1-Bromo-4-Fluorobenzene

Hongda Chemical

Specifications

HS Code	754275
Chemical Formula	C6H4BrF
Molar Mass	175.00 g/mol
Appearance	Colorless to light yellow liquid
Boiling Point	150 - 152 °C
Melting Point	-27 °C
Density	1.579 g/cm³
Solubility In Water	Insoluble
Flash Point	46 °C
Refractive Index	1.5445
Vapor Pressure	1.17 mmHg at 25 °C

As an accredited 1-Bromo-4-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	1 - bromo - 4 - fluorobenzene packaged in 500 - gram bottles for chemical use.
Storage	1 - Bromo - 4 - fluorobenzene should be stored in a cool, well - ventilated area, away from heat sources and open flames. Keep it in a tightly sealed container to prevent leakage and vapor escape. Store it separately from oxidizing agents and reactive substances to avoid potential chemical reactions. Follow proper safety protocols and label storage containers clearly.
Shipping	1 - bromo - 4 - fluorobenzene is shipped in well - sealed, corrosion - resistant containers. It follows strict hazardous chemical shipping regulations, ensuring proper labeling, secure packaging to prevent leaks during transport.

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General Information

Historical Development

1 - Bromo - 4 - Fluorobenzene is also an organic compound. Its historical development, at the beginning, the chemical sages studied and explored. At first, only a little bit of its molecular structure was known, and scholars have been working hard for many years to measure it by various experimental methods.
In the early days, it was difficult to separate and purify, and the obtained product was not pure. However, chemists are determined to improve their methods and gradually obtain pure 1 - Bromo - 4 - Fluorobenzene. With the passage of time, the precision of the instrument has risen, and the understanding of its structure has deepened.
Synthesis in the past, the steps were complicated and the yield was low. Chemists continue to improve the path, and new catalysts are introduced, resulting in milder reaction conditions and a significant increase in yield. Today, 1-Bromo-4-Fluorobenzene is widely used in materials, medicine and other fields. Its historical development is a testament to the wisdom and perseverance of chemists.

Product Overview

1 - Bromo - 4 - Fluorobenzene is an organic compound. It is a colorless liquid with a special odor. In this compound, bromine (Bromo) and fluorine (Fluor) atoms are attached to the benzene ring in a specific structure.
Looking at its properties, it has a certain chemical activity. Due to the electronegativity difference between bromine and fluorine, the molecule is polarized, which has a great impact on its physical and chemical properties. In the field of organic synthesis, 1 - Bromo - 4 - Fluorobenzene is widely used. Bromine atoms are highly active, and other functional groups can be introduced through substitution reactions to build complex organic molecular structures. The presence of fluorine atoms can change the electron cloud distribution of molecules, affecting their reactivity and biological activity.
In chemical production, 1-Bromo-4-Fluorobenzene is often prepared by a specific process. The reaction conditions, such as temperature, pressure, and the proportion of reactants, need to be precisely controlled to ensure the purity and yield of the product. Due to its special structure and properties, it has shown important application value in many fields such as medicine, pesticides, and materials science, providing strong support for the development of related fields.

Physical & Chemical Properties

1 - Bromo - 4 - Fluorobenzene is also an organic compound. Its physical and chemical properties are quite important to chemists.
Looking at its physical properties, at room temperature, this substance is in a liquid state, with a clear and transparent color. Its boiling point is suitable, which is convenient for separation and purification. As for the melting point, it is also a specific value, which is one of the key characteristics to identify this compound. Its density is moderate, which is related to its distribution and behavior in solvents.
On its chemical properties, it is unique because it contains two atoms of bromine and fluorine. Bromine atoms can lead to nucleophilic substitution reactions. Although fluorine atoms have high electronegativity, they make the electron clouds of molecules different and affect the orientation of the reaction. In the field of organic synthesis, this compound is often an important raw material. It can be converted into other valuable products through various reaction paths, and has potential applications in medicine, materials and other industries. Chemists often study its properties, hoping to expand its application scope and benefit the world.

