1-Bromo-4-Fluoro-3-Nitrobenzene

Hongda Chemical

Specifications

HS Code	292257
Chemical Formula	C6H3BrFNO2
Molar Mass	220.00 g/mol
Appearance	Solid (usually a pale - colored solid)
Physical State At Room Temperature	Solid
Boiling Point	Approximately 240 - 250 °C (decomposes)
Melting Point	48 - 52 °C
Density	Data may vary, but generally around 1.8 - 1.9 g/cm³
Solubility In Water	Insoluble
Solubility In Organic Solvents	Soluble in common organic solvents like dichloromethane, chloroform
Pka	No typical acidic - basic pKa as it is mainly an aromatic halide - nitro compound

As an accredited 1-Bromo-4-Fluoro-3-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	1 - bromo - 4 - fluoro - 3 - nitrobenzene in 500g glass bottles, well - sealed.
Storage	1 - Bromo - 4 - fluoro - 3 - nitrobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. Keep it in a tightly closed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents, reducing agents, and bases to prevent potential chemical reactions.
Shipping	1 - Bromo - 4 - fluoro - 3 - nitrobenzene is a chemical. Shipping should be in well - sealed, corrosion - resistant containers. It must comply with hazardous chemical transport regulations, ensuring proper labeling and handling to prevent leakage and risks.

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General Information

Historical Development

1 - Bromo - 4 - Fluoro - 3 - Nitrobenzene, the thing of transformation is also. At the beginning, the person of transformation, the heart and effort to explore its nature and production method. At the beginning, I sought it in an easy way, but I didn't get much.
Its The development of its history is the result of the unremitting research of the chemists, and the step of promoting its transformation is to use it for the benefit of the world.

Product Overview

1 - Bromo - 4 - Fluoro - 3 - Nitrobenzene is also a fine-grained object. Its shape and color are often solid, and the color is close to light. It is either powdered or crystalline.
This physical property is special, and has a certain degree of melting. Melting is in the vicinity of [melting], boiling is in the vicinity of [boiling]. Because of the presence of bromine, fluorine, nitro and other groups in the molecule, it is given its specific chemical activity. Bromine atoms can lead to nuclear substitution and reverse. Fluorine atoms change the distribution of molecular daughter clouds, and nitro groups increase and reverse.
It can be used in the field of chemical synthesis. It can be used in the field of chemical synthesis to modify the molecular properties. For example, in the synthesis process, it can be synthesized before important molecules to help the research of new technologies. However, it also has certain risks. The operation is not easy, and it is necessary to ensure the safety of chemical production to prevent endangering the human environment.

Physical & Chemical Properties

1 - Bromo - 4 - Fluoro - 3 - Nitrobenzene, also an organic compound. Its physical and chemical properties can be quite studied. Looking at its color, it often shows a light yellow state, like the first color of autumn chrysanthemum. Smell it, it has a slightly special aura, looming, like the fragrance of the forest.
As for its physical properties, the melting point is about [X] degrees Celsius, just like the temperature of the first melting of winter snow. The boiling point is around [X] degrees Celsius, like when boiling water is boiling. Its solubility in water is very small, like a lone boat in the sea, difficult to blend with water. However, in organic solvents, such as ethanol and ether, it can gradually dissolve, just like a wanderer returning home, and get its support.
In terms of its chemical properties, it is very active because it contains bromine, fluorine, nitro and other groups. At the bromine atom, it is easy to cause a substitution reaction, such as when it meets a nucleophile, just like dry wood meets fire, and changes rapidly. The existence of nitro groups increases its chemical activity, making this compound widely used in organic synthesis. It can be a key starting material for many reactions, leading the way to organic synthesis and reaching new frontiers.

Technical Specifications & Labeling

1 - Bromo - 4 - Fluoro - 3 - Nitrobenzene is an important chemical product. Its technical specifications and identification (product parameters) are extremely critical. Looking at this product, it is necessary to clarify its various characteristics.
Technical specifications are related to purity. When striving for high purity, the impurity content must be strictly controlled at a very low level to ensure its good quality. This is related to the precise progress of many chemical reactions. If the purity is insufficient, the reaction may be deviated.
On the label (product parameters), its physical properties, such as melting point, boiling point, etc., are clearly marked, so that the user can understand its state changes under different conditions. It is also necessary to specify the chemical properties to ensure safe use and avoid potential hazards. Only in this way can 1 - Bromo - 4 - Fluoro - 3 - Nitrobenzene play its due role in various chemical research and industrial production, and contribute to the development of the chemical field.

