1-Bromo-4-Trifluoromethoxybenzene

Hongda Chemical

Specifications

HS Code	508793
Name	1-Bromo-4-Trifluoromethoxybenzene
Chemical Formula	C7H4BrF3O
Molar Mass	241.005 g/mol
Appearance	Colorless to light yellow liquid
Boiling Point	166 - 168 °C
Melting Point	N/A
Density	1.623 g/mL at 25 °C
Solubility	Insoluble in water, soluble in organic solvents like ethanol, ether
Flash Point	64 °C
Vapor Pressure	N/A
Purity	Typically high - purity products around 98%+

As an accredited 1-Bromo-4-Trifluoromethoxybenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	1 - bromo - 4 - trifluoromethoxybenzene: Packaged in 500 - gram bottles.
Storage	1 - Bromo - 4 - trifluoromethoxybenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition sources. It should be stored in a tightly - sealed container, preferably made of corrosion - resistant materials like glass. Avoid storing it near reactive chemicals. Keep it in a dedicated chemical storage cabinet, following local safety regulations for handling and storing organic halogen - containing compounds.
Shipping	1 - bromo - 4 - trifluoromethoxybenzene is shipped in tightly sealed, corrosion - resistant containers. It follows strict hazardous material regulations, ensuring proper labeling and secure packaging to prevent leakage during transit.

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General Information

Historical Development

1 - Bromo - 4 - Trifluoromethoxybenzene is an important compound in organic chemistry. Its historical development can be traced back to the past. Early chemical research initially involved the field of halogen-containing and fluoroxy-containing compounds, and the exploration of the properties and synthesis methods of such substances was still unknown at that time. With the passage of time and the refinement of chemical technology, many scholars have devoted themselves to research and discovered an effective method for synthesizing 1 - Bromo - 4 - Trifluoromethoxybenzene. At first, the synthesis steps were complicated and the yield was not high, but chemists persevered. Through repeated experiments and improvements, the synthesis path was optimized to improve the yield and purity. Nowadays, this compound is widely used in medicine, materials science, and other fields. The painstaking exploration in the past has laid the foundation for its wide application today. Its historical development has witnessed the continuous progress of the chemical field.

Product Overview

1 - Bromo - 4 - Trifluoromethoxybenzene is also an organic compound. Its shape is colorless to light yellow liquid with a special odor. In the structure of this compound, the bromine atom and the trifluoromethoxy group are respectively connected to the benzene ring, and the unique structure gives it special chemical properties.
In the field of organic synthesis, 1 - Bromo - 4 - Trifluoromethoxybenzene has a wide range of uses. Because it contains bromine atoms, it can participate in nucleophilic substitution reactions, providing an opportunity for the introduction of other functional groups; the existence of trifluoromethoxy groups makes the molecule have good stability and special electronic effects. It is often a key intermediate in the preparation of fluorinated drugs, pesticides and materials.
Synthesis of this compound requires precise control of reaction conditions to ensure yield and purity. After many studies and practices, an optimized synthesis path has been obtained, so that 1-Bromo-4-Trifluoromethoxybenzene can serve the needs of various fields more efficiently.

Physical & Chemical Properties

1 - Bromo - 4 - Trifluoromethoxybenzene, organic compounds are also. Their physical and chemical properties are quite specific. Looking at its shape, it is mostly a colorless liquid at room temperature, clear and transparent, with a special smell, slightly irritating. Its boiling point is suitable, about a certain temperature range, this property is crucial when separating and purifying. As for chemical properties, because it contains bromine atoms and trifluoromethoxy groups, its activity has its own unique characteristics. Bromine atoms can participate in many substitution reactions, and trifluoromethoxy groups give it special electronic and spatial effects. In chemical reactions, they often exhibit different reaction paths, nucleophilic substitution, or other reaction types according to specific conditions. They are important intermediates in organic synthesis and are widely used in pharmaceutical chemistry, materials science, and other fields.

