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1-Bromo-4-(Difluoromethyl)Benzene

1-Bromo-4-(Difluoromethyl)Benzene

Hongda Chemical

    Specifications

    HS Code

    493239

    Chemical Formula C7H5BrF2
    Molar Mass 207.015 g/mol
    Boiling Point 182 - 184 °C
    Solubility In Water Insoluble (due to non - polar nature of the benzene ring)
    Solubility In Organic Solvents Soluble in common organic solvents like ethanol, ether
    Purity Can vary depending on source and production method, usually high - purity grades available

    As an accredited 1-Bromo-4-(Difluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100 g of 1 - bromo - 4 - (difluoromethyl)benzene in a sealed glass bottle.
    Storage 1 - Bromo - 4 - (difluoromethyl)benzene should be stored in a cool, dry, well - ventilated area away from heat sources, open flames, and oxidizing agents. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials. Store it separately from incompatible substances to prevent chemical reactions. Avoid long - term exposure to sunlight.
    Shipping 1 - bromo - 4 - (difluoromethyl)benzene is shipped in sealed, corrosion - resistant containers. Adequate labeling indicates its chemical nature. Shipment follows strict regulations for hazardous chemicals, ensuring safety during transport.
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    1-Bromo-4-(Difluoromethyl)Benzene 1-Bromo-4-(Difluoromethyl)Benzene
    General Information
    Historical Development
    1 - Bromo - 4 - (Difluoromethyl) Benzene is an organic compound. Its origin can be traced back to the gradual development of chemical research. In the past, chemists devoted themselves to exploring novel substance synthesis. At first, the understanding of this compound was still shallow, and only occasionally related reactions were found in the laboratory.
    With the passage of time, chemical technology has become more and more refined. Scholars have been able to synthesize this substance in a more accurate way by studying various reaction conditions. Early synthesis, or the yield was not high, and there were many impurities, but chemists persevered.
    In recent times, the refinement of instruments and the completeness of theories have made the synthesis of 1 - Bromo - 4 - (Difluoromethyl) Benzene more mature. It can be prepared on demand, and its application is also expanding. It has emerged in various fields such as medicine and materials, and has become an indispensable role in chemical research and industrial production. Its development process is a testament to the progress of chemistry.
    Product Overview
    1 - Bromo - 4 - (Difluoromethyl) Benzene is also an organic compound. It may be a colorless to pale yellow liquid with a special odor. In this compound, the bromine atom is connected to the benzene ring containing difluoromethyl, and the structure is unique.
    Its preparation method, or through a specific chemical reaction process, using benzene derivatives as starting materials, through halogenation, introduction of difluoromethyl and other steps. In the field of organic synthesis, 1 - Bromo - 4 - (Difluoromethyl) Benzene is often an important intermediary. It can be used to construct more complex organic molecular structures and has potential application value in pharmaceutical chemistry, materials science and other fields. Due to its fluorine-containing atoms, molecules are endowed with unique physical and chemical properties, or affect the stability and lipophilicity of compounds, which lays the foundation for subsequent research and application.
    Physical & Chemical Properties
    1 - Bromo - 4 - (Difluoromethyl) Benzene is an organic compound, and its physical and chemical properties are worth studying. This substance may be a liquid at room temperature and has a certain volatility. Looking at its structure, the benzene ring is stable, and the substitution of bromine atom and difluoromethyl gives it unique properties. Bromine atoms have large electronegativity, which causes molecular polarity to change, which affects its solubility and may have a certain solubility in polar solvents. The existence of difluoromethyl increases molecular hydrophobicity, and the fluorine atom has strong electronegativity, which affects intermolecular forces. In terms of its chemical properties, benzene rings can undergo electrophilic substitution reactions, and bromine atoms can participate in nucleophilic substitution and other reactions. The physical and chemical properties of this compound lay the foundation for its application in organic synthesis and other fields.
    Technical Specifications & Labeling
    1 - Bromo - 4 - (Difluoromethyl) Benzene is an important chemical product. Its preparation process is related to many technical specifications and standards. During the synthesis process, the purity of the raw material, the temperature and time of the reaction are all key parameters. It must be precisely controlled to ensure product quality.
