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1-Bromo-5-Chloro-2-Fluoro-4-Methylbenzene

1-Bromo-5-Chloro-2-Fluoro-4-Methylbenzene

Hongda Chemical

    Specifications

    HS Code

    829341

    Chemical Formula C7H5BrClF
    Molar Mass 225.47 g/mol
    Appearance Colorless to light yellow liquid
    Boiling Point Approximately 190 - 200 °C
    Solubility In Water Insoluble
    Solubility In Organic Solvents Soluble in common organic solvents like ethanol, ether
    Purity Typically sold as high - purity compound (e.g., 95%+)

    As an accredited 1-Bromo-5-Chloro-2-Fluoro-4-Methylbenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100g of 1 - bromo - 5 - chloro - 2 - fluoro - 4 - methylbenzene in sealed chemical - grade vial.
    Storage 1 - Bromo - 5 - chloro - 2 - fluoro - 4 - methylbenzene should be stored in a cool, dry, well - ventilated area away from sources of heat, ignition, and incompatible substances. Keep it in a tightly closed container made of materials resistant to its corrosive nature, like glass or certain plastics. Store it separately from oxidizing agents and bases to prevent potential reactions.
    Shipping 1 - bromo - 5 - chloro - 2 - fluoro - 4 - methylbenzene is shipped in well - sealed, corrosion - resistant containers. Shipment adheres to strict chemical transportation regulations, ensuring safety during transit to prevent any leakage or hazard.
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    Competitive 1-Bromo-5-Chloro-2-Fluoro-4-Methylbenzene prices that fit your budget—flexible terms and customized quotes for every order.

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    1-Bromo-5-Chloro-2-Fluoro-4-Methylbenzene 1-Bromo-5-Chloro-2-Fluoro-4-Methylbenzene
    General Information
    Historical Development
    1 - Bromo - 5 - Chloro - 2 - Fluoro - 4 - Methylbenzene is an organic compound with a rather tortuous history. In the past, chemists worked hard to explore the field of organic synthesis, striving to expand the types and uses of compounds. The advent of this compound depends on the evolution of chemical technology.
    In the early years, chemists focused on the study of basic organic reactions, with particular emphasis on the synthesis of halogenated aromatics. After countless attempts and improvements, Fang found an effective path to prepare 1 - Bromo - 5 - Chloro - 2 - Fluoro - 4 - Methylbenzene. At first, the synthesis steps were complicated and the yield was not ideal.
    However, with the prosperity of science and technology, instrumental analysis methods have become increasingly accurate, and the reaction mechanism has gradually become clearer. Chemists then optimized the synthesis method, making the reaction conditions milder and the yield significantly improved. The application prospects of this compound in many fields such as materials science and drug research and development are also broader, laying a solid foundation for subsequent scientific research and industrial production.
    Product Overview
    1 - Bromo - 5 - Chloro - 2 - Fluoro - 4 - Methylbenzene is an organic compound. Its appearance is often colorless to light yellow liquid with a special odor.
    This compound has a wide range of uses in the field of organic synthesis and plays an important role in the fields of medicine, pesticides and materials science. In pharmaceutical research and development, it may be used as a key intermediate to assist in the synthesis of drug molecules with specific biological activities; in the field of pesticides, through clever design and synthesis, high-efficiency and low-toxicity pesticide products may be born.
    From the structural point of view, the benzene ring is connected with bromine, chlorine, fluorine and methyl groups. The electronic effect and steric resistance of these groups have a profound impact on the physical and chemical properties of the compound. Its physical properties such as boiling point, melting point, solubility, etc. are all affected by the interaction of these groups.
    When synthesizing 1-Bromo-5-Chloro-2-Fluoro-4-Methylbenzene, the reaction route needs to be carefully planned, and the conditions and selectivity of each step of the reaction are considered to obtain a product with higher yield and purity.
