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1-Bromo-5-Fluoro-2-Methyl-3-Nitrobenzene

1-Bromo-5-Fluoro-2-Methyl-3-Nitrobenzene

Hongda Chemical

Specifications

HS Code

110882

Chemical Formula C7H5BrFNO2
Molecular Weight 236.02
Appearance Solid (likely)
Odor Pungent, likely due to nitro group
Solubility In Water Low (aromatic halonitro compounds are generally hydrophobic)
Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform

As an accredited 1-Bromo-5-Fluoro-2-Methyl-3-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 1 - bromo - 5 - fluoro - 2 - methyl - 3 - nitrobenzene packaged in a sealed glass bottle.
Storage 1 - Bromo - 5 - fluoro - 2 - methyl - 3 - nitrobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store it in a tightly sealed container to prevent vapor leakage. Label the container clearly. Store separately from incompatible substances to avoid potential reactions.
Shipping 1 - bromo - 5 - fluoro - 2 - methyl - 3 - nitrobenzene is shipped in well - sealed, corrosion - resistant containers. It follows strict hazardous chemical shipping regulations, ensuring proper handling and transport to prevent spills and environmental risks.
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1-Bromo-5-Fluoro-2-Methyl-3-Nitrobenzene 1-Bromo-5-Fluoro-2-Methyl-3-Nitrobenzene
General Information
Historical Development
1 - Bromo - 5 - Fluoro - 2 - Methyl - 3 - Nitrobenzene is an important chemical product. Going back in time, its research and development process has involved many difficulties and breakthroughs. In the early days, chemists noticed the unique properties of this substance when exploring the properties of various compounds.
At the beginning, the synthesis method was still crude, the yield was quite low, and the purity was not good. However, the previous chemists were not discouraged and worked hard to try new reaction conditions and reagent ratios. After countless experiments, a more effective synthesis path was found, resulting in significant improvement in both yield and purity.
With the passage of time, the research of this product has continued to deepen, and its potential applications in medicine, materials and other fields have gradually become clear. The historical development of this chemical product is like a chapter of unremitting exploration, which inspires our chemistry researchers to continue to forge ahead and contribute to the progress of chemical science.
Product Overview
1 - Bromo - 5 - Fluoro - 2 - Methyl - 3 - Nitrobenzene is also an organic compound. Its shape and color, at room temperature, are either solid or liquid, or light yellow to brown, depending on its purity and environment.
In this compound, bromo (Bromo), fluorine (Fluoro), methyl (Methyl) and nitro (Nitro) coexist on the benzene ring. The halogen atom of bromine and fluorine gives it a certain reactivity, which can involve various reactions such as nucleophilic substitution. Methyl is a hydrocarbon group, which slightly modifies the polarity and steric resistance of the molecule. Nitro groups have strong electron-absorbing properties, which affect the electron cloud distribution of molecules, reduce the electron cloud density of benzene rings, and show a passivation effect in electrophilic substitution reactions.
Due to its unique structure, it has great potential in the fields of medicine, material synthesis, etc. It can be used as an intermediate. After various chemical transformations, a variety of compounds with biological activities or special properties can be derived, opening up new avenues for scientific research and industrial applications.
Physical & Chemical Properties
1 - Bromo - 5 - Fluoro - 2 - Methyl - 3 - Nitrobenzene is also an organic compound. Its physical and chemical properties are quite important to scholars. Looking at its physical properties, it is at room temperature, or in a solid state, with a specific color and shape. Melting point and boiling point are important characteristics of it, and its phase change can be observed.
On its chemical properties, the existence of bromine, fluorine, methyl and nitro groups makes it have unique reactivity. Nitro has strong electron absorption, which reduces the electron cloud density of the benzene ring, making the check point and activity of electrophilic substitution reactions unusual. Bromine and fluorine atoms also affect the reaction direction of molecules due to their electronegativity. Although methyl groups are charged with electricity, they interact with various groups in this compound to co-shape its chemical behavior. Scholars explore the properties of this compound, hoping to develop its wide application in various fields such as organic synthesis and materials science, and uncover the secrets of the chemical world.
Technical Specifications & Labeling
1 - Bromo - 5 - Fluoro - 2 - Methyl - 3 - Nitrobenzene is also a chemical product. Its technical quality is not good (commodity quality) to the main.
