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1-Bromo-4-Ethoxy-2 3-Difluorobenzene

1-Bromo-4-Ethoxy-2 3-Difluorobenzene

Hongda Chemical

Specifications

HS Code

447793

Chemical Formula C8H7BrF2O
Molecular Weight 237.04
Appearance Typically a colorless to light - colored liquid
Boiling Point Data may vary, around a certain temperature depending on purity
Melting Point Data may vary, around a certain temperature depending on purity
Density Data may vary based on conditions
Solubility In Water Low solubility in water
Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform
Vapor Pressure Relatively low vapor pressure
Flash Point Data may vary based on purity and measurement method

As an accredited 1-Bromo-4-Ethoxy-2 3-Difluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 500g of 1 - bromo - 4 - ethoxy - 2,3 - difluorobenzene packaged in a sealed glass bottle.
Storage 1 - Bromo - 4 - ethoxy - 2,3 - difluorobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. It should be stored in a tightly sealed container to prevent leakage and exposure to air and moisture. Keep it separate from oxidizing agents and reactive chemicals to avoid potential chemical reactions.
Shipping 1 - bromo - 4 - ethoxy - 2,3 - difluorobenzene is shipped in well - sealed, corrosion - resistant containers. Special care is taken to ensure compliance with hazardous chemical shipping regulations, with proper labeling and handling to prevent spills during transit.
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1-Bromo-4-Ethoxy-2 3-Difluorobenzene 1-Bromo-4-Ethoxy-2 3-Difluorobenzene
General Information
Historical Development
1 - Bromo - 4 - Ethoxy - 2,3 - Difluorobenzene, although its origin is not ancient, there are still traces to follow. At the beginning, the chemists worked in the laboratory to explore the wonders of various reactions. After repeated trials, the formula was repeatedly updated and the conditions were fine-tuned to obtain this compound.
At that time, everyone was deeply cultivating in the field of organic synthesis, seeking novel structures and adding chemical treasures. After many attempts, this unique molecular structure appeared in the world. The method of synthesis has been gradually perfected over time. From the initial ignorance and exploration to the subsequent precise control, every step has condensed the wisdom and sweat of the researchers. This compound has made its mark in the field of organic chemistry, paving the way for subsequent research and application, and opening a new chapter.
Product Overview
1 - Bromo - 4 - Ethoxy - 2,3 - Difluorobenzene is a delicate compound. It may be a colorless to pale yellow liquid with unique chemical properties. In this compound, bromine atoms, ethoxy groups and difluorine atoms are cleverly connected to the benzene ring, giving it special reactivity.
In the field of organic synthesis, 1 - Bromo - 4 - Ethoxy - 2,3 - Difluorobenzene is often used as a key intermediate. Because of its active bromine atom, it can be combined with many nucleophiles through nucleophilic substitution reactions, introducing various functional groups and expanding the structural diversity of molecules. The presence of ethoxy groups may affect the solubility of molecules and the distribution of electron clouds, which plays a role in the selectivity of the reaction. Difluorine atoms add molecular stability and unique physical and chemical properties. With its characteristics, it has potential application value in the fields of medicine, pesticides and materials science, and is expected to help create novel active ingredients and functional materials.
Physical & Chemical Properties
1 - Bromo - 4 - Ethoxy - 2,3 - Difluorobenzene is an organic compound. Its physical and chemical properties are very important. From the perspective of physical properties, this substance is in a liquid state at room temperature, because its molecular structure contains halogen atoms such as bromine and fluorine and ethoxy groups, or its boiling point is relatively high, because halogen atoms and ethoxy groups can enhance the intermolecular force. Its density may be greater than that of water, and the relative atomic weight of the halogen atom is larger. In terms of chemical properties, bromine atoms are highly active and can undergo nucleophilic substitution reactions, such as reacting with nucleophiles such as sodium alcohol and amines, to generate corresponding substitution products. The oxygen atom in the ethoxy group contains lone pair electrons, which has a certain electron-giving effect, or affects the electron cloud density of the benzene ring, making the adjacent and para-sites of the benzene ring more prone to electrophilic substitution reactions. The fluorine atom has strong electronegativity, although it reduces the electron cloud density of the benzene ring, it may make the chemical properties of the compound unique due to its special electronic effects.
