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1-Bromo-4-Chloro-3,5-Difluorobenzene

1-Bromo-4-Chloro-3,5-Difluorobenzene

Hongda Chemical

    Specifications

    HS Code

    413220

    Chemical Formula C6H2BrClF2
    Molar Mass 227.43 g/mol
    Appearance Liquid (usually)
    Boiling Point Approximately 180 - 190 °C (estimated)
    Density Data may vary, around 1.8 - 2.0 g/cm³ (estimated)
    Solubility In Water Low solubility, organic - soluble
    Vapor Pressure Low vapor pressure at room temperature
    Odor Typical halogenated aromatic odor

    As an accredited 1-Bromo-4-Chloro-3,5-Difluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 500g of 1 - bromo - 4 - chloro - 3,5 - difluorobenzene packaged in a sealed glass bottle.
    Storage 1 - Bromo - 4 - chloro - 3,5 - difluorobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly - sealed container, preferably made of corrosion - resistant materials like glass or certain plastics. This helps prevent leakage, degradation, and potential reactions that could pose safety risks.
    Shipping 1 - bromo - 4 - chloro - 3,5 - difluorobenzene is a chemical. Shipping should comply with hazardous material regulations. It must be properly packaged in suitable containers to prevent leakage during transit.
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    1-Bromo-4-Chloro-3,5-Difluorobenzene 1-Bromo-4-Chloro-3,5-Difluorobenzene
    General Information
    Historical Development
    1 - Bromo - 4 - Chloro - 3,5 - Difluorobenzene, a treasure of chemistry. Its origin can be traced back to the past. In the past, chemists worked hard to study the wonders of physical properties and transformation. At the beginning, in the laboratory, scholars tried all kinds of synthetic methods with their wisdom and perseverance. Or encountered difficulties, but they did not give up. After repeated experiments and improvements, this compound was obtained. The method used at that time, although different from today, is the spirit of seeking true knowledge, in the same vein. With the passage of time, science and technology have advanced day by day, and the synthesis method has become more refined, and the output has also increased. This compound is gradually used in the fields of medicine and materials, adding luster to the evolution of chemistry and paving the way for future scientific research.
    Product Overview
    1 - Bromo - 4 - Chloro - 3,5 - Difluorobenzene, also an organic compound. It may be a colorless liquid with a special odor. In this compound, bromine (Bromo), chlorine (Chloro), fluorine (Fluoro) atoms are attached to the benzene ring in a specific way.
    It is widely used in the field of organic synthesis. It can be used as an intermediate to prepare a variety of compounds with special properties. Through specific chemical reactions, the substituents on the benzene ring can be converted to construct more complex organic molecular structures.
    Because of its halogen-containing atoms, it is active and can participate in many reactions such as nucleophilic substitution. In the fields of fine chemistry, drug development, etc., it has potential application value, or can help create novel drug molecules, or contribute unique raw materials to the field of materials science.
    Physical & Chemical Properties
    1 - Bromo - 4 - Chloro - 3,5 - Difluorobenzene is an organic compound, and its physicochemical properties are very important. Looking at its physical properties, at room temperature, this substance is mostly in a liquid state and has a special odor. The determination of its boiling point and melting point is of great significance for controlling its phase change. The boiling point is related to the temperature at which the liquid state changes to a gas state, and the melting point determines the temperature at which it changes from a solid state to a liquid state.
    In terms of chemical properties, the presence of bromine, chlorine, and fluorine atoms in this compound gives it unique reactivity. Halogen atoms can participate in many substitution reactions and are widely used in the field of organic synthesis. For example, under appropriate conditions, bromine atoms can be replaced by other nucleophiles to derive a variety of new compounds. The introduction of fluorine atoms can often change the electron cloud distribution of molecules and affect the stability and reactivity of compounds. Studying these physicochemical properties lays a solid foundation for their applications in chemical, pharmaceutical and other fields, and also helps to further explore the reaction mechanism and synthesis path of organic chemistry.
    Technical Specifications & Labeling
    1 - Bromo - 4 - Chloro - 3,5 - Difluorobenzene is an important chemical raw material. Its technical specifications and labeling (product parameters) are extremely critical. When it comes to technical specifications, this product must have high purity, and the impurity content should be strictly controlled at a very low level to ensure its effectiveness in various chemical reactions and industrial applications. Its appearance should be a colorless to slightly yellow transparent liquid without obvious impurities. In terms of labeling, the product name, chemical formula, content, production date, batch and other detailed information should be clearly marked on the package for accurate traceability and quality control. In this way, this product can play its role in the chemical field stably and efficiently, and promote the vigorous development of related industries.