If you want to use this product, you must follow the method of precision. The ratio of raw materials and the reverse parts are all determined. If the reverse degree is high, it must be controlled by a certain quality. No, or the reverse is not good, and the product is impure.
Its quality cannot be ignored. It is clear that the name of this product, its composition, physical properties and other commodities are good. In this way, the user can make good use of it and ensure safety. According to the ancient law, the technique of describing this thing is well-defined, seeking clarity, so as to apply it to the world, and to benefit the research and development of Huayu.
Preparation Method
The raw material is the key to the preparation of 1 - Bromo - 5 - Fluoro - 2 - Methyl - 3 - Nitrobenzene. 2 - methyl - 3 - nitroaniline can be used as the starting point. After diazotization, cuprous bromide is substituted for bromine to obtain 2 - bromo - 5 - methyl - 4 - nitrobenzene. After that, potassium fluoride is substituted under suitable solvents and conditions to obtain the target substance.
The reaction steps are as follows: first prepare diazonium salt, control temperature to prevent decomposition. Add cuprous bromide to promote substitution. Then add potassium fluoride to ensure sufficient reaction.
The catalytic mechanism is also important. When cuprous bromide is substituted for bromine, bromine ions replace diazo groups. In the reaction of potassium fluoride, there may be phase transfer catalysis to increase the contact of the reactants and increase the reaction rate. In this way, 1-Bromo-5-Fluoro-2-Methyl-3-Nitrobenzene can be obtained.
Chemical Reactions & Modifications
Taste the chemical things, reaction and change, very interesting. Today there is 1 - Bromo - 5 - Fluoro - 2 - Methyl - 3 - Nitrobenzene, this compound, its reaction is mysterious, the change is strange, it is worth exploring.
Chemical reactions, such as the change of yin and yang, the interaction of substances, the new substance is born. 1 - Bromo - 5 - Fluoro - 2 - Methyl - 3 - Nitrobenzene in a specific environment, meet with various reagents, or break bonds and recombine, or increase or decrease groups. Its halogen properties can lead to nucleophilic substitution; the ability of nitro groups can cause reduction changes.
There are also many ways to change its nature. Or adjusting the temperature and humidity, or changing the catalyst, can make the reaction different and the product special. This is the wonder of chemistry, which can turn the ordinary into magic, and make the nature of matter change at will. Therefore, in chemical research, insight into the principle of reaction, and control the method of change, we can explore the endless secrets in the microscopic domain.
Synonyms & Product Names
1 - Bromo - 5 - Fluoro - 2 - Methyl - 3 - Nitrobenzene, this substance is quite crucial in the study of chemistry. Its synonyms and trade names also need to be discussed in detail.
In the field of Guanfu Chemistry, the same substance often coexists in many places. 1 - Bromo - 5 - Fluoro - 2 - Methyl - 3 - Nitrobenzene, or other names, are born due to differences in research perspectives and application scenarios. Its trade name also changes with the needs of manufacturers and markets.
To clarify its synonyms, it is necessary to study the chemical structure and property relationships. The structure of this compound is unique, bromine, fluorine, methyl, nitro and benzene ring are connected, or due to similar structures and similar reaction characteristics, they have synonymous names. The determination of the trade name is related to commercial promotion and product positioning. Different manufacturers have their own names for their characteristics and market share.
When using and communicating with chemical researchers of our generation, they must understand their synonyms and trade names to avoid confusion, so as to accurately promote research and promote the progress of chemistry.
Safety & Operational Standards
1 - Bromo - 5 - Fluoro - 2 - Methyl - 3 - Nitrobenzene is an important chemical compound. During its preparation and application, safety and handling practices are of paramount importance.
To ensure safety, the first thing is to know the properties of this compound. 1 - Bromo - 5 - Fluoro - 2 - Methyl - 3 - Nitrobenzene has certain chemical activity and may be potentially harmful to the human body or the environment. When handling, appropriate protective equipment, such as protective clothing, gloves and goggles, must be worn to prevent skin contact and eye splashing.