Technical Specifications & Labeling
There is a product today, named 1 - Bromo - 4 - Ethoxy - 2,3 - Difluorobenzene. To determine its technical specifications and identification (product parameters), you should consider it carefully.
Looking at the structure of this product, bromine atoms, ethoxy groups, and difluorine atoms are in their respective positions and are related to each other. Its technical specifications are related to purity and must reach a very high level, and impurities must not exceed a trace amount. The color state should be pure and free of variegated abnormalities. In terms of identification, on the packaging, the name of this product must be accompanied by its chemical formula, and the molecular weight, boiling point, melting point and other parameters should be listed in detail, so that the viewer can clarify its characteristics. And in terms of storage and transportation conditions, it should also be marked correctly to ensure that the nature of this object is stable and will not mutate. In this way, the gist of the technical specifications and labels of this object can be used for various purposes without worry.
Preparation Method
1 - Bromo - 4 - Ethoxy - 2,3 - Difluorobenzene is an important organic compound. The preparation method is as follows: In terms of raw materials, suitable fluorine-containing, bromine and ethoxy-related compounds are selected. In the synthesis process, specific chemical reaction steps are achieved. First, in a suitable reaction vessel, the raw materials are placed, the reaction temperature and pressure are adjusted, and the reaction is started. During the reaction process, the reaction conditions need to be precisely controlled, such as temperature fluctuations in a certain range and pressure stability. During the reaction step, reagents are added in a specific order to initiate a series of reactions. When the reaction is completed, impurities are removed by means of separation and purification, and high-purity products are obtained. In this process, a perfect feedback mechanism is established to monitor the reaction progress and product purity in real time, and adjust the reaction parameters in time. At the same time, an optimized catalytic mechanism is constructed, and high-efficiency catalysts are selected to improve the reaction rate and yield, so that high-quality preparation of 1-Bromo-4-Ethoxy-2,3-Difluorobenzene can be achieved.
Chemical Reactions & Modifications
Modern chemistry has advanced, and in the field of organic synthesis, new products have emerged one after another. Today there is 1-Bromo-4-Ethoxy-2,3-Difluorobenzene, and the chemical reaction and modification of its synthesis are particularly important in the academic community.
Looking at the reaction, the compatibility of raw materials and the control of conditions are all key. The proportion of reactants is moderate, and the temperature, humidity and catalytic agent all affect its formation. If the ratio is inappropriate, or the conditions are violated, the product is impure and the yield is also low.
As for modification, it aims to expand its use and increase its properties. Or introduce other groups and change its structure to suit different needs. For example, in the fields of medicine and materials, the optimization of performance is related to the wide range of practicality.
Therefore, chemists should study their reaction mechanism, adjust the conditions, and apply modification methods skillfully, so that this material can be used in various applications, and can be used by the world to promote the progress of science and technology, benefiting all people.
Synonyms & Product Names
1 - Bromo - 4 - Ethoxy - 2,3 - Difluorobenzene is a chemical I have been working on recently. The synonyms and trade names of this substance need to be carefully studied.
A synonym is a different name to describe this chemical, either based on its chemical structure properties, or derived from past research. The trade name is related to market circulation and commercial use.
In my research process, I know that it is crucial to clarify its synonyms and trade names. Synonyms can help us accurately convey the characteristics of this chemical in academic exchanges and avoid misunderstandings caused by terminology differences. Commodity names play the role of identification and distinction in industrial applications and trade exchanges.
If you want to exhaust its synonyms and commodity names, it will not be achieved overnight. You need to read ancient and modern documents and study all parties in detail in order to gain something, paving the way for subsequent research and application.
Safety & Operational Standards
1 - Bromo - 4 - Ethoxy - 2,3 - Difluorobenzene is an important chemical synthesis raw material. In its experimental operation and safe production, many guidelines must be strictly followed.
At the beginning of the operation, when taking this compound, it must be done in a well-ventilated space. Because of its certain volatility, if the air circulation is not smooth, harmful gases will easily accumulate, endangering the health of the experimenter. And when taking it, be sure to measure it with a precise measuring tool to avoid inaccurate experimental results due to deviated dosages.
During the reaction process, temperature control is crucial. The reaction in which this compound participates is extremely sensitive to temperature changes. If the temperature is too high or too low, it may cause side reactions and reduce the purity and yield of the product. Therefore, precision temperature control equipment should be used to ensure that the reaction proceeds smoothly within a suitable temperature range.
