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1-Bromo-3-Fluorobenzene

1-Bromo-3-Fluorobenzene

Hongda Chemical

Specifications

HS Code

917890

Chemical Formula C6H4BrF
Molar Mass 175.00 g/mol
Appearance Colorless to light yellow liquid
Boiling Point 157 - 159 °C
Melting Point -30 °C
Density 1.575 g/mL at 25 °C
Flash Point 48 °C
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in common organic solvents like ethanol, ether
Odor Characteristic aromatic odor

As an accredited 1-Bromo-3-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 1 - bromo - 3 - fluorobenzene in 500 - mL glass bottle, quantity: 1 unit.
Storage 1 - Bromo - 3 - fluorobenzene should be stored in a cool, well - ventilated area away from heat and ignition sources. Keep it in a tightly closed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents and reactive chemicals to prevent unwanted reactions. Label the storage clearly for easy identification and to ensure proper handling.
Shipping 1 - bromo - 3 - fluorobenzene is shipped in tightly sealed, corrosion - resistant containers. Shipment adheres to strict chemical transportation regulations, ensuring safe handling and minimizing risk during transit.
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1-Bromo-3-Fluorobenzene 1-Bromo-3-Fluorobenzene
General Information
Historical Development
1 - Bromo - 3 - Fluorobenzene is an important chemical compound in organic chemistry. It has a long history of development. In the early years, chemical ancestors painstakingly explored the synthesis of various compounds in the laboratory. At that time, the technical means were limited, and the synthesis of 1 - Bromo - 3 - Fluorobenzene was difficult. However, the ancestors worked tirelessly, and after repeated attempts, they finally found a way to synthesize it. Initially, the yield was quite low, only a few. However, chemists continued to improve the process, optimize the reaction conditions, and explore in detail from the ratio of raw materials to the reaction temperature and duration. Over time, the synthesis technology became more and more mature, and the yield also increased significantly. Today, 1 - Bromo - 3 - Fluorobenzene is widely used in many fields such as medicine and materials, which is a brilliant achievement in the development of chemistry and a testament to the wisdom and unremitting efforts of chemical ancestors.
Product Overview
1 - Bromo - 3 - Fluorobenzene is also an organic compound. Its color is clear and transparent, and it has a special odor. In the molecular structure, on the benzene ring, the bromine atom and the fluorine atom are arranged in one place each, forming an intermediate position.
This compound has a wide range of uses in the field of organic synthesis. It can be used as an intermediate and participates in many reactions. For example, in the nucleophilic substitution reaction, its bromine atom is active and easy to be replaced by other nucleophiles, thereby deriving a variety of organic products. And because of its fluorine atom, it endows the product with unique chemical and physical properties, such as enhanced fat solubility, which has potential value in the creation of medicine and pesticides.
Preparation method, or from specific benzene derivatives, obtained by halogenation reaction. The control of reaction conditions is crucial, and factors such as temperature and reagent ratio are all related to the purity and yield of the product. After proper synthesis and refining, high purity 1-Bromo-3-Fluorobenzene can be obtained to meet the needs of all parties.
Physical & Chemical Properties
1 - Bromo - 3 - Fluorobenzene is an organic compound. It has unique physical and chemical properties. Looking at its physical properties, at room temperature, it is a colorless liquid with a specific odor. Its boiling point is suitable, about a specific temperature range, easy to separate and purify. And the density is different from water, and it has good solubility in organic solvents.
In terms of its chemical properties, the structure of the benzene ring gives it a certain stability. The substitution of bromine and fluorine atoms makes the compound reactive. It can participate in nucleophilic substitution reactions. Due to the electron-withdrawing effect of fluorine and bromine atoms, the electron cloud density of the benzene ring changes, which is conducive to the attack of nucleophilic reagents. It can also perform some typical aromatic reactions, such as the common conversion of halogenated benzene, providing a variety of pathways for organic synthesis, which is important in the fields of chemical industry and pharmaceutical research and development.
Technical Specifications & Labeling
1 - Bromo - 3 - Fluorobenzene is an organic compound, and it is crucial to the technical specifications and labeling (commodity parameters) of this product. Its technical specifications, when clear purity, should reach extremely high standards, and the impurity content must be extremely low to ensure its stable performance in various chemical reactions and applications. In terms of appearance, it should be a colorless to light yellow transparent liquid with no visible impurities.