In terms of operating specifications, the experimental site should be well ventilated to disperse possible harmful gases. When taking this compound, follow the steps of accurate measurement and do not exceed the required amount to avoid waste and increase risk. During the mixing or reaction process, it must be carried out in accordance with the established sequence and conditions, and close attention should be paid to reaction phenomena such as temperature, color change, etc. If there is any abnormality, the operation should be stopped immediately and appropriate measures should be taken.
Storage should not be ignored. 1 - Bromo - 5 - Fluoro - 2 - Methyl - 3 - Nitrobenzene should be stored in a cool, dry and ventilated place, away from fire sources and oxidants, to prevent accidental reactions. At the same time, it should be clearly marked, indicating the name, nature and precautions of the compound, etc., for easy identification and management.
Waste treatment must also be carried out in accordance with regulations. Residues or reaction by-products after experiments cannot be discarded at will. They should be collected in categories and handed over to professional institutions for treatment according to environmental protection requirements to reduce the impact on the environment.
Strict adherence to safety and operating standards can ensure the smooth development of 1-Bromo-5-Fluoro-2-Methyl-3-Nitrobenzene related work to ensure personnel safety and environmental safety.
Application Area
1 - Bromo - 5 - Fluoro - 2 - Methyl - 3 - Nitrobenzene has its potential in various application fields. In the field of pharmaceutical creation, it can be used as a key intermediate. By means of organic synthesis, through delicate steps, specific drugs can be prepared, which will help to heal diseases. In the place of material research and development, because of its unique structure, it may be able to integrate new materials to give specific properties of materials, such as improving their stability and conductivity, to meet diverse needs. In the field of fine chemicals, it can be used as a raw material to derive a variety of fine chemicals for the preparation of high-end coatings and dyes to improve product quality and characteristics. This is a good application environment for 1 - Bromo - 5 - Fluoro - 2 - Methyl - 3 - Nitrobenzene, and its potential in various fields needs to be further tapped to create more benefits.
Research & Development
In recent years, I have been familiar with chemical substances, 1 - Bromo - 5 - Fluoro - 2 - Methyl - 3 - Nitrobenzene. This product has unique characteristics and a wide range of uses, so I have devoted myself to studying it.
Begin to study the structure of this substance, explore the mystery of its atomic connections, and understand the reasons for its properties. Also observe its physical characteristics, such as color, taste, and degree of melting to clarify its properties. Then study its chemical properties, and explore more in the way of reaction. Or try various reagents, observe its changes, and seek the law of reaction.
As for the progress of research and development, I hope to optimize the production method, reduce its cost, and increase its yield. And hope to expand its application field, and make achievements in medicine and materials. I have always been diligent and dedicated to studying, hoping that this substance can be used by the world and benefit the progress of chemistry and people's livelihood.
Toxicity Research
The toxicity of 1 - Bromo - 5 - Fluoro - 2 - Methyl - 3 - Nitrobenzene is investigated. This compound contains bromine, fluorine, methyl and nitro groups, and has different structures.
Nitro groups are mostly toxic and can disturb the metabolism of organisms and damage the function of cells. And halogen elements bromine and fluorine may also affect the physicochemical properties and biological activities of the compound.
Looking at the experiments, this substance may be teratogenic and carcinogenic to organisms. When it enters the water, it can be a sewage source and harm aquatic organisms. When it enters the soil, it affects the growth of vegetation.
Although current research does not fully understand its toxicology, in order to protect the ecology and human health, during production and use, it is necessary to practice protection, investigate the toxicity in detail, avoid its harm, and ensure the safety of all things.
Future Prospects
The future of the future is very important for the research of chemical compounds. Today, 1 - Bromo - 5 - Fluoro - 2 - Methyl - 3 - Nitrobenzene has not been developed or can be developed in multiple ways. In terms of synthesis methods, it is hoped that it will be easy and efficient to produce less complex steps and reduce its cost. In addition, it is hoped that its synthesis process will be more guaranteed, and less raw materials will be produced, so as to improve the color.
In terms of applications, it may be possible to expand the field of technology, and it will be used in the field of materials to help new research and solve problems. The field of materials may also be exposed, adding new tiles to new materials.
However, if we want to achieve this state, we will make unremitting efforts to refine and research, and break through the technology and bottle, so that this compound can be widely used and benefit the world.
Where to Buy 1-Bromo-5-Fluoro-2-Methyl-3-Nitrobenzene in China?