Technical Specifications & Labeling

1 - Bromo - 4 - Fluorobenzene is an organic compound, and it is crucial to its technical specifications and identification (product parameters). Its technical specifications, the first purity, must reach a very high standard, and the impurity content must be strictly controlled to avoid affecting subsequent reactions and product performance. Appearance is also important, and it should be in a colorless and transparent liquid state, with no visible foreign matter.
As for the label, the chemical name "1 - Bromo - 4 - Fluorobenzene" must be clearly marked, and it cannot be confused. In terms of product parameters, accurately indicate the molecular weight, density, boiling point and other data. In this way, users can properly use it in various fields such as chemical synthesis and pharmaceutical research and development according to their characteristics, ensuring safe and accurate operation, and enabling the product to play its due role in the chemical process.

Preparation Method

1 - Bromo - 4 - Fluorobenzene is a compound commonly used in organic synthesis, and its preparation method is very important.
In the selection of raw materials, p-fluoroaniline can be used as the starting material. The preparation process is as follows: First, p-fluoroaniline is reacted with hydrobromic acid and sodium nitrite at low temperature. This step requires precise temperature control to ensure a smooth reaction. After forming the diazonium salt, cuprous bromide is added as a catalyst to promote the substitution of the diazonium group by the bromine atom to obtain 1 - Bromo - 4 - Fluorobenzene.
The reaction steps are rigorous and orderly. If the temperature is too high during the diazotization reaction, the diazonium salt is easy to decompose, resulting in a decrease in the yield of the product. When adding cuprous bromide catalysis, the dosage should be appropriate to ensure the efficient substitution reaction.
In addition, the reaction device needs to be well sealed to prevent the escape of harmful gases. When the product is separated and purified, conventional methods such as distillation and extraction can be used to obtain high-purity 1-Bromo-4-Fluorobenzene to meet the needs of subsequent scientific research or production.

Chemical Reactions & Modifications

1 - Bromo - 4 - Fluorobenzene is also an organic compound. In the field of chemistry, its reaction and modification are often studied by scholars.
Looking at its reaction, the way of nucleophilic substitution can cause special changes due to the different activities of halogen atoms. The activity of bromine is higher than that of fluorine, and nucleophilic reagents are easy to attack the bromine site, so that new bonds are generated and the structure is changed.
On its modification, introduce other groups to reduce its properties. Or add carbon functional groups to form a complex structure and change its physical and chemical properties, such as the genera of melting boiling point, solubility and reactivity. Or adjust it by electronic effect to make the charge distribution different, so as to meet the needs of diverse synthesis.
The reaction and modification of this compound is a method for increasing samples in organic synthesis, and it has promising applications in the fields of medicine and materials. Therefore, it is the focus of chemical researchers, and it is not limited to exploring, hoping to expand its potential.

Synonyms & Product Names

1 - Bromo - 4 - Fluorobenzene is also a chemical substance. Its synonymous name and the name of the commodity are quite elegant.
In the academic world, it may be called p-bromofluorobenzene, which is named according to its chemical structure position. The word "pair" indicates the relative position of bromine and fluorine in the benzene ring.
In the business world, there are also those who call it by a specific trade name. However, it is inseparable from its chemical essence. This substance is widely used in various fields of chemical industry. It can be used as a synthetic intermediate to produce various fine chemicals.
Its synonymous name and trade name, although the names are different, they all refer to this thing. For researchers, being familiar with its various titles allows them to navigate freely between academic exchanges and industrial applications, avoiding ambiguity and facilitating the smooth flow of chemical research and industrial production.

Safety & Operational Standards

1 - Bromo - 4 - Fluorobenzene is also a chemical substance. During its experimental preparation and use, safety and operating practices are of paramount importance.
First of all, it is related to safety. This substance has certain chemical activity, or poses potential hazards to the human body and the environment. Therefore, in the operating site, good ventilation facilities are necessary to prevent the accumulation of volatile gaseous substances, which can cause inhalation by the operator and damage the respiratory organs. Operators should also wear appropriate protective equipment, such as laboratory clothes, gloves and protective glasses, to prevent the substance from contacting the skin and eyes, causing discomfort and even injury.
Furthermore, the operating practices are discussed. When weighing, it is necessary to use a precise weighing instrument to ensure that the amount taken is accurate. During the reaction process, the reaction conditions, such as temperature, pressure and reaction time, are strictly controlled. Due to high or low temperature, the reaction may deviate from the expected path, or the reaction rate may be too slow or too fast, affecting the purity and yield of the product. Stirring must also be uniform and moderate, so that the reactants can be fully contacted to promote the smooth progress of the reaction.
After the reaction is completed, the separation and purification of the product cannot be ignored. Appropriate methods, such as distillation, extraction, recrystallization, etc., should be selected according to their physical and chemical properties to obtain high-purity 1-Bromo-4-Fluorobenzene. And the experimental waste should be properly disposed of in accordance with regulations and should not be discarded at will to avoid polluting the environment.
All these safety and operation standards are the key to ensuring the smooth development of 1-Bromo-4-Fluorobenzene related experiments, while ensuring the safety of personnel and the environment. It must not be taken lightly.