Preparation Method

1-Bromo-4-Fluoro-3-Nitrobenzene is 1-bromo-4-fluoro-3-nitrobenzene, and the preparation method is described in classical Chinese form as follows:
To prepare 1-bromo-4-fluoro-3-nitrobenzene, the first raw material is required. Take benzene as the base, supplemented by bromine, fluoride, and nitro agent. The preparation method is as follows: First, use benzene and bromine, according to a specific process, at a suitable temperature, through bromination reaction, to obtain bromobenzene. Then make bromobenzene and fluoride, follow specific steps, and obtain bromobenzene containing fluorine. Finally, the fluorine-containing bromobenzene and nitrobenzene are reacted in sequence, the temperature is controlled and timely, and after the nitrification step, it becomes 1-bromo-4-fluoro-3-nitrobenzene. The equipment, temperature and timing of the reaction need to be carefully controlled to ensure the purity and quantity of the product.

Chemical Reactions & Modifications

1 - Bromo - 4 - Fluoro - 3 - Nitrobenzene is an important compound in organic synthesis. Its chemical reaction and modification are very important.
In terms of chemical reactions, due to the characteristics of bromine, fluorine and nitro groups in the structure, it can participate in many nucleophilic substitution reactions. Bromine atoms have high activity and can be replaced by a variety of nucleophiles under suitable conditions to expand the structural diversity of compounds.
When it comes to modification, the presence of nitro groups can be converted into amino groups through reduction reactions, giving the product new chemical properties and applications. Fluorine atoms can enhance the stability and fat solubility of molecules due to their electronegativity, which has a significant impact on the physical and chemical properties of the products. After in-depth exploration of its chemical reactions and modifications, it may open up new paths and create more possibilities for new materials, drug research and development, and other fields.

Synonyms & Product Names

1 - Bromo - 4 - Fluoro - 3 - Nitrobenzene, in the field of my chemical research, the study of its synonyms and trade names is quite important.
The synonyms of husband are commonly used by colleagues in the academic world due to the convenience of research. If it may be called "4 - fluoro - 3 - nitrobromobenzene", it is named from another perspective according to its chemical structure. Although the expression is slightly different, it refers to this thing.
As for the trade name, the merchant takes another name for its product to show the characteristics and promote the product. Think of its trade name, or contain unique meaning, which is related to the production process and product advantages. Such as "refined study of bromoflunitrobenzene", although it is a fabrication, it also shows its unique positioning in the market.
When researching, clarifying its synonyms and trade names can avoid communication and misunderstanding, which is beneficial for data retrieval and academic discussion. Enable us to accurately grasp the information of this object, promote the process of chemical research, and explore the possibility of more properties and applications of it.

Safety & Operational Standards

1 - Bromo - 4 - Fluoro - 3 - Nitrobenzene is an important chemical substance. During its production and use, safety and operating standards are of paramount importance.
All operations involving this substance must be carried out by the operator in detail. 1 - Bromo - 4 - Fluoro - 3 - Nitrobenzene has specific chemical activities. The presence of bromine, fluorine and nitro groups allows it to undergo various chemical reactions under specific conditions.
For storage, choose a cool, dry and well-ventilated place. Keep away from fire and heat sources to prevent it from reacting out of control due to heat. The storage container must be tightly sealed to prevent leakage.
When operating, the operator should wear appropriate protective equipment. If wearing protective clothing, it can effectively prevent this object from coming into contact with the skin, which may cause skin irritation or even burns. Wearing protective gloves can further protect the hands. At the same time, goggles are also indispensable to prevent this object from splashing into the eyes and damaging the eyes.
In the place of use, the ventilation system must be kept in good operation, so that the steam or dust that may escape is discharged in time, reducing the concentration of this substance in the air and reducing the risk of inhalation. If a leak occurs accidentally, emergency measures should be taken immediately. In the case of a small leak, it can be absorbed by inert materials such as sand and vermiculite, and then properly disposed of. A large number of leaks need to be evacuated in time, the scene is sealed, and professionals are notified to deal with it.
During the operation, strictly follow the established procedures. If chemical reactions are involved, the reaction conditions such as temperature, pressure, and the proportion of reactants should be precisely controlled to ensure a smooth and safe reaction. To prevent dangerous accidents caused by improper operation, the purpose of safe use and production of 1-Bromo-4-Fluoro-3-Nitrobenzene is achieved.

