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1-Bromo-4-Fluoro-3-Iodobenzene

1-Bromo-4-Fluoro-3-Iodobenzene

Hongda Chemical

Specifications

HS Code

876618

Name 1-Bromo-4-fluoro-3-iodobenzene
Molecular Formula C6H3BrFI
Molecular Weight 300.89
Appearance Liquid (likely, typical for such aromatic halides)
Boiling Point data needed (usually higher due to halogen atoms increasing intermolecular forces)
Melting Point data needed
Density data needed (higher than water due to heavy halogens)
Solubility In Water Low (organic aromatic halide, non - polar nature)
Solubility In Organic Solvents Good (e.g., in dichloromethane, chloroform, as it is non - polar)
Flash Point data needed
Vapor Pressure Low (heavy molecule with strong intermolecular forces)

As an accredited 1-Bromo-4-Fluoro-3-Iodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 1 - bromo - 4 - fluoro - 3 - iodobenzene packaged in a sealed glass bottle.
Storage 1 - bromo - 4 - fluoro - 3 - iodobenzene should be stored in a cool, dry, well - ventilated area away from sources of heat, ignition, and strong oxidizing agents. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials like glass. Store it in a dedicated chemical storage cabinet, segregated from incompatible substances to prevent potential reactions.
Shipping 1 - bromo - 4 - fluoro - 3 - iodobenzene is shipped in well - sealed, corrosion - resistant containers. Special care is taken to prevent breakage during transit due to its chemical nature. Shipment follows strict hazardous materials regulations.
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1-Bromo-4-Fluoro-3-Iodobenzene 1-Bromo-4-Fluoro-3-Iodobenzene
General Information
Historical Development
1 - Bromo - 4 - Fluoro - 3 - Iodobenzene, an organic compound. Tracing its origin, many chemists have worked tirelessly for years and years to achieve this result. At the beginning, it only existed in the field of theory, and everyone worked hard to explore the way of its synthesis with various techniques.
After countless attempts, after repeated experiments, they may not be discouraged by setbacks, or they may be happy with minor progress. From simple raw materials, through ingenious reactions, such as halogenation techniques, careful proportions, and precise control of their conditions, temperature and pressure are all about success or failure.
Over the years, the synthesis method has gradually improved, and the yield has also gradually increased. From micro-preparation in the laboratory to mass production on an industrial scale, the application of this compound is also increasing. In the fields of pharmaceutical research and development and materials science, it has emerged, adding a strong touch to the process of scientific research and development.
Product Overview
1 - Bromo - 4 - Fluoro - 3 - Iodobenzene is a crucial compound in the field of organic synthesis. Its molecular structure is unique, containing three halogen atoms of bromine, fluorine and iodine, which are cleverly distributed at specific positions in the benzene ring. The presence of bromine atoms endows the compound with good nucleophilic substitution activity, which can act as an active check point in many chemical reactions, providing the possibility for the introduction of various functional groups. Fluorine atoms have strong electronegativity, which can significantly affect the distribution of molecular electron clouds, change the physical and chemical properties of compounds, and improve their stability and reaction selectivity. Although iodine atoms are relatively large and active, they can be used as leaving groups in some reactions to promote the smooth progress of the reaction.
This compound is widely used in the field of medicinal chemistry, or can be used as a key intermediate for the synthesis of drug molecules with specific biological activities. In the field of materials science, it may participate in the preparation of materials with special optical and electrical properties. In short, 1-Bromo-4-Fluoro-3-Iodobenzene has shown high potential value in many chemical research and industrial production fields due to its unique structure, providing rich possibilities and broad research space for chemical synthesis and material research and development.
Physical & Chemical Properties
1 - Bromo - 4 - Fluoro - 3 - Iodobenzene is also an organic compound. Its physical and chemical properties are related to many aspects.
Looking at its physical properties, at room temperature, the substance may be in a solid state, with a specific color and state. Melting point and boiling point are all important characteristics of it. The melting point is related to the temperature at which the substance changes from solid to liquid state; the boiling point is the key temperature for liquification to gaseous state.
As for chemical properties, the presence of halogen atoms in its structure gives it unique reactivity. Bromine, fluorine, and iodine atoms enable the compound to participate in reactions such as nucleophilic substitution. Under appropriate reaction conditions, it can interact with nucleophiles, and halogen atoms are replaced to derive a variety of organic products. This compound provides an important cornerstone for the preparation of complex organic molecules in the field of organic synthesis, or due to its unique physical and chemical properties, which contributes to the in-depth exploration and development of organic chemistry.