Application Area

1 - Bromo - 4 - Fluorobenzene is also an organic compound. Its application field is quite wide. In the field of pharmaceutical synthesis, it is often a key intermediate. Because of its unique structure, it can participate in a variety of chemical reactions and help create special drugs. For example, when preparing some anti-cancer drugs, this compound can introduce key structures through subtle reactions, making the drug more targeted, accurately acting on cancer cells, reducing its damage to normal cells.
In the field of materials science, it also has important uses. It can be used to synthesize polymer materials with special properties, such as polymers with excellent photoelectric properties. After clever polymerization, the structure is integrated into the polymer chain, so that the material can be used in optoelectronic devices, such as organic Light Emitting Diode (OLED), solar cells and other fields, showing excellent performance, improving device efficiency and stability. This is also a significant performance in the 1 - Bromo - 4 - Fluorobenzene application field.

Research & Development

In the field of chemical industry, new substances emerge from the layer. Among all kinds of reagents, 1-Bromo-4-Fluorobenzene can be studied in particular. Our generation studied its properties to understand its effectiveness in chemical industry.
At the beginning, explore the method of its preparation, and examine all the paths in detail. Or from the benzene ring, ingeniously introduce bromine and fluorine to find the best reaction conditions, hoping to obtain a high yield method. The temperature of the reaction, the length of time, and the choice of catalyst are all key.
Second, its properties, physical state, degree of melting, and solubility in various solvents are all concerned. Its chemical activity and the possibility of reacting with other substances are all discussed in detail.
As for the field of application, think of it in drug synthesis, or as a key intermediate, to help create new drugs. In the research and development of materials, it may also give new energy to materials. Future development, when tapping its potential, expand the boundaries of application, for the development of chemical industry, science and technology, exhaust our efforts, and hope to achieve new achievements, in order to benefit the world.

Toxicity Research

1 - Bromo - 4 - Fluorobenzene Toxicity Study
Taste of chemical substances, its sex is unpredictable, and its impact on the human body and the environment cannot be ignored. This study of 1 - Bromo - 4 - Fluorobenzene this substance to explore its toxicity.
If this substance enters the human body, or damages the internal organs. Absorbed through the skin, it can cause skin discomfort, erythema, and itching. If ingested orally, it may hurt the stomach, cause abdominal pain, and vomiting. And its air enters the lungs, or harms the respiratory system, causing cough and asthma.
As for the environment, it is scattered in water and soil, or is a harmful organism. Aquatic people, meet or die; vegetation in the soil, touch or decay. Its sexual stability, long-term accumulation is difficult to eliminate, tired of the environment, far-reaching harm.
Therefore, the toxicity of 1 - Bromo - 4 - Fluorobenzene is related to human safety. It is necessary to be careful. We must investigate its harm carefully in order to take precautions and ensure people's peace.

Future Prospects

1 - Bromo - 4 - Fluorobenzene is also an organic compound. Looking at the current development of chemistry, its future prospects are quite promising.
In the field of materials science, it may be possible to make novel functional materials with its unique structure. With its halogenated aromatics, or in polymerization reactions, it can contribute to the construction of polymer materials with special structures, which can be used in electronic devices, optical materials, etc., so that the device performance is better and the performance is better.
In pharmaceutical chemistry, this compound may become an important synthetic building block. The characteristics of its structure can be introduced into drug molecules to change the physical and chemical properties of drugs, improve their biological activity, solubility and stability, and bring hope for the creation of new specific drugs.
And with the popularity of green chemistry concepts, the development of more environmentally friendly and efficient synthesis methods of 1-Bromo-4-Fluorobenzene is also a major trend in the future. It is expected to reduce energy consumption, reduce waste generation, and meet the grand purpose of sustainable development. All of these demonstrate its unlimited potential for future development, which is an existence that cannot be ignored in the field of chemical research.

