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1-Bromo-4-Methoxy-2,3-Difluorobenzene

1-Bromo-4-Methoxy-2,3-Difluorobenzene

Hongda Chemical

Specifications

HS Code

396037

Chemical Formula C7H5BrF2O
Molar Mass 223.014 g/mol
Appearance likely a colorless to pale - yellow liquid
Boiling Point data may vary, but typically in a certain range related to its molecular structure
Melting Point specific value depending on its crystal structure
Density a characteristic value based on its molecular mass and packing
Solubility In Water low solubility as it is an organic halide with non - polar components
Solubility In Organic Solvents soluble in common organic solvents like dichloromethane, ether
Flash Point a value related to its flammability
Vapor Pressure a value indicating its tendency to vaporize

As an accredited 1-Bromo-4-Methoxy-2,3-Difluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 1 - bromo - 4 - methoxy - 2,3 - difluorobenzene packaged in a sealed glass bottle.
Storage 1 - Bromo - 4 - methoxy - 2,3 - difluorobenzene should be stored in a cool, dry, and well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly sealed container, preferably made of corrosion - resistant materials. Label the container clearly. This helps prevent decomposition, potential reactions, and ensures safety during storage.
Shipping 1 - bromo - 4 - methoxy - 2,3 - difluorobenzene is shipped in accordance with chemical transportation regulations. It's carefully packaged in suitable containers to prevent leakage, and transported via approved carriers ensuring safety during transit.
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1-Bromo-4-Methoxy-2,3-Difluorobenzene 1-Bromo-4-Methoxy-2,3-Difluorobenzene
General Information
Historical Development
The chemical industry is changing with each passing day, and various compounds are introducing new ones. Today, the birth of 1-Bromo-4-Methoxy-2,3-Difluorobenzene is not achieved overnight.
At the beginning, chemists studied and searched for the synthesis of various reaction mechanisms. After several years of cold and heat, countless attempts to prepare, or found inspiration in the method of organic synthesis, or found opportunities in the law of elemental synthesis.
From the origin of the original idea to the planning of the experimental steps, every step has been dedicated. Or because of the difficulty of finding raw materials, or because of the harsh reaction conditions, everyone is determined. The final optimization method enabled the stable production of this compound, opening the chapter of its application in the chemical industry, laying the foundation for subsequent research and production, and adding a unique touch to the long river of chemical development.
Product Overview
1 - Bromo - 4 - Methoxy - 2,3 - Difluorobenzene is also an organic compound. Its color is pure and uniform, and it has specific chemical properties. In the molecular structure, bromine atom, methoxy group and difluorine atom are cleverly named, each occupying its own position, giving this compound unique reactivity.
This compound is widely used in the field of organic synthesis. It can be used as a key intermediate and converted into various organic products with different functions through various chemical reactions. Its methoxy group can participate in nucleophilic substitution, bromine atom can initiate coupling reaction, and difluorine atom also has an important influence on the electron cloud distribution and spatial configuration of the molecule, which helps to accurately construct complex organic structures.
The synthesis method, often according to a specific chemical path, with the corresponding raw materials, through fine regulation of reaction conditions, such as temperature, catalyst, etc., can produce 1-Bromo-4-Methoxy-2,3-Difluorobenzene with high purity. Its value in chemical research and industrial production should not be underestimated.
Physical & Chemical Properties
1 - Bromo - 4 - Methoxy - 2,3 - Difluorobenzene, an organic compound. Its physical and chemical properties are quite specific. Looking at its shape, at room temperature, or as a colorless liquid, it has a special odor. Its boiling point and melting point are also key properties. The boiling point is related to the temperature of gasification, and the melting point depends on the degree of solidification, which are all factors that determine its physical state.
In terms of chemical properties, in its molecular structure, bromine, fluorine, and methoxy groups interact. Bromine atoms are active and easily participate in substitution reactions. They can interact with nucleophiles to cause bromine to be replaced. Methoxy groups have an electron cloud effect, which affects the electron cloud density of the benzene ring, and then affects its reactivity. Fluorine atoms have strong electronegativity, which changes the polarity of molecules and also affects the selectivity of reactions. This compound can contribute to the construction of various organic molecules due to its unique physical and chemical properties or as an important intermediate in the field of organic synthesis.
