1-Bromo-3-iodine-4- (trifluoromethoxy) benzene is an important chemical substance in the field of organic synthesis. Its main uses are many, and in the field of medicinal chemistry, it is often a key intermediate for the synthesis of specific drugs. Functional groups such as bromine, iodine and trifluoromethoxy attached to the benzene ring give this compound unique reactivity and properties. It can introduce other necessary structural fragments through various chemical reactions, such as nucleophilic substitution reactions, coupling reactions, etc., and then build complex drug molecular structures.
In the field of materials science, it also has important uses. With its reactivity, materials with special properties can be prepared, such as fluoropolymer materials. Due to its trifluoromethoxy content, it can give materials such as excellent chemical resistance and low surface energy, and is widely used in aerospace, electronics and other fields.
In addition, this compound also has a place in the synthesis of organic optoelectronic materials. Its structural properties can affect the electronic transmission and optical properties of materials, and contribute to the development of new organic Light Emitting Diode (OLED) materials or organic solar cell materials, contributing to the development of related fields.

1-Bromo-3-iodine-4- (trifluoromethoxy) benzene is one of the organic compounds. Its physical properties are quite important and are related to many chemical applications.
Looking at its appearance, under room temperature and pressure, it often appears colorless to light yellow liquid. This state is determined by its molecular structure and intermolecular forces. Its color and texture are one of the important characteristics to distinguish the compound.
As for the melting point, it is about -10 ° C to -5 ° C. The value of the melting point depends on the degree of close arrangement of molecules and the strength of interaction. In this temperature range, the attractive force and thermal motion energy balance between molecules are broken, and the substance changes from solid to liquid.
The boiling point is in the range of 170 ° C to 175 ° C. The boiling point reflects the energy required for the molecule to break free from the liquid phase. At this temperature, the molecular thermal motion is sufficient to overcome the intermolecular force and escape into a gaseous state.
The density is about 2.15 g/cm ³. This value indicates that the mass per unit volume is higher than that of common organic solvents, due to the heavy atoms such as bromine and iodine in the molecule.
In terms of solubility, it has good solubility in common organic solvents such as dichloromethane, chloroform, and ether. Due to the similar phase dissolution principle, its molecular structure is similar to that of organic solvents and can be mixed with each other. However, it has little solubility in water, because its molecular polarity is quite different from that of water molecules, and the interaction force is weak.
The low vapor pressure means that the tendency to volatilize to the gas phase at room temperature is small. This property makes the compound relatively stable, and it is not easy to be lost due to volatilization during storage and use.
The refractive index is about 1.520 - 1.530. The refractive index is related to the ability of molecules to refract light, and can be used for purity identification.
The above physical properties play a key role in the synthesis, separation, storage and application of 1-bromo-3-iodine-4- (trifluoromethoxy) benzene.

The synthesis of 1-bromo-3-iodine-4- (trifluoromethoxy) benzene is an important issue in the field of organic synthesis. To synthesize this substance, several ways can be achieved.
First, benzene derivatives containing trifluoromethoxy are used as starting materials. The bromine atom is first introduced into the benzene ring, and a suitable brominating agent, such as bromine (\ (Br_ {2}\)), can be selected, and an appropriate catalyst, such as iron powder (\ (Fe\)) or iron tribromide (\ (FeBr_ {3}\)), under suitable reaction conditions, such as heating in an organic solvent, so that the bromine atom selectively replaces the hydrogen atom at a specific position on the benzene ring, thereby obtaining an intermediate containing bromine and trifluoromethoxy.
Subsequently, this intermediate is further processed to introduce an iodine atom. An iodizing reagent, such as potassium iodide (\ (KI\)), can be used with a suitable oxidizing agent, such as hydrogen peroxide (\ (H_ {2} O_ {2}\)) or nitric acid (\ (HNO_ {3}\)), in a specific reaction environment, the iodine atom is substituted for the hydrogen atom at another suitable position on the benzene ring, and the final target product is 1-bromo-3-iodine-4- (trifluoromethoxy) benzene.
Second, the order of introducing bromine and iodine atoms can also be reversed. First, take the benzene derivative containing trifluoromethoxy as the starting material, and use a suitable iodization method, such as iodine elemental substance (\ (I_ {2}\)) and related additives, to connect the iodine atom to the benzene ring under certain conditions to form an intermediate containing iodine and trifluoromethoxy. Then, through a bromination reaction, a brominating agent and a catalyst are used to introduce the bromine atom into the desired position on the benzene ring to synthesize 1-bromo-3-iodine-4- (trifluoromethoxy) benzene.
In addition, it is necessary to pay attention to the control of reaction conditions at each step during the reaction process, such as temperature, reaction time, and the proportion of reactants, which all have a key impact on the yield and selectivity of the reaction. The choice of solvent is also very important. It is necessary to choose a solvent that can promote the reaction and has no adverse effect on the stability of the reactants and products. In this way, 1-bromo-3-iodine-4- (trifluoromethoxy) benzene can be effectively synthesized by carefully controlling each reaction step.

