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1-Bromo-3-(Trifluoromethyl)Benzene

1-Bromo-3-(Trifluoromethyl)Benzene

Hongda Chemical

    Specifications

    HS Code

    996670

    Chemical Formula C7H4BrF3
    Molecular Weight 225.006
    Appearance Colorless to light yellow liquid
    Boiling Point 166 - 168 °C
    Density 1.627 g/mL at 25 °C
    Solubility Insoluble in water, soluble in organic solvents like ethanol, ether
    Flash Point 64 °C
    Refractive Index 1.4675 - 1.4695

    As an accredited 1-Bromo-3-(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100 mL of 1 - bromo - 3 - (trifluoromethyl)benzene in a sealed glass bottle.
    Storage 1 - bromo - 3 - (trifluoromethyl)benzene should be stored in a cool, well - ventilated area, away from heat sources and ignition points. It should be kept in a tightly - sealed container, preferably made of corrosion - resistant materials. Since it's a chemical, store it separately from incompatible substances, like oxidizing agents and reactive metals, to prevent potential reactions.
    Shipping 1 - bromo - 3 - (trifluoromethyl)benzene is shipped in specialized, well - sealed containers. Compliance with hazardous chemical shipping regulations is ensured. It's carefully handled to prevent spills during transit, safeguarding people and the environment.
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    1-Bromo-3-(Trifluoromethyl)Benzene 1-Bromo-3-(Trifluoromethyl)Benzene
    General Information
    Historical Development
    1 - Bromo - 3 - (Trifluoromethyl) Benzene is an important raw material for organic synthesis, and its history is quite impressive. In the past, organic chemistry was just emerging, and many scholars were dedicated to the exploration of new compounds. At that time, the research on such halogenated aromatic hydrocarbons containing fluorides was still very limited.
    With the progress of science and technology, the analysis technology became more and more accurate, and chemists were able to deeply analyze its structure and properties. After repeated experiments and careful study, the method of synthesizing 1 - Bromo - 3 - (Trifluoromethyl) Benzene was mastered. This compound is gradually used in the fields of medicine and pesticides, and can be used as a key intermediate to help create special new drugs and efficient pesticides. With the progress of industry, its synthesis process has also been continuously optimized, the output has increased, and its application has become more extensive, leaving a strong imprint on the development of organic chemistry.
    Product Overview
    1 - Bromo - 3 - (Trifluoromethyl) Benzene is also an organic compound. Its shape is colorless to light yellow liquid with a special odor. The structure of this compound is above the benzene ring, with a bromo atom and trifluoromethyl in an interposition.
    Because of its unique structure, it has specific chemical properties. In the electrophilic substitution reaction, bromine atoms and trifluoromethyl have different effects on the electron cloud density of the benzene ring, so the reaction check point is different from that of ordinary benzene derivatives.
    In the field of organic synthesis, 1 - Bromo - 3 - (Trifluoromethyl) Benzene has a wide range of uses. It can be used as a key intermediate for the synthesis of various fluorinated drugs, pesticides and functional materials. When preparing specific targeted drugs, fluorine-containing groups are introduced to improve drug activity and stability by virtue of their structural characteristics.
    And its physical properties, such as boiling point, melting point, solubility, etc., also provide the basis for its application. Its boiling point is suitable, and it has good solubility in common organic solvents, which is convenient for operation and separation and purification in synthetic reactions.
    Physical & Chemical Properties
    1 - Bromo - 3 - (Trifluoromethyl) Benzene is an organic compound, and its physicochemical properties are quite important. Looking at its physical properties, it is mostly liquid at room temperature and has a special odor. Its boiling point is suitable, and it boils at a certain temperature. This property is related to its separation and purification. Density is also key. Compared with water and other common solvents, it has a unique performance and has a great influence on its distribution in solution.
    On chemical properties, due to the presence of bromine atoms and trifluoromethyl, the reactivity is unique. Bromine atoms can undergo substitution reactions, and under appropriate conditions, can be replaced by other groups to derive a variety of compounds. Trifluoromethyl gives it special electronic and spatial effects, which affect molecular stability and reaction check point selectivity. This compound is used in the field of organic synthesis, or as an intermediate, to participate in the construction of complex organics, and has made great contributions to chemical research and industrial production.