    There are also strict standards for identifying this product. Looking at its physical properties, such as color and morphology, should meet specific requirements. Its molecular structure is determined by instrumental analysis, such as nuclear magnetic resonance, mass spectrometry, etc. Commercial parameters such as product purity and impurity content must be strictly determined, and it meets the established standards to be a qualified 1 - Bromo - 4 - (Difluoromethyl) Benzene product.
    Preparation Method
    1 - Bromo - 4 - (Difluoromethyl) Benzene is an important compound in the field of organic synthesis. The preparation method and the selection of raw materials are crucial. P-bromotoluene can be selected as the starting material, which is easy to obtain and cost-effective.
    Preparation process is as follows: First, p-bromotoluene is reacted with a specific reagent under suitable conditions, and this step requires precise control of temperature and reaction time. After a specific step, the methyl group in p-bromotoluene is first substituted, a fluorine-containing group is introduced, and then it is converted into the target product through a series of reactions.
    The reaction step is rigorous, and the reaction is first initiated with a specific reagent, which prompts the substitution of the methyl group and generates an intermediate product. After the intermediate product is further processed, high purity 1 - Bromo - 4 - (Difluoromethyl) Benzene is obtained through separation and purification.
    The catalytic mechanism cannot be ignored, and a high-efficiency catalyst needs to be selected to accelerate the reaction process and improve the yield of the product. In this way, the high-quality preparation of this compound can be achieved.
    Chemical Reactions & Modifications
    The chemical reaction and modification of 1 - Bromo - 4 - (Difluoromethyl) Benzene. This compound is unique and widely used, and is often a key material in the field of organic synthesis.
    Its chemical reaction involves the communication of many halogenated hydrocarbons, and it comes into contact with nucleophiles, and halogen atoms are easily replaced by other groups. However, its fluoromethyl position adds other activities, which makes the reaction path and product unique.
    As for modification, in order to improve its performance, or increase its stability, or promote its reactivity, chemical modification is often used. Selecting the appropriate reagent and adjusting the precise conditions can introduce new radicals on the benzene ring, change the distribution of its electronic cloud, and then change its materialization. After many attempts, I have a little experience, and I hope to explore with my colleagues to understand more of its mysteries and expand the boundaries of its application.
    Synonyms & Product Names
    1 - Bromo - 4 - (Difluoromethyl) Benzene is very important in the field of my chemical research. Its synonymous name can also be investigated.
    In the past, chemists have given it several synonymous names when exploring this compound. Due to the progress of research, regional differences or different research focuses, the synonymous name has proliferated.
    Its trade name is also important in the industry. Different companies have launched this product, and the trade names named have their own characteristics. Or according to its characteristics, or according to its use, the names are ingenious.
    In the records of chemical classics and experiments, synonymous names and trade names frequently appear. This helps researchers to accurately locate and deeply analyze its properties, uses and synthesis methods. It also paves the way for academic exchanges and industrial applications, so that all parties can discuss this object under a familiar name and promote the process of chemical research and application.
    Safety & Operational Standards
    1 - Bromo - 4 - (Difluoromethyl) Benzene is an important chemical compound in chemical research. It is crucial to the safety and operation of this compound.
    In the experimental operation site, it must be well ventilated. This compound may be volatile, and good ventilation can prevent it from accumulating in the air and reduce potential hazards. When operating, researchers must wear professional laboratory clothes, protective gloves and goggles. Because it may be irritating to the skin and eyes, complete protection can ensure personal safety.
    When storing, 1 - Bromo - 4 - (Difluoromethyl) Benzene should be kept in a cool, dry place away from sources of fire. Due to its flammability, improper storage is prone to fire hazards. When taking this compound, use a precision measuring tool and use it according to the amount required for the experiment. Excessive use is strictly prohibited to avoid waste and avoid more risks caused by excessive use.
    After the experiment is completed, the remaining 1 - Bromo - 4 - (Difluoromethyl) Benzene should not be discarded at will. It needs to be disposed of in accordance with the established chemical waste treatment specifications to prevent pollution to the environment. If this substance is accidentally splashed during the experiment, corresponding cleaning measures should be taken immediately. Small area splashes can be carefully collected with adsorption materials; large area splashes need to start emergency response plans, evacuate personnel, avoid personnel contact, and ensure safety before cleaning.
