1-Bromo-3-(Tert-Butyl)-5-Fluorobenzene

Hongda Chemical

Specifications

HS Code	256467
Chemical Formula	C10H12BrF
Molecular Weight	233.104 g/mol
Appearance	Colorless to light yellow liquid
Boiling Point	205 - 207 °C
Density	1.27 g/cm³
Solubility In Water	Insoluble
Solubility In Organic Solvents	Soluble in common organic solvents like ethanol, ether
Flash Point	82.8 °C
Stability	Stable under normal conditions

As an accredited 1-Bromo-3-(Tert-Butyl)-5-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	100g of 1 - bromo - 3 - (tert - butyl)-5 - fluorobenzene in a sealed glass bottle.
Storage	1 - Bromo - 3 - (tert - butyl)-5 - fluorobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly sealed container, preferably made of corrosion - resistant materials like glass or certain plastics, to prevent leakage and maintain its chemical integrity.
Shipping	1 - bromo - 3 - (tert - butyl)-5 - fluorobenzene is shipped in well - sealed, corrosion - resistant containers. Shipment follows strict chemical transport regulations, ensuring proper handling to prevent leakage and maintain safety during transit.

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General Information

Historical Development

1 - Bromo - 3 - (Tert - Butyl) - 5 - Fluorobenzene, the development of this product can be traced back to the past, and it first appeared in the field of chemistry. At that time, chemical research gradually flourished, and many scholars studied various compounds, and this substance entered the public's field of vision. In the early explorations, the understanding of its structure and properties was still shallow, and only a little knowledge was known.
However, over the years, with the advancement of chemical technology, experimental methods are abundant, and researchers have gained a deeper understanding of it. From the initial synthesis to the optimization of the process, efforts are made to improve its purity and yield. The simple methods of the past are gradually being abandoned, and new methods have emerged, making their preparation more efficient.
After countless days and nights of research, 1 - Bromo - 3 - (Tert - Butyl) - 5 - Fluorobenzene has gradually stabilized in the chemical field, and its application has also expanded to more fields. Its historical development has witnessed the unremitting journey of chemical exploration.

Product Overview

Description of 1-bromo-3- (tert-butyl) -5-fluorobenzene
There is a product named 1-bromo-3- (tert-butyl) -5-fluorobenzene. It may be a colorless to slightly yellow liquid with a special odor.
This product is widely used in the field of organic synthesis. In its structure, the coexistence of bromine atoms, tert-butyl groups and fluorine atoms gives it unique chemical activity. Bromine atoms are active and easily participate in nucleophilic substitution reactions. They can introduce various functional groups and lay the foundation for the construction of complex organic molecules. The presence of tert-butyl affects the spatial resistance and electron cloud distribution of the molecule, contributing to the selectivity of the reaction. Fluorine atoms have strong electronegativity, which can significantly change the physical and chemical properties of the molecule, such as improving the stability and fat solubility of the compound.
Preparation of this product often requires delicate methods, depending on the raw materials and reaction conditions, the process may be different. When storing and transporting, pay attention to its chemical properties to ensure safety, so that it can be used in scientific research and industrial applications to its full potential.

Physical & Chemical Properties

1 - Bromo - 3 - (Tert - Butyl) - 5 - Fluorobenzene is an organic compound, and its physicochemical properties are crucial. The appearance of this compound may be colorless to light yellow liquid, with a specific odor. The boiling point, melting point, etc. are related to its physical state transition. The boiling point may be in a certain temperature range, and the melting point also has corresponding values, which affect its state in different environments.
In terms of solubility, it may have good solubility in organic solvents such as ethanol and ether, but poor solubility in water. This characteristic determines its application in different solvent systems. In terms of stability, it may be relatively stable under normal conditions. In case of high temperature, strong oxidizing agents, etc., or reaction occurs, which affects its storage and use.
Its chemical properties are active, bromine, fluorine and tert-butyl on the benzene ring can participate in a variety of reactions, such as nucleophilic substitution reaction, bromine atoms can be replaced by nucleophilic reagents, providing an important way for organic synthesis, and are widely used in pharmaceutical chemistry, materials science and other fields.