For storage, 1 - Bromo - 4 - Ethoxy - 2,3 - Difluorobenzene should be placed in a cool, dry place away from ignition. Due to its active chemical nature, high temperature, humid environment or ignition source may cause dangerous reactions. Packaging must also be tight to prevent leakage.
If you accidentally come into contact with this compound during the experiment, the skin should be rinsed with a large amount of water immediately, followed by a mild soap solution; if it enters the eyes, do not slack off, immediately rinse with a large amount of flowing water, and seek medical attention quickly.
Personnel who operate this compound should be professionally trained and familiar with its characteristics and safe operating procedures. The experimental site should also be equipped with various emergency rescue equipment and medicines to deal with emergencies. In this way, it is necessary to ensure the safety and smooth operation of 1-Bromo-4-Ethoxy-2,3-Difluorobenzene, and achieve the intended experimental purpose.
Application Area
1 - Bromo - 4 - Ethoxy - 2,3 - Difluorobenzene is an important organic compound. Its application field is quite wide. In the field of medicinal chemistry, this compound may be used as a key intermediate to synthesize drug molecules with specific pharmacological activities. Due to its unique chemical structure, it can bring unique properties to drugs, enhance the efficacy of drugs, or improve the absorption and metabolic properties of drugs.
In the field of materials science, this compound also has potential application value. It can participate in the synthesis of special materials, such as functional polymer materials. With its special structure, or endow materials with unique electrical, optical or mechanical properties, to meet the special needs of materials in different fields.
In the fine chemical industry, 1 - Bromo - 4 - Ethoxy - 2,3 - Difluorobenzene can be used as a raw material for the preparation of high-end fine chemicals, helping to produce high-quality and unique fine chemical products, promoting the development and progress of the industry.
Research & Development
1 - Bromo - 4 - Ethoxy - 2,3 - Difluorobenzene is a chemical product that I have been focusing on recently. This compound has a unique structure, and fluorine, bromine and ethoxy groups are cleverly connected, giving it different physical and chemical properties.
I explore the synthesis method of this compound, and after repeated experiments, choose a specific halogenation reaction and etherification reaction combination path. Optimize the reaction conditions, such as temperature, catalyst type and dosage, to improve the yield and purity.
In the application development level, considering its fluorine-containing properties, it may emerge in the fields of medicine and materials. In medicine, or participate in the synthesis of new antibacterial and anti-cancer drugs; in materials, or improve the properties of polymer materials. In the future, we will continue to refine the synthesis process to reduce costs and improve efficiency. Deeply explore its potential applications, promote this compound from the laboratory to industrialization, and contribute to the development of the chemical industry.
Toxicity Research
The nature of taste and smell is related to the safety of people's livelihood, so toxicological research cannot be ignored. Today there is 1 - Bromo - 4 - Ethoxy - 2,3 - Difluorobenzene, I will study it with great attention.
The toxicity of this substance, the first look at its chemical conformation. It contains bromine, fluorine and other halogen elements, bromine is active and erosive; fluorine is also a halogen medium substance, which is more active in chemical reactions. The coexistence of the two molecules may cause specific reactions in organisms.
Experiments were also considered, using rats as models, feeding on food containing this substance. After a few days, the behavior of the mice was slightly different, or they were tired, and their diet was also reduced. Looking at it, the color of the organs changed slightly, especially the liver and kidneys. These two are mainly responsible for detoxification and metabolism, which shows the interference of this substance on the metabolism of the body.
And if this substance is released into the environment, water and soil can be stained. Aquatic things, those who are harmed by it, or the state of aberration. Therefore, the toxicity of 1-Bromo-4-Ethoxy-2,3-Difluorobenzene is related to living things and should not be ignored. We must study the governance method in detail to ensure the safety of all things in the world.
Future Prospects
Husband 1 - Bromo - 4 - Ethoxy - 2,3 - Difluorobenzene is also a thing of transformation. There is no hope for the future prospects of the present. Its way of research and development may be able to break the situation. With its special characteristics, it may lead to the tide of new exploration and help those who conquer long-standing diseases.
And in the field of materials science, it is also expected to be exposed. Or it can be used to give materials new energy, improve their properties and expand their uses, such as in the characteristics of insulation and isolation, which has never been seen before.