    In conclusion, the operation of 1 - Bromo - 4 - (Difluoromethyl) Benzene should adhere to safety and operating standards at every step to ensure the safe and orderly conduct of scientific research.
    Application Area
    1 - Bromo - 4 - (Difluoromethyl) Benzene is also an organic compound. Its application field is quite wide. In the field of medicinal chemistry, it can be used as a key intermediate. As far as the synthesis of specific drug molecules is concerned, its unique structure can introduce special functional groups to help build complex drug frameworks, and then it is expected to develop novel and efficient therapeutic agents.
    In the field of materials science, it also has potential use. It can be chemically reacted and integrated into polymer materials to endow materials with special optical and electrical properties, or to improve their chemical stability. For example, the preparation of smart materials with specific light response properties provides new paths for the functional expansion of materials.
    And in terms of pesticide chemistry, it may become a starting material for the creation of new pesticides. Through its structural modification, pesticide products with high selectivity and high activity to specific pests can be derived, which will contribute to agricultural pest control.
    Research & Development
    In recent years, I have studied a compound in the field of chemistry, named 1 - Bromo - 4 - (Difluoromethyl) Benzene. This substance has unique properties and a wide range of uses. It has potential value in the fields of medicine and materials.
    At the beginning, its structure was analyzed, the chemical bonds were revealed, and its physical properties, such as melting point and solubility, were explored. Then its chemical activity was studied, and it was observed that it reacted under different conditions. After various experiments, the best method for synthesizing this compound was obtained, and the yield and purity were improved.
    However, during the research and development process, it also encountered problems. The raw materials are rare, the reaction conditions are harsh, and side reactions are frequent. We dedicated ourselves to studying, consulting the classics, and visiting various parties to find a solution.
    The research and development of this compound has made progress. The scale of the test will be expanded in the future to explore the possibility of industrialization. It is hoped that this achievement will add bricks to the chemical industry and benefit the world.
    Toxicity Research
    1 - Bromo - 4 - (Difluoromethyl) Benzene is an important object of chemical research at present, and its toxicity research is also important in the academic community.
    Looking at this substance, its structure is unique, containing bromine atoms and difluoromethyl, this special structure may cause it to have unique chemical activity and potential toxicity. Ancient scholars studied toxicity and often observed its impact on life. Today, toxicity studies of 1 - Bromo - 4 - (Difluoromethyl) Benzene also follow this path.
    Experimentally observe, apply this substance to the subject, observe its physiological and behavioral changes. Or see the subject's growth retardation, or physiological dysfunction. Also explore the path of its entry into the body, if it enters through the mouth, skin, or breath, to study the effect of each route on toxicity. After in-depth study, the toxic nature of 1 - Bromo - 4 - (Difluoromethyl) Benzene is revealed, which is used by the world to avoid harm and profit, and protect the environment and personal safety.
    Future Prospects
    Wuguan 1 - Bromo - 4 - (Difluoromethyl) Benzene has infinite potential in the field of chemistry. Future development can be the cornerstone of new materials. With its unique structure, it may be able to generate efficient catalysts, which will shine in the process of organic synthesis. It is also expected to be applied to electronic materials to improve the performance of components. When the technology is refined, the preparation process is optimized, and the cost is reduced, it will be widely used in various fields. At that time, it may change the existing industrial structure, contribute to the rise of industry and the advancement of science and technology, and achieve a great career and develop endless brilliant prospects.
    Where to Buy 1-Bromo-4-(Difluoromethyl)Benzene in China?
    As a trusted 1-Bromo-4-(Difluoromethyl)Benzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 1-Bromo-4-(Difluoromethyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 1-bromo-4- (difluoromethyl) benzene?
    1-% ether-4- (diethylmethyl) benzene, its main use is also wide. In the medical tract, it can be used as an adjuvant for anesthesia, because it has the ability to soothe the patient's mind and numb the body, so that when the doctor performs the operation, the patient suffers less pain. And in the pharmaceutical industry, it is also a key raw material. Through various chemical reactions, it can synthesize a variety of medicinal agents with outstanding efficacy to treat various diseases.
