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1-Bromo-3-Fluoro-5-Chloro Benzene

1-Bromo-3-Fluoro-5-Chloro Benzene

Hongda Chemical

Specifications

HS Code

122459

Chemical Formula C6H3BrClF
Molar Mass 209.44 g/mol
Appearance Colorless to pale yellow liquid
Boiling Point 185 - 187 °C
Melting Point N/A
Density 1.709 g/cm³
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in common organic solvents like ethanol, ether
Flash Point 76 °C
Vapor Pressure Low at room temperature
Stability Stable under normal conditions, but may react with strong oxidizing agents

As an accredited 1-Bromo-3-Fluoro-5-Chloro Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 1 - bromo - 3 - fluoro - 5 - chloro benzene: Packed in 500 - gram bottles for chemical use.
Storage 1 - Bromo - 3 - fluoro - 5 - chloro benzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. Keep it in a tightly sealed container to prevent evaporation and contact with air or moisture. Store it separately from oxidizing agents and reactive chemicals to avoid potential chemical reactions.
Shipping 1 - bromo - 3 - fluoro - 5 - chloro benzene, a hazardous chemical, is shipped in well - sealed, corrosion - resistant containers. Transport follows strict regulations, with proper labeling indicating its properties to ensure safe handling during transit.
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1-Bromo-3-Fluoro-5-Chloro Benzene 1-Bromo-3-Fluoro-5-Chloro Benzene
General Information
Historical Development
1 - Bromo - 3 - Fluoro - 5 - Chloro Benzene, the historical development of this substance, the beginning of organic chemistry in the past, chemists dedicated to exploring various halogenated aromatic hydrocarbons. At that time, the research on such polyhalogenated benzene derivatives containing bromine, fluorine and chlorine was still shallow.
With the passage of time, chemical analysis technology has gradually refined, and researchers have been able to accurately analyze its structure. Synthetic methods have also evolved, relying on complicated and inefficient steps in the early stage. After unremitting research, more concise and efficient routes have been developed.
In the industrial field, due to its unique chemical properties, it has emerged in the fields of materials science, drug development and other fields. Scientists continue to explore its reactivity and application potential, making it a niche research object in the laboratory and an indispensable key raw material in many fields. Future development is also highly anticipated.
Product Overview
1 - Bromo - 3 - Fluoro - 5 - Chloro Benzene is an organic compound. In its molecular structure, on the benzene ring, there is one atom of bromine, fluorine and chlorine. Bromine, one of the halogen elements, has active chemical properties; fluorine, the most active element in the halogen group, has strong electronegativity; chlorine is also a halogen element, and has active properties.
This compound has unique physical and chemical properties due to the substitution of bromine, fluorine and chlorine atoms. Its physical properties are related to melting boiling point, solubility, etc. Chemically, it can participate in many organic reactions, such as nucleophilic substitution reactions. Due to the existence of halogen atoms, the electron cloud density of the benzene ring changes, making it different in its reactivity to nucleophiles.
The preparation of this compound requires fine chemical steps, or through the halogenation reaction of benzene, the reaction conditions are precisely controlled, so that the bromine, fluorine and chlorine atoms are replaced at specific positions to obtain this target product. In the field of organic synthesis, 1 - Bromo - 3 - Fluoro - 5 - Chloro Benzene is often a key intermediate for the synthesis of complex organic molecules, which has important application prospects in many fields such as medicine and materials science.
Physical & Chemical Properties
1 - Bromo - 3 - Fluoro - 5 - Chloro Benzene is an organic compound, and its physicochemical properties are quite important. From the perspective of physical properties, this compound is mostly liquid at room temperature and has a special odor. Its boiling point is within a specific range due to factors such as intermolecular forces, but the exact value needs to be accurately determined by experiments.
Talking about chemical properties, because it contains halogen atoms, it has certain reactivity. Bromine, fluorine and chlorine atoms can participate in many chemical reactions under different conditions. For example, in a nucleophilic substitution reaction, halogen atoms can be replaced by nucleophilic reagents to form new compounds. This reactivity is due to the electronegativity of halogen atoms and the difference in atomic radius, which cause them to exhibit unique properties in chemical reactions. The study of its physicochemical properties is of great significance to the fields of organic synthesis, drug development, etc., which can optimize the reaction conditions and improve the purity and yield of the product.
Technical Specifications & Labeling
There is a product today, named 1 - Bromo - 3 - Fluoro - 5 - Chloro Benzene. In order to clarify its technical specifications and labels (commodity parameters), it should be carefully examined.
Looking at this product, its chemical composition is unique, bromine (Bromo), fluorine (Fluoro), chlorine (Chloro) are connected to the benzene ring. In the technical specifications, its purity must be determined, and the amount of impurities must be strictly controlled to ensure excellent quality. Its reactivity, stability and other characteristics also need to be accurately determined to lay the foundation for subsequent applications.
In terms of identification (commodity parameters), in addition to the chemical name, physical parameters such as molecular weight, melting point, and boiling point should be clearly marked. This is the key to recognizing and applying the object, allowing the user to understand its characteristics, apply it, and avoid errors, in accordance with technical specifications and identification (product parameters).
