4 - Nitro - Benzene is an important chemical product. Its process specifications and labeling (product parameters) are related to the quality and application of this product.
In the process specifications, it is necessary to ensure the precise positioning and content of bromine, fluorine, methyl and nitro groups. To synthesize this product, the reaction conditions are extremely critical, and the temperature, pressure and reaction time must be strictly controlled. If the reaction temperature is high or low, side reactions may occur and affect the purity of the product.
In terms of labeling, product parameters should be clearly marked. It is not only necessary to indicate the chemical name and molecular formula, but also to detail the purity, impurity content and other indicators. In this way, users can choose this product reasonably according to their needs. And clear and accurate identification is also conducive to product circulation and quality traceability.
Preparation Method
This product is made of 1 - Bromo - 5 - Fluoro - 2 - Methyl - 4 - Nitro - Benzene. The method is as follows:
Raw materials and production process: Take an appropriate amount of fluorobenzene, add brominating agent and nitrating agent in a certain ratio and sequence. Fluorobenzene first reacts with brominating agent at a suitable temperature and pressure, and bromine atoms gradually enter its benzene ring. Then add a nitrifying agent, and then control the temperature to react, so that the nitro group also enters the benzene ring and is substituted at a specific position.
Reaction steps: First, wash and dry the reaction vessel and fill it with inert gas. Next, measure the fluorobenzene into the container, open and stir, slowly add the brominating agent, and control the temperature for several hours. After the bromination reaction is completed, it is slightly cold, and the nitrifying agent is added in sequence, and the reaction continues at temperature.
Catalytic mechanism: Select a specific catalyst, which can reduce the activation energy of the reaction, promote the bromination and nitrification reactions to proceed efficiently. And it can guide bromine atoms and nitro groups into the predetermined position of the benzene ring to increase the selectivity of the product. In this way, 1-Bromo-5-Fluoro-2-Methyl-4-Nitro-Benzene can be prepared.
Chemical Reactions & Modifications
Today there is a thing called 1 - Bromo - 5 - Fluoro - 2 - Methyl - 4 - Nitro - Benzene. In the field of chemistry, its reaction and modification are of great importance to us.
Looking at its reaction, it can change differently depending on the conditions. To make its performance better, it is necessary to observe its structure and study the chemical principles. Or adjust the temperature, pressure, or add specific agents to improve its properties.
This compound, if it can make good use of the reaction method, or can obtain new substances, has different properties. In the process of scientific research, we should carefully study the rules of reaction and observe the effect of modification in order to achieve the purpose of optimization and contribute to the progress of chemistry.
Synonyms & Product Names
1 - Bromo - 5 - Fluoro - 2 - Methyl - 4 - Nitro - Benzene, the synonym and trade name of this substance, is also an important item for our generation. Its synonyms are many, or it is named according to its chemical structure characteristics, or according to its use characteristics. As for the trade name, it varies depending on the manufacturer and the market.
Looking at its chemical structure, it contains bromine, fluorine, methyl and nitro groups, which are widely used in the field of organic synthesis. Or as an intermediary for the preparation of special drugs, or as a raw material for the creation of new materials. Its synonyms can help the academic community to communicate accurately, and the establishment of the trade name will facilitate the marketing activities of the merchant.
Our chemical researchers must study the synonyms and trade names in detail, understand their similarities and differences, and know their application. Only by making good use of them in scientific research and industry can they make new achievements and contribute to the progress of chemistry.
Safety & Operational Standards
1 - Bromo - 5 - Fluoro - 2 - Methyl - 4 - Nitro - Benzene is an important chemical. Safety and handling practices are of paramount importance during its experimental operation and storage.
This chemical is dangerous to some extent. When operating, it is necessary to strictly follow laboratory safety procedures. Experimenters should wear appropriate protective equipment, such as lab clothes, protective gloves and goggles, to prevent contact with skin and eyes. Because it may be irritating, in case of accidental contact, rinse with plenty of water immediately and seek medical attention according to the specific situation.
For storage, it should be placed in a cool, dry and well-ventilated place, away from fire sources and oxidants. It needs to be stored in a specific container, and the container should be well sealed to prevent leakage.
During operation, accurate measurement and careful operation are indispensable. When taking the chemical, the utensils used must be clean and dry to avoid impurities from mixing and affecting its quality. The reaction process needs to strictly control temperature, pressure and other conditions, and operate according to the established reaction process and parameters, and must not be changed without authorization.
