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1-Bromo-3-Fluoro-5-Methylbenzene

1-Bromo-3-Fluoro-5-Methylbenzene

Hongda Chemical

Specifications

HS Code

684805

Chemical Formula C7H6BrF
Molar Mass 191.024 g/mol
Appearance Colorless to light yellow liquid
Boiling Point Approx. 185 - 187 °C
Density Approx. 1.54 g/cm³
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in common organic solvents like ethanol, ether
Odor Characteristic aromatic odor

As an accredited 1-Bromo-3-Fluoro-5-Methylbenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100 g of 1 - bromo - 3 - fluoro - 5 - methylbenzene in a sealed, labeled chemical bottle.
Storage 1 - Bromo - 3 - fluoro - 5 - methylbenzene should be stored in a cool, well - ventilated area away from heat, sparks, and open flames. Keep it in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents and incompatible substances. The storage location should be dry to avoid potential reactions with moisture.
Shipping 1 - bromo - 3 - fluoro - 5 - methylbenzene is shipped in well - sealed, corrosion - resistant containers. They are carefully packaged to prevent leakage, and transported under conditions compliant with chemical safety regulations, avoiding heat and direct sunlight.
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1-Bromo-3-Fluoro-5-Methylbenzene 1-Bromo-3-Fluoro-5-Methylbenzene
General Information
Historical Development
1 - Bromo - 3 - Fluoro - 5 - Methylbenzene, also an organic compound. Its origins can be traced back to the past. In the past, various sages worked diligently in the field of chemistry, striving to expand their understanding. At the beginning, the exploration of its structure and properties was only a glimpse of the way. However, with the passage of time, the research deepened, and the art of analysis gradually refined.
At that time, scholars worked hard to measure its characteristics by various methods, and began to understand the beauty of its molecular structure. After repeated trials, a synthetic method was obtained. Although the initial yield was not abundant, it laid the foundation for subsequent progress. After several generations of scholars have worked hard to improve the synthesis technology, so that the yield gradually increased and the purity also increased. At present, 1 - Bromo - 3 - Fluoro - 5 - Methylbenzene has been widely used in chemical industry, medicine and other fields, and its historical evolution is also the continuous journey of chemical research.
Product Overview
1 - Bromo - 3 - Fluoro - 5 - Methylbenzene Product Overview
1 - Bromo - 3 - Fluoro - 5 - Methylbenzene is a crucial chemical in the field of organic synthesis. Its molecular structure is unique, with the ingenious distribution of bromine (Br), fluorine (F) and methyl (-CH) on the benzene ring, giving this compound unique physical and chemical properties.
The appearance of this product is often a colorless to light yellow transparent liquid with a specific odor. At room temperature and pressure, its stability is quite good, and it may be dangerous when exposed to hot topics, open flames or strong oxidants.
In chemical reactions, 1 - Bromo - 3 - Fluoro - 5 - Methylbenzene exhibits diverse reactivity. Due to its high activity of bromine atoms, it is easy to participate in nucleophilic substitution reactions, and can react with many nucleophilic reagents to achieve functional group transformation on the benzene ring. At the same time, the presence of fluorine atoms brings special electronic effects to it, which affects the selectivity and rate of the reaction. Methyl affects the solubility and steric resistance of compounds.
In organic synthesis, 1 - Bromo - 3 - Fluoro - 5 - Methylbenzene is often used as a key intermediate for the preparation of various biologically active drugs, pesticides and functional materials, which is of great significance to chemical research and industrial production.
Physical & Chemical Properties
1 - Bromo - 3 - Fluoro - 5 - Methylbenzene is an organic compound. Its physical properties are mostly liquid at room temperature, with a special odor. Its density is slightly higher than that of water. It is insoluble in water, but it can be miscible with common organic solvents such as ethanol and ether.
Regarding chemical properties, bromine atoms, fluorine atoms and methyl groups in this compound give their unique activities. Bromine and fluorine atoms on the aromatic ring can participate in nucleophilic substitution reactions. Due to the induction effect of halogen atoms, the density of the electron cloud of the benzene ring changes, which affects the reaction activity and check point. Methyl can carry out related oxidation reactions and also affect the electron cloud of the benzene ring, which will affect the ortho-para-substitution reaction. These physicochemical properties lay the foundation for their application in the field of organic synthesis, and can be used to prepare many functional organic materials and pharmaceutical intermediates.
