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1-Bromo-5-Chloro-2-Fluorobenzene

1-Bromo-5-Chloro-2-Fluorobenzene

Hongda Chemical

Specifications

HS Code

613901

Chemical Formula C6H3BrClF
Molar Mass 209.44 g/mol
Appearance Colorless to light yellow liquid
Boiling Point 188 - 190 °C
Melting Point N/A
Density 1.72 g/cm³
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in common organic solvents like ethanol, ether
Flash Point 77 °C
Refractive Index 1.543

As an accredited 1-Bromo-5-Chloro-2-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 1 - bromo - 5 - chloro - 2 - fluorobenzene packaged in a sealed glass bottle.
Storage 1 - Bromo - 5 - chloro - 2 - fluorobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition points. Keep it in a tightly closed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents, reducing agents, and other reactive chemicals to prevent potential reactions. Label the storage container clearly with the chemical name and relevant hazard information.
Shipping 1 - bromo - 5 - chloro - 2 - fluorobenzene is shipped in well - sealed, corrosion - resistant containers. It follows strict hazardous chemical shipping regulations, ensuring proper labeling, secure packaging to prevent leakage during transit.
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1-Bromo-5-Chloro-2-Fluorobenzene 1-Bromo-5-Chloro-2-Fluorobenzene
General Information
Historical Development
1 - Bromo - 5 - Chloro - 2 - Fluorobenzene is an important compound in organic chemistry. Back in the past, the road of chemical exploration was long. At first, chemists worked tirelessly on the preparation of halogenated aromatics in the field of organic synthesis.
In the early days, due to technical and cognitive limitations, it was difficult to synthesize such compounds containing various halogens. However, with the passage of time, chemical theory has gradually improved, and experimental methods have also been continuously refined.
Chemists have repeatedly tried different reaction paths to explore the effects of various catalysts. From the initial exploration of simple halogenation reactions, to the precise control of substitution positions and halogen species. After numerous failures and improvements, a highly efficient method for synthesizing 1-Bromo-5-Chloro-2-Fluorobenzene was successfully developed. The birth of this compound is an important milestone in the history of chemistry, opening up a new path for subsequent organic synthesis, drug development and many other fields, and promoting the continuous progress of chemistry.
Product Overview
1 - Bromo - 5 - Chloro - 2 - Fluorobenzene is an important organic halogenated aromatic hydrocarbon. It is a colorless to light yellow liquid with a unique chemical structure. Three halogen atoms of bromine, chlorine and fluorine are cleverly arranged on the benzene ring.
This compound is widely used in the field of organic synthesis. Because it contains a variety of active halogens, it can be replaced by nucleophiles and interact with many nucleophiles to form carbon-carbon and carbon-heteroatom bonds to prepare various functional organic compounds. In medicinal chemistry, it can be used as a key intermediate to assist in the synthesis of drug molecules with specific biological activities. In materials science, it can also be used as a raw material to synthesize materials with special optoelectronic properties.
There are many ways to prepare 1 - Bromo - 5 - Chloro - 2 - Fluorobenzene. Benzene derivatives are often used as the starting material. After halogenation, the reaction conditions and the proportion of reagents are precisely controlled to achieve the introduction of halogen atoms at specific positions to achieve the synthesis of the target product.
Overall, 1 - Bromo - 5 - Chloro - 2 - Fluorobenzene occupies an important position in chemical research and industrial production due to its unique structure and active reactivity.
Physical & Chemical Properties
1 - Bromo - 5 - Chloro - 2 - Fluorobenzene is an organic compound, and its physicochemical properties are particularly important. Looking at its physical properties, at room temperature, this substance may be in a liquid state, with specific boiling points and melting points, which are related to its phase transition. The level of its boiling point can indicate the strength of the intermolecular force. If the boiling point is high, it can be known that the intermolecular attractive force is large.
In terms of its chemical properties, it has active chemical activity because it contains halogen atoms such as bromine, chlorine, and fluorine. Halogen atoms can cause changes in the density of electron clouds in the benzene ring, making them behave differently in electrophilic substitution reactions. In case of electrophilic reagents, a substitution reaction can occur, and the position and properties of the halogen atoms will affect the rate and direction of the reaction. And the activities of different halogen atoms in the compound are also different. Fluorine atoms have strong electronegativity, which has a significant impact on the reaction. In many chemical reactions, they exhibit unique chemical behaviors, which are valued in the fields of organic synthesis and other fields.