Waste disposal should also not be ignored. The waste generated by the experiment containing the chemical should be collected in accordance with regulations, properly disposed of, and should not be discarded at will to avoid pollution to the environment.
Only by strictly following safety and operating practices can the experimental operation of 1 - Bromo - 5 - Fluoro - 2 - Methyl - 4 - Nitro - Benzene be guaranteed to be safe, and the quality and accuracy of the experimental results can be guaranteed.
Application Area
1 - Bromo - 5 - Fluoro - 2 - Methyl - 4 - Nitro - Benzene has a wide range of uses in my chemical research. It can be used as a key intermediate in the field of pharmaceutical creation. In terms of synthesizing specific drugs, through delicate reaction steps, it can be cleverly combined with other compounds to generate drugs with unique curative effects for the treatment of various diseases.
In the field of material research and development, it also has its place. With specific process processing, it can be integrated into new materials to give materials such as special photoelectric properties or increase their chemical stability.
Furthermore, in the field of fine chemicals, it is also indispensable. It can be converted into a series of fine chemicals with special functions, which are used in paints, fragrances and many other categories to add unique characteristics to the product. From this point of view, 1 - Bromo - 5 - Fluoro - 2 - Methyl - 4 - Nitro - Benzene has significant power in various application fields.
Research & Development
Recently, in my research, I focused on 1 - Bromo - 5 - Fluoro - 2 - Methyl - 4 - Nitro - Benzene. At first, I studied its physicochemical properties in detail, explored its molecular structure, physicochemical characteristics, and understood its reaction situation under specific conditions.
Then, study the synthesis method. After several attempts, either adjust the temperature of the reaction, or change the amount of reagents, or choose more solvents. During this time, I encountered many obstacles, the reaction yield was not as expected, and impurities also disturbed the purity of the synthesis. However, I did not give up, analyzed the crux of the problem in detail, and referred to the literature to ask colleagues for advice.
Fortunately, the method of optimizing the synthesis has been achieved, and the yield has gradually increased, and the purity has also met the requirements. Looking to the future, I want to expand the application field of this substance and study its potential in the fields of medicine and materials, with the aim of advancing scientific research and promoting the industry. I will do my best to promote its long-term development.
Toxicity Research
Modern chemistry is advanced, and the study of toxicants is particularly important. Today, there is a name 1 - Bromo - 5 - Fluoro - 2 - Methyl - 4 - Nitro - Benzene, which is common in chemical products. The study of its toxicity is related to everyone's safety.
This compound, bromine, fluorine, methyl and nitro coexist on the benzene ring. Looking at its structure, the strong electron absorption of nitro groups, or making this substance have special chemical activity, which in turn affects its toxicity. In the past, people studied poisons and looked at their effects on organisms. Try insects, mice, etc., to observe the changes caused by 1 - Bromo - 5 - Fluoro - 2 - Methyl - 4 - Nitro - Benzene.
It may damage biological cells and disrupt their physiological order. At the cellular level, or the integrity of the broken membrane, it disturbs the activity of enzymes. Long-term contact with it, or cause biological lesions and stunted development. Therefore, studying its toxicity and setting its safety threshold can help the world to avoid disasters and protect their lives when using this substance. In the chemical industry, there is also a right path.
Future Prospects
My View 1 - Bromo - 5 - Fluoro - 2 - Methyl - 4 - Nitro - Benzene This object is unique in nature and exquisite in structure. Although the current world's research on it is still in its infancy, my heart is full of endless longing for the future.
It is expected that in the future, with advanced scientific research, we will be able to gain insight into its deeper nature and understand its potential applications in various fields. In medicine, it may be able to create a miraculous medicine based on it, saving thousands of patients from pain; in the study of materials, it may be able to use its characteristics to develop new materials, which will fuel the progress of science and technology.
I firmly believe that over time, through the unremitting research of our researchers, 1 - Bromo - 5 - Fluoro - 2 - Methyl - 4 - Nitro - Benzene will shine, making great achievements for the well-being of mankind and the progress of the world. The bright future is like the stars shining in the sky, which is fascinating.
Where to Buy 1-Bromo-5-Fluoro-2-Methyl-4-Nitro-Benzene in China?
As a trusted 1-Bromo-5-Fluoro-2-Methyl-4-Nitro-Benzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 1-Bromo-5-Fluoro-2-Methyl-4-Nitro-Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-Bromo-5-Fluoro-2-Methyl-4-Nitro-Benzene?