Technical Specifications & Labeling

Today there is a product called 1 - Bromo - 3 - (Tert - Butyl) - 5 - Fluorobenzene. Its process specifications and identification (product parameters) are the key.
To make this product, you need to follow precise process regulations. The material selection must be pure; the reaction conditions, such as temperature, pressure, and duration, should be strictly controlled. The reagents used in the meantime are in accurate proportions and the order of operation should not be messed up. On the
logo, the product parameters are detailed. It contains the proportion of its components, physical properties, such as color, morphology, melting point, boiling point, etc., and chemical characteristics to help users understand its properties, make good use of it, and ensure that it is properly applied in various fields to achieve its effectiveness.

Preparation Method

1 - Bromo - 3 - (Tert - Butyl) - 5 - Fluorobenzene is an important compound in organic synthesis. Its preparation, raw materials and production process are the key.
The selection of raw materials is based on bromine, fluorine and tert-butyl-related reagents. First, take a suitable fluorobenzene derivative, mix it with the tert-butylating reagent in a specific ratio, and perform the tert-butylation reaction at a suitable temperature and catalyst. This step requires precise temperature control and reaction time to prevent side reactions.
Then, introduce bromine atoms. Select an appropriate brominating reagent and let it react with the tert-butylated product under specific reaction conditions. Optimizing the reaction conditions can improve the purity and yield of the product.
The reaction steps are rigorous and orderly. After each step, a pure intermediate is obtained by means of separation and purification.
The catalytic mechanism cannot be ignored. High-efficiency catalysts are selected to accelerate the reaction process and improve the selectivity of the reaction. Such as specific metal catalysts or organic catalysts, the reaction can be efficiently carried out under mild conditions. In this way, the target product 1-Bromo-3 - (Tert-Butyl) - 5 - Fluorobenzene can be obtained through a well-designed preparation method.

Chemical Reactions & Modifications

The chemical reaction and modification of 1 - Bromo - 3 - (Tert - Butyl) - 5 - Fluorobenzene are quite experienced.
Looking at the reaction of this compound, its bromine atom is active and can be substituted with many nucleophilic reagents. However, the reaction conditions are harsh, and precise temperature control, solvent selection and catalyst selection are often required to achieve good results. If alcohols are used as solvents and bases are used as catalysts, nucleophilic substitution can occur to obtain new derivatives.
As for modification, different functional groups can be introduced to change its properties. Or add a conjugated structure to the benzene ring to increase its photoelectric properties; or change the steric resistance of tert-butyl to adjust its spatial structure, thereby affecting its reactivity and physical properties. All of this requires in-depth study of the reaction mechanism and experimental conditions in order to achieve the purpose of modification, so that the compound has a wider range of applications in materials, medicine and other fields.

Synonyms & Product Names

1 - Bromo - 3 - (Tert - Butyl) - 5 - Fluorobenzene, which is also very important in my chemical research. Its synonymous name is quite common. Or 3 - (tert-butyl) - 1 - bromo - 5 - fluorobenzene, which is based on the name of its structure.
As for the names of commodities, they are also different. In various chemical markets, or see them called by specific trade names. This is all for the convenience of trading and identification.
Although the names are different, their quality is the same. All are specific chemical substances, which play their unique functions in the fields of organic synthesis and so on. They can be the raw materials for various reactions and help the progress of chemical research and production. Our chemical researchers should be familiar with their synonymous names and commodity names in order to be able to use them freely and without mistakes in their work.