Technical Specifications & Labeling
Today there is a thing called 1 - Bromo - 5 - Chloro - 2 - Fluorobenzene. The technique of making it is related to technical specifications and identification (product parameters), which is very important.
In order to make this thing, it is necessary to clarify the materials used in advance, select carefully, and ensure that it is pure and free of impurities. In the method of handling, precise rules must be followed. When reacting, the temperature and pressure must be appropriate, and if it is slightly worse, it will be wrong.
As for the logo (product parameters), it should be made clear in detail. Show its color, taste, and state, and say its purity is geometric, and the impurities are few. In this way, the user knows it in the chest and uses it correctly.
Technical specifications and labels (product parameters), which complement each other, are the foundation for making this thing and cannot be ignored.
Preparation Method
1 - Bromo - 5 - Chloro - 2 - Fluorobenzene is an organic compound. The preparation method is related to the raw materials and production process, reaction steps and catalytic mechanism.
To prepare this compound, you can first take suitable aromatic compounds as raw materials, such as specific benzene derivatives. After halogenation, bromine, chlorine and fluorine atoms are introduced in an orderly manner. First, by bromination method, select the appropriate brominating reagent, and under specific reaction conditions, such as suitable temperature, pressure and catalyst, connect the bromine atom to the designated position of the benzene ring.
Then chlorination, according to the reaction activity and positioning rules, precisely substitutes the chlorine atom at the corresponding check point of the benzene ring. Finally, the fluorination reagent is selected to strictly control the reaction conditions to ensure the successful integration of fluorine atoms to achieve the preparation of 1-Bromo-5-Chloro-2-Fluorobenzene. Each step of the reaction requires fine regulation, paying attention to the reaction process and product purity to achieve the best preparation effect.
Chemical Reactions & Modifications
1 - Bromo - 5 - Chloro - 2 - Fluorobenzene is an organic compound, which is of great significance in chemical research. It is valuable to explore its chemical reaction and modification.
In the past, the synthesis of this compound followed the traditional path, but its steps may be complicated and the yield is not high. At present, researchers are trying to find ways to optimize.
In terms of chemical reactions, nucleophilic substitution reactions can be used to interact with specific reagents to introduce new groups and expand their chemical properties. If it encounters a nucleophilic reagent, the bromine atom may be substituted to derive another compound, adding new possibilities for organic synthesis.
When it comes to modification, its properties can be adjusted by physical or chemical means. After specific treatment, its stability can be increased or its solubility can be changed, and it is more suitable for different application scenarios. This is the direction of deep cultivation for chemical researchers, hoping to make new breakthroughs and contribute to the development of the chemical field.
Synonyms & Product Names
1 - Bromo - 5 - Chloro - 2 - Fluorobenzene, this substance is very important in our chemical research. There are many opinions on its synonymous names. It is called "5-chloro-2-fluorobenzene", and it is also called "2-fluoro-5-chlorobenzene".
The use of trade names also varies. In the market, or sold under the name of a specific brand, they all refer to this same substance. This compound has unique chemical properties due to the ingenious arrangement of bromine, chlorine and fluorine atoms.
It is often a key intermediate in the process of synthesis. Although its synonymous names are different, they all refer to the same, and chemists choose to use them according to habit and convenience. The determination of the business name may involve brand strategy and market distinction. Only by knowing its various terms can we study and trade everything without error and smoothness.
Safety & Operational Standards
1 - Bromo - 5 - Chloro - 2 - Fluorobenzene Safety and Operation Specifications
Husband 1 - Bromo - 5 - Chloro - 2 - Fluorobenzene is an important raw material for organic synthesis and is widely used in chemical industry, pharmaceutical research and development and other fields. However, it has certain hazards, so safety and operation specifications are of paramount importance.
#1. Storage Method
This substance should be stored in a cool, dry and well-ventilated place. Keep away from fire, heat sources, and direct sunlight. Because it is a chemical compound, it is easy to cause violent reactions in case of high temperature, open flame or oxidant, and may cause fire or explosion. The storage container must be sealed to prevent leakage. It should be stored separately from oxidants, alkalis, etc., and should not be mixed.
#2. Rules of Operation
When operating, the operator must undergo special training and strictly follow the operation procedures. Appropriate protective clothing, protective gloves and goggles must be worn to prevent skin and eye contact. The operating environment should be well ventilated. If in a laboratory, operate in a fume hood.