Technical Specifications & Labeling
Today there is a product called 1 - Bromo - 4 - Fluoro - 3 - Iodobenzene. The technical specifications and labels for its preparation (commodity parameters) are related to the quality of this product and its wide range of uses.
The preparation of this product requires precise chemical procedures. From the selection of raw materials, it is necessary to be pure and free of impurities, and the proportion of quantities should be in line with scientific standards. The reaction conditions, such as temperature and pressure, must be strictly controlled. High temperature will cause the reaction to be too fast or produce impurities; low temperature will cause the reaction to be slow and difficult to achieve the expected quality. The same is true for pressure, and improper will affect the polymerization and transformation of molecules.
Identify this substance, and list its chemical properties in detail, such as molecular formula and molecular weight, so that it can be seen to clarify its chemical composition. Physical properties, such as color, odor, melting point, and boiling point, are also indispensable as evidence for identification. As for the standard of purity, it is even more necessary to be precise, which is the key to measuring the quality of commodities. In this way, this substance can be used in the chemical industry to make the best use of it, without error.
Preparation Method
To prepare 1 - Bromo - 4 - Fluoro - 3 - Iodobenzene, all raw materials need to be prepared first. Start with fluorobenzene, and after bromination, when stored at an appropriate temperature and catalyst, the bromine will react with it to obtain 4 - fluorobenzene.
Then, take 4 - fluorobenzene and introduce an iodine group. In a specific reaction environment, such as with a suitable solvent and reagent, make it react with an iodine-containing reagent. After a series of operations, Suisheng 1 - Bromo - 4 - Fluoro - 3 - Iodobenzene.
In the reaction process, temperature control, agent selection and punctuality are all important. When brominating, the temperature should not be high to avoid side reactions; when iodine is substituted, the reagents and solvents should be selected to promote the reaction and increase the yield of the product. And a monitoring mechanism should be set up to check the purity and yield after each step, so as to adjust the subsequent operation and ensure that the product meets the requirements.
Chemical Reactions & Modifications
Recently, we have studied 1 - Bromo - 4 - Fluoro - 3 - Iodobenzene, and the modification of this product can be investigated. In the past, there were many methods of reversal, but the rate of reversal was not satisfactory.
We have studied hard, and it is easier to reproduce the product. Different dissolution, the degree of reversal, and the effect of catalysis. In the past, with ordinary solvents, the reversal was slow, and the reversal was also more. Today, special dissolution is used instead, and the rate of reversal is greatly increased, and the reversal is less.
The degree of realignment is also low. At first, it was often used, and the reversal is recommended. The degree of reversal increases, and the reversal is beneficial, but the decomposition of the high-yield material is not expected. Repeat, get the best degree, and the rate can be improved.
As for the catalytic effect, the effect is poor. The best way to get one product is to effectively promote the reaction, make the reaction more ideal, and the modification effect is also good, which is a great development.
Synonyms & Product Names
1 - Bromo - 4 - Fluoro - 3 - Iodobenzene This thing, in the way of my chemical investigation, is quite interesting to study its synonyms and trade names.
The name of the husband chemical substance is like the name of the ancient name, which is correct in the scientific name and widely spread in the common name. 1 - Bromo - 4 - Fluoro - 3 - Iodobenzene, its scientific name is rigorous, according to the chemical naming rules, indicating the position and type of its atoms. However, in the community, either because of convenience or because of old habits, there are also different names.
Looking at the past, the naming of chemical objects often changes with the situation and characteristics of discovery. The same thing, or because of a significant characteristic, has gradually developed a different name in different regions and different users. Although this synonym is unorthodox, it is widely known in a specific range and period, and is also useful in business exchanges, experimental exchanges.
The name of the product is also linked to market demand and product positioning. Merchants establish a different name in order to recognize its uniqueness, or according to its use or take advantage of its advantages. This name is concise and easy to remember, so as to attract people's attention and promote its circulation. However, when investigating its root, it all refers to this 1-Bromo-4-Fluoro-3-Iodobenzene. Our generation explores its synonyms and trade names, just like searching for seclusion and secrets. In the forest of chemistry, we get a different scenery, which also helps us better understand the ins and outs of this thing and use it.