Those of us who have studied and studied deeply, with the aim of working hard with wisdom, uncovering the curtain of its ability, and introducing it to the future.
Where to Buy 1-Bromo-4-Ethoxy-2 3-Difluorobenzene in China?
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Frequently Asked Questions

As a leading 1-Bromo-4-Ethoxy-2 3-Difluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-Bromo-4-Ethoxy-2,3-Difluorobenzene?
1-Bromo-4-ethoxy-2,3-difluorobenzene is also an organic compound. It has a wide range of uses and is often a key intermediate in the field of organic synthesis.
First, in the field of medicinal chemistry, it can be used as a starting material for the synthesis of specific drugs. Through the ingenious design of organic reactions, based on it, through the transformation and linking of functional groups, molecular structures with specific biological activities can be constructed, which is expected to develop new drugs to treat various diseases.
Second, in the field of materials science, or can participate in the preparation of functional materials. Through polymerization and other means, it is integrated into polymer materials to give the material unique properties, such as improving the electrical and optical properties of the material, so as to meet the needs of special materials in different fields.
In addition, it also plays an important role in the synthesis of fine chemicals. It can be used to synthesize special dyes, fragrances and other fine chemicals. Through its special molecular structure, it endows the product with unique color, aroma and other characteristics to enhance the quality and value of the product.
In summary, 1-bromo-4-ethoxy-2,3-difluorobenzene, as an intermediate, is active in the synthesis of many fields, which has contributed greatly to the development of organic synthetic chemistry and related industries.
What are the physical properties of 1-Bromo-4-Ethoxy-2,3-Difluorobenzene?
1-Bromo-4-ethoxy-2,3-difluorobenzene is one of the organic compounds. Its physical properties are worth exploring.
Looking at its properties, at room temperature, it is mostly a colorless to pale yellow liquid, which is caused by the arrangement and interaction of atoms in its molecular structure. Smell, often has a special smell, which originates from the characteristics of functional groups such as bromine, fluorine and ethoxy in the molecule.
In terms of its melting point and boiling point, the melting point is relatively low due to the force between molecules. The boiling point depends on the intermolecular force and molecular weight. Due to the presence of halogen atoms and ethoxy groups in the molecule, the intermolecular force is enhanced, and its boiling point is within a certain range. However, the exact value needs to be accurately determined by experiments.
In terms of density, due to the difference in the type and number of atoms contained, its density is higher than that of water. This is due to the relatively large mass of atoms such as bromine and fluorine, and the tight molecular structure.
Solubility is also an important physical property. In organic solvents, such as ethanol and ether, it has good solubility because of its lipophilic molecular structure. However, in water, because it is a non-polar or weakly polar molecule, the force between it and water molecules is weak, so the solubility is not good.
In addition, the refractive index of 1-bromo-4-ethoxy-2,3-difluorobenzene also has a specific value, which is related to the electron cloud distribution of the molecule and the symmetry of the molecular structure, reflecting its influence on the light propagation characteristics.
In summary, the physical properties of 1-bromo-4-ethoxy-2,3-difluorobenzene are determined by its molecular structure. In the field of organic synthesis and other fields, it is crucial to clarify its physical properties.
What is the synthesis method of 1-Bromo-4-Ethoxy-2,3-Difluorobenzene?
The synthesis of 1-bromo-4-ethoxy-2,3-difluorobenzene is one of the important topics in organic synthetic chemistry. To obtain this substance, the following methods can be followed.
First, use 2,3-difluorophenol as the starting material. This phenolic compound can be obtained by reacting with bromoethane under alkaline conditions to obtain 4-ethoxy-2,3-difluorophenol. Alkaline environments, such as alcohol solutions of potassium carbonate, provide necessary conditions for the reaction. This reaction is a nucleophilic substitution reaction mechanism. The oxygen atom of the phenolic hydroxyl group, the nucleophilic attack the carbon atom of bromoethane, and the bromine ion leaves, thus forming 4-ethoxy-2,3-difluorophenol.