    Technical Specifications & Labeling
    1 - Bromo - 3 - (Trifluoromethyl) Benzene is an important chemical raw material, and its preparation requires specific technical specifications and standards. As far as technical specifications are concerned, the purity of the raw material is crucial, and it must be strictly screened, and impurities need to be reduced to extremely low levels. The temperature and pressure of the reaction also need to be precisely controlled. For example, in a specific reaction stage, the temperature should be maintained at [X] ° C and the pressure should be at [X] kPa to ensure the high efficiency and stability of the reaction.
    When it comes to the product identification (commodity parameters), the appearance should be a colorless to slightly yellow transparent liquid with a specific smell. The purity must be above [X]%, which is the key indicator. And its density, boiling point and other physical parameters are also clearly stipulated. The density should be at [X] g/cm ³, and the boiling point should be at [X] ° C to ensure the uniformity and stability of product quality and provide reliable protection for subsequent industrial applications.
    Preparation Method
    1 - Bromo - 3 - (Trifluoromethyl) Benzene is an important compound in organic synthesis. The preparation method and the selection of raw materials are crucial. Commonly used raw materials include compounds containing benzene rings, and bromine atoms and trifluoromethyl groups need to be introduced at specific positions.
    In terms of preparation process, the reaction steps are fine. First, bromine atoms are introduced at the 3rd position of the benzene ring through halogenation of a specific benzene-containing substrate under appropriate conditions. This step requires controlling the reaction temperature, time and reagent ratio to ensure the selectivity of the reaction.
    Then, after a specific reaction, trifluoromethyl is introduced at the ortho-position of the bromine atom. The reaction conditions used in this process are harsh, requiring an anhydrous and oxygen-free environment, and the choice of catalyst is also crucial, which can effectively regulate the reaction rate and product purity.
    In the production process, a perfect catalytic mechanism needs to be constructed. Selecting an efficient and stable catalyst can improve the reaction efficiency and reduce the production cost. At the same time, the reaction process is closely monitored to ensure the smooth progress of each step to obtain high-purity 1 - Bromo - 3 - (Trifluoromethyl) Benzene.
    Chemical Reactions & Modifications
    Guanfu 1 - Bromo - 3 - (Trifluoromethyl) Benzene, its chemical reaction and modification are quite important for learners.
    The chemical reaction in the past, or follow the old method, but if you want better results, you must think about changes. In the chemical reaction, all the conditions are crucial, such as temperature, pressure, catalyst. Looking at the reaction in the past, or the yield is not high, or there are many side reactions, all of which need to be improved.
    If you want to modify this substance, you should study the molecular structure. Observe the characteristics of its bonds and think about how to optimize it. Or introduce new radicals to change its properties. In the choice of chemical application, it is appropriate to adopt efficient and environmentally friendly methods, which not only increase the quality of the product, but also reduce the harm to the environment. In this way, the best environment of chemical application and modification can be achieved, so that 1 - Bromo - 3 - (Trifluoromethyl) Benzene can be used in various fields to the best of its ability.
    Synonyms & Product Names
    1 - Bromo - 3 - (Trifluoromethyl) Benzene is very important in my chemical research. Its synonymous name and commodity name are also of inquiry value.
    covers the name of the chemical substance, or according to its structure, or according to its nature, or because of the person and place where it was discovered. 1 - Bromo - 3 - (Trifluoromethyl) Benzene, from its structure, this name accurately describes its molecular composition. Bromine atoms and trifluoromethyl are at a specific position in the benzene ring. However, in practical applications, the world often calls it by different synonymous names, and it is also called a unique commodity.
    As recorded in past studies, there are people who call it a specific code name. This code name may have been set up for the convenience of experiments at that time and circulated in specific academic circles. The trade name is related to business operation. In order to make the product show its characteristics and attract customers, merchants give it a unique trade name. Exploring such synonyms and trade names is beneficial to chemical communication and commercial circulation, and can help all parties to clarify this thing and promote the development of the chemical field.
    Safety & Operational Standards
    1 - Bromo - 3 - (Trifluoromethyl) Benzene, this chemical substance is related to safety and operation standards, and is extremely important. It should be discussed in detail.
    All operations involving this substance should prioritize the safety of the environment. In a well-ventilated place, if it is in a secret room, poisonous gas will accumulate, which may cause serious harm. Therefore, a ventilation device must be set up to make the air smooth and the harmful gas can be dissipated in time.