Where to Buy 1-Bromo-4-Fluorobenzene in China?

As a trusted 1-Bromo-4-Fluorobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.

Frequently Asked Questions

As a leading 1-Bromo-4-Fluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-Bromo-4-Fluorobenzene?

1-Bromo-4-fluorobenzene is also an organic compound. It has a wide range of uses and is important in various fields.
First, in the field of medicinal chemistry, this compound is often a key intermediate. Due to the special chemical properties of bromine and fluorine, the molecule can have unique activities and properties. In terms of synthesizing specific drugs, chemists can skillfully construct complex drug molecular structures through the functional groups of 1-bromo-4-fluorobenzene. For example, it can be combined with other compounds containing active groups through specific chemical reactions to generate drugs with specific pharmacological activities, or for antibacterial, antiviral, or therapeutic effects on specific diseases.
Second, in materials science, 1-bromo-4-fluorobenzene also has a place. When preparing special polymer materials, this compound can be introduced. The presence of fluorine atoms can significantly improve the stability, corrosion resistance and heat resistance of the material. For example, when preparing high-performance engineering plastics or insulating materials for electronic devices, the materials prepared by the reaction of 1-bromo-4-fluorobenzene can meet higher environmental requirements and performance standards.
Third, in the field of pesticide chemistry, its use should not be underestimated. The atomic properties of bromine and fluorine can endow the prepared pesticides with excellent biological activity. Taking synthetic insecticides as an example, compounds based on 1-bromo-4-fluorobenzene synthesis have efficient poisoning effects on pests, and can control drug residues and environmental impacts to a certain extent, achieving the purpose of high efficiency and low toxicity.
In summary, 1-bromo-4-fluorobenzene is an indispensable raw material in many fields such as medicine, materials, and pesticides, and it has an important role in promoting the development of various industries.

What are the physical properties of 1-Bromo-4-Fluorobenzene?

1-Bromo-4-fluorobenzene is also an organic compound. It has unique physical properties, let me tell you one by one.
Looking at its appearance, under room temperature and pressure, it is mostly colorless to light yellow liquid, clear and has a special smell. Although this smell is not pungent or intolerable, it is also different from common odorless substances. Those with a keen sense of smell can easily detect it.
When it comes to the melting point, its melting point is about -27 ° C, and the boiling point is between 150-151 ° C. The low melting point makes it a liquid at room temperature, which is similar to many organic halides. The boiling point is in such a range, indicating that its relative volatility is moderate, neither highly volatile such as ether nor difficult to volatilize.
In terms of density, it is about 1.57 g/mL (at 25 ° C), which is heavier than water. If it is placed in a container with water, it will sink to the bottom of the water. This is due to the difference in density.
In terms of solubility, 1-bromo-4-fluorobenzene is insoluble in water. Due to its molecular structure, the presence of bromine and fluorine atoms makes the molecular polarity limited, and it is difficult to form a strong interaction with water molecules, so it is not easily soluble in water. However, it is soluble in many organic solvents, such as ethanol, ether, acetone, etc. This is due to the principle of "similar miscibility". The molecular structure of organic solvents is similar to that of 1-bromo-4-fluorobenzene, and the force between them is appropriate, so they are mutually soluble.
Furthermore, the vapor pressure of 1-bromo-4-fluorobenzene also has its value at a specific temperature, which is related to its equilibrium situation in the gas and liquid phases, and its volatility and diffusivity in different environments.
From the above, the physical properties of 1-bromo-4-fluorobenzene are important considerations in many fields such as organic synthesis and chemical production, which affect the way it is prepared, stored, transported, and applied.

What is the chemistry of 1-Bromo-4-Fluorobenzene?