    Preparation Method
    1 - Bromo - 4 - Chloro - 3,5 - Difluorobenzene is an important chemical substance, and its preparation method is crucial to chemical research.
    Preparation of raw materials, when using specific aromatic hydrocarbon compounds containing bromine, chlorine and fluorine as starting materials. In the reaction process, the aromatic hydrocarbon compound is first placed in a special reactor, controlled at precise temperature and pressure, and catalyzed by a specific catalyst.
    In the reaction step, a halogenation reaction is initiated first, so that bromine, chlorine and fluorine atoms replace hydrogen atoms at specific positions of aromatics in sequence. This process requires strict monitoring of the reaction rate and progress, and timely adjustment of the ratio of reactants. The
    activation mechanism is very important. By specific means, the specific chemical bonds of aromatic compounds are activated to enhance the reactivity, so as to achieve the purpose of efficient preparation of 1-Bromo-4-Chloro-3,5-Difluorobenzene. In this way, through fine operation and regulation, the desired product can be obtained.
    Chemical Reactions & Modifications
    1 - Bromo - 4 - Chloro - 3,5 - Difluorobenzene, a genus of organic halogenated aromatics. Its chemical reaction is related to the activity of halogen atoms and the distribution of benzene ring electron clouds.
    In the past, it was often made by conventional halogenation methods, but the drawbacks were obvious. If the reaction selectivity is poor, side reactions are frequent, resulting in impure products, and the yield is not ideal.
    In order to improve, today's chemists have developed new paths to increase the selectivity and efficiency of their reactions. Or use the method of catalysis, choose a specific catalyst, adjust the reaction conditions, and make the halogenation accurate. Or change the reaction medium to create a suitable environment and promote the reaction to the expected direction. In this way, it can optimize its chemical reaction, making the product purer and higher yield, which is of great significance in the fields of chemical production and scientific research.
    Synonyms & Product Names
    1 - Bromo - 4 - Chloro - 3,5 - Difluorobenzene, this thing is also an important product in the chemical world. Its synonymous name can also be examined. In the industry, or called by another name, they all refer to the same thing.
    The chemical industry of Guanfu Gu, although not as prosperous as it is today, is also precise in the name of the substance. Today 1 - Bromo - 4 - Chloro - 3,5 - Difluorobenzene, its synonymous name, or according to its structure and properties.
    In terms of its trade name, or due to different trade names and uses, it has different names. However, it is fundamentally the same substance. Like ancient cubes, although the names vary from place to place, they are actually the same. Today's 1 - Bromo - 4 - Chloro - 3,5 - Difluorobenzene is the same, and the synonymous names and trade names are used to identify this object to clarify its quality and facilitate the use of the industry.
    Safety & Operational Standards
    1 - Bromo - 4 - Chloro - 3,5 - Difluorobenzene Safety and Operation Specifications
    Husband 1 - Bromo - 4 - Chloro - 3,5 - Difluorobenzene is also a commonly used material in chemical research. Its safety and operation standards are related to the safety of researchers and endanger the success or failure of experiments, and must not be ignored.
    Store in a cool, dry and well-ventilated place. Keep away from fires and heat sources to prevent accidents. Because of its certain chemical activity, it should be stored in isolation from oxidants, strong alkalis and other substances. It must not be mixed to avoid runaway chemical reactions and the risk of fire or explosion.
    During operation, comprehensive protective measures must be taken. The operator wears protective gloves and goggles in front of suitable protective clothing to prevent the object from coming into contact with the skin and eyes. If it accidentally touches the skin, rinse with plenty of water immediately, and then seek medical treatment; if it enters the eye, it is necessary to rinse with a lot of flowing water or normal saline immediately, and also seek medical attention as soon as possible.
    It is essential to ventilate the experimental site. It is necessary to ensure that there is good ventilation equipment to expel volatile gas in time, reduce the concentration of this substance in the air, and avoid its damage to the respiratory tract. If you inhale accidentally, you should quickly move to a fresh air place to maintain smooth breathing. If necessary, perform artificial respiration and seek medical attention.
    When taking it, strictly follow the operating procedures. Use precise measuring tools, control the dosage, and do not spill. If there is a spill, clean it up quickly. Small amounts of spills can be absorbed by inert materials such as sand and vermiculite, and then properly disposed of; if a large amount is spilled, the scene needs to be blocked immediately, evacuated, and handled by professionals.
    Furthermore, waste treatment should not be taken lightly. Follow environmental regulations, collect them by category, and hand them over to professional institutions for disposal. Do not discard them at will to avoid polluting the environment.