    Furthermore, the protection of the person who handles it should not be ignored. In front of a special protective clothing, this clothing can resist the erosion of chemical substances and protect the person. And protective gloves must be worn, the material is tough, and it can isolate poisons. Do not let the skin come into contact with it. Goggles should also be prepared to prevent substances from splashing into the eyes and damaging the eyesight.
    There are also rules for storing this object. It should be placed in a cool and dry place, away from fire and heat sources. Due to heat, the activity of the substance will change, or it may cause explosion or combustion. And it must be placed separately from oxidants, strong alkalis, etc., to prevent violent chemical reactions.
    When taking it, the action should be slow and careful. Take it with a precise instrument, do not pour it at will, so that the amount is small and inaccurate, and prevent substances from spilling. If it is accidentally spilled, clean it up as soon as possible according to the established method. First cover it with adsorbed substances, such as vermiculite and sand, and then collect it properly. Do not leave it on the ground.
    If someone accidentally comes into contact with this substance, or inhales its volatile gas, the emergency method must not be known. If the skin touches it, rinse it with a lot of water quickly, and then wash it with soap; if it enters the eye, rinse it with water urgently, and seek medical treatment. Those who inhale, quickly move to a fresh air place. If the breathing is not smooth, apply artificial respiration, and also need to rush to the hospital.
    This is all 1 - Bromo - 3 - (Trifluoromethyl) Benzene. The importance of safety and operating standards must be kept in mind. Do not slack a little to ensure the safety of the experiment and the safety of personnel.
    Application Area
    1 - Bromo - 3 - (Trifluoromethyl) Benzene is a crucial raw material in organic synthesis. Its application field is quite wide, in the field of medicinal chemistry, it is often a key intermediate for the synthesis of specific drugs. Through exquisite chemical reactions, it can be cleverly converted into structural units with specific pharmacological activities, which can help the research and development of new drugs.
    In the field of materials science, this compound also shows unique value. It can participate in the preparation of functional materials with excellent performance, such as materials with special optical and electrical properties, so as to meet the strict needs of high-performance materials in electronic devices, optical instruments and other fields.
    In the field of pesticide chemistry, 1 - Bromo - 3 - (Trifluoromethyl) Benzene can be used as a basic raw material to synthesize high-efficiency, low-toxicity and environmentally friendly pesticide products through a series of reactions, providing strong support for agricultural pest control. With its unique chemical structure, it can effectively improve the efficacy and stability of pesticides and play an important role in agricultural production.
    Research & Development
    Today there is a product called 1 - Bromo - 3 - (Trifluoromethyl) Benzene. As a chemical researcher, I have been exploring this product for a long time.
    Its unique nature is often the key agent in the reaction. At the beginning, everyone's understanding of it was still shallow, and it was only seen on the surface, but not yet understood. However, we worked tirelessly to study it, with various experiments, analyze its structure, and explore its characteristics.
    After years, it has gradually become clear that it has great potential in organic synthesis. It can be used as a raw material to produce a variety of compounds, adding to the chemical industry.
    We also study its preparation method and strive to improve. After repeated attempts to improve the process, we hope to improve its yield and reduce its cost.
    Looking at the development of this product, from ignorance and ignorance to gradual improvement, it all depends on the diligence of scientific researchers. In the future, we must go to the next level and develop our capabilities in various fields of chemical industry to promote the prosperity of the industry.
    Toxicity Research
    Toxicity Study of 1 - Bromo - 3 - (Trifluoromethyl) Benzene
    Modern chemical refinement, new layers out, 1 - Bromo - 3 - (Trifluoromethyl) Benzene is also one of the chemical production. In toxicity studies, it is crucial.
    Examine the properties of this substance, or enter the body through inhalation, contact with skin, ingestion, etc. Inhalation may harm the respiratory system, causing airway discomfort, cough, shortness of breath, etc. Contact with skin, or irritation, redness, swelling, itching. If ingested by mistake, it may hurt the stomach, and cause nausea and vomiting.
    However, the depth of toxicity also varies depending on the dose and duration. A small amount of short touch, or mild and curable; a large amount of long exposure, the damage is large and difficult to recover. Today's research still needs extensive data to investigate its toxicological mechanism in detail, in order to find ways to protect and treat, to ensure the safety of workers and survivors, and to avoid the harm of this substance.