1-Bromo-5-fluoro-2-methyl-4-nitrobenzene is also an organic compound. It has a wide range of uses and has important applications in the chemical and pharmaceutical fields.
In chemical industry, it is often a key intermediate in organic synthesis. Because its molecular structure contains different functional groups such as bromine, fluorine, methyl and nitro, it can be converted into other complex organic compounds by various chemical reactions, such as nucleophilic substitution, coupling reaction, etc. Taking nucleophilic substitution as an example, bromine atoms have high activity and are easily replaced by other nucleophilic reagents, introducing new functional groups, thereby constructing compounds with multiple structures, laying the foundation for the synthesis of special materials and functional organic molecules.
In the field of medicine, it also has potential value. Functional groups such as nitro and fluorine atoms have a great impact on drug activity. By reasonably modifying the structure of this compound, new drugs may be created. Scientists often use it as a starting material to optimize the molecular structure through multi-step reactions to achieve specific pharmacological activities. For example, when developing antibacterial, anti-tumor and other drugs, it can be used as an important starting structural unit. After modification, the affinity and selectivity of the drug to the target can be improved, thereby improving the efficacy and reducing side effects. In conclusion, the unique structure of 1-bromo-5-fluoro-2-methyl-4-nitrophenyl is an indispensable and important substance in the process of chemical and pharmaceutical research and development.
What are the physical properties of 1-Bromo-5-Fluoro-2-Methyl-4-Nitro-Benzene?
1-Bromo-5-fluoro-2-methyl-4-nitrobenzene is a kind of organic compound. Its physical properties are quite important, and these properties are often the key considerations in the research and application of chemical industry, medicine and other fields.
First of all, under room temperature, 1-bromo-5-fluoro-2-methyl-4-nitrobenzene is mostly in a solid state. Due to the intermolecular force, the atoms are arranged in an orderly manner, so it is in a solid state. Its appearance is often a light yellow or off-white crystalline powder, with a bright color and easy to see with the naked eye.
When it comes to the melting point, the melting point of this compound has been accurately determined to be within a certain temperature range. The determination of the melting point is of great significance for the determination of its purity. If the purity is high, the melting point range is narrow and approaches the theoretical value; if it contains impurities, the melting point decreases and the range becomes wider. Therefore, the melting point is one of the important indicators to measure its quality.
In addition, the boiling point, although the boiling point is quite high in the atmospheric pressure environment, under certain decompression conditions, the boiling point can be reduced, which is useful when separating and purifying. By controlling the pressure and temperature, the effective separation of this compound from other substances can be achieved.
Solubility is also a key physical property. 1-Bromo-5-fluoro-2-methyl-4-nitrobenzene has a certain solubility in organic solvents, such as common ethanol, ether, etc. However, it has little solubility in water, which is due to the characteristics of its molecular structure. The polarity is weak, and the force between water molecules is small, so it is difficult to dissolve.
In addition, density is also one of its physical properties. Accurate determination of its density is helpful for accurate measurement and proportioning of materials in experiments and industrial production. The physical properties of 1-bromo-5-fluoro-2-methyl-4-nitrobenzene, such as its properties, melting point, boiling point, solubility and density, are of great significance to its research, production and application, and provide a key basis for related work in many fields.
What is 1-Bromo-5-Fluoro-2-Methyl-4-Nitro-Benzene synthesis method?
The synthesis of 1-bromo-5-fluoro-2-methyl-4-nitrobenzene is a key issue in the field of organic synthesis. To obtain this compound, the following steps can be followed.
First, start with suitable starting materials. Methylbenzene derivatives are often used as initial substrates, because their structures contain methyl, which are consistent with the structural framework of the target product. On this basis, a halogenation reaction can introduce bromine atoms and fluorine atoms. Appropriate halogenating reagents, such as N-bromosuccinimide (NBS), can be used for bromination reaction. Under appropriate reaction conditions, such as in the presence of initiators and heated environments, bromine atoms can be selectively introduced at specific positions in the benzene ring. When introducing fluorine atoms, nucleophilic substitution reaction can be used, and suitable fluorine-containing reagents can be used to interact with the substrate. After optimizing the reaction conditions, fluorine atoms can be successfully connected to the benzene ring.