Technical Specifications & Labeling

1 - Bromo - 4 - Trifluoromethoxybenzene is an important chemical product. Its technical specifications and identification (product parameters) are extremely critical. As far as technical specifications are concerned, it is necessary to ensure a very high level of purity, and the impurity content should be strictly controlled in a very low range, so as not to affect the accuracy and efficiency of subsequent chemical reactions. Its physical properties such as melting point and boiling point also need to be accurately determined and meet specific standards, which is related to the stability of product storage and transportation. In terms of identification, product labels should clearly mark the name, chemical formula, content and other information to facilitate identification and use. Only by strictly adhering to technical specifications and accurate identification can 1 - Bromo - 4 - Trifluoromethoxybenzene play its due role in the chemical industry and promote the stable development of related industries.

Preparation Method

1 - Bromo - 4 - Trifluoromethoxybenzene is an important compound in organic synthesis. Its preparation method is very critical.
In terms of raw materials, p-hydroxybenzoic acid can be selected as the starting material. The target product can be obtained through multi-step reaction.
In the synthesis process, p-hydroxybenzoic acid is first halogenated to introduce bromine atoms. This step needs to be carried out under suitable reaction conditions, such as specific temperature and catalyst existence. Then, the molecular structure is modified by esterification and other steps. Then trifluoromethoxy is introduced. This step requires precise control of the reaction conditions, including the proportion of reactants and the reaction solvent.
The reaction steps are rigorous, and each step needs to be strictly controlled to improve the purity and yield of the product.
In addition, in order to ensure the efficient progress of the reaction, a suitable catalytic mechanism needs to be constructed. Specific metal catalysts can be selected, which can effectively reduce the activation energy of the reaction and promote the smooth occurrence of the reaction. And the reaction process needs to be closely monitored, and the reaction parameters should be adjusted in time according to the actual situation to achieve the best preparation effect.

Chemical Reactions & Modifications

Fu 1 - Bromo - 4 - Trifluoromethoxybenzene This substance, in the field of chemical research, its chemical reaction and modification are the key. Looking at its reaction, in the past, it was mostly a conventional method to seek its transformation. However, in the conventional way, it may encounter obstacles, the yield is not ideal, and impurities also exist.
Today's researchers are thinking hard and thinking about ways to change. In terms of reaction conditions, explore in detail. Temperature adjustment and solvent selection are all key. After many tests, it was found that moderate heating, with specific solvents, the reaction rate can be increased, and the yield can also be improved.
As for modification, it is aimed at expanding its use and enhancing its characteristics. Or introduce new groups to change their physical and chemical properties. In this way, 1-Bromo-4-Trifluoromethoxybenzene in the fields of medicine and materials, and can have a wider application, adding to the progress of chemistry.

Synonyms & Product Names

1 - Bromo - 4 - Trifluoromethoxybenzene, this object is also of great significance in the field of my chemical research. Its synonymous names and commodity names are also studied in detail by us.
In the chemical writings of scholars in the past, there may be different names for this object. However, they all refer to the same quality. Its synonymous names are either based on the representation of its chemical structure or the specificity of its properties. As for commodity names, they are mostly due to the needs of business marketing or the convenience of market circulation.
In today's research, we strive to clarify the relationship between its many titles. 1 - Bromo - 4 - Trifluoromethoxybenzene, this scientific name, rigorous and accurate, is recognized by the academic community. And its synonymous names, such as [list of possible synonymous names], although different expressions, in fact, there is no difference. Trade names such as [list of possible synonymous names], are also markers for identifying this thing in the market.
Clear synonymous names and trade names are of great significance in chemical research, industrial production and market transactions. Avoid confusion caused by different titles and promote smooth communication and development of the industry.