    Physical & Chemical Properties
    1 - Bromo - 5 - Chloro - 2 - Fluoro - 4 - Methylbenzene is an organic compound. In terms of physical properties, it is mostly liquid at room temperature and has a specific density. Due to intermolecular forces, it has a certain volatility. The boiling point or is in a specific range, which can be inferred from the molecular structure and relative molecular mass.
    Chemically, the compound contains a halogen atom and a methyl group. The halogen atom changes the electron cloud density of the benzene ring, making it more prone to electrophilic substitution reactions. Methyl is the power supply radical, which also affects the activity of the benzene ring. In case of electrophilic reagents, the adjacent para-position of the halogen atom is more vulnerable to attack. And the halogen atom can undergo substitution reactions and can be replaced by other groups under appropriate conditions. This compound may have important uses in the field of organic synthesis, and can be used as an intermediate to participate in various organic reactions and build complex organic molecular structures.
    Technical Specifications & Labeling
    Today there is a product, the name is 1 - Bromo - 5 - Chloro - 2 - Fluoro - 4 - Methylbenzene. In this product, the process specification and identification (commodity parameters) are the key.
    In terms of the process specification, from the selection of raw materials, it must be pure and free of impurities, which is in line with the standard. The preparation method must follow precise steps, including temperature control, speed regulation, and timing. Each step is related to the quality of the finished product.
    As for the identification (commodity parameters), it must be clear that its ingredients, bromine, chlorine, fluorine, and methyl content ratios, must be detailed and correct. Physical properties, such as color, taste, and state, must also be confirmed. More chemical properties, melting point, boiling point and other parameters are all required by users. In this way, this product can achieve its efficacy and ensure its safety when it is applied. The process specifications and identification (commodity parameters) are complete, and this product is a good product that can be used.
    Preparation Method
    To prepare 1 - Bromo - 5 - Chloro - 2 - Fluoro - 4 - Methylbenzene, the raw materials and production process are crucial. The selection of raw materials needs to be pure and excellent to ensure the quality of the product. In the production process, the reaction steps also need to be precisely controlled.
    First take a suitable halogenated reagent and mix it with the aromatic hydrocarbon raw material containing methyl in a specific ratio. Under specific temperature and pressure conditions, make it substitution reaction. During this reaction process, close attention should be paid to the change of temperature to prevent side reactions.
    After the reaction is completed, the impurities are removed by separation and purification. Distillation, extraction and other methods can be used to achieve the purpose of product purity.
    As for the catalytic mechanism, choosing a high-efficiency catalyst can increase the reaction rate and reduce the energy required for the reaction. And the amount and activity of the catalyst have a great impact on the reaction, which needs to be carefully debugged. In this way, high-quality 1-Bromo-5-Chloro-2-Fluoro-4-Methylbenzene products can be obtained.
    Chemical Reactions & Modifications
    1 - Bromo - 5 - Chloro - 2 - Fluoro - 4 - Methylbenzene is an organic compound, which is related to the chemical reaction and modification of this compound, and has important research value.
    Looking at the reaction, the nucleophilic substitution reaction can be used to replace the halogen atom of this compound with other functional groups, and then new compounds can be derived. The control of this reaction condition, such as temperature, solvent, and catalyst, has a significant impact on the reaction rate and product selectivity.
    As for modification, different substituents can be introduced to modify its physical and chemical properties. In order to improve its solubility, or to change its electron cloud density, thereby affecting its reactivity.
    To study the reaction and modification of this compound, it is necessary to study various reaction mechanisms and investigate the interaction of various factors in detail. Only in this way can the purpose of precisely regulating the reaction and preparing compounds with specific properties be achieved, and its important functions can be developed in organic synthesis and other fields.
    Synonyms & Product Names
    1 - Bromo - 5 - Chloro - 2 - Fluoro - 4 - Methylbenzene is an important chemical substance. The discussion of its synonyms and trade names is crucial in the field of chemical research in China.