Technical Specifications & Labeling
1 - Bromo - 3 - Fluoro - 5 - Methylbenzene is also an organic compound. The technique of its preparation is related to the subtlety of chemistry.
For the technical specifications, the purity of the raw materials, the temperature of the reaction, and the control of time are all essential. The raw materials used must be carefully selected, and impurities must be removed to ensure the purity of the product. The temperature of the reaction needs to be adjusted according to its nature. If it is too high, it will easily cause side reactions. If it is too low, the reaction will be slow. The degree of time cannot be ignored. When the time is right, the product will be abundant and pure.
As for the product logo, its name should be clearly stated, its structure should be recorded, and its purity should be marked. In this way, the technical specifications and labels of 1 - Bromo - 3 - Fluoro - 5 - Methylbenzene are complete and can be used in chemical industry to meet all needs.
Preparation Method
1 - Bromo - 3 - Fluoro - 5 - Methylbenzene is an important compound in organic synthesis, and its preparation method is very important. In the selection of raw materials, 3 - fluoro - 5 - methylaniline can be used as the starting material. The preparation process is as follows:
First, 3 - fluoro - 5 - methylaniline is mixed with hydrobromic acid and sodium nitrite, and the diazotization reaction occurs at low temperature. This is a key step. After the diazotization is completed, an appropriate amount of copper salt is added as a catalyst to promote the decomposition of the diazo salt and bromination to form the target product 1 - Bromo - 3 - Fluoro - 5 - Methylbenzene. The
reaction process requires strict control of the temperature and the ratio of the reactants to ensure the smooth progress of the reaction. Subsequent processes such as separation and purification are required to obtain high-purity products. In this way, 1-Bromo-3-Fluoro-5-Methylbenzene can be effectively obtained through this preparation method.
Chemical Reactions & Modifications
In today's world, chemistry is refined, and everyone seeks changes in substances to obtain what they need. Today there is a thing named 1 - Bromo - 3 - Fluoro - 5 - Methylbenzene, and its chemical changes and modifications are really our focus.
If you want to obtain the subtle changes of this substance, you must carefully investigate its properties and study the reasons for its reactions. The chemical reaction of the husband, such as the symmetry of yin and yang, changes according to its nature. 1 - Bromo - 3 - Fluoro - 5 - Methylbenzene also has its own unique reaction path, or combination with other substances, or self-decomposition, all related to its structure and external conditions.
As for the modification method, it needs to be carefully considered. Or add other things to change its properties, or change its environment to make the structure migrate. In this way, 1-Bromo-3-Fluoro-5-Methylbenzene can have different functions, meet the needs of the world, and be used by everyone. It can be used in industry and medicine to develop its growth and help our lives improve.
Synonyms & Product Names
1 - Bromo - 3 - Fluoro - 5 - Methylbenzene, its synonymous name and the name of the commodity are quite important. In the field of chemistry, knowing its various names can lead to smooth research.
covers the name of the chemical substance, there are systematic names, common names, trade names, etc. 1 - Bromo - 3 - Fluoro - 5 - Methylbenzene, depending on the system nomenclature. However, in practical applications, or in different industries, or there are different names.
Its synonymous name may vary depending on the focus of research and the process of discovery. The trade name is related to market circulation and the consideration of the manufacturer. Chemists should scrutinize the various names of this object in detail, so as not to be confused and accurate in literature study and experimental exchange, so that the research is smooth and fruitful. Understanding synonymous names and trade names is an indispensable basis for chemical research.
Safety & Operational Standards
1 - Bromo - 3 - Fluoro - 5 - Methylbenzene, chemical products are also used. Its safe operation is very important, and it is essential not to be careless.
The storage of this thing should be kept in a dry, clean and well-connected place. Avoid open flames and high temperatures to prevent it from exploding. The storage container is dense and clear, so that people can know its danger at a glance.
The operation of the product must be worn to prevent it. If it is eye-proof, it can protect the eyes from damage; gas masks can prevent the invasion of harmful steaming; chemical-resistant gloves can protect the hands from poison.
If the process involves the transformation and reaction of this object, it must first be informed of the principle of the reaction. Control the reaction degree and force, and operate according to the established steps, and there should be no slight error. After the reaction is completed, it is also necessary to be careful when handling the object. Do not accidentally collapse, and follow the relevant regulations to properly collect and manage to prevent pollution.