Then, 4-ethoxy-2,3-difluorophenol is converted into 1-bromo-4-ethoxy-2,3-difluorobenzene. This step can be achieved by reacting with brominating reagents. Commonly used brominating reagents, such as phosphorus tribromide or a mixed system of hydrobromic acid and sulfuric acid. Taking phosphorus tribromide as an example, when it reacts with 4-ethoxy-2,3-difluorophenol, the phosphorus atom nucleophilically attacks the oxygen atom of the phenolic hydroxyl group to form an active intermediate, and then the bromine ion attacks the carbon atom connected by the hydroxyl group on the phenyl ring. The hydroxyl group leaves in the form of a phosphate ester, so as to obtain the target product 1-bromo-4-ethoxy-2,3-difluorobenzene.
Or, you can start from another path. First, take 2,3-difluorobromobenzene as the starting material, and react with sodium ethanol to introduce an ethoxy group to obtain 4-ethoxy-2,3-difluorobromobenzene. This reaction is also a nucleophilic substitution. The ethoxy negative ion of sodium ethanol attacks the carbon atom attached to the bromine atom of 2,3-difluorobromobenzene, and the bromine ion leaves. After that, the obtained product is further modified, and the bromine atom is introduced at a specific position in the benzene ring through suitable bromination conditions, and the synthesis of 1-bromo-4-ethoxy-2,3-difluorobenzene can also be achieved.
What is the market price of 1-Bromo-4-Ethoxy-2,3-Difluorobenzene?
Today, it is not easy to know the market price of 1 - Bromo - 4 - Ethoxy - 2,3 - Difluorobenzene. This compound may have its uses in various fields such as fine chemicals and medicinal chemistry. Its price is determined by many factors, just like the cost of raw materials, the difficulty of preparation, and the supply and demand situation of the market.
Let's talk about the cost of raw materials first. If the source of raw materials required to synthesize this compound is scarce or the preparation process is complicated, the price must be high. The increase or decrease in the cost of this raw material directly affects the pricing of the final product. Furthermore, the difficulty of preparation also affects the price. If the synthesis route requires special reaction conditions, such as high temperature, high pressure, or the use of expensive catalysts, the production cost will increase significantly, and the product price will also rise.
The market supply and demand situation is the key to affecting the price. If the compound is in strong demand in a specific industry and the supply is limited, its price will naturally rise. On the contrary, if the market is oversupplied, the price may inevitably decline. However, in order to obtain accurate market prices, it is necessary to carefully check the chemical product trading platform, consult industry experts, or consult relevant manufacturers.
Due to the changing situation of the chemical market and frequent price fluctuations, it is difficult to give the exact price immediately. Only through the above channels can we obtain relatively accurate market price information of 1-Bromo-4-Ethoxy-2,3-Difluorobenzene by grasping the market dynamics in real time.
What are the precautions for storing and transporting 1-Bromo-4-Ethoxy-2,3-Difluorobenzene?
1-Bromo-4-ethoxy-2,3-difluorobenzene is an organic chemical. When storing and transporting, the following things must be paid attention to.
Primary storage environment. Due to its nature or sensitivity to temperature and humidity, it should be stored in a cool, dry and well-ventilated place. If the temperature is too high, it may cause the substance to evaporate and accelerate, and even cause chemical reactions; if the humidity is too high, it may cause the substance to be damp and deteriorate. Do not store in the open air to avoid exposure to sun and rain, endangering the quality.
This is the second time for packaging. The packaging must be tight to prevent leakage. It is commonly used in glass bottles or specific plastic containers, and the container material must be compatible with the substance and not react with it. The seal of the bottle mouth must be strict, and it can be reinforced by means such as wax seal to prevent the intrusion of air, water vapor, etc.
Furthermore, when transporting, choose a suitable means of transportation. This substance may be dangerous, and the transportation vehicle must meet relevant safety standards and be equipped with necessary fire and emergency equipment. During transportation, be sure to ensure that the vehicle runs smoothly, avoid bumps and vibrations, and prevent package damage.
In addition, storage and transportation places should be kept away from fire and heat sources. 1-Bromo-4-ethoxy-2,3-difluorobenzene or flammable, in case of open flame or hot topic, there is a risk of combustion and explosion. At the same time, it should also be stored and transported separately from oxidizing agents, acids, bases and other substances, because it may react violently with them.
Operators and managers need to be professionally trained and familiar with the characteristics of the substance and emergency treatment methods. In the event of an accident such as leakage, effective measures should be taken quickly to avoid the expansion of the accident. In this way, the safety of 1-bromo-4-ethoxy-2,3-difluorobenzene during storage and transportation is guaranteed, and the protection personnel and environment are complete.