Furthermore, after the introduction of bromine and fluorine atoms, nitrification reaction is carried out. The mixed acid system of concentrated nitric acid and concentrated sulfuric acid is selected as the nitrifying reagent. This mixed acid system can effectively provide nitro positive ions, and then electrophilic substitution reaction with the benzene ring occurs. The reaction temperature and time are strictly controlled to ensure that the nitro group accurately enters the target position, that is, the 4-position, so as to obtain the target product 1-bromo-5-fluoro-2-methyl-4-nitrobenzene.
After each step of the reaction, it needs to be separated and purified, such as column chromatography, recrystallization, etc., to ensure the purity of the obtained product before it can be used in the next reaction or as the final product. In this way, after ingeniously designing the reaction steps and carefully controlling the reaction conditions, 1-bromo-5-fluoro-2-methyl-4-nitrobenzene can be successfully synthesized.
1-Bromo-5-Fluoro-2-Methyl-4-Nitro-Benzene need to pay attention to when storing
1-Bromo-5-fluoro-2-methyl-4-nitrobenzene is an organic compound with many characteristics. When storing, you must pay attention to the following things.
The first thing to pay attention to is its chemical properties. This compound contains bromine, fluorine, methyl and nitro groups. The nitro group has strong oxidation, and bromine and fluorine atoms also affect its activity. Because of its oxidation and activity, it is advisable to avoid co-storage with reducing substances and active metals. Reductive substances are prone to redox reactions with nitro groups. Active metals such as sodium and potassium may cause violent reactions and cause dangerous reactions.
Secondary stability. Although it is relatively stable at room temperature and pressure, it may be exposed to heat, light or contact with specific catalysts, or cause reactions such as decomposition and isomerization. Therefore, the storage place should be cool, dry and protected from light, and the temperature should be controlled in a lower range, generally not exceeding 30 ° C, to prevent it from decomposing due to excessive temperature.
Furthermore, this substance may be toxic and irritating. When storing, ensure that the storage container is well sealed to prevent it from evaporating and escaping, polluting the environment and endangering personal safety. When taking and storing, wear appropriate protective equipment, such as gloves, goggles and gas masks.
In addition, the storage place should be well ventilated. If it evaporates in the air, ventilation can reduce its concentration and reduce the risk of explosion and poisoning. And the storage place should be kept away from fire and heat sources, because it may be flammable, in case of open flame, hot topic or cause combustion and explosion.
The choice of storage container is also critical. Corrosion-resistant materials such as glass, specific plastics, etc. should be used. Corrosion of the container is caused by bromine, fluorine compounds or reaction with some metal containers, which also affects the purity of the compound.
In summary, when storing 1-bromo-5-fluoro-2-methyl-4-nitrobenzene, when considering its chemical properties, stability, toxicity, ventilation and container selection, etc., abide by relevant specifications and operating procedures to ensure storage safety and avoid accidents.
1-Bromo-5-Fluoro-2-Methyl-4-Nitro-Benzene impact on the environment
1-Bromo-5-fluoro-2-methyl-4-nitrobenzene, an organic compound, has a complex impact on the environment.
Its chemical properties are active, difficult to degrade in the natural environment, and can be retained for a long time. If released into the soil, it may change the soil physical and chemical properties and affect the structure and function of soil microbial communities. Because it contains bromine, fluorine, nitro and other groups, it may inhibit the growth and reproduction of beneficial microorganisms in the soil, thereby affecting soil fertility and ecosystem balance.
If it enters the water body, the compound may cause toxicity to aquatic organisms. The bromine, fluorine atoms and nitro groups in its structure may interfere with the normal physiological metabolism of aquatic organisms, affecting their growth, development and reproduction. At high concentrations, it may directly lead to the death of aquatic organisms and destroy the biodiversity of aquatic ecosystems.
In the atmosphere, 1-bromo-5-fluoro-2-methyl-4-nitrobenzene may participate in photochemical reactions, produce harmful secondary pollutants, and affect air quality. And after it evaporates into the atmosphere, it can be transported over long distances, affecting a wider range of environments.
In addition, if this compound is transmitted and enriched through the food chain, it may pose a threat to organisms at an advanced position in the food chain, including human health. Because of its potential toxicity, long-term exposure or ingestion, or cause various health problems.
From this point of view, 1-bromo-5-fluoro-2-methyl-4-nitrobenzene has adverse effects on the environment in many aspects. During production, use and disposal, careful prevention and control are required to reduce its harm to the environment.