Safety & Operational Standards
1 - Bromo - 4 - Fluoro - 3 - Iodobenzene is an important chemical. In terms of experimental operation and safety, it is necessary to strictly follow specific norms.
When operating, ensure that the experimental environment is well ventilated. Due to its certain volatility, if operated in a confined space, harmful gases will accumulate and may cause damage to the experimenter's body. Experimenters should wear professional laboratory clothes, protective gloves and goggles, which are all necessary measures to ensure their own safety.
When taking 1 - Bromo - 4 - Fluoro - 3 - Iodobenzene, the movements must be precise and careful. Due to its active chemical properties, improper operation can easily trigger chemical reactions and cause danger. The weighing process requires precise instruments to ensure that the dose is correct, so as to avoid inaccurate experimental results due to dose deviations or unnecessary chemical reactions.
For storage, 1 - Bromo - 4 - Fluoro - 3 - Iodobenzene should be placed in a cool, dry and dark place. Because it is more sensitive to light and heat, high temperature and light may cause their decomposition and deterioration, which affects the quality and performance of the product. At the same time, it needs to be stored separately from other chemicals to prevent mutual reaction.
If you accidentally come into contact with 1 - Bromo - 4 - Fluoro - 3 - Iodobenzene during the experiment, you should immediately rinse the contact area with a large amount of water. If the situation is serious, you need to seek medical attention quickly. In the event of a leak, people should be evacuated immediately, and fire should be strictly prohibited from approaching. Use suitable materials to absorb the leak and dispose of it properly to prevent environmental pollution.
Only by strictly adhering to safety and operating standards can we ensure the smooth development of 1 - Bromo - 4 - Fluoro - 3 - Iodobenzene-related experiments and ensure the safety of the experimenters and the environment.
Application Area
1 - Bromo - 4 - Fluoro - 3 - Iodobenzene has a wide range of application fields. In the field of pharmaceutical synthesis, it can be used as a key intermediate to help create new specific drugs. Its unique chemical structure can accurately participate in the reaction, providing a key structure for the construction of drug molecules, or can play an important role in the treatment of specific diseases.
In the field of materials science, due to its own characteristics, it may be able to participate in the synthesis of materials with special photoelectric properties. After ingenious design and reaction, the resulting materials have shown excellent performance in the fields of optoelectronic devices, such as Light Emitting Diodes, solar cells, etc., and promote the progress of related technologies.
In organic synthetic chemistry, it is an important synthetic building block. With its halogen atoms, chemists can build complex and diverse organic molecular structures through various classical reactions, such as coupling reactions, according to different needs, expand the types and functions of organic compounds, and lay the material foundation for the development of many fields.
Research & Development
In recent years, I have focused on the research of 1 - Bromo - 4 - Fluoro - 3 - Iodobenzene. Its unique structure has great potential in the field of organic synthesis.
Initially, explore its synthesis method. After many attempts, based on halogenation reaction, adjust various reaction parameters, such as temperature, reagent ratio, etc. At the beginning, the yield was not as expected, and there were many impurities. However, relentless research was made to improve the process and optimize the conditions, and gradually obtained a pure product, and the yield was steadily increased.
Then, study its reactivity. Interact with different reagents to observe its reaction path and product. It was found that it exhibits specific activities in nucleophilic substitution reactions and can introduce various functional groups, laying the foundation for the creation of new compounds.
Looking to the future, we hope to expand new paths in organic synthesis and develop materials with unique properties based on this. This will contribute to the development of the chemical field, promote the research of this substance to wide application, and open a new chapter of development.
Toxicity Research
There is a substance today, named 1 - Bromo - 4 - Fluoro - 3 - Iodobenzene. As a chemical researcher, I often study the toxicity of this substance. The toxicity of this substance is related to the health of everyone and the safety of the environment, and cannot be ignored.
After months of study, I have carefully observed its properties. In the experiment, I took all kinds of creatures as samples to observe their appearance after contact with this substance. See the changes in its physiology or the differences in its behavior. And in the environment, this substance can also cause the transformation of water quality and soil quality, affecting the ecological balance.
However, the study of toxicity cannot be done overnight. It needs multiple methods and comprehensive consideration. Not only to observe its immediate effect, but also to observe its long-term response. Hope to be fully aware of the toxicity of this product, provide evidence for protection policies and governance methods, and ensure the safety of people and the environment.