    Future Prospects
    1 - Bromo - 3 - (Trifluoromethyl) Benzene is also an organic compound. Looking at today's chemical research, this substance is gradually showing its ability in various fields. In the field of pharmaceutical creation, it is expected to be the basis for new agents, help solve difficult diseases, and save people's suffering. In industrial manufacturing, it may be used as a key raw material to promote the refinement of materials and make utensils strong and durable. In scientific research and exploration, its unique properties have attracted scholars to study, uncover the mysteries of chemistry, and expand new frontiers of knowledge. Future development is expected to take advantage of the long wind of science and technology and travel rapidly on the road of innovation. Or give birth to more efficient synthesis methods, reduce energy consumption and increase production; or cooperate with cutting-edge technologies, such as nano and quantum, to open up new application fields. Therefore, the future of 1 - Bromo - 3 - (Trifluoromethyl) Benzene is as bright as the dawn, full of hope and bright prospects.
    Where to Buy 1-Bromo-3-(Trifluoromethyl)Benzene in China?
    As a trusted 1-Bromo-3-(Trifluoromethyl)Benzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 1-Bromo-3-(Trifluoromethyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What is the main use of 1 - Bromo - 3 - (Trifluoromethyl) Benzene?
    1-Bromo-3- (trifluoromethyl) benzene has a wide range of uses. In the field of organic synthesis, this is an important intermediate. It can be converted into various high-value organic compounds through many reaction pathways.
    For example, in nucleophilic substitution reactions, bromine atoms can be replaced by other nucleophilic reagents. If it encounters nitrogen-containing nucleophilic reagents, it can form nitrogen-containing aromatic compounds. Such compounds often have important uses in the field of medicine, or are potential pharmaceutical active ingredients, which can be used to develop drugs for the treatment of specific diseases.
    In the field of materials science, 1-bromo-3- (trifluoromethyl) benzene also has its uses. Through a specific polymerization reaction, it can be built into the structure of polymer materials. Due to the special properties of trifluoromethyl, polymer materials can be endowed with unique properties, such as enhancing the chemical stability and corrosion resistance of materials, or changing the surface properties of materials to make them hydrophobic, etc., and then expand the application of materials in special environments, such as in chemical equipment protective coatings.
    Furthermore, in fine chemical production, it can be used as a starting material to prepare fine chemicals through multi-step reactions. These fine chemicals may be key intermediates of fragrances and dyes, which can have an important impact on the color, odor and other properties of products, helping to improve the quality and added value of fine chemical products. In conclusion, 1-bromo-3- (trifluoromethyl) benzene plays an indispensable role in the fields of organic synthesis, materials science, and fine chemistry.
    What are the physical properties of 1 - Bromo - 3 - (Trifluoromethyl) Benzene
    1-Bromo-3- (trifluoromethyl) benzene is an important compound in organic chemistry. Looking at its physical properties, it is mostly liquid at room temperature and has a specific odor. Its boiling point is about 197-199 ° C. This boiling point value enables it to change from liquid to gaseous at a specific temperature. The melting point is about -27 ° C, which means that when the temperature is lower, the compound will solidify into a solid state.
    Furthermore, its density is about 1.72 g/mL, which is higher than that of water, so it will sink to the bottom when mixed with water. This compound is insoluble in water, but soluble in common organic solvents such as ethanol, ether, and dichloromethane. This solubility property has important applications in the extraction and separation steps of organic synthesis. Because it can be miscible with specific organic solvents, it can be effectively separated from the reaction mixture and improve the purity of the product.
    1-bromo-3- (trifluoromethyl) benzene has a low vapor pressure, indicating that it evaporates relatively slowly at room temperature. And its refractive index is about 1.477. This optical property can be used as an important basis for the identification and analysis of the compound. By measuring the refractive index, it can assist in confirming the purity and structure of the compound. In conclusion, the various physical properties of 1-bromo-3- (trifluoromethyl) benzene provide a solid foundation for its research and application in the field of organic chemistry.
    What are the chemical properties of 1 - Bromo - 3 - (Trifluoromethyl) Benzene
    1-Bromo-3- (trifluoromethyl) benzene is also an organic compound. It has various chemical properties and is very important in the field of organic synthesis.