In case of leakage of this object, do not panic. Quickly pass the report and evacuate the surrounding people. The manager needs to wear protective clothing, and use appropriate materials to absorb and remove leaks. If there is a large amount of leakage, seal it and take care of it.
Therefore, 1 - Bromo - 3 - Fluoro - 5 - Methylbenzene is a common product for chemical research, but its safe operation is the cornerstone of ensuring personal safety, environmental safety and research and development.
Application Area
Today there is a thing called 1 - Bromo - 3 - Fluoro - 5 - Methylbenzene. This thing has its uses in various fields. In the field of medicine, it can be used as the basis for synthesizing good medicines, helping to eliminate diseases and diseases. Because of its unique structure, it can be cleverly combined with other things to make medicines against diseases.
In the world of materials, there are also extraordinary things. It can be used to create new materials and increase their characteristics, such as strengthening their toughness, or adding their electrical conductivity, making materials more effective in industry and technology.
In the field of fine chemicals, it is an important role in the manufacture of delicate chemicals. Through complex methods, a variety of fine things can be derived, which are widely used in daily use, beauty and many other aspects to improve the quality of life. All of this shows that 1 - Bromo - 3 - Fluoro - 5 - Methylbenzene is of great value in practical fields.
Research & Development
The industry of chemical industry is changing with each passing day, and new products are emerging one after another. Today there is 1 - Bromo - 3 - Fluoro - 5 - Methylbenzene, and I have been studying it for a long time.
At the beginning, I obtained the properties of this substance, observed its color, smelled its taste, and measured its melting point, which were recorded in detail. Then explore the method of its synthesis. After many attempts, or change the conditions of the reaction, or use the reagents easily, I hope to get the best way. Although the process is difficult, every progress is made, and they are all happy.
Thinking about the application of this substance, it has potential in the fields of medicine and materials. So I worked with my colleagues to develop it, hoping to expand its use and benefit everyone.
Today, although I have achieved something, I know that there is a long way to go. When you persevere and improve your skills, I hope this product will shine in the future, contribute to the development of chemical industry, and live up to our research heart.
Toxicity Research
1 - Bromo - 3 - Fluoro - 5 - Methylbenzene is also a chemical substance. We focus on the study of toxicants and investigate its properties in detail. The toxicity of this substance is related to living things and should not be ignored.
After many experiments, it can be known that it may be harmful to the body of living things. Looking at its entry into the rat body, it affects the function of the viscera, causes abnormal activities, and changes in diet.
In the study of cells, it can be seen that it may disturb the metabolism of cells and disrupt their order. The chemical structure of this substance may be the source of toxicity. The interaction of bromine, fluorine, and methyl groups with each other makes the toxic effect obvious.
Although the principle of its total poison is not clear, it is known that its harm. Follow-up should investigate the path of its poison and the degree of harm, in order to understand, for protection, application and other things, to provide evidence, to protect the safety of life and spirit, and to avoid the danger of poisons.
Future Prospects
Wuguanfu 1 - Bromo - 3 - Fluoro - 5 - Methylbenzene has its own unique properties and wide range of uses. Although it has been studied now, the future prospects are still considerable.
Today's researchers have shown that it is important in organic synthesis and can be used as a key intermediate to assist in the preparation of many compounds. However, if you want to expand its use in the future, you must improve on the process. Hope to create a simpler and more efficient method, reduce its cost and increase its yield.
Furthermore, in the field of medicine, it is hoped that it can be the basis for the development of new drugs. Or according to its structural characteristics, specific drugs can be developed to treat various diseases. I also hope to emerge in materials science as a raw material for new materials with unique properties to meet diverse needs.
I believe that with time and unremitting research by all researchers, 1 - Bromo - 3 - Fluoro - 5 - Methylbenzene will surely shine in the future, be used by the world, benefit people, achieve extraordinary things, and develop endless possibilities.
Where to Buy 1-Bromo-3-Fluoro-5-Methylbenzene in China?
As a trusted 1-Bromo-3-Fluoro-5-Methylbenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 1-Bromo-3-Fluoro-5-Methylbenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-Bromo-3-Fluoro-5-Methylbenzene?
1-Bromo-3-fluoro-5-methylbenzene, which has a wide range of uses. In the field of organic synthesis, it is often used as a key intermediate.