Labeling (commodity parameters) cannot be ignored. The chemical name "1 - Bromo - 3 - Fluorobenzene" must be clearly marked, and the exact molecular formula "C H BrF" should be clearly marked. The molecular weight should also be indicated, accurate to the appropriate decimal place. At the same time, the identification of its dangerous characteristics, such as whether it is flammable, toxic, etc., must be clearly marked so that users can safely operate and store it properly. In this way, this product can be used correctly in scientific research, production and other fields.
Preparation Method
The method of making 1 - Bromo - 3 - Fluorobenzene is the key to raw materials and manufacturing process. Take benzene as the initial material, first use the method of bromination, and under suitable conditions, make benzene and bromine substitution reaction to obtain bromobenzene. In this step, attention should be paid to the choice of reaction temperature and catalyst. Iron filings are often used as catalysis, and the temperature control is about 50-60 degrees Celsius.
Then, bromobenzene is fluorinated. With a specific fluorination reagent, in a suitable reaction environment, the bromine atom in bromobenzene is replaced by a fluorine atom. The reaction conditions of this process are severe, and factors such as pressure and temperature need to be precisely regulated. The design of the reaction device is also crucial to establish a reasonable cycle and separation mechanism to ensure the purity and yield of the product. After this series of steps, 1-Bromo-3-Fluorobenzene can be obtained. This method can achieve high efficiency and quality, which is a good strategy for the preparation of this chemical.
Chemical Reactions & Modifications
1 - Bromo - 3 - Fluorobenzene is a commonly used raw material in organic synthesis, and there is much to be studied about its chemical reaction and modification.
Looking at its chemical reactions, nucleophilic substitution reactions are common. Under certain conditions, its halogen atoms can be replaced by nucleophilic reagents. For example, when heating an alcohol solution of a strong base, bromine atoms can be replaced by hydroxyl groups to generate 3 - fluorophenol. The reaction mechanism lies in the attack of the nucleophilic tester on the halogenated aromatics, and the halogen atoms leave to form new chemical bonds.
When it comes to modification, its physical and chemical properties can be changed by introducing different substituents. Such as electrophilic substitution reaction, the introduction of alkyl or acyl groups on the benzene ring can change its solubility and stability. Due to the electronic and spatial effects of different substituents, the overall properties of the molecule are affected. Through exquisite design of such reactions and modifications, the applications of 1-Bromo-3-Fluorobenzene in materials science, medicinal chemistry and many other fields can be expanded.
Synonyms & Product Names
1 - Bromo - 3 - Fluorobenzene, this thing is also an important product of chemistry. Its synonyms and trade names are also what we should study.
In the past, chemists have not decided on the naming of substances. Or because of the place of discovery, or the special characteristics of fate, the naming is different. 1 - Bromo - 3 - Fluorobenzene, according to the system naming convention, its atomic position and composition. However, between business and business, there may be different names.
In the past, chemists discovered this compound, and it was first called by its characteristics. Later, according to the standard, this scientific name was determined. However, the merchants are easy to remember, or use a simple name, or take a name that is easy to remember. This is the reason for the synonym and trade name of the same thing.
In this world, there are many people who study this compound. Knowing its synonym and trade name is an important task in academic exchanges and business exchanges. Although the names are different but the quality is the same, it is necessary to clarify the names, so that we can travel freely in the field of chemistry.
Safety & Operational Standards
1 - Bromo - 3 - Fluorobenzene is an important chemical compound in organic chemistry. Safety and operating standards are of paramount importance in its experimental operation and production process.
For the operation of 1 - Bromo - 3 - Fluorobenzene, the experimenter must first wear suitable protective equipment. Among them, protective glasses can protect the eyes from splashing hazards; gas masks can filter out volatile gaseous harmful substances and ensure the safety of the respiratory system; chemically resistant gloves and laboratory clothes are also indispensable to protect the skin from direct contact with the compound, so as to avoid corrosion or allergic reactions.
When storing 1-Bromo-3-Fluorobenzene, choose a cool, dry and well-ventilated place. The compound must be sealed and stored to prevent excessive concentration in the volatile environment, and to avoid co-storage with strong oxidants, strong bases and other substances, because the two may cause violent chemical reactions and cause safety accidents.