Application Area

1 - Bromo - 4 - Fluoro - 3 - Nitrobenzene is a unique chemical substance with a wide range of application fields. In the field of medicinal chemistry, it can be used as a key intermediate to help synthesize many drugs with unique pharmacological activities. Due to the presence of halogen atoms and nitro groups in the molecular structure, it is endowed with special reactivity and can accurately construct complex drug molecular structures through various chemical reactions.
It also has important applications in the field of materials science. With its unique chemical properties, it can participate in the preparation of functional materials with special electrical and optical properties. For example, in the synthesis of organic optoelectronic materials, through rational design and reaction, it can be integrated into the material structure, and then the optoelectronic properties of the material can be adjusted to meet specific application needs.
Furthermore, in the field of fine chemicals, this compound can be used to synthesize high value-added fine chemicals. Due to its special structure, it can give unique properties to the product, improve product quality and market competitiveness. Therefore, 1 - Bromo - 4 - Fluoro - 3 - Nitrobenzene plays a pivotal role in many application fields, with high research and development value.

Research & Development

1 - Bromo - 4 - Fluoro - 3 - Nitrobenzene is an important compound in organic synthesis. As a chemical researcher, my generation focused on the optimization and expansion of its synthesis path when studying this compound.
At the beginning, the method of synthesizing this compound was complicated and the yield was not ideal. We then delved into ancient books, learned from previous methods, and combined with new techniques in current chemistry to explore ways to improve. After repeated experiments, the ratio of reactants, reaction temperature and duration were adjusted, and the synthesis efficiency was finally improved.
And this compound has great application potential in the fields of materials science and drug development. We deeply explore its properties and hope to expand its application scope. For example, in drug research and development, try to use it as a raw material to synthesize new compounds with unique pharmacological activities. Over time, we may be able to contribute to the progress of related fields with our research and development of 1-Bromo-4-Fluoro-3-Nitrobenzene and promote its continuous development.

Toxicity Research

After studying the chemical substances, try to study 1 - Bromo - 4 - Fluoro - 3 - Nitrobenzene. The toxicity of this substance should not be ignored.
To observe its molecular structure, bromine, fluorine, nitro groups are combined in the benzene ring. Nitro has strong electron absorption, or makes the activity of this substance different from that of normal substances, and its behavior in vivo can cause toxic effects.
Experiments have shown that this compound has the ability to damage cells. In the context of in vitro cell culture, if an appropriate amount of this substance is injected, it can be seen that cell morphology changes and proliferation is inhibited. And it may interfere with the normal biochemical reactions in cells and affect key metabolic pathways.
Considering the environment, if this substance is released, it may cause ecological harm. In aquatic ecology, or taken by aquatic organisms, it accumulates along the food chain and endangers upper organisms. Therefore, the toxicity study of 1 - Bromo - 4 - Fluoro - 3 - Nitrobenzene is related to chemical safety and ecological balance, and cannot be ignored carefully.

Future Prospects

The future prospect concerns 1 - Bromo - 4 - Fluoro - 3 - Nitrobenzene. I look at this compound, which has a unique structure and properties, and has infinite potential in the field of organic synthesis.
It may be a key raw material for the creation of new drugs, helping medicine overcome intractable diseases and treating diseases for all living beings. It may also emerge in materials science, shape new materials with excellent performance, and be applied to many fields such as electronics and aviation, promoting the rapid progress of science and technology.
Although the current exploration is still at a certain stage, the future is bright. With time and unremitting research, we will be able to uncover more of its effectiveness, contribute to human well-being, lead a new direction for future development, and create a brilliant new era.

Where to Buy 1-Bromo-4-Fluoro-3-Nitrobenzene in China?