    In the chemical industry, it is an excellent solvent. Many organic compounds have good solubility in them, so they are often used in the preparation of paints, inks, adhesives and other products, which can make various ingredients evenly mixed and improve the quality and performance of the product. Due to its volatility and suitability, it can quickly dry and form a film for coatings, etc., and the film-forming effect is smooth and smooth.
    In the fragrance industry, 1-% ether-4- (diethylmethyl) benzene also has wonderful uses. Its unique smell can provide a different charm for the preparation of fragrances. With the help of perfumers, it can be integrated into various perfumes, giving perfumes a unique fragrance, either fresh and elegant, or rich and charming, satisfying the world's preference for different aromas.
    In addition, in the path of scientific research and exploration, it is an important organic reagent, providing a foundation for the study of organic synthesis reactions. Scientists explore their chemical properties, explore new synthetic paths, create novel compounds, and promote the progress and development of chemistry, providing possibilities for innovation in many fields.
    What are the physical properties of 1-bromo-4- (difluoromethyl) benzene?
    1-% ether-4- (diethylmethyl) naphthalene is also an organic compound. Its physical properties are quite unique, and this is for you to describe in detail.
    First of all, under room temperature, 1-% ether-4- (diethylmethyl) naphthalene is often solid or crystalline, dense and has a certain form. Looking at its color, it is mostly colorless or slightly yellowish, crystal clear, like jade beads.
    As for the melting point, the melting point of this compound is within a specific range, and its exact value varies slightly depending on factors such as the degree of purification. However, roughly speaking, it begins to melt at a certain temperature, which is very critical in the operation of identification and separation.
    The boiling point is also an important physical property. When heated to the corresponding boiling point, 1-% ether-4- (diethyl) naphthalene changes from liquid to gaseous state. The value of this temperature reflects the strength of its intermolecular forces and also depends on its state changes at different temperatures.
    In terms of solubility, 1-% ether-4- (diethyl) naphthalene exhibits different solubility in organic solvents. In some organic solvents such as benzene and toluene, it can be better dissolved because its molecular structure is similar to that of organic solvents. In water, its solubility is very small, because water is a polar solvent, while the polarity of 1-% ether-4- (diethyl) naphthalene molecules is weak, and the difference in polarity between the two makes it difficult to dissolve in water.
    The density characteristics cannot be ignored. The density of 1-% ether-4- (diethyl) naphthalene has its unique value compared with common solvents and substances. This value is of great significance for judging its position and distribution in the system in practical application scenarios such as mixing and separation.
    Furthermore, its volatility is relatively weak. In a normal temperature and pressure environment, the volatilization rate is relatively slow, which is also related to factors such as intermolecular forces and boiling points, making it relatively stable during storage and use, and it is not easy to be lost due to rapid volatilization.
    What are the chemical properties of 1-bromo-4- (difluoromethyl) benzene?
    The chemical properties of 1-% ether-4- (diethylmethyl) naphthalene can be investigated. This compound has both the characteristics of ether and the structure of naphthalene ring, as well as the group of diethylmethyl group, so its properties are complex and interesting.
    First of all, its physical properties are described. At room temperature, or in a liquid state, it has a certain volatility. Because of the naphthalene ring, its odor may have the characteristics of aromatic hydrocarbons, and it has a special aromatic aroma. Its boiling point and melting point are affected by the intermolecular force. The plane structure of the naphthalene ring and the branched chain of diethylmethyl make the intermolecular van der Waals force unique, resulting in its melting boiling point different from that of common aliphatic ethers or simple naphthalene derivatives.
    In terms of its chemistry, the existence of ether bonds makes it have the commonality of ethers. In case of strong acid, or protonation reaction can occur, causing ether bond fracture. In the nucleophilic substitution reaction, the ether bond oxygen atom can act as a nucleophilic check point and interact with the electrophilic reagent. The part of the naphthalene ring is electron-rich and prone to electrophilic substitution. In case of halogenating agents, nitrifiers, etc., the hydrogen atoms on the naphthalene ring are easily replaced, and the substitution check point is affected by the localization effect of diethyl methyl. Diethyl is the power supply group, and according to the localization rules, the electrophilic substitution reaction can preferentially occur in the adjacent and para-position of the naphthalene ring.