    Looking at this compound, "1 - Bromo - 5 - Chloro - 2 - Fluoro - 4 - Methylbenzene" can be regarded as a common synonym, which is accurately named according to its chemical structure. As for the trade name, it may vary according to different manufacturers and application scenarios.
    In many chemical literature and practical applications, people in different industries may give it different titles based on their own needs. However, the root cause is the substance with this specific chemical structure. Detailed sorting out of its synonyms and trade names will help the industry to communicate accurately, clarify the same substance referred to by different terms, and also help the efficient advancement of chemical research, industrial production and other links to avoid work mistakes due to name confusion.
    Safety & Operational Standards
    1 - Bromo - 5 - Chloro - 2 - Fluoro - 4 - Methylbenzene is an important chemical product, and its safety and operating practices need to be discussed in detail.
    This chemical, in the laboratory or industrial preparation process, is the first priority to ventilate the environment. It is necessary to keep the air flowing in the place where the operation is located to prevent the accumulation of harmful gases and endanger personal safety. This is the priority of creating a safe operating space.
    Furthermore, the operator must wear appropriate protective equipment. Protective clothing should be able to resist the erosion of the chemical, and gloves should be well chemically resistant to prevent damage to the skin when exposed. Eye protection is also essential. Goggles or masks can prevent it from splashing into the eyes and causing serious injury.
    When storing, follow the rules. It should be placed in a cool, dry and well-ventilated place, away from fire and heat sources. This chemical may be active in nature and may be dangerous in case of heat or open flames. It should be placed separately from other chemicals to prevent mutual reaction and cause accidents.
    During operation, the action should be steady and careful. Measure the required amount accurately to avoid waste and prevent danger from excessive use. If it is accidentally spilled, it should be handled immediately according to the established procedures. Cover with appropriate adsorption materials first, collect it carefully, and then dispose of it properly. Do not discard it at will to avoid polluting the environment.
    After use, the appliance should be cleaned promptly and thoroughly. Make sure that there is no residue of the chemical to prevent the next use, mixing with other experiments or production processes, affecting the results or causing danger.
    In conclusion, the safety and operation specifications of 1 - Bromo - 5 - Chloro - 2 - Fluoro - 4 - Methylbenzene cover all aspects of preparation, storage, use and aftercare. Operators must be vigilant at all times and strictly follow the procedures to ensure safety and smooth production or experiment.
    Application Area
    1 - Bromo - 5 - Chloro - 2 - Fluoro - 4 - Methylbenzene is a delicate compound. In many application fields, it has shown extraordinary use.
    In the field of pharmaceutical research and development, this compound can be used as a key intermediate to help create new drugs due to its unique structure. The activity given by its special substituents may be able to precisely act on specific targets, providing the possibility to overcome difficult diseases.
    In the field of materials science, it is also possible. Through clever chemical reactions, it can be introduced into polymer materials to improve the properties of materials, such as enhancing stability and optimizing optical properties.
    In the field of fine chemicals, 1 - Bromo - 5 - Chloro - 2 - Fluoro - 4 - Methylbenzene is used as a raw material. After a series of transformations, it can generate many high-value-added products, which contribute to the development of the chemical industry.
    This compound has potential in many fields. With time and in-depth research, more application values will be discovered to benefit human society.
    Research & Development
    In the field of chemistry, I have been studying for many years, and now I focus on 1 - Bromo - 5 - Chloro - 2 - Fluoro - 4 - Methylbenzene. At the beginning, explore its molecular structure to clarify the basis of its chemical properties. Detailed analysis of the atomic connection formula and the spatial arrangement of the state, to find its reactivity check point.
    Then, observe its synthesis method. Count the attempts, try different raw materials and conditions, to obtain an efficient and pure synthesis path. Or adjust the temperature, pressure, or choose another catalyst to improve the yield and purity.
    At the end of the application, explore its possibilities. In materials science, we hope to make new functional materials based on this; in drug research and development, we will consider whether it can become a key intermediate and contribute to the creation of new drugs.
