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What are the chemical properties of 1-Bromo-5-Chloro-2-Fluoro-4-Methylbenzene?
1-Bromo-5-chloro-2-fluoro-4-methylbenzene is a kind of organic compound. In its molecular structure, on the benzene ring, the substituents such as bromine, chlorine, fluorine, and methyl are in specific positions. The chemical properties of this compound are unique due to the conjugation system of the functional groups contained and the benzene ring.
As for its halogenated groups (bromine, chlorine, fluorine), they all have certain reactivity. Bromine atoms, chlorine atoms, and fluorine atoms can all participate in nucleophilic substitution reactions under suitable conditions. Among them, the fluorine atom has a high electronegativity, resulting in a larger C-F bond energy, and its nucleophilic substitution reaction conditions are often more severe than those participated in by bromine and chlorine atoms. Nucleophilic reagents need to overcome a large energy barrier if they want to attack the carbon atoms connected to them.
The C-Br and C-Cl bonds connected by bromine and chlorine atoms have relatively small bond energies and are more prone to fracture in many nucleophilic substitution reactions. For example, when reacting with nucleophilic reagents such as sodium alcohol and amines, bromine and chlorine atoms can be replaced by corresponding nucleophilic groups, thereby forming new carbon-heteroatom bonds, and realizing structural transformation and derivatization of organic compounds.
Furthermore, methyl is attached to the benzene ring, which affects the electron cloud density distribution of the benzene ring. Methyl is the power supply radical, which can increase the electron cloud density of the ortho and para-sites of the benzene ring, resulting in the ortho and para-sites of the benzene ring in the electrophilic substitution reaction. For example, in the electrophilic substitution reactions such as halogenation, nitrification, and sulfonation, the reaction check points tend to be ortho and para-sites of methyl. However, due to the existence of other halogenated groups on the benzene ring, their localization effects will also compete with and affect each other. The selectivity of the final reaction check point is determined by the relative strength of the localization effect of each group and the reaction conditions.
In addition, the chemical properties of 1-bromo-5-chloro-2-fluoro-4-methylbenzene are also reflected in the redox reaction. Under the action of specific strong oxidants, the benzene ring may undergo reactions such as oxidation and ring opening; while the halogenated group may be reduced to the corresponding hydride in some reduction systems, thereby realizing the structural modification and transformation of the compound. Overall, the chemical properties of 1-bromo-5-chloro-2-fluoro-4-methylbenzene are rich and diverse. In the field of organic synthesis, various reactions can be carried out by virtue of the characteristics of the functional groups it contains to prepare organic compounds with more complex structures and unique functions.
What are the common uses of 1-Bromo-5-Chloro-2-Fluoro-4-Methylbenzene?
1-Bromo-5-chloro-2-fluoro-4-methylbenzene, this is an organic compound with many common uses. In the field of organic synthesis, it is often used as a key intermediate. Because its molecular structure contains halogen atoms and methyl groups, other organic compounds can be derived through many chemical reactions.
First, nucleophilic substitution reaction is a common route. Halogen atoms are highly active, and nucleophiles such as hydroxyl and amino groups can replace halogen atoms to synthesize compounds containing corresponding functional groups. For example, when treated with sodium hydroxide solution, bromine atoms or chlorine atoms can be replaced by hydroxyl groups to form corresponding phenolic compounds. This phenolic compound has important uses in the pharmaceutical, fragrance and other industries.
Second, it is used to construct carbon-carbon bonds. With the help of metal-catalyzed coupling reactions, such as Suzuki coupling reaction, Heck reaction, etc. In the presence of suitable catalysts, ligands and bases, it can react with compounds containing borate esters or olefins to form new carbon-carbon bonds, expand the carbon skeleton of molecules, lay the foundation for the synthesis of complex organic molecules, and is widely used in drug development and materials science.
Third, it also plays a role in the field of pesticides. Due to its special chemical structure, it has certain biological activity to some pests or pathogens. After rational structural modification and optimization, it can be developed into a new type of pesticide for the control of agricultural pests and diseases, helping to ensure crop yield and quality.
Fourth, in the field of materials science, the introduction of polymer systems through specific reactions can endow materials with special properties. For example, improving the flame retardancy and chemical resistance of materials has great potential for the improvement of plastics, coatings and other materials.
All of these, the unique structure of 1-bromo-5-chloro-2-fluoro-4-methylbenzene plays an important role in many fields such as organic synthesis, medicine, pesticides, materials, etc., providing key raw materials and intermediates for the development of related industries.
What are 1-Bromo-5-Chloro-2-Fluoro-4-Methylbenzene synthesis methods?