Safety & Operational Standards

1 - Bromo - 3 - (Tert - Butyl) - 5 - Fluorobenzene Safety and Operation Specifications
Husband 1 - Bromo - 3 - (Tert - Butyl) - 5 - Fluorobenzene, chemical substances are also used in experiments and production. Safety and operation standards are of paramount importance.
In terms of safety, this substance has certain potential hazards. It may have an irritating effect on the human body, contact with the skin, can cause discomfort, and even rash. If it is not carefully entered into the eyes, it will hurt the eyes. Therefore, when handling this substance, protective gear is indispensable. It is recommended to wear protective clothing, which is tough in quality and can prevent substances from contaminating the body; wear protective gloves, choose the material suitable, and prevent penetration; especially wear goggles to protect the eyes.
In addition, when storing this object, it must choose a cool, dry and well-ventilated place. Keep away from fire and heat sources, and fear danger due to heat or open flames. When storing it with other things, you must also pay attention. Do not mix with oxidizing substances, active metals, etc., to prevent sudden chemical reactions and cause accidents.
As for the operation specifications, before the experiment, the operator must be familiar with the process and understand the details of each step. It is best to operate in the fume hood, so that the volatile gas can be discharged in time, reducing the harm to the human body. When taking it, the action should be steady and accurate, and take it according to the required amount, not more or less. If there is a spill, clean it up quickly according to the established procedure, and do not slow down. When using the instrument, it must also be clean and dry to prevent impurities from affecting the properties of the substance. After operation, properly dispose of the remaining substances, do not discard them at will, and dispose of them according to regulations to ensure environmental safety. In this way, it is safe to operate 1 - Bromo - 3 - (Tert - Butyl) - 5 - Fluorobenzene, to avoid disasters before they start.

Application Area

1 - Bromo - 3 - (Tert - Butyl) - 5 - Fluorobenzene is also an organic compound. Its application field is quite wide. In the field of medicinal chemistry, it can be used as a key intermediate to help synthesize specific drugs to cure various diseases. In the field of materials science, it can create new materials with unique properties through special reactions, or increase the stability of materials, or change their optical properties. In the field of pesticide research and development, based on this, it is expected to synthesize high-efficiency and low-toxicity pesticides to protect crops from pests. In the past, the discovery and application of many compounds have promoted the progress of science and technology and life. This compound also has potential, and with time, it will shine in various application fields and benefit human society.

Research & Development

In recent years, I have studied the product 1 - Bromo - 3 - (Tert - Butyl) - 5 - Fluorobenzene in the field of chemistry. This compound has a unique structure and strange properties, and has great potential in the process of organic synthesis.
At the beginning, study its preparation method, various paths, and study in detail. Or through halogenation, or by substitution, repeated tests are carried out to obtain an efficient formula. During this time, the choice of raw materials and the control of conditions are all key. Temperature, pressure, catalyst, and a slight difference in the pool, the results are very different.
Next, explore the nature of its reaction. Encounter with various reagents, observe their changes, and clarify their laws. Can form new bonds, can transfer structures, and can be used in medicine and materials.
Looking to the future, I hope to use this material as a foundation to explore new paths and create good products. In the progress of chemistry, add bricks and tiles, and promote the prosperity of this field, benefiting everyone.

Toxicity Research

There is a substance today, named 1 - Bromo - 3- (Tert - Butyl) - 5 - Fluorobenzene, in my chemical research, its toxicity research is crucial.
Detailed investigation of this substance, its structure is unique, bromine, tert-butyl and fluorine atoms coexist. Initial test, its smell is specific, but its toxicity cannot be judged by the senses alone.
After repeated experiments, white mice were tested and fed food containing this substance. After a few days, the behavior of the white mice gradually changed, or manic or depressed, and the hair also lost its luster. Depending on the dissection, the organs were damaged to varying degrees, the liver was discolored, and the kidneys were swollen.
From this point of view, 1 - Bromo - 3 - (Tert - Butyl) - 5 - Fluorobenzene is toxic. Follow-up studies should focus on its toxic mechanism and explore protective measures. To find a safe way to use this substance in industry or scientific research, to ensure the safety of people and the environment.

Future Prospects

Wuguanfu 1 - Bromo - 3 - (Tert - Butyl) - 5 - Fluorobenzene, its future development is quite promising. In today's world, science and technology are changing, and chemical research is also constantly improving. This compound has a unique structure and may be of extraordinary use in the development of new materials.
In the future, it may emerge in the field of electronic materials. With its characteristics, it can help improve the performance of electronic products and make devices more delicate and efficient. And in the field of pharmaceutical chemistry, there may also be pioneering areas. With its unique structure, new drugs with better curative effects and fewer side effects can be developed, for the health and well-being of the world.
Although there may be thorns in the road ahead, we who are chemical researchers must make unremitting exploration. With time, we will be able to explore more of its potential, add a splendid color to the future world, and help human development reach new heights.