Technical Specifications & Labeling
1 - Bromo - 4 - Methoxy - 2,3 - Difluorobenzene is an important chemical product. Its technical specifications and labeling (product parameters) are crucial. When it comes to technical specifications, the substance needs to have a specific purity, and the impurity content must be strictly controlled. Its physical properties, such as melting point, boiling point, appearance color, etc., must meet the established standards.
In terms of labeling, the product packaging must be clearly marked with basic information such as chemical name, molecular formula, molecular weight, etc. At the same time, hazard labeling is also indispensable to warn users of its potential danger. Such strict specification of technical specifications and labeling can ensure that this product can be used safely and efficiently in various application scenarios and play its due value.
Preparation Method
1 - Bromo - 4 - Methoxy - 2,3 - Difluorobenzene is an important chemical product. Its preparation method is crucial. In terms of raw materials, specific halogenated aromatics, methoxy-containing reagents and fluorine-containing compounds are often required. In the production process, the proportion of each raw material needs to be carefully adjusted to ensure the accuracy of the reaction. The reaction steps are as follows. First, the halogenated aromatics and methoxy-containing reagents are substituted under suitable reaction conditions, such as specific temperature, pressure and catalyst, and methoxy groups are introduced. Subsequently, fluorine-containing compounds are added and reacted under specific conditions to successfully introduce fluorine atoms. In this process, the mechanism of regulating the reaction rate and process is extremely important. It is necessary to precisely control the reaction temperature, pH and other factors to ensure the purity and yield of the product, so as to effectively prepare 1-Bromo-4-Methoxy-2,3-Difluorobenzene.
Chemical Reactions & Modifications
1 - Bromo - 4 - Methoxy - 2,3 - Difluorobenzene has been studied in recent years. It is very difficult to think about the reaction and modification of this product. The way of reaction needs to find an appropriate way to make each product combine to form the required quality. At the beginning, it was tried according to the usual method, but the yield did not reach the expected, and there were many impurities.
Then think about changing it, observe the structure of its molecules, and study its properties. Know the characteristics of its groups, or change the reaction environment, adjust the amount and order of reagents. After many trials and errors, the reaction temperature and solvent selection have been focused on. It is easy to use a special solvent to control the temperature in a specific range, and it has been effective. The yield gradually increases, and there are few impurities.
When modifying, think of its wide range of uses, and hope to increase its properties in some aspects. Looking at similar things, get inspired. Introduce a functional group to change its properties. After several attempts, the final success. 1 - Bromo - 4 - Methoxy - 2,3 - Difluorobenzene properties, suitable for more scenes, in various fields, or can be used more widely.
Synonyms & Product Names
Today there is a thing called 1 - Bromo - 4 - Methoxy - 2,3 - Difluorobenzene. Although its name is different from the common saying, it also has many synonymous names. The synonymous names of this thing are often used by those who know it, to indicate its characteristics and the category it belongs to.
As for the trade names, they are also different. However, they all aim to highlight the characteristics of this thing, so that merchants can trade and the world can identify it. Either because of its unique chemical structure, or because of its unique uses, the synonymous names and trade names have specific meanings.
For our chemical researchers, only by being familiar with their synonymous names and trade names can we be accurate in our research and avoid confusion. We can also understand each other during communication, promoting academic progress and industrial development. These are all important points that cannot be ignored in chemical research.
Safety & Operational Standards
1 - Bromo - 4 - Methoxy - 2,3 - Difluorobenzene is an important chemical. Safety and handling practices are of paramount importance when researching and producing this chemical.
This chemical has certain chemical activity and requires strict follow of specific procedures when handling. For storage, choose a dry, cool and well-ventilated place, away from fire, heat and oxidants, etc., to prevent accidents. Storage containers should also be well sealed to avoid leakage.
When operating, the experimenter must wear appropriate protective equipment, such as protective gloves, goggles and lab clothes, to protect their own safety. The operating environment needs to have good ventilation facilities to prevent the accumulation of harmful gases. If you accidentally come into contact with this chemical during operation, you should immediately rinse the contact area with a large amount of water. If the situation is serious, you need to seek medical attention immediately.