    Although we have achieved something today, the road ahead is still far away. Continue to refine the technology of synthesis and expand the boundaries of application. We hope that this compound can shine in scientific research and industry, promote the development of the chemical field, and seek progress for human well-being.
    Toxicity Research
    Yu has dedicated himself to the study of chemical properties, and recently focused on the compound 1 - Bromo - 5 - Chloro - 2 - Fluoro - 4 - Methylbenzene. The investigation of its toxicity is quite critical in chemical studies.
    Looking at the structure of this compound, bromine, chlorine, and fluorine are coexisting halogen elements, and are connected by methyl groups. Halogen elements are mostly active or affect their toxicity. The presence of methyl groups may also increase or decrease the pathway and intensity of their toxic effects.
    In the past, toxicants were studied, and their effects on organisms were viewed. If this compound enters the organism, or due to the activity of halogen elements, it interacts with biological macromolecules such as proteins, nucleic acids, etc., resulting in biological dysfunction. The lipophilicity of methyl group may help it cross the biofilm, which makes it easier to reach the target of action and increases the possibility of its toxicity.
    However, the study of toxicity still needs multiple methods. When based on experiments, select a suitable biological model, measure its half lethal dose and other parameters, and analyze its toxicity intensity in detail. It is also necessary to study its metabolic pathway to understand the transformation in the organism and the toxicity of the transformation products. In this way, its toxicity can be fully known and provide evidence for application and protection.
    Future Prospects
    Today, 1 - Bromo - 5 - Chloro - 2 - Fluoro - 4 - Methylbenzene has great potential in the field of chemistry. The future development can be looked forward to.
    I expect that from now on, the research on it will become more and more refined. Chemists will know more about its properties and explore the reaction mechanism more deeply. This will help to optimize the synthesis method, increase the yield and reduce its cost.
    And it may be useful in various fields such as medicine and materials. In medicine, it may assist in the research of specific drugs to treat various diseases; in the material industry, it may be able to create new materials with specific properties.
    Furthermore, with the advance of science and technology, the analysis and detection techniques will also be more refined, and the purity and impurities of 1-Bromo-5-Chloro-2-Fluoro-4-Methylbenzene will be more accurately controlled. Its future development will surely shine like a shining star in the chemical firmament.
    Where to Buy 1-Bromo-5-Chloro-2-Fluoro-4-Methylbenzene in China?
    As a trusted 1-Bromo-5-Chloro-2-Fluoro-4-Methylbenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 1-Bromo-5-Chloro-2-Fluoro-4-Methylbenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the chemical properties of 1-Bromo-5-Chloro-2-Fluoro-4-Methylbenzene?
    1-Bromo-5-chloro-2-fluoro-4-methylbenzene is a kind of organic compound. In its molecular structure, on the benzene ring, the substituents such as bromine, chlorine, fluorine, and methyl are in specific positions. The chemical properties of this compound are unique due to the conjugation system of the functional groups contained and the benzene ring.
    As for its halogenated groups (bromine, chlorine, fluorine), they all have certain reactivity. Bromine atoms, chlorine atoms, and fluorine atoms can all participate in nucleophilic substitution reactions under suitable conditions. Among them, the fluorine atom has a high electronegativity, resulting in a larger C-F bond energy, and its nucleophilic substitution reaction conditions are often more severe than those participated in by bromine and chlorine atoms. Nucleophilic reagents need to overcome a large energy barrier if they want to attack the carbon atoms connected to them.
    The C-Br and C-Cl bonds connected by bromine and chlorine atoms have relatively small bond energies and are more prone to fracture in many nucleophilic substitution reactions. For example, when reacting with nucleophilic reagents such as sodium alcohol and amines, bromine and chlorine atoms can be replaced by corresponding nucleophilic groups, thereby forming new carbon-heteroatom bonds, and realizing structural transformation and derivatization of organic compounds.