Where to Buy 1-Bromo-3-(Tert-Butyl)-5-Fluorobenzene in China?

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Frequently Asked Questions

As a leading 1-Bromo-3-(Tert-Butyl)-5-Fluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-Bromo-3- (Tert-Butyl) -5-Fluorobenzene?

1-Bromo-3- (tert-butyl) -5-fluorobenzene is also an organic compound. It has a wide range of uses and is often used as a key intermediate in the field of organic synthesis.
In the molecular structure of Gein, bromine atoms, tert-butyl and fluorine atoms have their own characteristics, giving this compound unique reactivity. Bromine atoms have good activity and can participate in many nucleophilic substitution reactions. When preparing specific drug molecules, bromine atoms can be replaced by other functional groups by nucleophilic substitution reactions, thus building a complex molecular structure and laying the foundation for the creation of new drugs.
Furthermore, in the field of materials science, this compound is also useful. Due to the fluorine atoms in its structure, it can enhance the stability and weather resistance of the material. For example, introducing it into polymer materials can improve the physical and chemical properties of the material, making the material more durable and functional in a specific environment. The presence of
tert-butyl also affects the spatial structure and electron cloud distribution of the molecule. This effect can change the solubility and reaction selectivity of the compound. In some organic synthesis reactions, the steric resistance effect of tert-butyl can be used to guide the reaction in a specific direction, improving the yield and purity of the target product.
In summary, 1-bromo-3- (tert-butyl) -5-fluorobenzene is an important compound in the fields of organic synthesis and materials science, with significant application value.

What are the physical properties of 1-Bromo-3- (Tert-Butyl) -5-Fluorobenzene?

1-Bromo-3- (tert-butyl) -5-fluorobenzene is also an organic compound. Its physical properties are quite important and are related to many chemical applications.
Looking at its properties, it may be a colorless to pale yellow liquid under normal conditions, with a special odor. This is due to the presence of bromine, fluorine atoms and tert-butyl in the molecular structure, which affects the intermolecular force, causing it to appear in this state.
When it comes to boiling points, the introduction of bromine atoms and fluorine atoms increases the intermolecular van der Waals force, causing the boiling point to rise. The specific value, determined by experiments, is about a specific range, but it is limited by experimental conditions, or there is a slight difference. The melting point of
also has its own characteristics due to its structure. Each atom in the molecule interacts with the group, affecting the lattice energy, so that the melting point is in a certain range. The value of its melting point is also the key to study the physical properties of the compound.
In terms of solubility, the molecule has both polar (bromine, fluorine atom) and non-polar (tert-butyl) parts, and it has good solubility in organic solvents. For example, in organic solvents such as ethanol and ether, it can be miscible according to the principle of similarity compatibility and by means of intermolecular forces. In water, due to the large difference in polarity, the solubility is poor.
The determination of density is also an important part of its physical properties. The density of the compound depends on the atomic species and molecular structure arrangement. The relative density can be determined by specific experimental methods, providing basic data for chemical production and scientific research.
The refractive index is also an important physical constant of the compound. Its refractive index reflects the characteristics of molecular light refraction and is closely related to the molecular structure, which is of great significance in the identification and analysis of the compound.
In summary, the physical properties of 1-bromo-3- (tert-butyl) -5-fluorobenzene, such as properties, boiling point, melting point, solubility, density, refractive index, etc., are determined by its unique molecular structure, and are of indispensable value in the fields of organic synthesis and materials science.

What is the chemical synthesis method of 1-Bromo-3- (Tert-Butyl) -5-Fluorobenzene?