In the chemical reaction operation steps, the reaction conditions should be precisely controlled, such as temperature, pressure and the proportion of reactants. Any deviation may lead to the reaction being out of control and dangerous. The product treatment after the reaction should also be cautious, follow environmental protection and safety standards, and properly dispose of waste. It must not be discarded at will to avoid pollution to the environment.
In addition, the transportation of this chemical should not be taken lightly. Appropriate packaging materials and transportation methods should be used in accordance with relevant transportation regulations to ensure safety during transportation. Only in this way can we ensure the safety of personnel and environment during the research and use of 1-Bromo-4-Methoxy-2,3-Difluorobenzene, and at the same time ensure the scientific and standardized operation.
Application Area
1 - Bromo - 4 - Methoxy - 2,3 - Difluorobenzene is a delicate chemical substance. Its application field is quite extensive. In the field of medicinal chemistry, it can be used as a key intermediate to help synthesize many drugs with specific curative effects to cure various diseases and protect the health of the world. In the field of materials science, it may be able to participate in the creation of novel functional materials, such as materials with unique optical and electrical properties, which contribute to the progress of science and technology. In the fine chemical industry, it can be used to prepare high-end fine chemicals to improve product quality and performance. Its potential value in various fields is like a pearl hidden in the deep sea, and it is urgent for us to explore and fully explore it, so that it can maximize its function and benefit all people in the world.
Research & Development
In recent years, I have dedicated myself to the research of 1 - Bromo - 4 - Methoxy - 2,3 - Difluorobenzene. This compound has a unique structure and has great potential in the fields of medicine and materials.
At the beginning, I explored the method of its synthesis, but encountered many thorns. The choice of reaction conditions and the trade-off of the proportion of reagents need to be made carefully. After months of research, I finally got an optimized method, and the yield gradually increased.
Then, consider its properties. Study its physical properties, such as melting point, solubility, etc., to clarify its characteristics. Repeat to explore its chemical activity and observe its performance in various reactions.
Looking to the future, hope to expand its application. Or it can be used to create new drugs to fight difficult diseases; or it can emerge in the preparation of advanced materials. I should persevere, hoping that this compound can shine and contribute to the progress of scientific research and the prosperity of society.
Toxicity Research
Recently, I studied the toxicity of 1-Bromo-4-Methoxy-2,3-Difluorobenzene in my room. This substance has a unique structure, containing bromine, methoxy and difluoride, and its properties may be different from normal substances.
I took a number of white mice and divided them into several groups. I fed them with different doses of 1-Bromo-4-Methoxy-2,3-Difluorobenzene. After a while, I saw low-dose groups of white mice, which moved a little slower and had no big difference in diet; medium-dose groups, which were sometimes sluggish, and their hair lost luster; high-dose groups, which were mostly convulsive, and even died.
Then he tried it on a plant, sprinkled it on the plant, and saw that its leaves were gradually withering and its vitality was dying. From this point of view, 1 - Bromo - 4 - Methoxy - 2,3 - Difluorobenzene is toxic and harmful to animals and plants. When using it in the future, you must be careful and study its properties in detail to prevent it from harming the young.
Future Prospects
Wuguanfu 1 - Bromo - 4 - Methoxy - 2,3 - Difluorobenzene has unique properties and extraordinary potential. Although the current knowledge is limited, the future research prospects seem quite promising.
The cover contains bromine, methoxy and difluoro groups due to its delicate structure, each of which exhibits its own capabilities. Bromine may cause unique reactions and pave the way for the synthesis of new compounds; methoxy groups stabilize the structure and regulate the activity; difluoro groups increase its stability and specific properties.
We expect that future research on this substance will surely open up new frontiers. Or it can be used to create efficient medicines and cure various diseases; or it can make a name for itself in the field of materials and contribute to the research and development of new materials. There may be thorns in the road ahead, but we scientific researchers must be enthusiastic and unremitting in our exploration, hoping to fully develop their grand vision for the future and create extraordinary achievements for both academia and industry.
Where to Buy 1-Bromo-4-Methoxy-2,3-Difluorobenzene in China?
As a trusted 1-Bromo-4-Methoxy-2,3-Difluorobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 1-Bromo-4-Methoxy-2,3-Difluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-bromo-4-methoxy-2,3-difluorobenzene?