1-Bromo-3-iodine-4- (trifluoromethoxy) benzene-based organic compounds need to pay attention to many key matters during storage and transportation.
First of all, storage, this compound should be placed in a cool and well-ventilated place. Because a cool environment can effectively slow down its chemical reaction rate, avoid the decomposition or deterioration of the compound due to excessive temperature. Well-ventilated can disperse harmful gases that may evaporate in time, reducing safety risks. Furthermore, make sure that the storage area is dry and away from fire and heat sources. The compound may be sensitive to humidity, humid environment or cause reactions such as hydrolysis, which affects its quality. And fire and heat sources can significantly increase the possibility of fire and even explosion, so special attention is required. At the same time, it should be stored separately from oxidants, acids, alkalis, etc., and must not be mixed. Due to its active chemical properties, contact with these substances is very likely to cause violent reactions, resulting in dangerous conditions.
As for transportation, it is necessary to strictly follow the relevant regulations on the transportation of hazardous chemicals. Transportation vehicles should be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment. During transportation, it is necessary to ensure that the container does not leak, collapse, fall or damage. If this compound leaks, it will not only cause environmental pollution, but also may pose a threat to human health. The speed of the vehicle during transportation should not be too fast, and it is not allowed to forcibly overtake to prevent packaging damage due to bumps, collisions, etc. The loading and unloading personnel should handle the goods lightly during operation to avoid rough operation and ensure the safety of the transportation process to the greatest extent possible.

1-Bromo-3-iodine-4- (trifluoromethoxy) benzene is an important fine chemical in the field of organic synthesis. However, its market price range is difficult to describe in a nutshell. Due to the intertwined factors, its price fluctuates.
First, the difficulty of the preparation process has a great impact on the price. If the preparation of this compound requires complicated steps, harsh reaction conditions, or rare raw materials or special catalysts, the cost will be high and the price will be high. For example, if some preparation processes that require multiple steps and poor yield in low temperature and high pressure environments will undoubtedly push up the price of the product.
Second, the market supply and demand situation is also a key factor. If the compound is in strong demand in the pharmaceutical, pesticide, material and other industries, but the supply is relatively scarce, its price will rise. On the contrary, if the market demand is limited, and there are many manufacturers and sufficient supply, the price will stabilize or decline.
Third, the fluctuation of raw material costs has a significant impact on its price. If the price of bromide, iodide and raw materials containing trifluoromethoxy for synthesis fluctuates, it will be transmitted to the price of finished products. If the price of iodine raw materials rises due to resource scarcity or international situation, the price of 1-bromo-3-iodine-4- (trifluoromethoxy) benzene will also rise.
Fourth, the production scale and the region where the manufacturer is located also affect the price. Due to the scale effect, the cost of large-scale production may be reduced, and the price is more competitive. Different regions have different product prices due to differences in labor costs, tax policies, transportation costs, etc.
Overall, the market price range of 1-bromo-3-iodine-4 - (trifluoromethoxy) benzene, or due to the above factors, ranges from tens to hundreds of yuan per gram, or even higher. However, if you want to know the exact price, you need to consult the relevant chemical product suppliers in detail, or check the latest quotations on the chemical product trading platform.