    First of all, the bromine atom in this compound is quite active. Because it is a halogen atom, nucleophilic substitution reactions can occur. When encountering nucleophilic reagents, such as alkoxides and amines, bromine atoms can be replaced. Taking alkoxides as an example, under appropriate conditions, the anion of alcohol and oxygen acts as a nucleophilic reagent to attack the carbon atom connected to the bromine atom, and the bromine ion leaves to form an ether compound. This reaction mechanism is that the nucleophilic reagent provides an electron pair to bond with the carbon atom in the substrate that lacks electrons, and the leaving group leaves with a pair of electrons
    Furthermore, the properties of the benzene ring cannot be ignored. The benzene ring is aromatic and relatively stable. However, due to the existence of trifluoromethyl, this group has strong electron-absorbing properties, which can reduce the electron cloud density of the benzene ring. Therefore, when it undergoes electrophilic substitution reaction, its activity is slightly reduced compared with ordinary benzene. When the electrophilic reagent attacks the benzene ring, it tends to enter the trifluoromethyl meso. Due to the electron-absorbing effect of trifluoromethyl, the electron cloud density of the ortho and para-sites decreases more, and the meso is relatively high, and the electrophilic reagent is more likely to attack the meso.
    In addition, 1-bromo-3- (trifluoromethyl) benzene can also participate For example, under the catalysis of palladium, it can couple with carbon-containing nucleophiles to form new carbon-carbon bonds, which is extremely useful for constructing complex organic molecular structures. Through such reactions, various functionalized carbon chains can be introduced to expand the structural complexity of molecules, and then organic materials, drugs and other compounds with specific functions can be prepared.
    What are the synthesis methods of 1 - Bromo - 3 - (Trifluoromethyl) Benzene
    There are many methods for synthesizing 1-bromo-3- (trifluoromethyl) benzene. One is to use m-trifluoromethylaniline as the starting material, through diazotization reaction, followed by cuprous bromide as the catalyst, and hydrobromic acid. In this process, the diazotization reaction needs to be carefully operated at low temperature to ensure the smooth reaction and product purity.
    Furthermore, m-trifluoromethylbenzoic acid can be started, first converted into acyl chloride, then reduced to aldehyde, and then brominated to obtain the target product. In this route, the reduction step is very critical, and the selection of suitable reducing agent and reaction conditions is related to the yield of the product.
    Another one uses m-bromotoluene as a raw material, first introducing bromine atoms through halogenation reaction, and then introducing trifluoromethyl through nucleophilic substitution reaction. In this path, the control of the conditions of nucleophilic substitution reaction, such as reaction temperature, solvent selection, etc., has a great impact on the success or failure of the reaction.
    Another one uses m-bromotoluene as a starting material, and finally synthesizes 1-bromo-3- (trifluoromethyl) benzene through a series of reactions, such as esterification, reduction, halogenation, etc. This synthesis method has many steps, but if the reaction conditions of each step can be precisely controlled, satisfactory results can also be obtained.
    There are various methods for synthesizing 1-bromo-3- (trifluoromethyl) benzene, each method has its advantages and disadvantages, and the appropriate method should be selected according to the actual situation, such as raw material availability, cost, product purity requirements, etc.
    1 - Bromo - 3 - (Trifluoromethyl) Benzene during storage and transportation
    1-Bromo-3- (trifluoromethyl) benzene is an organic chemical, and many things must be paid attention to when storing and transporting it.
    First of all, storage, this substance should be stored in a cool and ventilated warehouse. Because of its certain chemical activity, high temperature or chemical reaction, it is dangerous, so the temperature must be strictly controlled, generally 2-8 ° C. And the humidity in the warehouse cannot be ignored. If the humidity is too high or the substance deteriorates, the humidity should usually be maintained at 40% -60%. In addition, it needs to be stored separately from oxidants and alkalis, and must not be mixed. This is because 1-bromo-3- (trifluoromethyl) benzene comes into contact with oxidizing agents, or undergoes a violent oxidation reaction, encounters with alkalis, and may also undergo chemical reactions, causing changes in the properties of substances and even forming dangerous products. The warehouse needs to be equipped with the corresponding variety and quantity of fire-fighting equipment and leakage emergency treatment equipment to prepare for emergencies.
    As for transportation, it is necessary to ensure that the packaging is complete and the loading is secure before transportation. The packaging material should have good sealing and corrosion resistance to prevent leakage. During transportation, it is necessary to ensure that the container does not leak, collapse, fall or damage. This substance should be transported according to the specified route and do not stop in residential areas and densely populated areas. If a leak occurs, it will pose a serious threat to the health and environment of many people in a densely populated area. Transportation vehicles should also be equipped with corresponding types and quantities of fire-fighting equipment and leakage emergency treatment equipment. In the event of an accident during transportation, timely measures can be taken to reduce the harm.