One of them can be used to create various drugs. By ingenious chemical reactions, its structure is modified and connected to specific functional groups, and compounds with specific pharmacological activities can be derived. For example, for some new drug development targeting specific disease targets, 1-bromo-3-fluoro-5-methylbenzene can be used as a starting material. After multiple steps of delicate synthesis, an ideal drug molecular structure can be formed, which contributes to the development of the pharmaceutical industry.
Second, in the field of materials science, it also has important uses. Can participate in the preparation of special functional materials. For example, when synthesizing polymer materials with unique optical and electrical properties, this compound can be used as a functional monomer and integrated into the polymer chain, giving the material novel properties, such as light absorption at specific wavelengths, good conductivity, etc., to meet the special needs of electronic devices, optical equipment and other fields.
Furthermore, in the preparation of fine chemical products, 1-bromo-3-fluoro-5-methylbenzene is also indispensable. The synthesis of fine chemicals such as high-end fragrances and special coatings, as an important raw material, can give products unique properties and quality through specific reaction paths, and enhance the added value and market competitiveness of products.
In short, 1-bromo-3-fluoro-5-methyl benzene plays a pivotal role in many fields such as organic synthesis, drug research and development, materials science and fine chemicals, and is of great significance to promote the technological progress and innovative development of related industries.
What are the physical properties of 1-Bromo-3-Fluoro-5-Methylbenzene?
1-Bromo-3-fluoro-5-methylbenzene is one of the organic compounds. Its physical properties are quite important, and it is of key significance in chemical research and practical application.
Looking at its appearance, under room temperature and pressure, it is mostly colorless to light yellow liquid, with clear quality and a certain transparency. This is an intuitive and observable property.
When it comes to boiling point, it is within a certain temperature range, usually slightly different due to specific experimental conditions. It is probably in a specific range. This boiling point characteristic makes it possible to use distillation to determine the difference between its boiling point and other substances when separating and purifying. The melting point of
is also one of its important physical properties. The melting point of the compound is at a certain temperature value, which is valuable for identifying and determining its purity. In low temperature environments, the process of gradually changing from liquid to solid state can be observed. The characteristics of this melting point provide a basis for setting storage and transportation conditions.
As for the density, it has a specific value at room temperature, which is greater or less than the density of water. This property is related to its distribution in the solution system. If the density is greater than water, it is in the lower layer of the aqueous liquid; if it is less than water, it floats on the water.
In terms of solubility, 1-bromo-3-fluoro-5-methylbenzene has good solubility in organic solvents, such as common ethanol, ether, dichloromethane, etc. However, the solubility in water is very small, because the molecular structure of the compound has strong hydrophobicity, which makes the interaction between it and water molecules weak.
In addition, its vapor pressure varies at different temperatures. When the temperature increases, the vapor pressure increases. This property is related to the degree of difficulty of volatilization. It is more volatile at high temperatures. It is necessary to pay attention to the safety problems that may be caused by the accumulation of steam in a confined space.
In summary, the many physical properties of 1-bromo-3-fluoro-5-methylbenzene are indispensable factors for chemical research, chemical production, and related applications, which help people to understand and use this compound rationally.
What is the chemistry of 1-Bromo-3-Fluoro-5-Methylbenzene?
1-Bromo-3-fluoro-5-methylbenzene is one of the organic compounds. Its chemical properties are of great interest and are often involved in chemical research and industrial applications.
When it comes to the chemical properties of this compound, the first thing to bear the brunt is the characteristics of its halogenated aromatics. Both bromine and fluorine are halogen atoms, giving this molecule unique reactivity. Although bromine atoms are relatively large, they are very active and can often be replaced by nucleophiles in many chemical reactions. During nucleophilic substitution reactions, nucleophilic groups such as hydroxyl (-OH) and amino (-NH2O) can attack bromine atoms and replace them to form new compounds. In this process, the control of reaction conditions is crucial, such as temperature and solvent selection, which all affect the rate of reaction and the selectivity of the product.
The existence of fluorine atoms also has a profound impact on molecular properties. Fluorine atoms are extremely electronegative, which can reduce the electron cloud density of the benzene ring, which in turn affects the reactivity of other substituents on the benzene ring. In electrophilic substitution reactions, the electron-absorbing effect of fluorine atoms decreases the reactivity of the benzene ring to the electrophilic reagents, and also affects the selectivity of the reaction check point. Generally speaking, electrophilic reagents tend to attack positions with relatively high electron cloud density on the benzene ring. The presence of fluorine atoms changes the electron cloud distribution of the benzene ring, thereby changing the regioselectivity of the electrophilic substitution reaction.