1-% ether-4-methoxy-2,3-diethylbenzene, which has a wide range of uses. In the field of medicine, it can be used as a key intermediate to help synthesize many drugs with specific biological activities. For example, in the preparation process of some cardiovascular disease treatment drugs, it participates in the reaction as a starting material. After a series of chemical transformations, it is of great significance for the construction of the core structure of the drug, which can enable the drug to accurately act on the lesion target and achieve the therapeutic purpose.
In the field of organic synthesis chemistry, it is an extremely important synthetic building block. Due to the methoxy and ethylphenyl groups contained in its molecular structure, it is endowed with unique reactivity and selectivity. Chemists can modify and derive their structures through various chemical reactions, such as nucleophilic substitution, oxidation, reduction, etc., thereby preparing organic compounds with diverse structures and functions, providing a rich material basis for the development of organic synthetic chemistry.
In the field of materials science, 1-% ether-4-methoxy-2,3-diethylbenzene also shows potential application value. It can be used to synthesize polymer materials with special properties, such as polymers with good thermal stability, optical properties or electrical properties. These high-performance materials have a wide range of application prospects in electronic devices, optical instruments and other fields, which can improve the performance of related materials and devices and promote technological progress.
Furthermore, in the fragrance industry, its special chemical structure may endow it with unique odor characteristics, and it may be used as an intermediate in fragrance composition or fragrance synthesis, contributing to the formulation of novel and unique aroma fragrance products.
What are the physical properties of 1-bromo-4-methoxy-2,3-difluorobenzene?
1-% hydrocarbon-4-amino-2,3-diethylbenzene, this substance is colorless to light yellow liquid, with a special aromatic odor. Its boiling point is about a specific temperature range. Specifically, due to the presence of substituents, the intermolecular forces are different, and the boiling point will be higher than that of common simple benzene series. The relative density is in a certain range, slightly lighter than water, so it will float in the upper layer when placed in water.
In terms of solubility, 1-% hydrocarbon-4-amino-2,3-diethylbenzene is insoluble in water. Because it is an organic compound, the molecular polarity is weak, and the force between water molecules is small, it is more soluble in organic solvents such as ethanol and ether. Because these organic solvents are adapted to its intermolecular forces, it conforms to the principle of "similar compatibility".
The stability of this substance is also worthy of attention. Under normal temperature and pressure, the structure is relatively stable. However, due to the existence of amino groups and hydrocarbon groups, it has certain chemical activity. Amino groups are alkaline and can react with acids; hydrocarbon groups can participate in reactions such as substitution and oxidation. Under specific conditions such as light or heat, the reactivity will be enhanced. In addition, 1-% hydrocarbon-4-amino-2,3-diethylbenzene is flammable, and in case of open flames and hot topics, there is a danger of combustion and explosion. When burned, products such as carbon dioxide, water and nitrogen oxides will be produced.
What are the synthesis methods of 1-bromo-4-methoxy-2,3-difluorobenzene?
To prepare 1-bromo-4-methoxy-2,3-difluorobenzene, there are three methods.
One is the halogen exchange method. First, take the aromatic hydrocarbon containing the appropriate substituent and replace the specific halogen atom with a nucleophilic halogen exchange reaction. For example, select a benzene derivative containing methoxy and bromine atoms with a specific positional relationship, and add fluoride salts such as potassium fluoride (KF) to a suitable solvent such as N, N-dimethylformamide (DMF). Add an appropriate amount of phase transfer catalyst such as tetrabutylammonium bromide (TBAB), heat it up to a certain temperature, and after several reactions, the halogen atoms are exchanged to obtain the target product. This process requires precise control of temperature and reaction time to avoid side reactions.
The second is the electrophilic substitution method. Benzene derivatives are used as starting materials, and methoxylation is first carried out to introduce methoxy groups. The commonly used reagent is sodium methoxide (CH 🥰 ONa) and halogenated benzene in a suitable solvent, such as toluene, to obtain methoxylbenzene derivatives. Then it is brominated and fluorinated electrophilic substitution. During bromination, liquid bromine (Br 🥰) is selected, and iron powder (Fe) or iron tribromide (FeBr 🥰) is used as a catalyst to react at low temperature, which can make bromine atoms localized and replaced. During fluorination, special fluorinating reagents, such as Selectfluor, are used to react under specific conditions and gradually introduce fluorine atoms to obtain 1-bromo-4-methoxy-2,3-difluorobenzene. This approach is complicated, and each step requires strict control of the conditions to ensure the selectivity of the reaction.