During operation, be careful when using 1-Bromo-3-Fluorobenzene. Appropriate pipette or dropper should be used, the required dose should be accurately measured, and the operation should be carried out in the fume hood to ensure that the volatile gaseous substances can be discharged in time and reduce the risk of exposure to the experimenter. If 1 - Bromo - 3 - Fluorobenzene spills in the experiment, emergency measures should be initiated immediately. Small amounts of spills can be covered and adsorbed with materials with good adsorption properties, such as vermiculite, sand, etc., and then carefully collected in a specific container and disposed of according to regulations. In the case of a large amount of spills, in addition to evacuating personnel quickly, the scene should be immediately sealed and notified to professionals to deal with it.
After the experiment is completed, the unused 1 - Bromo - 3 - Fluorobenzene should not be discarded at will. It must be properly stored in a designated container in accordance with relevant regulations and recycled and disposed of by a professional organization. The utensils used in the experiment, such as glassware, should be cleaned with a suitable solvent in a timely manner to ensure that there is no residue. After washing, it
In summary, strict adherence to the safety and operation specifications of 1-Bromo-3-Fluorobenzene can effectively prevent accidents, ensure the safety of experimenters and the smooth progress of the experiment.
Application Area
1 - Bromo - 3 - Fluorobenzene is also an organic compound. Its application field is quite wide. In the field of medicinal chemistry, it can be used as a key intermediate to help synthesize many specific drugs to cure various diseases. In the field of materials science, after specific reactions, it can be converted into materials with special properties for the production of electronic devices, etc., to improve their performance. In the field of pesticide chemistry, it also has important uses, and can participate in the synthesis of highly efficient and low-toxicity pesticides to protect crops from pests and diseases. Therefore, 1 - Bromo - 3 - Fluorobenzene plays an important role in many fields and is indispensable for promoting the development of related industries.
Research & Development
I have been studying chemistry for a long time, and recently I focused on the investigation of 1 - Bromo - 3 - Fluorobenzene. This compound has both bromine and fluorine, and its unique properties are quite valuable for research.
After repeated experiments, its reaction mechanism has been observed, and its performance varies under different conditions. At high temperature, when interacting with a reagent, a new substance can be obtained with a special structure, which is expected to be used in fine chemicals. At low temperature, the reaction path is different, and the product is also different.
The purpose of research is to clarify its characteristics and expand the application field. It is expected to make breakthroughs in pharmaceutical synthesis, material research and development, etc. The road to this research is long, but I must persevere and hope to make progress, contributing to the development of chemistry, so as to promote the wide application and further development of this compound.
Toxicity Research
Modern chemistry has been refined, and the nature of various things has been investigated in detail, and the study of poisons is particularly important. Today there is 1-Bromo-3-Fluorobenzene, and I will study its toxicity in detail.
After various experiments, observe the transformation of its phase with various things, and observe its effect on living people. It has a certain toxicity. Touching it, smelling it, or eating it can cause the body to violate. After entering the body, it may disturb the flow of qi and blood, or mess up the functions of the internal organs.
However, if you want to understand its details, it still needs to be widely tested and studied over the years. Don't make a quick assertion, you must wait for conclusive evidence. In the future, we can fully understand its toxicity and take preventive measures to protect the people from it. Chemical research can also be used by the world for well-being.
Future Prospects
I often think about the future of 1 - Bromo - 3 - Fluorobenzene. Its unique nature, in the field of organic synthesis, the potential is infinite.
Looking at the current chemical progress, new materials are superimposed, all rely on the delicate combination of various compounds. 1 - Bromo - 3 - Fluorobenzene contains bromine and fluorine diatoms, and its activity and selectivity can be the basis for creating novel materials.
In the process of pharmaceutical research and development, it may be able to use its structure to make special drugs and treat various difficult diseases. Or in electronic materials, endowing devices with excellent performance makes the electronic world more delicate and convenient.
Although the road ahead is long, with the progress of science and the study of everyone, I believe that 1 - Bromo - 3 - Fluorobenzene will bloom in the vast world of the future, open up new frontiers, and achieve great things, so we have unfulfilled expectations.
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Frequently Asked Questions

As a leading 1-Bromo-3-Fluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the physical properties of 1-Bromo-3-Fluorobenzene?
1-Bromo-3-fluorobenzene is also an organic compound. Its physical properties are worth exploring.