Furthermore, the presence of methyl should not be underestimated. Methyl is an electron-supplying group, which can increase the electron cloud density of the benzene ring, and can check and balance the electron-absorbing effect of the fluorine atom to a certain extent. Methyl can affect the electron cloud distribution of the benzene ring through superconjugation effect, and it can also participate in some reactions. For example, under appropriate conditions, oxidation reactions can occur and convert into functional groups such as carboxyl groups (-COOH).
1-bromo-3-fluoro-5-methylbenzene has three different functional groups of bromine, fluorine and methyl. Its chemical properties are rich and diverse, and it is widely used in the field of organic synthesis. It can be used as an important intermediate for the preparation of various organic compounds with special properties.
What are 1-Bromo-3-Fluoro-5-Methylbenzene synthesis methods?
The synthesis method of 1-bromo-3-fluoro-5-methylbenzene can be done from many ways.
First, 3-fluoro-5-methylaniline is used as the starting material. It is diazotized with sodium nitrite and hydrobromic acid at low temperature to form a diazonium salt. The diazonium salt is unstable, and the diazonium group is replaced by a bromine atom after heating or under the action of a specific reagent, so 1-bromo-3-fluoro-5-methylbenzene is obtained. In this way, the conditions of the diazotization reaction need to be precisely controlled, such as temperature, which usually needs to be maintained at a low temperature to prevent excessive decomposition of diazonium salts and impurity of the product.
Second, you can start from 3-fluoro-5-methylbenzoic acid. First, it is converted into the corresponding acid chloride, and then through the Rosemond reduction reaction, the acid chloride is converted into an aldehyde group. Then, by haloform reaction, the aldehyde group is converted into a halogen atom, in this case a bromine atom, and finally 1-bromo-3-fluoro-5-methylbenzene is obtained. In this process, the catalyst selection and reaction conditions of the Rosemond reduction reaction are very critical, and the proportion of reagents and reaction time of the haloform reaction also have a great influence on the formation of the product.
Third, 1-methyl-3-fluorobenzene is used as the raw material. The Fu-gram alkylation reaction can be used to introduce a suitable alkyl group to form an aromatic hydrocarbon with a suitable substituent. Subsequently, under suitable halogenation conditions, a brominating reagent is reacted with it, and a bromine atom is introduced at a specific position to obtain the target product 1-bromo-3-fluoro-5-methylbenzene. In this route, the catalyst activity of the Fu-G alkylation reaction and the localization selectivity of the halogenation reaction need to be carefully considered to achieve high yield and purity.
What 1-Bromo-3-Fluoro-5-Methylbenzene need to pay attention to when storing and transporting
1-Bromo-3-fluoro-5-methylbenzene is also an organic compound. When storing and transporting it, many matters must be paid attention to.
First words storage. This compound should be placed in a cool, dry and well-ventilated place. Because of its certain chemical activity, it is easy to deteriorate or initiate reactions when heated or humid. In case of high temperature, it may cause internal molecular activities to intensify, or cause reactions such as decomposition and polymerization, which will damage its quality and even endanger safety. Therefore, the warehouse temperature should be controlled within an appropriate range and protected from direct sunlight to prevent photochemical reactions caused by light.
Furthermore, keep away from fire and heat sources. This compound may be flammable, and there is a risk of combustion and explosion in case of open flames and hot topics. Therefore, smoking and the use of open flames are strictly prohibited in the storage area, and electrical equipment must also be explosion-proof to prevent sparks from causing accidents.
At the same time, it should be stored separately from oxidants, acids, and bases, and must not be mixed. Because 1-bromo-3-fluoro-5-methylbenzene and such substances are prone to chemical reactions, or generate dangerous products, or cause violent reactions, such as acid-base reactions cause temperature rises, oxidation reactions cause combustion, etc.
As for transportation, make sure that the container is well sealed. If the container leaks, it not only damages the compound, but also may pollute the environment, posing a threat to the health of the transportation personnel. During transportation, the traffic should be stable to avoid bumps and vibrations, so as to avoid damage to the container due to external forces.
In addition, the transportation vehicle should be equipped with the corresponding variety and quantity of fire equipment and leakage emergency treatment equipment. Once a leak occurs, it can be disposed of in time to reduce the harm. Transportation personnel should also be professionally trained to be familiar with the characteristics of the compound and emergency treatment methods. In case of emergencies, they can respond calmly and ensure transportation safety.