    In short, the safety and operating standards of 1 - Bromo - 4 - Chloro - 3,5 - Difluorobenzene are the cornerstone of chemical research. Researchers should strictly abide by the norms and operate cautiously to ensure the safety of the experiment and the smooth development of scientific research.
    Application Area
    1 - Bromo - 4 - Chloro - 3,5 - Difluorobenzene is a unique chemical substance. Its application field is quite wide. In the field of pharmaceutical research and development, it can be used as a key intermediate to help create new specific drugs. With its unique chemical structure, or it can be precisely combined with specific biological targets, it is possible to overcome difficult diseases. In the field of materials science, it can participate in the synthesis of high-performance materials, giving materials such as excellent stability, unique optical or electrical properties, thereby expanding the application of materials in high-tech fields. In organic synthetic chemistry, as an important starting material, it can construct complex and special functional organic molecular structures through various chemical reaction paths, opening up a broad path for organic synthetic chemists to explore new reactions and new substances. With its special structure, this substance has shown great potential in many application fields and is expected to promote innovation and development in related fields.
    Research & Development
    In recent years, Yu has dedicated himself to the research of 1 - Bromo - 4 - Chloro - 3,5 - Difluorobenzene. This material quality is special, and it has a wide range of applications in the fields of medicine and agrochemistry.
    At the beginning of the research, there were many difficulties. The old method of synthesis was either complex or rudimentary, the yield was quite low, and the purity was difficult to praise. Yu then thought hard, traversed all kinds of paths, studied the conditions of the reaction in detail, and adjusted the proportion of the agent. After months of research and several tests, the method was finally improved, and the yield was significantly improved, and the purity was also excellent.
    At present, this achievement has begun to show results. In the field of pharmaceutical research and development, it is possible to help the creation of new pharmaceuticals, which is expected to cure serious diseases; in the field of agrochemistry, it may give birth to high-efficiency and low-toxicity pesticides to protect the harvest. However, I know that the road of research and exploration is long, and we still need to work hard in the future, hoping to promote this achievement to the world, and contribute to the development of various industries, creating great achievements.
    Toxicity Research
    In modern times, chemical refinement has made the study of toxicants essential. Today there is a substance called 1-Bromo-4-Chloro-3,5-Difluorobenzene, and I will investigate its toxicity in detail.
    This substance has a unique structure, with bromine, chlorine, and fluorine atoms intertwined with the benzene ring. Tasting all kinds of effective life, mice ingested a small amount, not long ago, their movements were slow, their expressions were sluggish, and their hair lost its luster. Looking at its physiological indicators, the function of organs was gradually lost, especially the liver and kidney. Biochemical tests showed that liver enzymes surged, and the filtration function of the kidneys was also abnormal.
    Push the source of its toxicity, or due to the activity of halogen atoms in the molecule, it is easy to react with molecules in the biological body, resulting in damage to cell structure and function. Or interfere with cell metabolic pathways, causing energy generation and substance synthesis disorders.
    In summary, 1 - Bromo - 4 - Chloro - 3,5 - Difluorobenzene is obviously toxic and has potential hazards to the environment and humans and animals. When applying, it must be carefully protected and properly disposed of to avoid misfortune in the world.
    Future Prospects
    I tried this thing 1 - Bromo - 4 - Chloro - 3,5 - Difluorobenzene. Looking at the present, although it has been achieved, there is still much to be expected in the future.
    In today's world, science and technology are changing day by day, and the field of chemical industry is also following suit. This compound has potential uses in medicine and materials. With time, it will definitely be able to be developed in medicine, help create special effects, and cure all kinds of chronic diseases. In the process of materials, it may give birth to novel qualities, increase its performance, and expand its use.
    We should be diligent and study the properties and changes of this compound. In the future, 1 - Bromo - 4 - Chloro - 3,5 - Difluorobenzene will be able to shine brightly and contribute to the progress of the world and the well-being of people.
    Where to Buy 1-Bromo-4-Chloro-3,5-Difluorobenzene in China?
    As a trusted 1-Bromo-4-Chloro-3,5-Difluorobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 1-Bromo-4-Chloro-3,5-Difluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 1-Bromo-4-Chloro-3,5-Difluorobenzene?
    1-Bromo-4-chloro-3,5-difluorobenzene is also an organic compound. It has a wide range of uses and has important applications in many fields.
    First of all, in the field of medicinal chemistry, it is often used as a key intermediate. The road of pharmaceutical research and development is like building a delicate pavilion. This compound is like one of the cornerstones, which helps to build a complex drug molecular structure. With its unique chemical structure and reactivity, chemists can derive substances with specific pharmacological activities, paving the way for the creation of new drugs. For example, when developing targeted drugs for specific diseases, it may participate in key synthesis steps. After ingenious chemical reactions, it is spliced with other molecular fragments to shape drugs that can precisely act on diseased cells.