First of all, its appearance, at room temperature, 1-bromo-3-fluorobenzene is a colorless to light yellow transparent liquid, clear and with a certain fluidity. Looking at it, under light, it may have a faint luster, like a liquid bead hiding light.
Second of all, its melting point. The melting point is about -38 ° C, which means that when the temperature drops below this value, it will gradually condense from liquid to solid, and the molecular arrangement will tend to be orderly from disorder. The boiling point is about 150-152 ° C. When the temperature rises, the molecules are energized enough to break free from the liquid phase and escape into the gas phase.
As for the density, it is about 1.72 g/mL, which is heavier than water, so if mixed with water, it will sink underwater, and the two are clearly defined.
In terms of solubility, 1-bromo-3-fluorobenzene has little solubility in water, because it is an organic compound, the molecular polarity is weak, and the force between water molecules is small, making it difficult to dissolve. However, in organic solvents such as ethanol, ether, acetone, etc., the solubility is quite good, and it is similar to the force between organic solvent molecules, following the principle of "similar phase dissolution".
In addition, 1-bromo-3-fluorobenzene has a certain volatility. In the air, the molecules are constantly moving, slowly escaping, and have a special smell. Although it is not pungent and intolerable, it also has a unique smell, which can be perceived by the sense of smell. Its vapor pressure has a certain value at room temperature, reflecting the tendency of molecules to escape from the liquid phase into the gas phase, which affects the rate of their diffusion in the environment.
What are the main uses of 1-Bromo-3-Fluorobenzene?
1-Bromo-3-fluorobenzene has a wide range of uses. In the field of organic synthesis, it can be called a key intermediate.
First, it can be used to create medicine. The construction of many drug molecules depends on its participation in reactions. For example, when developing specific antibacterial drugs, 1-bromo-3-fluorobenzene can introduce key structural fragments through a series of reactions, thereby shaping the molecular structure of drugs with antibacterial activity, opening up new avenues for pharmaceutical research and development.
Second, it is also indispensable in pesticide manufacturing. With its unique chemical properties, it can be converted into pesticide ingredients with insecticidal, weeding and other effects. By ingeniously designing reactions, 1-bromo-3-fluorobenzene is combined with other compounds to generate pesticides that have high inhibitory effects on specific pests or weeds, and help agricultural pest prevention and control.
Furthermore, in the field of materials science, 1-bromo-3-fluorobenzene is also useful. It can be used as a starting material for the synthesis of special functional materials. For example, when preparing polymer materials with special optical and electrical properties, it can act as a key structural unit and be integrated into the polymer chain, giving the material unique properties to meet the special needs of electronic devices, optical equipment and other fields.
In addition, in the synthesis of fine chemical products, 1-bromo-3-fluorobenzene is often used as an important raw material. Like the preparation of some high-performance coatings, fragrances and other products, it will use its participation in the reaction to give the product unique properties and quality, and enhance the competitiveness of the product in the market. In short, 1-bromo-3-fluorobenzene plays an important role in many fields and is of great significance to promote the development of related industries.
What are 1-Bromo-3-Fluorobenzene synthesis methods?
The synthesis methods of 1-bromo-3-fluorobenzene are quite diverse, and each has its own ingenuity. First, m-fluoroaniline can be started, and then reacted with cuprous bromide through diazotization. This is the classic Sandmeier reaction. M-fluoroaniline and sodium nitrite react in a low temperature and acidic environment to form diazonium salts, and then react with cuprous bromide. The diazonium group is replaced by a bromine atom to obtain 1-bromo-3-fluorobenzene. This method has clear steps and relatively easy to control conditions. However, it is necessary to pay attention to the temperature of the diazotization reaction to prevent the decomposition of diazonium salts.
Second, using isafluorophenylboronic acid as raw material, it reacts with brominated reagents such as N-bromosuccinimide (NBS) in the presence of an appropriate catalyst. This reaction is based on the principle of Suzuki reaction, in which the boron group of isafluorophenylboronic acid is coupled with the bromine atom of the brominated reagent to form the target product. This method has good selectivity and few side reactions, and also has specific requirements for the reaction conditions. The choice and dosage of catalysts have a great influence on the reaction.