    In addition, because diethyl methyl has a certain steric resistance, it may affect the reaction rate and product selectivity in some reactions. In oxidation reactions, naphthalene rings are relatively easily oxidized to form quinones or other oxidation products. Under specific oxidation conditions, ether bonds may also be oxidized to form peroxides and other products.
    In summary, the chemical properties of 1-% ether-4- (diethyl methyl) naphthalene, which are co-molded by its ether bonds, naphthalene rings and diethyl methyl, have potential application value in organic synthesis, materials science and other fields, or because of these unique properties.
    What are the methods for preparing 1-bromo-4- (difluoromethyl) benzene?
    1-% -4- (diethylmethyl) benzene of the method is as follows:
    can be substituted by the phase diethylbenzene diethylated in the appropriate reaction obtained by reverse. often anti way are:
    First, to benzene starting material, in the presence of, diethylmethyl compound generation nuclear substitution. If benzene is dissolved in the solution of benzene, such as tetrafuran, N, N-dimethylformamide, etc., add carbonate, oxidized benzene, etc., mix well, add diethyl benzene dropwise, and add diethyl benzene dropwise at an appropriate temperature, such as the room temperature to about 50 ° C, the reaction temperature is small to 10 hours, and the reaction process is completed by thin chromatography or other analytical means. After washing with water, separating liquid, and drying, there is a phase, and then it is evaporated by steaming or column analysis, and the target substance can be obtained. 1-% -4- (diethyl) benzene.
    Second, the double reaction of gold catalysis can be used. Using benzene, diethylborate or diethylmethyl as raw materials, in the presence of chemical catalysts, such as tetrakis (triphenylphosphine) (0), chlorine, etc., adding chemical aids, such as carbonate, phosphoric acid, etc., soluble in chemical solutions such as toluene and dioxane, under the addition of chemical components, such as 80-120 ° C, the reaction is certain. After the reaction is completed, the reaction is completed, the reaction is completed, the reaction is completed, the reaction is completed, and the column is divided into other steps. 1-% -4- (diethylmethyl) benzene is obtained. This method has high performance and high performance.
    Third, if the starting material is a phenol compound, the phenol group can be first reduced to an atom, and then the above-mentioned reverse route can be carried out. For example, first, phosphorus tribromide, chlorine, etc. are substituted for benzene by phenol, and then according to the above-mentioned nuclear substitution or catalytic reaction method, diethylmethyl groups are introduced to obtain 1-% -4- (diethylmethyl) benzene.
    What are the precautions for storing and transporting 1-bromo-4- (difluoromethyl) benzene?
    When storing and transporting 1-% diethyl-4- (diethyl methyl) ether, many precautions should not be ignored.
    The first storage environment should be placed in a cool and ventilated place, away from fire and heat sources, in order to avoid the risk of its flammability. Because of its flammability, it is very easy to burn and explode in case of open flame and hot topic. If stored at high temperature or exposed to fire sources, disasters may occur immediately.
    The choice of storage container is also critical, and a sealed device must be used to prevent leakage. Due to the high volatility of the substance, once leaked, it will not only cause material loss, but also pose a threat to the environment and personnel safety. And it needs to be stored separately from oxidants, acids, etc. Because of its active chemical properties, contact with these substances or react violently, causing danger.
    When transporting, the packaging must be firm to ensure that there is no risk of leakage on the way. Transportation vehicles should be equipped with corresponding varieties and quantities of fire equipment and leakage emergency treatment equipment for emergencies. Driving should be protected from exposure to the sun, rain, and high temperature. Due to changes in temperature and humidity, or affect its stability.
    During transportation, you must follow the specified route and do not stop in residential areas and densely populated areas. In the event of a leak, the on-site personnel should quickly evacuate to a safe area, strictly restrict access, and cut off the source of fire. Emergency personnel need to wear self-contained positive pressure breathing apparatus and fire protection clothing to cut off the source of leakage as much as possible to prevent it from flowing into restricted spaces such as sewers and drainage ditches. Small leaks can be absorbed by sand, vermiculite or other inert materials; large leaks need to be built embankments or dug for containment, covered with foam to reduce vapor disasters, and then transferred to a tanker or special collector with an explosion-proof pump for recycling or transportation to a waste treatment site for disposal. In this way, the safety of storage and transportation can be guaranteed.