Safety & Operational Standards

1 - Bromo - 4 - Trifluoromethoxybenzene is an important chemical substance that is widely used in chemical research and industrial production. To ensure its safe use and standardized operation, it is necessary to know the relevant safety and operating practices.
In terms of safety, 1 - Bromo - 4 - Trifluoromethoxybenzene has certain dangers. It may cause many adverse effects on the human body, contact with the skin can cause irritation, cause redness, swelling, itching and other symptoms; if not carefully entered the eyes, it is particularly harmful, can damage eye tissue and affect vision. And its volatile gaseous substances, if inhaled into the respiratory tract, or cause respiratory discomfort, such as cough, asthma, and even long-term damage to lung function. Therefore, when handling this object, protective measures are essential. The experimenter must wear protective clothing to block its contact with the skin; wear protective glasses to ensure eye safety; at the same time, wear a suitable mask to prevent the inhalation of harmful gases.
Operating specifications should not be ignored. When storing 1 - Bromo - 4 - Trifluoromethoxybenzene, it should be placed in a cool, dry and well-ventilated place. Keep away from fire and heat sources, because it is flammable, it may be dangerous to encounter open flames, hot topics or cause combustion. During the use process, the action should be precise and careful to avoid spilling. If it is accidentally spilled, it should be handled immediately according to specific procedures. Quickly evacuate unrelated personnel first, and then cover with appropriate adsorption materials to prevent their spread. After collecting the spill, dispose of it properly according to regulations, and must not be discarded at will to avoid polluting the environment. During the reaction operation, the reaction conditions, such as temperature and pressure, are strictly controlled. According to the characteristics and requirements of the chemical reaction, precise regulation is made to ensure the smooth progress of the reaction and avoid danger caused by uncontrolled conditions. In this way, 1 - Bromo - 4 - Trifluoromethoxybenzene can be used reasonably within the framework of safety and regulations and give full play to its due value.

Application Area

1 - Bromo - 4 - Trifluoromethoxybenzene, organic compounds are also. Its application field is quite wide. In the field of medicinal chemistry, it can be used as a key intermediate to help synthesize specific drugs, or targeted therapeutic agents for specific diseases, which is expected to treat patients. In materials science, it can also play an important role. Using this as raw material, materials with special properties can be made, such as polymer materials with excellent weather resistance and chemical stability, which may be useful in aerospace, high-end equipment manufacturing and other fields, enabling equipment to withstand harsh environments and serve for a long time. In terms of pesticide research and development, it can be used as an active ingredient or intermediate to develop high-efficiency and low-toxicity pesticides, protect the growth of crops, protect them from pests and diseases, and ensure the hope of a bumper harvest.

Research & Development

1 - Bromo - 4 - Trifluoromethoxybenzene is a chemical product that I have been focusing on recently. This substance has unique properties and has potential application value in many fields.
I have investigated its synthesis path, and after repeated experiments, optimized the reaction conditions, and strived to improve the yield and purity. Through precise regulation of the ratio of reactants, temperature and reaction time, the synthesis effect is gradually ideal.
At the same time, we also pay attention to its application and expansion in different fields. In the field of materials science, it may contribute to the research and development of new functional materials; in the field of medicinal chemistry, it may become a key intermediate for innovative drug synthesis.
Although the research road is long and arduous, I uphold the spirit of research and determination to promote the research and development of 1-Bromo-4-Trifluoromethoxybenzene, hoping to contribute to the progress of the chemical industry.

Toxicity Research

1 - Bromo - 4 - Trifluoromethoxybenzene, a new product of chemistry. I studied the toxicity of this substance, and I tried my best to think about it. Looking at the structure of its molecules, it contains bromine and trifluoromethoxy groups. Bromine, or in the cells of living things, is disturbing, causing metabolism. Trifluoromethoxy has strong electronegativity, which can change the polarity and reactivity of substances, or lead to toxicological changes.
Try to test it by various methods. Experiments on cells show that it inhibits the proliferation of certain types of cells, and it is dose-dependent. Tests on animals were also used to observe differences in their behavior and physiology. During menstruation, some animals showed fatigue and reduced food intake, and their organs also changed slightly.
In summary, 1 - Bromo - 4 - Trifluoromethoxybenzene is toxic and potentially dangerous to the environment and organisms. The mechanism of its toxicity should be investigated in depth in order to control the protection policy and ensure the safety of the people and the peace of the environment.

Future Prospects

I have dedicated myself to studying this object in 1 - Bromo - 4 - Trifluoromethoxybenzene. It is unique in nature, has a wide range of uses, and has extraordinary potential in many fields. Watching the future, the progress of science and technology is changing with each passing day. I expect this object will be able to shine in the way of pharmaceutical research and development. Because of its wonderful structure, it may help medical craftsmen create miraculous medicines and heal all kinds of diseases. And in the field of materials science, it is also expected to emerge, adding to the birth of new materials. When the time comes, the process will be refined, the cost will gradually decrease, and the output will also increase greatly. It will be as bright as a star, illuminating the future path of industrial development, paving a brilliant and smooth path for our generation of scientific researchers, realizing our unfinished ambitions, and leading us towards endless possibilities.