Third, using 3-fluoroanisole as the starting material, bromine atoms are first introduced through halogenation reaction, and then demethylated. During halogenation, a suitable halogenating agent can be selected to replace the hydrogen on the benzene ring with bromine atoms Then demethylation, common reagents such as hydrobromic acid, etc., through this step can obtain 1-bromo-3-fluorobenzene. However, this process has a little more steps, and each step needs to be carefully controlled to improve the yield.
Fourth, using 3-fluorobenzoic acid as raw material, the carboxyl group is first converted into an easy-to-leave group, and then reacted with a brominating reagent to introduce bromine atoms, and finally the introduced group is removed to obtain the target product. Although this approach is complicated, the reagents and conditions of each step can be flexibly selected according to different needs to achieve effective synthesis of 1-bromo-3-fluorobenzene.
The above synthesis methods have their own advantages and disadvantages. In practical application, it is necessary to comprehensively consider factors such as the availability of raw materials, cost, yield and product purity, and carefully choose to achieve the ideal synthesis effect.
1-Bromo-3-Fluorobenzene what are the precautions during storage and transportation?
1-Bromo-3-fluorobenzene is an organic compound. During storage and transportation, many matters must be paid attention to.
First, storage, because it has a certain chemical activity, should be stored in a cool and ventilated warehouse. High temperature can cause its volatilization to intensify, and may cause chemical reactions to cause its deterioration. The warehouse temperature should not be too high, generally not exceeding 30 ° C. At the same time, be sure to keep away from fire and heat sources, which can cause it to catch fire or even explode, which is dangerous.
Furthermore, the compound should be stored separately from oxidants, acids, bases, etc., and should not be mixed. When it meets with an oxidizing agent, it is prone to oxidation reactions; contact with acid and alkali, or cause severe chemical reactions, and even endanger safety. The storage place also needs to be equipped with suitable materials to contain the leakage, so as to prevent accidental leakage, and it can be properly handled in time to avoid greater harm.
As for transportation, 1-bromo-3-fluorobenzene must be transported in a special chemical transportation vehicle. Vehicles need to be well sealed to prevent it from evaporating and escaping. During transportation, drivers and escorts must always be vigilant and strictly abide by the operating procedures. Pay close attention to changes in temperature and pressure. If there is any abnormality, dispose of it immediately.
In addition, transportation vehicles should follow the prescribed route, avoiding densely populated areas and traffic arteries. This is to avoid the occurrence of leaks or accidents that affect many people and cause major casualties and losses. And before transportation, all kinds of documents and procedures required by relevant departments must be prepared and transported in accordance with regulations, so that security is safe.
What are the effects of 1-Bromo-3-Fluorobenzene on the environment and human health?
1-Bromo-3-fluorobenzene is also an organic compound. Its impact on the environment and human health is truly imperceptible.
First, the impact of the environment. If 1-bromo-3-fluorobenzene is released in nature, in the atmosphere, because it is volatile to a certain extent, or participates in photochemical reactions, it disturbs the chemical balance of the atmosphere, but due to its characteristics such as vapor pressure, this effect may be limited. In aquatic ecosystems, its hydrophobicity makes it easy to adsorb on suspended particles or sediments and gradually accumulate. If aquatic organisms touch it, there may be adverse consequences. Override it or affect the physiological functions of organisms, such as interfering with the respiration, feeding and reproduction of fish, causing population changes. In the soil environment, 1-bromo-3-fluorobenzene can be adsorbed by soil particles, hindering the normal metabolism and activities of soil microorganisms, thereby damaging soil ecological functions, changing soil fertility, and affecting plant growth.
As for the impact on human health. When entering the human body through the respiratory tract, it is irritating or causes respiratory discomfort, such as cough, asthma, poor breathing, long-term exposure, or damage to lung function, increasing the risk of respiratory diseases. Through skin contact, it can enter the body through the skin barrier, or cause skin allergies, redness, swelling, and itching. If eaten by mistake, it can be in the digestive system, or irritate the stomach, causing nausea, vomiting, abdominal pain, etc. And 1-bromo-3-fluorobenzene may have potential neurotoxicity, long-term exposure, or damage the nervous system, causing headaches, dizziness, fatigue, memory loss and other neurological symptoms. What's more, it may be mutagenic, interfere with human genetic material, and in the long run, may increase the risk of cancer.
Therefore, 1-bromo-3-fluorobenzene poses a potential threat to the environment and human health. When it is produced, used and disposed of, proper protection and disposal measures should be taken with caution to reduce its harm.