When taking it, the action should be slow and stable to avoid spilling. Use the finished utensils and wash it immediately to prevent residue. During the experiment, if it is accidentally spilled, immediately evacuate the scene and send unrelated personnel to a safe place. A small amount of leakage should be absorbed by inert materials such as sand and vermiculite; if a large amount of leakage is leaked, the embankment will be blocked and then properly disposed of.
#3. Emergency measures
If skin contact, quickly remove contaminated clothing, rinse with a large amount of flowing water for at least 15 minutes, and seek medical attention. Eye contact, lift eyelids, rinse with flowing water or normal saline, and also seek medical attention. If inhaled, quickly go to a fresh place with fresh air to keep the respiratory tract unobstructed. When breathing difficulties, give oxygen and stop breathing, that is, perform artificial respiration and seek medical attention.
In short, when dealing with 1 - Bromo - 5 - Chloro - 2 - Fluorobenzene, safety and operating standards must be adhered to, and problems must be prevented in order to ensure personnel safety, experimentation, and production.
Application Area
1 - Bromo - 5 - Chloro - 2 - Fluorobenzene is a special organic compound. Its application field is quite wide. In the field of pharmaceutical research and development, this compound may be a key intermediate. Because of its unique chemical structure, it may be able to help synthesize drug molecules with specific biological activities to deal with various diseases.
In the field of materials science, it may be used to prepare materials with special functions. For example, with its halogen atom properties, or adjustable electronic and optical properties of materials, it brings new opportunities for optoelectronic materials and other fields.
Furthermore, in organic synthetic chemistry, it is also an important building block. Chemists can modify and transform them through various reactions to create more complex organic molecules with specific functions, thus promoting the development of organic synthetic chemistry.
Research & Development
In recent years, I have had some experience in the study of organic compound 1 - Bromo - 5 - Chloro - 2 - Fluorobenzene. This compound has a unique structure and different properties, and has great potential in the field of organic synthesis.
At the beginning, I explored the synthesis method, tried many times, and experienced twists and turns. Or due to the harsh reaction conditions, or due to the wrong ratio of raw materials, the obtained product is often not what I want. However, I did not give up, tried repeatedly, and finally obtained a method, controlled the reaction, and obtained a purer product.
Then, explore its properties. Experiments show that it is highly active in nucleophilic substitution reactions, and this property may help it participate in various organic reactions, paving the way for the creation of new compounds.
Looking forward to the future, I want to deepen its research. Hope to expand its application, find new ways in medicine, materials and other fields, promote its development, and contribute to the progress of organic chemistry.
Toxicity Research
In recent years, Yu devoted himself to the research of chemical substances, especially the toxicity of 1-Bromo-5-Chloro-2-Fluorobenzene. This compound has certain uses in industry and scientific research, but its potential harm has not been investigated in detail.
Observe its molecular structure, the existence of bromine, chlorine, and fluorine atoms, or cause it to have special chemical activities. After various experiments, animals were used as samples to observe the reaction after ingesting this compound. At first, it can be seen that the behavior of the tested animals is slightly different, followed by physiological manifestations, such as slight changes in organ function.
From this point of view, although 1 - Bromo - 5 - Chloro - 2 - Fluorobenzene has functions, its toxicity should not be underestimated. The road of scientific research is long, and our generation should be careful to explore its toxicity mechanism in detail. It is the basis for safe use and prevention in the future. It must not be ignored because of its benefits, causing suffering to life and damage to the environment.
Future Prospects
Prospects of the future, in 1 - Bromo - 5 - Chloro - 2 - Fluorobenzene, this thing is possible. Its characteristics are unique, it is exquisite, and it can be used in the field of transformation.
In the process of synthesis, or in the first place, it can be introduced and reversed to create new compounds, and it can be transformed. Research and development, or energy-based, help new technologies, and save people. The field of materials is also expected to add brilliance, and materials can be made with special properties.
The road ahead may be difficult, but the wisdom of the technology and the technology will be able to break through. In the next few days, 1 - Bromo - 5 - Chloro - 2 - Fluorobenzene will be greatly improved, and the next step will be taken to create happiness in the world and achieve the unseen glory.
Where to Buy 1-Bromo-5-Chloro-2-Fluorobenzene in China?
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Frequently Asked Questions

As a leading 1-Bromo-5-Chloro-2-Fluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the physical properties of 1-bromo-5-chloro-2-fluorobenzene?