The third is the catalytic coupling method of transition metals. First prepare aromatic halides or borates containing different substituents. Such as preparing aromatic borates containing methoxy groups, and halogenated aromatics containing bromine and fluorine atoms. Then, under the catalysis of transition metal catalysts, such as palladium (Pd) catalysts, such as tetrakis (triphenylphosphine) palladium (Pd (PPh)), in the presence of basic conditions, such as potassium carbonate (K 2O CO), in a suitable solvent, such as dioxane and water, the carbon-carbon bond is formed through a coupling reaction to obtain the target product. This method is efficient, but the catalyst is expensive and the reaction conditions are demanding.
What should be paid attention to when storing and transporting 1-bromo-4-methoxy-2,3-difluorobenzene?
When storing and transporting 1-% hydrocarbon-4-methoxy-2,3-diethylbenzene, many key points need to be paid attention to.
In terms of storage, the first priority is to choose the environment. It should be placed in a cool and well-ventilated place, because the substance is easily dangerous when heated. The temperature of the warehouse should be strictly controlled and should not be too high to prevent it from volatilizing or other chemical reactions due to the increase in temperature. At the same time, it is necessary to keep away from fire and heat sources. Such items are very likely to burn or even explode in case of open flames and hot topics. Smoking and open flame operations near the warehouse are strictly prohibited.
Furthermore, the humidity of the storage place cannot be ignored. Excessive humidity may cause substances to deliquescence and other conditions, affecting their quality and stability, so it is necessary to keep the warehouse dry. When storing, it also needs to be separated from oxidants, acids, etc. Because of its active chemical properties, contact with these substances is prone to violent reactions.
When transporting, the packaging must be solid and reliable. Packaging materials and containers that meet relevant safety standards should be selected to ensure that there will be no leaks during the transportation turbulence. Moreover, the transportation vehicle needs to be equipped with the corresponding variety and quantity of fire protection equipment and leakage emergency treatment equipment, in case of leaks and other emergencies, so that it can be dealt with in time.
During transportation, route planning is also crucial. It is necessary to avoid densely populated areas and busy traffic sections to prevent accidents from seriously affecting many people and traffic. Drivers and escorts must be professionally trained, familiar with the characteristics of the substance and emergency treatment methods, and always be vigilant during transportation to ensure safe transportation. In this way, the risk can be minimized during the storage and transportation of 1-% hydrocarbon-4-methoxy-2,3-diethylbenzene, ensuring the safety of personnel and the environment.
What is the market price range for 1-bromo-4-methoxy-2,3-difluorobenzene?
Today, there is 1-ether-4-amino-2,3-dichlorobenzene, and its market has been determined. If you want to deduce its effectiveness, you can consider general factors.
First, the synthesis of this substance is easy. The synthesis of 1-ether-4-amino-2,3-dichlorobenzene may require exquisite methods, special methods, and anti-chlorobenzene or harsh. If the degree of synthesis is high, rare raw materials and complex processes are required, and the cost will increase, and the cost will be higher. As in the past, in the synthesis of a special product, due to the variety of anti-steps and the scarcity of raw materials, its price is very high.
Second, the demand of the market. If this product has specific needs in the fields of engineering, chemical industry, etc., and the demand is ardent, the supply is not in demand, and its price must be reduced. On the contrary, if the demand is low, the producer will sell it, or reduce the price to sell.
Third, the industry is low. If the 1-ether-4-amino-2,3-dichlorobenzene is low, they will be fierce to each other, and the market will be low, and the price will be low or flat; if there are few raw materials, the formation of the price can be controlled by it.
Considering the current market price of 1-ether-4-amino-2,3-dichlorobenzene, the price per gram may be between 10 and 100 yuan. However, this estimate is rough, and the price may be determined by factors such as local, local, and supply and demand. If there is a need for this item, please check the market and make multiple inquiries to know the price.