Future Prospects
Today there is a thing called 1 - Bromo - 4 - Fluoro - 3 - Iodobenzene. My generation is a chemical researcher, and I have always been obsessed with the future prospects of this thing.
This thing has unique properties and exquisite structure, and has great potential in the field of organic synthesis. In the future, it may be able to use its characteristics to develop novel drugs to help patients in the world. It is also expected to be used to create high-performance materials and add bricks to various industries.
Furthermore, if the synthesis method can be refined, it will definitely reduce costs and increase efficiency. When the process is mature and mass-produced, it can be widely beneficial to the world. We should study it diligently, make good use of it, and hope that in the future, this thing will bloom, contribute to the progress of chemistry and the prosperity of mankind, and live up to the prospect of the future.
Where to Buy 1-Bromo-4-Fluoro-3-Iodobenzene in China?
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Frequently Asked Questions

As a leading 1-Bromo-4-Fluoro-3-Iodobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-Bromo-4-Fluoro-3-Iodobenzene?
1-Bromo-4-fluoro-3-iodobenzene is a crucial compound in the field of organic synthesis. Its main uses involve a wide range of fields of medicine, pesticides and materials science.
In the field of medicine, this compound is often used as a key intermediate to help create new drugs. Due to its unique structure and the characteristics of halogen atoms, it can participate in a variety of organic reactions to build complex molecular structures, providing the possibility for the development of drug molecules with specific biological activities. For example, by means of coupling reactions, it is combined with other compounds containing specific functional groups to synthesize drugs with antibacterial, antitumor and other pharmacological activities.
In the field of pesticides, 1-bromo-4-fluoro-3-iodobenzene also has important functions. It can be converted into pesticide components with efficient pest control effects through a series of organic synthesis steps. Its halogen atoms help to enhance the interaction between molecules and specific targets in pests, improve the biological activity and stability of pesticides, and then provide strong support for pest control in agricultural production.
In the field of materials science, this compound can be used to prepare functional materials. By chemically modifying or copolymerizing with other organic or inorganic materials, the material is endowed with unique electrical, optical or thermal properties. For example, in the field of organic optoelectronic materials, through rational design and synthesis, it is expected to improve the charge transport performance or luminous efficiency of materials, and contribute to the development of organic Light Emitting Diodes (OLEDs), solar cells and other optoelectronic devices.
In conclusion, 1-bromo-4-fluoro-3-iodobenzene plays an indispensable role in many fields due to its unique structure and active reactivity, and makes great contributions to promoting scientific and technological progress in related fields.
What are the physical properties of 1-Bromo-4-Fluoro-3-Iodobenzene?
1-Bromo-4-fluoro-3-iodobenzene is one of the organic compounds. Its physical properties are quite impressive, as follows:
1. ** Properties **: Under normal conditions, this substance is mostly colorless to light yellow liquid, with a clear and translucent appearance. The appearance of this color state is related to the arrangement of atoms in the molecule and the distribution of electron clouds. Electrons transition to absorb specific wavelengths of light, resulting in this color state.
2. ** Melting point and boiling point **: The melting point is extremely low, about -20 ° C. As for the boiling point, it is between 220 and 230 ° C. The melting point is low, because the intermolecular force is weak, the electron is easy to break free when heated; the boiling point is high, because the relative mass of the molecule is large, and the presence of halogen atoms enhances the intermolecular force, requiring higher energy to make it boil.
3. ** Density **: The density is greater than that of water, about 2.3 g/cm ³. This is due to the presence of halogen atoms with relatively large atomic mass such as bromine and iodine in the molecule, resulting in an increase in unit volume mass.
4. ** Solubility **: The solubility in water is very small, because it is a non-polar or weakly polar molecule, and water is a polar molecule. According to the principle of "similar miscibility", the two are difficult to dissolve. However, in common organic solvents, such as ethanol, ether, dichloromethane, etc., it has good solubility, because organic solvents are similar to the polarity of the compound.
5. ** Volatility **: has a certain volatility, but due to the intermolecular force, the volatility is slightly weaker than some small molecule organic compounds. In room temperature environment, it can slowly evaporate into the air.
6. ** Odor **: emits a special odor, the odor is pungent and irritating, this odor originates from the presence of halogen atoms in the molecular structure and its special chemical environment.