The physical properties of 1-% mercury-5-% boron-2-% beryllium are as follows:
Mercury, the only metal that is liquid at room temperature, is silver-white and has a metallic luster. Its density is relatively large, 13.59 g/cm3. At standard atmospheric pressure, the melting point is -38.87 ° C, and the boiling point is 356.6 ° C. Mercury has poor thermal conductivity, but good electrical conductivity. Mercury has a certain volatility, and its vapor is highly toxic. Mercury can dissolve many metals to form amalgam. This property has applications in metallurgy and other fields.
Boron, elemental boron has a variety of allotropes. Amorphous boron is a black powder. Crystalline boron is gray-black. Its hardness is second only to diamond, and its texture is more brittle. Boron has a density of 2.34 g/cm3, a melting point of 2076 ° C, and a boiling point of 3927 ° C. Boron is relatively stable at room temperature, and can react with many non-metals at high temperatures. Its electrical conductivity is low, belonging to typical semiconductor materials, and has important uses in the electronics industry.
Beryllium, is steel gray and shiny. The density is small, 1.85 g/cm3, a melting point of 1287 ° C, and a boiling point of 2970 ° C. Beryllium has a higher hardness than metals of the same group, good ductility, and can be made into thin sheets. Beryllium has excellent thermal conductivity, second only to silver, copper, and gold among metals. It also has excellent nuclear properties, such as small absorption cross section for neutrons, large scattering cross section, etc., and has important applications in nuclear reactors. At the same time, most of the compounds of beryllium are highly toxic and should be used with caution.
What are the main uses of 1-bromo-5-chloro-2-fluorobenzene?
1 mercury, 5 arsenic, and 2 lead and cadmium are all highly toxic substances, and their uses are related to people's livelihood. However, they also hide serious disasters and cannot be ignored.
Mercury has been used in alchemy techniques. Ancient alchemists, wanting to live forever, used mercury as the base of the pill to refine the so-called elixir. Although this vain move is not advisable, mercury has also had a place in medicine. In the past, elixirs, some of which contained mercury, were used to treat scabies and diseases. However, their toxicity was severe, and if they were not careful, they would harm themselves. And in the metallurgical industry, mercury can be used as a medium for extracting gold and silver, and by the method of amalgam, the precious gold in the mine can be separated.
The use of arsenic also has its uses. In agriculture, arsenic-containing agents were used in the past to repel insects and protect seedlings, and to maintain the prosperity of crops. In the production of pigments, arsenic-containing pigments have bright colors, which can add color to paintings. However, the poison of arsenic is well known to the world. Misuse and accidental ingestion will cause damage to the viscera and worry about life.
Lead and cadmium, both of which are heavy and soft, can be used in construction, as a waterproof material for roof tiles, and in coinage, used to be an important raw material. Cadmium was commonly used in electroplating processes in the past to increase the corrosion and wear resistance of utensils. However, lead and cadmium enter the body, which can easily cause loss of qi and blood, weakness and weakness, especially in children, affect mental development, and cause endless harm.
Although each of these numbers has its own uses, they are extremely toxic. Use them with caution, and they must be controlled by scientific laws and strict regulations. They must not be used lightly because of their use.
What are the synthesis methods of 1-bromo-5-chloro-2-fluorobenzene?
To prepare 1-bromo-5-fluoro-2-chlorobenzene, the following ancient methods can be used.
First, halogenation is used. First, a suitable benzene substrate is taken, and in a specific reaction environment, a brominating reagent such as liquid bromine is used. Under the catalysis of a catalyst such as iron filings or iron tribromide, the bromine atom is selected to replace the hydrogen atom on the benzene ring to obtain a bromine-containing intermediate. Then, the reaction conditions are carefully regulated, and fluorine-containing reagents, such as potassium fluoride, are introduced, and the reaction mechanism such as nucleophilic substitution, so that the fluorine atom is also connected to the benzene ring. Finally, a chlorination reagent, such as chlorine, is used in a suitable catalytic system to replace the hydrogen atom at a specific position on the benzene ring with a chlorine atom. After a multi-step halogenation reaction, 1-bromo-5-fluoro-2-chlorobenzene is finally obtained.
Second, the method of functional group conversion. Benzene derivatives containing other convertible functional groups can be prepared first, such as phenyl series containing hydroxyl groups or amino groups. If it is a hydroxyl group, the hydroxyl group can be converted into a halogen atom through a specific reaction, such as hydrogen halide or a halogen-containing reagent under suitable conditions, to achieve the transformation of hydroxyl groups into halogen atoms. If it is an amino group, the amino group can be converted into a halogen atom through diazotization reaction and subsequent reaction with halogenating reagents. After gradual ingenious transformation and regulation of functional groups, bromine, fluorine and chlorine atoms are introduced in an orderly manner to synthesize the target product 1-bromo-5-fluoro-2-chlorobenzene.
