1-Bromo-4-fluoro-2-iodobenzene is an organohalogenated aromatic hydrocarbon compound. Its chemical properties are unique and valuable for investigation.
As far as nucleophilic substitution is concerned, the bromine, fluorine and iodine atoms in this compound can all become the check points for nucleophilic attack. However, different halogen atoms have different activities. Iodine atoms have relatively small C-I bond energy due to their large atomic radius. They are highly active in nucleophilic substitution reactions and are more likely to be replaced by nucleophilic reagents. In contrast, fluorine atoms have strong electronegativity, large C-F bond energy, and low nucleophilic substitution activity. Bromine atom activity is between the two.
In the aromatic electrophilic substitution reaction, the halogen atom on the benzene ring is an ortho-para-localization group. Although the electron cloud density of the benzene ring is reduced and the electrophilic substitution activity of the benzene ring is weakened compared with that of benzene, it can still guide the electrophilic reagents to attack the ortho-site and para-site of the halogen atom due to the p-π conjugation effect. In the 1-bromo-4-fluoro-2-iodobenzene molecule, the influence of each halogen atom on the electron cloud density of the benzene ring restricts each other, making the regioselectivity of the electrophilic substitution reaction more complicated.
In the aspect of redox reaction, the For example, under certain conditions, halogen atoms can be reduced to corresponding metal halides, or under the action of oxidizing agents, the oxidation reaction of halogen atoms occurs, but such reactions usually require specific reaction conditions and suitable oxidizing agents or reducing agents.
1-bromo-4-fluoro-2-iodobenzene is an important intermediate in organic synthesis. With its unique chemical properties, it can construct a variety of organic compounds through various reactions and is widely used in the field of organic synthesis chemistry.

1-Bromo-4-fluoro-2-iodobenzene is an important chemical substance in organic synthesis. It has a wide range of main uses and is often a key intermediate in the synthesis of new drugs in the field of medicinal chemistry. Due to its unique structure, containing bromine, fluorine, iodine and other halogen atoms, it can construct complex drug molecular structures through various chemical reactions, which helps to develop drugs with specific biological activities and pharmacological properties.
In the field of materials science, it also has important uses. Through the reactions it participates in, materials with special optoelectronic properties can be prepared. For example, by polymerizing or modifying with other organic compounds, materials with unique properties in the fields of organic Light Emitting Diodes (OLEDs) and solar cells can be obtained, which is expected to improve the efficiency and stability of such devices.
Furthermore, in the study of organic synthetic chemistry, 1-bromo-4-fluoro-2-iodobenzene can participate in many classical organic reactions, such as palladium-catalyzed coupling reactions. This reaction can connect the halogens on the phenyl ring with other organic groups to build a diverse organic molecular skeleton, providing an effective means for organic synthetic chemists to explore the synthesis path of new compounds, and promoting the development and innovation of organic synthetic chemistry.

The synthesis of 1-bromo-4-fluoro-2-iodobenzene is particularly important. As recorded in past books, the synthesis of this compound probably follows the following steps.
First, a suitable benzene derivative is used as the starting material. This material needs to contain modifiable groups to facilitate the subsequent introduction of bromine, fluorine and iodine atoms. Benzene ring compounds with active check points, such as phenols and aniline derivatives, are often selected because of their check point activity. When introducing bromine atoms, liquid bromine is mostly used as the bromine source, supplemented by suitable catalysts, such as iron or iron salts. Under appropriate reaction conditions, such as a specific temperature and solvent environment, bromine atoms can be selectively added to the designated position of the benzene ring. During the reaction, it is necessary to pay attention to the control of temperature, because the temperature is too high or the side reactions occur frequently, which affects the purity of the product.
Then fluorine atoms are introduced, and nucleophilic substitution is often used. React with brominated intermediates with fluorinated reagents, such as potassium fluoride, etc. This step requires a specific solvent, such as dimethyl sulfoxide (DMSO), to promote the nucleophilic activity of fluoride ions, so that they can smoothly replace the corresponding check point groups on the benzene ring to achieve the introduction of fluorine atoms.
As for the introduction of iodine atoms, most of the iodizing reagents, such as potassium iodide, work synergistically with oxidants. The oxidant can activate iodine ions, making it easy to react with the benzene ring. Common oxidants include hydrogen peroxide, etc. Under mild reaction conditions, iodine atoms can be added to the predetermined position of the benzene ring, resulting in 1-bromo-4-fluoro-2-iodobenzene.
However, the whole process of synthesis requires fine regulation of the reaction conditions of each step, including temperature, solvent, reactant ratio, etc., to ensure the high efficiency of each step and the purity of the product. And after each step of the reaction, it must be separated and purified, such as column chromatography, recrystallization, etc., to obtain the pure target product 1-bromo-4-fluoro-2-iodobenzene.

1-Bromo-4-fluoro-2-iodobenzene is also an organic compound. During storage and transportation, many matters need to be paid careful attention.
The first thing to pay attention to is its chemical properties. This compound contains bromine, fluorine, and iodine halogen atoms, which are active in nature. When storing, it must be placed in a cool, dry and well-ventilated place, away from fires and heat sources. Edge halogenated aromatics may be at risk of combustion or explosion at high temperatures or in case of open flames, endangering safety.
Secondary discussion on packaging. It must be packed in a suitable sealed container to prevent leakage. Due to its volatility and irritation, leakage not only causes material loss, but also pollutes the environment and endangers human health. Commonly used packaging materials, glass bottles, plastic bottles or metal drums can be used, but the selected container must be able to withstand the corrosion of this compound.
In addition, during transportation, extra care is also required. According to its dangerous characteristics, the use of compliant transportation tools should be selected. When handling, light loading and unloading, do not drop, heavy pressure, avoid packaging damage.
In addition, staff protection is also indispensable. When storing and transporting operations, operators should wear appropriate protective equipment, such as protective gloves, goggles, gas masks, etc., to avoid contact and inhalation of this compound and ensure their own safety.
In summary, the storage and transportation of 1-bromo-4-fluoro-2-iodobenzene requires strict compliance with regulations in terms of environment, packaging, transportation operations, and personnel protection to ensure safety and avoid accidents.

1-Bromo-4-fluoro-2-iodobenzene, this substance is on the market, its price is variable, and it is made for many reasons.
First, the price of raw materials is often the key. If the market is abundant in bromine, fluorine and iodine materials required for its synthesis, the price must be easy; if it is scarce, the price will surge. And the preparation of this compound, the process is complicated, there are many steps, and the price of raw materials in any link can cause the price of finished products to change.
Second, the preparation method also has an impact. The ingenious method may save materials and time, reduce its cost, and the price will also decrease; if the method is clumsy and time-consuming, the cost will be high, and the market price will also be high.
Furthermore, market supply and demand are oriented by price. If there are many people who want, but the production cannot respond, the price will rise; if the supply exceeds the demand, the merchant will often reduce the price to promote the sale of their goods.
In addition, the manufacturer's regulations and technology are related to the cost. Large factories have the benefits of scale, excellent technology and high production, cost control, price or close to the people; small factories have weak regulations and small skills, and the cost is difficult to reduce, and the price may be the highest.
In summary, the market price of 1-bromo-4-fluoro-2-iodobenzene can range from tens of yuan per gram to hundreds of yuan, or even higher. It varies with various factors. To know the exact price, it is necessary to carefully observe the real-time situation of the market and consult the supplier to obtain an accurate figure.