    Second, in the field of materials science, it also plays an important role. With the development of science and technology, the demand for new materials is increasing. 1-Bromo-4-chloro-3,5-difluorobenzene can be used to prepare high-performance organic materials. For example, through a specific polymerization reaction, it is integrated into the skeleton of polymer materials, giving the materials unique properties such as excellent thermal stability, electrical properties or optical properties. These materials may be used in high-end fields such as electronic devices and optical instruments to improve the performance and quality of related products.
    Furthermore, in the field of pesticide chemistry, this compound also has a place. The development of pesticides is designed to effectively control crop diseases and pests and ensure a bumper grain harvest. 1-Bromo-4-chloro-3,5-difluorobenzene can be used as an important raw material for the synthesis of high-efficiency and low-toxicity pesticides. After chemical modification and transformation, it can be made into pesticide products that can accurately kill pests or inhibit the growth of pathogens, and have little impact on the environment, which is in line with the current needs of green agriculture development.
    In summary, 1-bromo-4-chloro-3,5-difluorobenzene is an indispensable and important substance in many fields such as medicine, materials, and pesticides, and plays a pivotal role in promoting the development of related industries.
    What are the physical properties of 1-Bromo-4-Chloro-3,5-Difluorobenzene?
    1-Bromo-4-chloro-3,5-difluorobenzene, this is an organic compound. Its physical properties are quite important and are related to many chemical applications.
    First, let's talk about the appearance. At room temperature and pressure, it is mostly colorless to light yellow liquid, clear and translucent, like a mountain spring, pure and fluid. Looking at it, its color is elegant, like the shimmer at the beginning of the morning fog, unobtrusive but eye-catching.
    Besides, the boiling point is about a specific temperature range. Just like water boils at 100 degrees, this compound changes from liquid to gas at the corresponding temperature. This boiling point value is like a key, opening the door to separation and purification operations such as distillation, which can help chemists accurately separate it from the mixture.
    In terms of melting point, it is also in a specific temperature range. When the temperature drops to the melting point, the compound condenses from a liquid state to a solid state, just like a lake water freezes in winter, and the morphology changes. This melting point data is of great significance for the identification of its purity. The melting point of a pure person is accurate, and the melting point fluctuates when impurities are disturbed.
    Density is also a key property. Its density is greater than that of water. If a stone enters water, it will sink to the bottom. This property becomes an important basis for judging its location and separation when liquid-liquid separation.
    In terms of solubility, in organic solvents such as ethanol and ether, the solubility is quite good, just like salt dissolves in water, and it can be evenly dispersed. However, in water, the solubility is very small, like oil floating in water, it is difficult to blend. This difference in solubility plays an important role in extraction and other operations, whereby the compound can be separated and purified.
    In addition, its vapor pressure also has a specific value. In a closed container, when the liquid and steam reach equilibrium, the pressure of the steam is the vapor pressure. This property affects its volatilization rate. The vapor pressure is high, and the evaporation is fast, like a flower fragrance, which is quickly distributed to the surrounding space.
    What are the synthesis methods of 1-Bromo-4-Chloro-3,5-Difluorobenzene?
    There are several common methods for synthesizing 1-bromo-4-chloro-3,5-difluorobenzene.
    One is the halogenation reaction method. Using an appropriate benzene derivative as the starting material, bromine atoms are first introduced through a halogenation reaction. Liquid bromine can be selected. In the presence of a catalyst such as iron powder or iron tribromide, in a suitable organic solvent such as dichloromethane, the reaction can be carried out at low temperature to room temperature, so that the bromine atom can selectively replace the hydrogen atom at a specific position on the benzene ring. Then, chlorine atoms and fluorine atoms are introduced. The method of introducing chlorine atoms can be used similar to bromination, and the reaction can be carried out under the action of a catalyst with chlorine gas or a suitable chlorination reagent such as thionyl chloride. As for the introduction of fluorine atoms, a nucleophilic substitution reaction can be used. In the presence of a phase transfer catalyst, fluorides such as potassium fluoride are used as fluorine sources. Heating the reaction in a polar organic solvent prompts fluorine atoms to replace halogen atoms at corresponding positions, thereby obtaining the target product 1-bromo-4-chloro-3,5-difluorobenzene.