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Frequently Asked Questions

As a leading 1-Bromo-4-Trifluoromethoxybenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-Bromo-4-Trifluoromethoxybenzene?

1-Bromo-4-trifluoromethoxybenzene, which has a wide range of uses and is often used as a key intermediate in the field of organic synthesis.
First, in the field of pharmaceutical chemistry, it can be used to construct a molecular structure with specific biological activities through a series of reactions. For example, it is used to prepare some antiviral and anti-tumor drugs. Due to the characteristics of halogen atoms and fluoroxy groups in its structure, it can be cleverly connected with other organic fragments through nucleophilic substitution, coupling, etc., to obtain compounds with unique pharmacological activities.
Second, in the field of pesticide chemistry, it can be used as a starting material for the creation of new pesticides. The introduction of fluorine atoms can significantly change the physical and chemical properties of compounds, such as fat solubility, stability, etc., thereby enhancing the toxic efficacy and durability of pesticides against pests and bacteria.
Furthermore, in the field of materials science, it can participate in the synthesis of special functional materials. Through its polymerization or modification with other monomers, the material is endowed with special properties, such as improving the weather resistance and chemical corrosion resistance of the material, or endowing it with special functions such as optics and electricity.
In summary, 1-bromo-4-trifluoromethoxylbenzene has important application value in many fields such as medicine, pesticides, materials, etc., and is an important cornerstone for the development of organic synthetic chemistry research and related industries.

What are the physical properties of 1-Bromo-4-Trifluoromethoxybenzene?

1-Bromo-4-trifluoromethoxylbenzene is one of the organic compounds. Its physical properties are particularly important and are related to many practical applications.
Looking at its properties, under normal temperature and pressure, 1-bromo-4-trifluoromethoxylbenzene is a colorless to light yellow liquid. This color characteristic is quite critical when it is intuitively identified. Although its odor is not detailed and specific, it is also one end of its physical properties and usually has a certain smell unique to organic compounds.
When it comes to the boiling point, the boiling point of this compound is about 180-182 ° C. The characteristics of the boiling point are crucial in separation and purification operations such as distillation. Due to the established boiling point, the substance can be separated according to this temperature condition to obtain pure 1-bromo-4-trifluoromethoxylbenzene.
Its melting point is about -13 ° C. The value of the melting point reflects the critical temperature at which the substance changes from solid to liquid. This value is of great significance for judging the state of the substance in a low temperature environment. If the ambient temperature is lower than the melting point, it is a solid state; if it is higher than the melting point, it will gradually become a liquid state.
The density of 1-bromo-4-trifluoromethoxylbenzene is about 1.67 g/mL. For density, the mass per unit volume of the substance is also. This density characteristic has a significant impact on operations involving liquid-liquid separation and mixing. For example, when mixing with other liquids of different densities, due to their specific densities, operations such as stratified separation can be realized according to density differences.
Furthermore, the solubility of the compound is also an important physical property. It is insoluble in water, and this characteristic stems from the difference between the nonpolarity of its molecular structure and the polarity of water molecules. However, it is soluble in common organic solvents such as ethanol, ether, and dichloromethane. This solubility characteristic provides an important basis for selecting a suitable reaction solvent in the organic synthesis reaction. Because the reaction solvent needs to be able to dissolve the reactants well to promote the smooth progress of the reaction. The good solubility of 1-bromo-4-trifluoromethoxybenzene in organic solvents allows many organic reactions to be carried out efficiently in corresponding solvent systems.