Third, in the way of coupling reaction. First prepare different active benzene fragments containing bromine, fluorine and chlorine, such as bromine-containing phenylboronic acid derivatives, fluorine-containing halobenzene and chlorine-containing halobenzene. Then, under the action of transition metal catalysts such as palladium catalysts, through coupling reactions such as Suzuki coupling and Stille coupling, the fragments are connected to each other and skillfully spliced to achieve the synthesis of 1-bromo-5-fluoro-2-chlorobenzene. These coupling reactions have mild conditions and good selectivity, and are quite commonly used in the synthesis of complex halogenated benzene.
What are the precautions for storing and transporting 1-bromo-5-chloro-2-fluorobenzene?
1% mercury, 5% arsenic, 2% lead and zinc during storage and transportation, when discussed in the ancient classical Chinese style of "Tiangong Kaiwu", there are many precautions.
Mercury is toxic and volatile. Hidden, it needs to be tightly sealed, preferably a pottery urn, because its material can slow the escape of mercury. Place in a cool and dry place, away from direct sunlight, exposed to sunlight, mercury volatilizes rapidly. When shipping, the package must be firm, wrapped in thick felt, and placed in the vehicle and ship, stable and do not shake to prevent it from dumping. If mercury is released, poisonous gas will overflow and hurt people.
Arsenic, a highly toxic thing. The storage should be placed in a secret room, far away from other things, to prevent it from being contaminated with other things and causing poisoning. The room should be well ventilated, but not close to the fire source. Arsenic is prone to highly toxic gases in case of fire. During transportation, carefully select containers, seal them with metal cans, and wrap them in protective materials, such as thick wooden boxes. Escorts need protective equipment, and the transportation route should avoid crowded places.
Although lead and zinc are slightly less toxic than mercury and arsenic, storage should not be ignored. It should be moisture-proof, moisture is easy to rust, it is appropriate to dry the warehouse, and the ground can be covered with lime to prevent moisture. Stacked in an orderly manner, it is easy to check and use. During transportation, fix it securely to prevent package damage caused by collision. The vehicles or boats used are clean and stain-free, so as not to mix impurities and affect the quality of lead and zinc.
All storage and transportation of these items requires a special person to be responsible, record the entry and exit and flow direction in detail, and follow the rules to ensure safety and avoid disasters.
What are the effects of 1-bromo-5-chloro-2-fluorobenzene on the environment and human health?
1% mercury, 5% arsenic, and 2% lead and cadmium are all harmful to the environment and human health.
Mercury is highly toxic. In the natural environment, mercury can be recycled in various ways. Industrial activities such as mining and smelting often cause mercury to be released into the environment. Its gaseous mercury can be transported over a long range and deposited into soil and water bodies through dry and wet deposition. In water bodies, mercury is converted into methylmercury by microbial action, which is particularly toxic. Aquatic organisms are prone to enrich methylmercury. If humans eat fish and shells containing methylmercury, mercury will enter the human body, damage the nervous system, cause cognitive impairment, movement disorders, and pregnant women eat it. Mercury can be transmitted to the fetus through the placenta, causing neurological development and congenital diseases.
Arsenic is also highly toxic. Natural sources such as volcanic eruptions and rock weathering can cause arsenic to enter the environment, and man-made sources such as pesticides and chemicals can also increase arsenic in the environment. High arsenic in soil will inhibit plant growth and reduce crop yield and quality. Excessive arsenic in water bodies can cause skin lesions, such as skin pigmentation and keratinization, and increase the risk of skin cancer, bladder cancer and other cancers over time.
Both lead and cadmium are also extremely harmful. Lead enters the human body, accumulates in bones and teeth, and interferes with the function of the hematopoietic system and nervous system. Children are sensitive to lead, and low-dose lead exposure affects intellectual development, learning and memory. Cadmium is difficult to degrade in the environment and is easily absorbed by plants. People eat cadmium-containing foods for a long time. Cadmium accumulates in the kidney, liver and other organs, damaging kidney function, causing bone pain, osteomalacia, osteoporosis, bone deformity, and pain.
In short, 1% mercury, 5% arsenic, and 2% lead and cadmium are all major threats to the ecological balance of the environment and human health. Efforts should be made to control its emissions and reduce its content in the environment to protect the ecology and human well-being.