As a trusted 1-Bromo-5-Fluoro-2-Methyl-3-Nitrobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 1-Bromo-5-Fluoro-2-Methyl-3-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-Bromo-5-Fluoro-2-Methyl-3-Nitrobenzene?
1-Bromo-5-fluoro-2-methyl-3-nitrobenzene, an organic compound. Its main use is in the field of organic synthesis.
In the field of medicinal chemistry, it can be used as a key intermediate. Through a series of organic reactions, such as nucleophilic substitution, reduction, etc., it can be converted into compounds with specific biological activities, thus paving the way for the development of new drugs. For example, in the synthesis of drugs with antibacterial and anti-inflammatory properties, 1-bromo-5-fluoro-2-methyl-3-nitrobenzene can be used as a starting material to build the basic structure of drug molecules through ingenious reaction design.
In materials science, it also has potential applications. After appropriate chemical modification and polymerization, polymer materials with special properties may be prepared. For example, by introducing this compound, the material can be endowed with unique electrical and optical properties, which can be used in optoelectronic devices, sensors and other fields.
In addition, in the field of pesticide chemistry, based on this, the compounds derived from the reaction may have biological activities such as insecticidal and weeding, which can help the creation of new pesticides.
In short, 1-bromo-5-fluoro-2-methyl-3-nitrobenzene, as an important building block in organic synthesis, has shown important uses in many fields such as medicine, materials, and pesticides, providing a key material basis for innovation and development in various fields.
What are the physical properties of 1-Bromo-5-Fluoro-2-Methyl-3-Nitrobenzene?
1-Bromo-5-fluoro-2-methyl-3-nitrobenzene is also an organic compound. Its physical properties are particularly important and related to applications in various fields of chemical industry.
First, its appearance, under normal conditions, or light yellow to light brown crystalline powder, fine and uniform in quality, with a special color in view, this is a sign of preliminary identification.
Secondary and melting point, about [X] ℃, the melting point, the critical temperature at which the substance changes from solid to liquid. When heated to this temperature, 1-bromo-5-fluoro-2-methyl-3-nitrobenzene begins to melt. This property is quite useful in the purification and identification of substances.
Furthermore, the boiling point is about [X] ° C, and the boiling point is the temperature at which the liquid boils. At this temperature, the compound converts from a liquid state to a gaseous state. This property is related to separation operations such as distillation, which helps to obtain high-purity substances.
Its density is about [X] g/cm ³, and the density is the mass of the substance per unit volume. This value reflects its density and has guiding significance in mixing, proportioning and other processes.
The solubility of 1-bromo-5-fluoro-2-methyl-3-nitrobenzene cannot be ignored. It is slightly soluble in water because water is a polar solvent, and the polarity of the compound is weak. However, it is soluble in organic solvents such as dichloromethane, chloroform, and ether. This property is crucial for the dissolution of raw materials and the choice of reaction medium in organic synthesis.
In addition, the compound is volatile and can evaporate slowly in air. This volatilization affects its storage and use environment and needs to be properly disposed of to prevent loss or harm due to fugitive dispersion.
In summary, the physical properties of 1-bromo-5-fluoro-2-methyl-3-nitrobenzene are complex and orderly, and the properties are interrelated. They are all key elements in chemical industry and scientific research. Only by making good use of them can we maximize their function.
What is 1-Bromo-5-Fluoro-2-Methyl-3-Nitrobenzene synthesis method?
The preparation of 1-bromo-5-fluoro-2-methyl-3-nitrobenzene can be achieved by a multi-step reaction from suitable starting materials.
The first step is to choose o-methylbenzoic acid as the starting material. First, the o-methylbenzoic acid is heated with a mixed acid (a mixture of sulfuric acid and nitric acid) to carry out a nitrification reaction. In this reaction, sulfuric acid is used as the catalyst, nitric acid provides the nitro group, and the nitro group is introduced into the specific position of the benzene ring. The reaction conditions need to be precisely controlled, and the temperature and the proportion of mixed acid affect the selectivity and yield of the product. The suitable temperature range is about 50-60 ℃. Under this condition, the nitro group can be mainly introduced into the specific position of the benzene ring of o-toluic acid to obtain 3-nitro-2-methylbenzoic acid.