1-Bromo-4-fluorobenzene is also an organic compound. In its molecule, bromine and fluorine are in alignment with phenyl rings. This unique structure gives it specific chemical properties.
On its chemical activity, 1-bromo-4-fluorobenzene can be involved in many chemical reactions due to the existence of halogen atoms. Bromine atoms have good activity and are often attacked by nucleophiles in nucleophilic substitution reactions. They leave and bond with nucleophiles. For example, when encountering hydroxyl negative ions, bromine can be replaced by hydroxyl groups to obtain p-fluorophenol. This reaction is more likely to occur in an alkaline environment and at a suitable temperature.
Although fluorine atoms are highly electronegative, they are more difficult to participate in nucleophilic substitution reactions on benzene rings than bromine. However, under certain conditions, such as strong nucleophilic reagents and high temperatures, fluorine can also be replaced. In addition, the benzene ring of 1-bromo-4-fluorobenzene is aromatic and can undergo electrophilic substitution reactions. Because the halogen atom is an ortho-para-site, the new electrophilic reagent attacks the ortho or para-site of the benzene ring. For example, when reacting with bromine elemental matter catalyzed by iron bromide, another bromine atom can be introduced into the benzene ring, and the main products are 1,2-dibromo-4-fluorobenzene and 1-bromo-3,4-di
Because of its halogen-containing atoms, 1-bromo-4-fluorobenzene can be used to construct carbon-carbon bonds. For example, under the catalysis of palladium, coupling reactions occur with carbon-containing nucleophiles, which is an important means to construct complex molecular structures in organic synthesis. In summary, 1-bromo-4-fluorobenzene has rich chemical properties and is widely used in the field of organic synthesis. It is a key raw material for the preparation of various fine chemicals, drugs, etc.

What are 1-Bromo-4-Fluorobenzene synthesis methods?

The synthesis method of 1-bromo-4-fluorobenzene has been used in ancient times, and now it is Junchen.
First, p-fluoroaniline is used as the starting material. The diazotization reaction of p-fluoroaniline with sodium nitrite and hydrochloric acid at low temperature is a key step, and the temperature needs to be carefully controlled to prevent accidents. After forming a diazonium salt, it is then co-heated with the hydrobromic acid solution of cuprous bromide and reacted by Sandmeier to obtain 1-bromo-4-fluorobenzene. This approach step is slightly complicated, but the yield is acceptable, and it needs fine operation to achieve the desired effect.
Second, starting from p-fluorobrobenzene. In the presence of suitable catalysts, such as some transition metal catalysts, react with fluorinated reagents. This reaction condition is very critical, and the temperature, pressure and catalyst dosage need to be precisely regulated. Through nucleophilic substitution reaction, fluorine atoms replace groups at specific positions on the benzene ring to obtain 1-bromo-4-fluorobenzene. This method is relatively simple, but the reaction conditions are demanding and need to be carefully considered.
Third, benzene is used as the initial material. The benzene is brominated first, so that bromine atoms are introduced into the benzene ring, and then the fluorination reaction is carried out. In this process, the sequence of bromination and fluorination and the control of reaction conditions are crucial. Pre-bromination can make the subsequent fluorination reaction have a certain selectivity, but it is necessary to pay attention to the occurrence of side reactions. After multi-step reaction, 1-bromo-4-fluorobenzene is finally obtained. Although this route has many steps, the raw materials are easy to obtain, and it is also a commonly used method.
All this synthesis method has advantages and disadvantages. It needs to be comprehensively weighed according to actual demand, raw material availability and cost, and a careful choice can be made to synthesize 1-bromo-4-fluorobenzene efficiently.

What 1-Bromo-4-Fluorobenzene need to pay attention to when storing and transporting

1-Bromo-4-fluorobenzene is also an organic compound. During storage and transportation, many matters need to be paid attention to.
First words storage, this compound should be placed in a cool and ventilated warehouse. Due to high temperature or poor air circulation, or its properties change. And must be away from fire and heat sources, both of which can cause danger, such as combustion or even explosion. Because of its certain chemical activity, it is easy to react in case of heat or open flame.
Furthermore, it should be stored separately from oxidants, alkalis, etc., and must not be mixed. Borderline oxidants and alkalis can chemically react with 1-bromo-4-fluorobenzene, or cause dangerous conditions, such as generating harmful gases and causing fires. In the warehouse, there should also be suitable materials for containing leaks, in case of leakage, which can be dealt with in time to prevent its spread from causing greater harm.
As for transportation, make sure that the container is well sealed before transportation, and there is no risk of leakage. During transportation, make sure that the container does not collapse, fall, or damage. Transportation vehicles should also be equipped with the corresponding variety and quantity of fire fighting equipment and leakage emergency treatment equipment. The choice of driving routes is also crucial, and it is necessary to avoid densely populated areas and traffic arteries to prevent injuries to many people in case of accidents.
In conclusion, 1-bromo-4-fluorobenzene should be stored and transported with caution in terms of the environment, item isolation, container status, and emergency preparedness, so as to ensure safety and avoid disasters.