1-Bromo-4-Fluoro-3-Iodobenzene chemical synthesis methods
The chemical synthesis method of 1-bromo-4-fluoro-3-iodobenzene often involves several paths. First, the halogenation reaction is used as the basis. First, a suitable benzene derivative, such as 4-fluoro-3-iodoaniline, is taken. After the diazotization reaction, the amino group is converted to a diazonium salt, and then reacted with cuprous bromide to achieve the substitution of the diazonium group by the bromine atom to obtain the target product. This way, the reaction conditions, such as temperature and pH, need to be carefully controlled to ensure the smooth diazotization and substitution steps.
Furthermore, the cross-coupling reaction is catalyzed by metal. Using 1-bromo-4-fluorobenzene as the starting material, the coupling reaction occurs with the iodine substitution reagent in the presence of palladium, nickel and other metal catalysts and ligands. The activity of the catalyst and the structure of the ligand have a great influence on the reaction efficiency and selectivity. Selecting suitable catalysts and ligands and optimizing the reaction conditions can improve the yield and purity of the product.
Another method is to gradually introduce halogen atoms on the benzene ring. First, the specific position of the benzene ring is brominated, and the bromine atom is introduced into the desired position by using the positioning effect, and then the fluorine atom is introduced through the fluorination reaction, and finally the iodine atom is In this process, the control of reaction conditions and the separation and purification of intermediates at each step are very important, and the appropriate reaction solvent, base and temperature need to be selected according to different reaction characteristics.
The above synthesis methods have their own advantages and disadvantages. In practical application, it is necessary to comprehensively weigh factors such as raw material availability, cost considerations, and product purity requirements, and choose the optimal path to achieve the purpose of efficient synthesis of 1-bromo-4-fluoro-3-iodobenzene.
1-Bromo-4-Fluoro-3-Iodobenzene What are the precautions during storage and transportation?
1-Bromo-4-fluoro-3-iodobenzene is also an organic compound. During storage and transportation, many matters need to be paid attention to.
First words storage. This compound should be stored in a cool, dry and well-ventilated place. Because of its certain chemical activity, it is easy to deteriorate in high temperature and humid environments. For example, humid gas can cause reactions such as hydrolysis, which will damage its purity and quality. And it should be kept away from fires and heat sources to prevent fires. Because of its flammability, it may be dangerous to encounter open flames, hot topics or. In addition, it needs to be stored separately from oxidants, acids, etc., to avoid mixed storage. Occurring oxidant and acid substances or react violently with them, causing accidents.
Second talk about transportation. When transporting, the packaging must be tight. Choose appropriate packaging materials to ensure that there is no leakage during transportation. If it is road transportation, it should be driven according to the specified route, not near densely populated areas and residential areas. When transporting by rail, relevant regulations must also be followed. The means of transportation should be clean and free of other residual chemicals to prevent cross-contamination. The handling process should be light and light, and the packaging should not be damaged. The loading and unloading personnel should also be familiar with its characteristics and emergency treatment methods. If there is any leakage, they can be properly disposed of in time.
In conclusion, 1-bromo-4-fluoro-3-iodobenzene needs to be stored and transported with caution according to its chemical properties to ensure safety.
1-Bromo-4-Fluoro-3-Iodobenzene impact on the environment and human health
1-Bromo-4-fluoro-3-iodobenzene is also an organic compound. The impact of this substance on the environment and human health cannot be ignored.
In the environment, 1-bromo-4-fluoro-3-iodobenzene may have certain stability and is difficult to degrade naturally. If it is released into the soil or seeps into the ground, it pollutes the water source, causing harm to aquatic organisms and organisms that depend on this water. And it may be enriched in the food chain, starting from tiny organisms, gradually accumulating in high-rise organisms, affecting the ecological balance.
As for human health, this compound may enter the body through respiration, skin contact or diet. Its halogen atoms may cause chemical reactions in the body and interfere with normal physiological processes. Long-term exposure, or damage to human organs, such as liver and kidney. Liver, the main metabolic detoxification, damage to the function or disorder; renal excretion, or because of the function impaired. And may have potential carcinogenicity, although there is no conclusive conclusion, it must be prevented. Or affect the nervous system, causing headache, vertigo, fatigue and other diseases.
In summary, 1-bromo-4-fluoro-3-iodobenzene poses a potential threat to the environment and human health. When producing, using and disposing, care must be taken to prevent its harm.