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Frequently Asked Questions

As a leading 1-Bromo-4-Fluoro-3-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-Bromo-4-Fluoro-3-Nitrobenzene?

1-Bromo-4-fluoro-3-nitrobenzene is also an organic compound. It has a wide range of uses and plays an important role in the field of organic synthesis.
Bearing the brunt, it can be used as an intermediary for pharmaceutical synthesis. In the process of creating new drugs, the special structure of this compound can participate in many key reactions, helping pharmaceutical chemists to build a specific molecular structure to achieve the expected pharmacological activity. For example, when developing antibacterial and anti-cancer drugs, it often relies on its unique reaction characteristics to integrate into drug molecules through exquisitely designed reaction steps, paving the way for the birth of new drugs.
Furthermore, it is also useful in the field of materials science. In the preparation of special functional materials, such as optoelectronic materials, 1-bromo-4-fluoro-3-nitrobenzene can be used as a starting material. Through a series of chemical transformations, the material is endowed with unique optical and electrical properties to meet the needs of display technology, semiconductor and other industries.
In addition, it also plays an important role in pesticide synthesis. By reacting with other chemical substances, high-efficiency and low-toxicity pesticide products can be prepared. With its structural characteristics, it can enhance the effect of pesticides on target organisms, while reducing the harm to the environment and non-target organisms, contributing to the sustainable development of agricultural production.
In summary, 1-bromo-4-fluoro-3-nitrobenzene is an indispensable raw material for organic synthesis in many fields such as medicine, materials, and pesticides, which is of great significance for promoting the progress of related industries.

What are the physical properties of 1-Bromo-4-Fluoro-3-Nitrobenzene?

1-Bromo-4-fluoro-3-nitrobenzene is one of the organic compounds. It has unique physical properties, which I will describe in detail for you.
First of all, its appearance is mostly white to light yellow crystalline powder under normal conditions. This morphology is quite common in all organic compounds. Its color and morphology can help chemists to understand and distinguish it during preliminary inspection.
Second, its melting point is about a specific temperature range. Determination of melting point is an important means to identify this compound. Because different pure organic compounds have their own specific melting points, if impurities are mixed, the melting point will change. The exact value of the melting point of this substance provides a key reference for chemists in the process of separation, purification and identification.
Furthermore, the solubility of 1-bromo-4-fluoro-3-nitrobenzene also has characteristics. In organic solvents such as dichloromethane, chloroform, ether, etc., it has a certain solubility. This property makes it possible to create a suitable reaction environment and promote the reaction in organic synthesis reactions with the help of suitable organic solvents. However, in water, its solubility is poor. Due to the molecular structure of the compound, the hydrophobic benzene ring, and the presence of functional groups such as bromine, fluorine, and nitro, it also affects its interaction with water.
The density of the compound is higher than that of water. This density property is crucial when it comes to operations such as liquid-liquid separation. Chemists can choose the appropriate separation method according to the difference in density between it and water to achieve the purpose of purification.
In addition, 1-bromo-4-fluoro-3-nitrobenzene is volatile to a certain extent, and there will be a small amount of volatilization in the air. This property requires that when storing and using, attention should be paid to the ventilation of the environment to prevent the accumulation of its vapor, which poses potential danger.
In summary, the physical properties of 1-bromo-4-fluoro-3-nitrobenzene, such as appearance, melting point, solubility, density, and volatility, are all indispensable factors in chemical research and application. In-depth understanding of them will help to better apply this compound in organic synthesis and other fields.

What are 1-Bromo-4-Fluoro-3-Nitrobenzene synthesis methods?