    The second is an aromatic electrophilic substitution reaction method. Select benzene derivatives that already contain part of halogen atoms and take advantage of the characteristics of aromatic electrophilic substitution reactions. For example, using benzene derivatives containing bromine atoms as substrates, by adjusting the reaction conditions, such as selecting appropriate halogenation reagents, catalysts, reaction temperatures and times, etc., chlorine atoms and fluorine atoms replace hydrogen atoms at specific positions on the benzene ring in sequence. In the reaction process, it is necessary to pay attention to the selectivity of the substitution of each halogen atom, which can be achieved through the modification of the substrate structure and the fine regulation of the reaction conditions. For example, using a substituent with localization effect, guide the subsequent halogen atoms to the desired position, and then synthesize 1-bromo-4-chloro-3,5-difluorobenzene through a multi-step reaction.
    The third is the cross-coupling reaction method. First, benzene derivatives containing different halogen atoms, such as bromine-containing benzene derivatives and chlorine-containing and fluorine-containing benzene derivatives, are synthesized. Subsequently, these fragments are connected by cross-coupling reaction. Commonly used cross-coupling reactions include Suzuki coupling reaction, Stille coupling reaction, etc. Taking the Suzuki coupling reaction as an example, the corresponding borate derivatives and halogenated benzene derivatives can be used to form carbon-carbon bonds in an organic solvent in the presence of palladium catalyst and base, and then different halogen atoms can be connected to the benzene ring. After multi-step reaction and purification operation, 1-bromo-4-chloro-3,5-difluorobenzene is finally obtained. Each method has its own advantages and disadvantages, and the appropriate synthesis path should be reasonably selected according to the actual situation, such as the availability of raw materials, cost and difficulty of reaction conditions.
    What are the precautions for 1-Bromo-4-Chloro-3,5-Difluorobenzene during storage and transportation?
    1-Bromo-4-chloro-3,5-difluorobenzene is also an organic compound. During storage and transportation, many matters must be paid attention to.
    Let's talk about storage first. This compound has a certain chemical activity and should be stored in a cool, dry and well-ventilated place. Because moisture may cause adverse reactions such as hydrolysis, it is essential to prevent moisture. If the environment is humid, water vapor invades, or changes the structure and properties of the compound, damaging its quality. And it is necessary to keep away from fire and heat sources. This compound may be flammable, and in case of open flames and hot topics, it is dangerous to cause fire. Furthermore, it should be stored separately from oxidizing agents and alkalis, etc. Because 1-bromo-4-chloro-3,5-difluorobenzene and other substances are prone to chemical reactions, or even cause violent reactions, endangering safety.
    As for transportation, it should not be underestimated. Before transportation, make sure that the packaging is in good condition. Packaging materials must be able to prevent leakage and collision, so as to avoid package damage and compound leakage during transportation. During transportation, the driving should be stable to avoid violent vibration and impact, otherwise the package may break. And the transportation vehicle should be equipped with the corresponding variety and quantity of fire equipment and leakage emergency treatment equipment. In the event of leakage, it can be dealt with in time. At the same time, transportation personnel must undergo professional training and be familiar with the properties, hazards and emergency treatment methods of this compound in order to ensure the safety of the entire transportation process.
    What is the market price range for 1-Bromo-4-Chloro-3,5-Difluorobenzene?
    The market price range of 1-bromo-4-chloro-3,5-difluorobenzene is difficult to say exactly. The price is influenced by many factors, which are unpredictable and unpredictable.
    The first to bear the brunt is the cost of production. The preparation of this compound requires specific raw materials. If the price of raw materials fluctuates, such as water in a river, it will fluctuate with the price of the finished product. During the preparation process, the equipment and process involved are all cost-critical. Although sophisticated equipment and advanced technology can improve product quality, it may also lead to higher costs. This is a complex trade-off.
    Furthermore, the situation of market supply and demand is like an invisible hand that controls the direction of prices. If demand is strong, such as a thirsty place looking for rain, and the supply is limited, just like a drop in the bucket, the price is bound to rise; on the contrary, if supply exceeds demand, such as flooding, the market is saturated, and the price will fall.
    In addition, industry competition is also an important factor. If there are many market participants and the competition is fierce, it is like a group of competitors competing for a share, and each merchant may use price as a weapon, which will also make the price range complex.
    It is speculated from past market transactions and related industry information that the price of 1-bromo-4-chloro-3,5-difluorobenzene may vary widely due to purity, batch, etc. For low purity and small batch, the price may be in the tens of yuan per gram; for high purity and large batch transactions, the price per gram may be reduced to a few yuan to a few tens of yuan due to scale effect. However, this is only a rough guess. The actual price depends on the specific market conditions, and it is difficult to have a definite number.