The synthesis of 1-bromo-5-chloro-2-fluoro-4-methylbenzene is an important topic in organic synthetic chemistry. To synthesize this compound, there are many common paths.
First, aromatic hydrocarbons are used as starting materials and halogenation is used. The benzene derivative containing methyl can be taken first, and bromine, chlorine and fluorine atoms are introduced in sequence by suitable halogenating agents, such as brominating agents, chlorinating agents and fluorinating agents. If bromine atoms are introduced at specific positions in the benzene ring under specific conditions, this condition needs to take into account the reaction activity and selectivity, such as controlling the reaction temperature, solvent and catalyst. After the bromination reaction is completed, chlorination is carried out with a chlorinating agent. At this time, the reaction parameters need to be carefully adjusted to make the chlorine atoms connect according to the target position. Finally, fluorine atoms are introduced with a fluorinating agent to complete the synthesis.
Second, the substitution reaction of halogenated aromatic hydrocarbons can be carried out. Select an appropriate halogenated benzene and use a nucleophilic substitution reaction to replace it with a reagent containing the desired halogen and methyl. For example, use a halogenated benzene as a substrate, react with a reagent containing methyl, introduce methyl, and then gradually introduce bromine, chlorine, and fluorine atoms through the subsequent halogen substitution reaction. This process requires attention to the differences in the substitution reaction conditions, such as the choice of reagent activity, reaction solvent, and base, to ensure the smooth progress
Third, the coupling reaction catalyzed by transition metals is used. Transition metal catalysts, such as palladium and nickel, are used to promote the coupling of different halogenated aromatics or halogenated and methyl reagents. This method can accurately construct carbon-carbon bonds and carbon-halogen bonds to achieve the synthesis of target molecules. However, careful selection of catalysts, ligands and reaction conditions is required to optimize the reaction effect and improve the purity and yield of the product.
Synthesis methods have their own advantages and disadvantages. In practical applications, the appropriate synthesis route should be carefully selected according to factors such as raw material availability, cost, ease of control of reaction conditions and product purity requirements.
What are 1-Bromo-5-Chloro-2-Fluoro-4-Methylbenzene storage conditions?
1-Bromo-5-chloro-2-fluoro-4-methylbenzene is also an organic compound. Its storage conditions are related to the stability and safety of the substance and cannot be ignored.
This compound should be stored in a cool and ventilated warehouse. In a cool place, the temperature should not be too high, because high temperature can easily cause chemical reactions in the compound, or cause it to decompose and deteriorate, damaging its chemical properties. Good ventilation can disperse harmful gases that may evaporate, reducing the risk of explosion and poisoning.
Furthermore, keep away from fire and heat sources. Both fire and heat sources can cause the compound to burn or explode, and its chemical structure contains halogen atoms and methyl groups, which are prone to danger in case of open flames and hot topics. When the lighting, ventilation and other facilities of the warehouse are explosion-proof, the switch should also be located outside the warehouse to prevent the spark ignition of compounds generated by electrical equipment.
When storing, it should be stored separately from oxidants and edible chemicals, and mixed storage should not be avoided. Oxidants have strong oxidizing properties, contact with the compound, or cause severe redox reactions; and mixed storage with edible chemicals, if there is an accident such as leakage, it is easy to contaminate edible chemicals and endanger human health.
At the same time, the storage area should be equipped with suitable materials to contain leaks. Once a leak occurs, it can be collected in time to prevent its spread and reduce pollution to the environment and harm to personnel. It is necessary to regularly check the storage container for leakage and ensure that the packaging is well sealed to prevent the compound from evaporating or reacting with external substances. In this way, 1-bromo-5-chloro-2-fluoro-4-methyl benzene can be properly stored to ensure its quality and safety.
What is the price range of 1-Bromo-5-Chloro-2-Fluoro-4-Methylbenzene in the market?
I don't know the price range of 1 - Bromo - 5 - Chloro - 2 - Fluoro - 4 - Methylbenzene in the market. The price of this compound often varies due to many factors, one is purity, and the price of high purity must be higher than that of low purity. The second is the situation of supply and demand. If there are many applicants and few suppliers, the price will increase; conversely, if the supply exceeds the demand, the price will decrease. Furthermore, the difficulty of preparation is also related to the price. If the preparation requires difficult methods and high consumption, the price will also be high.
If you want to know the price, you can consult the chemical raw material trading platform and chemical supplier. On these platforms or merchants, you can check the quotations of this compound under different specifications and purity, and then clarify its price range. Or you can contact the chemical seller to inquire about its price in detail. I regret that I cannot directly disclose the price range, but I hope this advice can help you get the required price information.