    Furthermore, methyl is attached to the benzene ring, which affects the electron cloud density distribution of the benzene ring. Methyl is the power supply radical, which can increase the electron cloud density of the ortho and para-sites of the benzene ring, resulting in the ortho and para-sites of the benzene ring in the electrophilic substitution reaction. For example, in the electrophilic substitution reactions such as halogenation, nitrification, and sulfonation, the reaction check points tend to be ortho and para-sites of methyl. However, due to the existence of other halogenated groups on the benzene ring, their localization effects will also compete with and affect each other. The selectivity of the final reaction check point is determined by the relative strength of the localization effect of each group and the reaction conditions.
    In addition, the chemical properties of 1-bromo-5-chloro-2-fluoro-4-methylbenzene are also reflected in the redox reaction. Under the action of specific strong oxidants, the benzene ring may undergo reactions such as oxidation and ring opening; while the halogenated group may be reduced to the corresponding hydride in some reduction systems, thereby realizing the structural modification and transformation of the compound. Overall, the chemical properties of 1-bromo-5-chloro-2-fluoro-4-methylbenzene are rich and diverse. In the field of organic synthesis, various reactions can be carried out by virtue of the characteristics of the functional groups it contains to prepare organic compounds with more complex structures and unique functions.
    What are the common uses of 1-Bromo-5-Chloro-2-Fluoro-4-Methylbenzene?
    1-Bromo-5-chloro-2-fluoro-4-methylbenzene, this is an organic compound with many common uses. In the field of organic synthesis, it is often used as a key intermediate. Because its molecular structure contains halogen atoms and methyl groups, other organic compounds can be derived through many chemical reactions.
    First, nucleophilic substitution reaction is a common route. Halogen atoms are highly active, and nucleophiles such as hydroxyl and amino groups can replace halogen atoms to synthesize compounds containing corresponding functional groups. For example, when treated with sodium hydroxide solution, bromine atoms or chlorine atoms can be replaced by hydroxyl groups to form corresponding phenolic compounds. This phenolic compound has important uses in the pharmaceutical, fragrance and other industries.
    Second, it is used to construct carbon-carbon bonds. With the help of metal-catalyzed coupling reactions, such as Suzuki coupling reaction, Heck reaction, etc. In the presence of suitable catalysts, ligands and bases, it can react with compounds containing borate esters or olefins to form new carbon-carbon bonds, expand the carbon skeleton of molecules, lay the foundation for the synthesis of complex organic molecules, and is widely used in drug development and materials science.
    Third, it also plays a role in the field of pesticides. Due to its special chemical structure, it has certain biological activity to some pests or pathogens. After rational structural modification and optimization, it can be developed into a new type of pesticide for the control of agricultural pests and diseases, helping to ensure crop yield and quality.
    Fourth, in the field of materials science, the introduction of polymer systems through specific reactions can endow materials with special properties. For example, improving the flame retardancy and chemical resistance of materials has great potential for the improvement of plastics, coatings and other materials.
    All of these, the unique structure of 1-bromo-5-chloro-2-fluoro-4-methylbenzene plays an important role in many fields such as organic synthesis, medicine, pesticides, materials, etc., providing key raw materials and intermediates for the development of related industries.
    What are 1-Bromo-5-Chloro-2-Fluoro-4-Methylbenzene synthesis methods?
    The synthesis of 1-bromo-5-chloro-2-fluoro-4-methylbenzene is an important topic in organic synthetic chemistry. To synthesize this compound, there are many common paths.
    First, aromatic hydrocarbons are used as starting materials and halogenation is used. The benzene derivative containing methyl can be taken first, and bromine, chlorine and fluorine atoms are introduced in sequence by suitable halogenating agents, such as brominating agents, chlorinating agents and fluorinating agents. If bromine atoms are introduced at specific positions in the benzene ring under specific conditions, this condition needs to take into account the reaction activity and selectivity, such as controlling the reaction temperature, solvent and catalyst. After the bromination reaction is completed, chlorination is carried out with a chlorinating agent. At this time, the reaction parameters need to be carefully adjusted to make the chlorine atoms connect according to the target position. Finally, fluorine atoms are introduced with a fluorinating agent to complete the synthesis.