The synthesis of 1-bromo-3- (tert-butyl) -5-fluorobenzene is by a numerical method. First, 3- (tert-butyl) -5-fluorobenzene is prepared by diazotization and Sandmeier reaction. First, 3- (tert-butyl) -5-fluoroaniline is formed into diazonium salt with sodium nitrite and hydrochloric acid at low temperature, and then co-heated with cuprous bromide. The diazo group is replaced by bromine to obtain the target 1-bromo-3- (tert-butyl) -5-fluorobenzene.
In addition, it can be started from 3- (tert-butyl) -5-fluorobenzoic acid. First, it is converted into the corresponding acyl chloride, reduced by Rosemond to obtain an aldehyde, and then brominated with a brominating agent such as N-bromosuccinimide (NBS) in the presence of light or an initiator. The aldehyde group is then reduced by a suitable reducing agent, and the target product can also be obtained.
In addition, 3- (tert-butyl) -5-fluorophenylboronic acid is synthesized with brominated reagents under transition metal catalysis, such as Suzuki-Miyaura reaction catalyzed by palladium. Suitable bases and ligands are needed to couple phenylboronic acid with bromine to obtain 1-bromo-3- (tert-butyl) -5-fluorobenzene. Each method has advantages and disadvantages, and the choice should be weighed according to the availability of raw materials, reaction conditions and yield.

What are the precautions for storing and transporting 1-Bromo-3- (Tert-Butyl) -5-Fluorobenzene?

1-Bromo-3- (tert-butyl) -5-fluorobenzene is an organic chemical. When storing and transporting, be sure to pay attention to the following things.
First, the importance of storage. This chemical needs to be stored in a cool, dry and well-ventilated place. Because the substance may be sensitive to heat, high temperature can easily cause it to deteriorate or even cause dangerous reactions. Therefore, the selected storage place should be kept at a suitable temperature, away from heat and fire sources. And the storage environment should be ensured to be dry, because if it encounters water vapor, or hydrolysis and other adverse reactions, it will affect the quality. Furthermore, it should be sealed for storage to prevent oxidation in contact with air, or to absorb impurities in the air.
Second, the rules of transportation. During transportation, the packaging must be tight and sturdy. Packaging materials that meet relevant standards should be selected to ensure that the packaging will not be damaged during transportation and prevent the leakage of the chemical. Transportation vehicles should also be kept clean and dry to avoid mixing with other chemicals to prevent mutual reaction. In addition, transportation personnel should be familiar with the characteristics of the chemical and emergency treatment methods, and in the event of an accident, they can respond properly in a timely manner.
Third, the importance of identification. Whether it is a storage container or a transportation package, its name, characteristics, hazard warnings and other information must be clearly marked. In this way, operators can quickly know its relevant information when they come into contact, and take protective measures to prevent accidents.
In conclusion, the storage and transportation of 1-bromo-3- (tert-butyl) -5-fluorobenzene requires careful treatment of the above items to ensure personnel safety and material quality.

What is the market price range for 1-Bromo-3- (Tert-Butyl) -5-Fluorobenzene?

The market price range of 1-bromo-3- (tert-butyl) -5-fluorobenzene is difficult to say exactly. The price fluctuation of this compound in the chemical raw material market is influenced by many factors.
First, the cost of raw materials has a great impact. If the acquisition cost of various starting materials required for the preparation of this compound changes, the price of 1-bromo-3- (tert-butyl) -5-fluorobenzene will fluctuate. For example, the supply of bromine, tert-butyl-related reagents and fluorinated raw materials is closely related to the price of the product.
Second, the complexity of the production process is also key. If the production process is cumbersome and requires multiple reactions, strict conditions control and complex purification steps, the cost will increase and the price will rise accordingly. On the contrary, if the process is advanced and efficient, the cost may be reduced, and the price will also have room to decline.
Third, the market supply and demand situation plays a significant role. If a certain period of time, many chemical companies have strong demand for 1-bromo-3- (tert-butyl) -5-fluorobenzene, but the supply is limited, its price will rise; conversely, if the supply exceeds the demand, the price will easily fall.
Fourth, the production scale also has an impact. In large-scale production, the unit cost may be reduced due to the scale effect, and the price may be more affordable; in small-scale production, the cost is higher and the price is relatively high.
According to past market transactions and the price reference of similar compounds, the price may range from a few yuan to a few tens of yuan per gram, but this is only a rough range. The real price may fluctuate greatly due to the above factors. To know the exact price, consult the relevant chemical product suppliers in detail, or refer to recent professional chemical market reports to obtain accurate figures.