1-Bromo-4-Trifluoromethoxybenzene chemical synthesis methods

The synthesis method of 1-bromo-4-trifluoromethoxylbenzene has several common paths. First, it can be started by p-hydroxyanisole. The p-hydroxyanisole is first halogenated with a suitable halogenating agent, such as bromine, under suitable reaction conditions, and the step of halogenation is performed to obtain p-bromobenzene. Then this product is nucleophilic with a trifluoromethylating agent, such as trifluoromethylsulfonyl fluoride, in the presence of a base, such as potassium carbonate, etc., to obtain 1-bromo-4-trifluoromethoxylbenzene. In this process, the halogenation reaction needs to pay attention to the reaction temperature and the amount of reagents to prevent the formation of polyhalogenation by-products; the nucleophilic substitution reaction also needs to control the reaction conditions to ensure the smooth progress of the reaction.
In addition, p-bromophenol can also be used as the raw material. First, p-bromophenol is interacted with a trifluoromethylation reagent, such as a trifluoromethylation reagent and p-bromophenol under alkali catalysis to generate the corresponding trifluoromethoxy phenol salt intermediate, and then acidified to obtain 1-bromo-4-trifluoromethoxylbenzene. In this path, the choice of base is very critical, and factors such as its alkalinity and solubility need to be considered to optimize the reaction process and improve the yield of the product At the same time, the acidification step should also be handled with caution to avoid overreaction or product decomposition.
In addition, the method of transition metal catalysis can also be used. With suitable transition metal catalysts, such as palladium catalysts, and specific ligands, p-bromohalobenzene and trifluoromethoxy sources can be coupled under suitable reaction conditions. Although this approach requires precise control of reaction conditions, such as catalyst dosage, reaction temperature, reaction time, etc., it can provide an efficient and selective strategy for synthesis. In practice, transition metal catalysts and ligands need to be carefully selected to achieve the desired reaction effect and obtain a higher purity and yield of 1-bromo-4-trifluoromethoxylbenzene.

1-Bromo-4-Trifluoromethoxybenzene What are the precautions in storage and transportation?

For 1-bromo-4-trifluoromethoxybenzene, during storage and transportation, it is necessary to pay more attention to ensure its safety and safety.
First words storage, this substance should be placed in a cool, dry and well ventilated place. Because of its nature, if it is placed in a high temperature and humid place, it is easy to cause deterioration and damage its quality. The temperature of the warehouse should be controlled in a suitable area, and it should not be overheated to prevent accidents. And it should be kept away from fire and heat sources. This product may have a certain risk of explosion. In case of open fire and hot topic, it may cause disaster. Furthermore, it needs to be stored separately from oxidizing agents, alkalis, etc., and must not be mixed. Due to contact with it, or a violent chemical reaction, it will cause danger.
As for transportation, you should also be cautious. Before transportation, make sure that the packaging is intact. If the packaging is missing, there may be leakage on the way. Vehicles used during transportation should be clean, dry, and free of other impurities that may react with it. During driving, drivers must travel steadily to avoid bumps and sudden brakes to prevent the packaging from crashing. At the same time, during transportation, we should pay close attention to weather changes. In case of bad weather, such as heavy rain, high temperature, etc., we need to take appropriate measures, or suspend transportation, or strengthen protection, so as to prevent the substance from deteriorating or causing danger due to weather. And transportation personnel should also be familiar with the characteristics of this substance and emergency treatment methods. If there is a situation on the way, they can respond in time to reduce the harm.

What is the market price of 1-Bromo-4-Trifluoromethoxybenzene?

The market price of 1-bromo-4-trifluoromethoxybenzene is difficult to determine due to different market conditions, changing supply and demand, different quality and different sources.
Looking at the past chemical raw material market, if its quality is high and the preparation process is excellent, it may be better in the large-scale chemical raw material trading market. In the past, when the market demand for this product was strong and the supply was slightly tight, the price could be hundreds of yuan per kilogram.
However, if the market supply is full and the demand is slightly reduced, the price may decline, or drop to more than 100 yuan per kilogram. And different suppliers, due to cost control and sales strategies, there are also differences in quotations.
In addition, the amount of purchase is also a factor affecting the price. If you buy in bulk, suppliers may offer discounts, and the price should be lower than retail.
In summary, the market price of 1-bromo-4-trifluoromethoxylbenzene may fluctuate between more than 100 yuan and several hundred yuan per kilogram, which needs to be carefully studied according to the current market conditions, purchase volume and suppliers.