    Second, the substitution reaction of halogenated aromatic hydrocarbons can be carried out. Select an appropriate halogenated benzene and use a nucleophilic substitution reaction to replace it with a reagent containing the desired halogen and methyl. For example, use a halogenated benzene as a substrate, react with a reagent containing methyl, introduce methyl, and then gradually introduce bromine, chlorine, and fluorine atoms through the subsequent halogen substitution reaction. This process requires attention to the differences in the substitution reaction conditions, such as the choice of reagent activity, reaction solvent, and base, to ensure the smooth progress
    Third, the coupling reaction catalyzed by transition metals is used. Transition metal catalysts, such as palladium and nickel, are used to promote the coupling of different halogenated aromatics or halogenated and methyl reagents. This method can accurately construct carbon-carbon bonds and carbon-halogen bonds to achieve the synthesis of target molecules. However, careful selection of catalysts, ligands and reaction conditions is required to optimize the reaction effect and improve the purity and yield of the product.
    Synthesis methods have their own advantages and disadvantages. In practical applications, the appropriate synthesis route should be carefully selected according to factors such as raw material availability, cost, ease of control of reaction conditions and product purity requirements.
    What are 1-Bromo-5-Chloro-2-Fluoro-4-Methylbenzene storage conditions?
    1-Bromo-5-chloro-2-fluoro-4-methylbenzene is also an organic compound. Its storage conditions are related to the stability and safety of the substance and cannot be ignored.
    This compound should be stored in a cool and ventilated warehouse. In a cool place, the temperature should not be too high, because high temperature can easily cause chemical reactions in the compound, or cause it to decompose and deteriorate, damaging its chemical properties. Good ventilation can disperse harmful gases that may evaporate, reducing the risk of explosion and poisoning.
    Furthermore, keep away from fire and heat sources. Both fire and heat sources can cause the compound to burn or explode, and its chemical structure contains halogen atoms and methyl groups, which are prone to danger in case of open flames and hot topics. When the lighting, ventilation and other facilities of the warehouse are explosion-proof, the switch should also be located outside the warehouse to prevent the spark ignition of compounds generated by electrical equipment.
    When storing, it should be stored separately from oxidants and edible chemicals, and mixed storage should not be avoided. Oxidants have strong oxidizing properties, contact with the compound, or cause severe redox reactions; and mixed storage with edible chemicals, if there is an accident such as leakage, it is easy to contaminate edible chemicals and endanger human health.
    At the same time, the storage area should be equipped with suitable materials to contain leaks. Once a leak occurs, it can be collected in time to prevent its spread and reduce pollution to the environment and harm to personnel. It is necessary to regularly check the storage container for leakage and ensure that the packaging is well sealed to prevent the compound from evaporating or reacting with external substances. In this way, 1-bromo-5-chloro-2-fluoro-4-methyl benzene can be properly stored to ensure its quality and safety.
    What is the price range of 1-Bromo-5-Chloro-2-Fluoro-4-Methylbenzene in the market?
    I don't know the price range of 1 - Bromo - 5 - Chloro - 2 - Fluoro - 4 - Methylbenzene in the market. The price of this compound often varies due to many factors, one is purity, and the price of high purity must be higher than that of low purity. The second is the situation of supply and demand. If there are many applicants and few suppliers, the price will increase; conversely, if the supply exceeds the demand, the price will decrease. Furthermore, the difficulty of preparation is also related to the price. If the preparation requires difficult methods and high consumption, the price will also be high.
    If you want to know the price, you can consult the chemical raw material trading platform and chemical supplier. On these platforms or merchants, you can check the quotations of this compound under different specifications and purity, and then clarify its price range. Or you can contact the chemical seller to inquire about its price in detail. I regret that I cannot directly disclose the price range, but I hope this advice can help you get the required price information.