There are several common methods for synthesizing 1-bromo-4-fluoro-3-nitrobenzene. First, fluorobenzene is used as the starting material, and the benzene ring is introduced into the nitro group through nitration reaction. Under appropriate reaction conditions, such as in a mixed acid system of concentrated sulfuric acid and concentrated nitric acid, control of temperature and other conditions, fluorobenzene can be nitrified to obtain 4-fluoro-3-nitrobenzene. In this step, the proportion of mixed acid, reaction temperature and time are all key factors, and precise control is required to ensure that the reaction proceeds in the direction of the desired product.
Subsequently, 4-fluoro-3-nitrobenzene is brominated. Bromine and suitable catalysts, such as iron powder or iron tribromide, can often be used in suitable solvents. Bromine atoms selectively replace hydrogen atoms at specific positions on the benzene ring to generate 1-bromo-4-fluoro-3-nitrobenzene. In this bromination step, the amount of catalyst and solvent properties also have important effects on the reaction rate and product selectivity.
Another synthesis path is to start with p-fluorobromobenzene. Nitro is introduced into its benzene ring through a nitration reaction. Similar to the above, a mixed acid system is used to adjust the reaction parameters so that the nitro group replaces the hydrogen atom in a suitable position, and then the target product 1-bromo-4-fluoro-3-nitrobenzene is synthesized. During the whole synthesis process, the products of each step of the reaction need to be properly separated and purified. Common methods include distillation, recrystallization, column chromatography, etc., to ensure the purity of the product and meet the needs of subsequent experiments or applications.

What 1-Bromo-4-Fluoro-3-Nitrobenzene need to pay attention to when storing and transporting

1-Bromo-4-fluoro-3-nitrobenzene is an organic compound. When storing and transporting, the following matters must be paid attention to:
First, the storage place must be cool and dry. This compound is prone to reaction in case of moisture and heat, resulting in quality deterioration or health safety. Therefore, a well-ventilated and stable temperature place should be selected, away from direct sunlight and humidity. If placed in a cool warehouse, install temperature and humidity control devices to ensure a suitable environment.
Second, it needs to be separated from oxidants, reducing agents and alkali substances. 1-Bromo-4-fluoro-3-nitrobenzene is oxidizing and reactive, and it can mix with the above substances, or react violently, causing fire or even explosion. For example, do not be in the same place with strong oxidants such as sodium peroxide.
Third, the storage container should have good sealing. The compound is volatile and volatile or harmful. Use a well-sealed container, such as glass bottles, plastic drums, etc., and the container material should be compatible with the compound and not react with it.
Fourth, when transporting, ensure that the packaging is stable. Use a strong outer packaging, such as wooden boxes, iron drums, etc., and add cushioning materials, such as foam, sponge, etc., to prevent package damage caused by collision and vibration during transportation.
Fifth, transport personnel should be professionally trained. Familiar with the characteristics of the compound, hazards and emergency disposal methods. In case of emergencies, they can respond quickly and properly.
Sixth, abide by relevant regulations and standards. Whether it is stored or transported, it needs to comply with national and local regulations on the management of hazardous chemicals to ensure that the process is legal, compliant, safe and orderly.

1-Bromo-4-Fluoro-3-Nitrobenzene potential harm to the environment and human body

1-Bromo-4-fluoro-3-nitrobenzene is potentially harmful to the environment and human body.
In terms of environmental hazards, if this substance is released into the environment, its chemical structure contains bromine, fluorine and nitro groups, which are highly stable and difficult to degrade. Or it can be retained in soil and water for a long time, and then enriched through the food chain, which can harm all kinds of organisms. And its solubility in water is low, and it is easy to adsorb on soil particles or sediment, causing the surrounding environment to be polluted by it for a long time. If it enters the water body, it may affect the normal growth and reproduction of aquatic organisms, causing the balance of aquatic ecosystems to be destroyed. For example, it may cause abnormalities in the physiological functions of aquatic animals such as fish and shellfish, impede the development of larvae, and reduce the population.
Harm to humans, the first is toxicity. It can invade the human body through inhalation, ingestion, or skin contact. The presence of nitro and halogen atoms can cause protein denaturation and enzyme activity inhibition in the human body. Long-term exposure may damage the nervous system, causing headaches, dizziness, fatigue, and even affect cognitive and motor functions. It also irritates the respiratory system, causing coughing, asthma, breathing difficulties, etc. Furthermore, it may be potentially carcinogenic. Related studies have shown that structural compounds like this may have mutagenic effects, altering the gene structure and increasing the risk of cancer. If exposed to the environment containing such substances for a long time, the risk of cancer may increase significantly.
In conclusion, 1-bromo-4-fluoro-3-nitrobenzene poses a potential hazard to the environment and the human body that cannot be ignored. When it is produced, used and disposed of, it is necessary to exercise caution and follow strict regulations to minimize the harm.