In the second step, the 3-nitro-2-methylbenzoic acid is reduced to the carboxyl group with a suitable reducing agent. Strong reducing agents such as lithium aluminum hydride can be selected to react in organic solvents such as anhydrous ether. This step can convert the carboxyl group to methyl, thereby obtaining 2-methyl-3-nitrobenzene.
In another step, the halogenation reaction of 2-methyl-3-nitrobenzene is carried out. First, fluorine atoms are introduced, and fluorinated reagents such as Selectfluor are used to react with alkali in a suitable solvent to obtain 5-fluoro-2-methyl-3-nitrobenzene.
Finally, 5-fluoro-2-methyl-3-nitrobenzene is brominated. Using liquid bromine as the bromine source, under the action of catalysts such as iron powder or iron tribromide, bromine atoms are substituted for hydrogen atoms at specific positions on the benzene ring, and finally 1-bromo-5-fluoro-2-methyl-3-nitrobenzene is obtained. After each step of the reaction, it is necessary to undergo separation and purification operations, such as extraction, distillation, recrystallization, etc., to obtain high-purity products.
What are the precautions in storage and transportation of 1-Bromo-5-Fluoro-2-Methyl-3-Nitrobenzene?
1-Bromo-5-fluoro-2-methyl-3-nitrobenzene is an organic compound. During storage and transportation, many matters need to be paid attention to to to ensure safety and protection from loss.
First, when storing, choose a cool, dry and well-ventilated place. This compound is easily decomposed by heat, and humidity will also affect its stability, so it is crucial to control the temperature and humidity of the environment. The temperature should be controlled below 25 ° C, and the relative humidity should not exceed 60%.
Second, because of its certain toxicity and corrosiveness, it must be stored separately from oxidants, acids, alkalis and other substances, and must not be mixed. In order to prevent severe chemical reactions from occurring, causing serious accidents such as fires and explosions.
Third, storage containers should also be selected carefully. Corrosion-resistant materials, such as glass, stainless steel, etc., should be used, and the container must be tightly sealed to prevent leakage. Packaging should be sturdy and reliable to resist bumps and collisions during transportation.
Fourth, during transportation, relevant regulations and operating procedures should be strictly observed. Transportation vehicles must be equipped with corresponding fire-fighting equipment and leakage emergency treatment equipment. Transportation personnel should also be familiar with the characteristics of the compound and emergency treatment methods.
Fifth, whether it is storage or transportation, clear warning signs should be set up to remind personnel to pay attention to safety. At the same time, the storage and transportation process is strictly recorded and monitored so that abnormal conditions can be detected in time and properly handled. In this way, the safety of 1-bromo-5-fluoro-2-methyl-3-nitrobenzene in storage and transportation can be guaranteed.
1-Bromo-5-Fluoro-2-Methyl-3-Nitrobenzene impact on the environment and human health
1-Bromo-5-fluoro-2-methyl-3-nitrobenzene, this is an organic compound. Its impact on the environment and human health cannot be underestimated.
In terms of the environment, if it enters the natural environment, it may be difficult to degrade, resulting in long-term residues. Because of its specific chemical structure, it can be transported by water flow and soil, and then spread to a wider area. Entering the soil, or affecting the soil microbial community, interfering with the normal function of the soil ecosystem, causing changes in soil fertility, and affecting plant growth. Entering the water body, or harming aquatic organisms, causing a decrease in biodiversity, and interfering with the balance of aquatic ecology.
As for human health, after inhalation, skin contact or accidental ingestion into the human body, there are many hazards. Bromine, fluorine, nitro and other groups in this compound are toxic to a certain extent. Nitro can cause methemoglobinemia, affect oxygen delivery, cause hypoxia in tissues and organs, and cause symptoms such as dizziness, fatigue, shortness of breath, etc. Bromine and fluorine elements may affect the normal function of the nervous system, long-term contact or damage the nervous system, causing memory loss, insomnia and other problems. Skin contact may cause allergies, redness, swelling, tingling and other inflammatory reactions. If ingested by mistake, or damage the digestive system, nausea, vomiting, abdominal pain and other symptoms will occur.
In summary, 1-bromo-5-fluoro-2-methyl-3-nitrobenzene poses latent risks to the environment and human health, and its production, use and disposal must be carried out with caution and follow relevant safety regulations to reduce hazards.