Preparation Method
1 - Bromo - 3 - Fluoro - 5 - Chloro Benzene is an important organic compound. The preparation method involves raw materials, production processes, reaction steps and catalytic mechanisms.
To prepare this compound, suitable raw materials can be selected. Take an aromatic compound as the starting material and undergo a halogenation reaction to introduce bromine, fluorine and chlorine atoms. In the first step, the aromatic raw material is placed in a specific reaction vessel, and a bromine-containing reagent is added in proportion. At a suitable temperature and pressure, according to the electrophilic substitution mechanism, the bromine atom gradually enters the specific position of the aromatic ring.
Second, the fluorine atom is introduced. Adjust the reaction conditions, add a fluorine-containing reagent, and through a series of reaction steps, the fluorine atom precisely replaces the hydrogen atom in the corresponding position.
As for the introduction of chlorine atoms, it is also necessary to fine-tune the reaction conditions, select the appropriate chlorine-containing reagent, follow the established reaction steps, and successfully connect it to the aromatic ring, and finally obtain 1-Bromo-3-Fluoro-5-Chloro Benzene. In this process, the catalytic mechanism is crucial, and the selection of high-efficiency catalysts can accelerate the reaction process and improve the yield and purity of the product.
Chemical Reactions & Modifications
To taste the wonders of chemical industry, it is related to the change of substances, reaction and modification, which is really the key. Today, 1-Bromo-3-Fluoro-5-Chloro Benzene is discussed.
Its chemical reaction is mainly in the selection of methods and agents. The properties of halogenated aromatics can be replaced by nucleophilic substitution. In case of nucleophilic reagents, bromine, chlorine, fluorine atoms or translocations, because of the atomic activity are different. Although fluorine has strong electronegativity, it is weak to leave; bromine and chlorine are relatively easy to separate, so the control of reaction conditions is essential, and temperature, pressure, and catalyst can all turn around.
As for modification, new radicals can be introduced to expand its use. Or add functional groups to the benzene ring to adjust its physicochemical properties. If the base containing nitrogen and oxygen is attached, it can be changed to its pole, soluble, or endowed with biological activity. All this depends on fine design and repeated tests to achieve the ideal quality and develop its growth in chemical, pharmaceutical and other fields.
Synonyms & Product Names
Today there is a thing called 1-Bromo-3-Fluoro-5-Chloro Benzene. This thing is quite important in the field of chemistry. Its synonymous names are also numerous.
Or "3-fluoro-5-chlorobromobenzene", this name is derived from the arrangement and type of its atoms, and its structure is explained in Chinese. Or it is called "m-fluoro-chlorobromobenzene", which is based on its positional relationship above the benzene ring.
As for the names of products, there are also differences. In order to recognize its characteristics, the merchant may name it "Excellent 1-Bromo-3-Fluoro-5-Chlorobenzene" to show its quality; or the cloud "High Purity 1-Bromo-3-Fluoro-5-Chloro Benzene" to show its high purity.
Although the names of synonymous names and commodity names are different, they actually refer to the same thing. In chemical research and industrial production, they are all called by different names according to their needs.
Safety & Operational Standards
1 - Bromo - 3 - Fluoro - 5 - Chloro Benzene is an important chemical substance, which needs to be explained in detail in terms of its safety and operating practices.
The chemical substance is the safest. 1 - Bromo - 3 - Fluoro - 5 - Chloro Benzene has certain chemical activity and potential harm. When storing, keep in a cool, dry and well ventilated place, away from fire and heat sources, to prevent accidents. Because of its flammability, if it encounters open flames or hot topics, it may cause fire.
The operating specifications should not be underestimated. When handling this chemical, the operator must wear appropriate protective clothing, such as chemical protective clothing, and wear protective gloves, goggles and other equipment to protect their own safety. The operating environment should have complete ventilation facilities, so that the volatile gas can be discharged in time to avoid accumulation.
When weighing and transferring the substance, the action should be cautious and gentle to avoid spillage. If it is accidentally spilled, do not panic, and should be disposed of immediately according to established procedures. Small spills can be absorbed by inert materials such as sand and vermiculite and collected in a suitable container; if a large amount of spills, it is necessary to quickly evacuate personnel, delineate a warning area, and deal with it by professionals.
After the experiment is completed, the remaining 1 - Bromo - 3 - Fluoro - 5 - Chloro Benzene should be properly stored and must not be discarded at will. The utensils used should also be cleaned in time to remove residues to prevent interference with subsequent experiments.
In short, during the use of 1 - Bromo - 3 - Fluoro - 5 - Chloro Benzene, strict safety and operating standards should be followed to ensure the safety of personnel and the smooth operation of the experiment.
Application Area
1 - Bromo - 3 - Fluoro - 5 - Chloro Benzene This compound has a crucial application field. In the field of pharmaceutical research and development, it can be used as a key intermediate to help synthesize specific drugs, or for specific diseases, to exert precise curative effects, providing new paths for doctors to treat diseases. In the field of materials science, it can be integrated into new materials through special reactions, giving materials unique physical and chemical properties, such as enhancing stability and changing optical properties, which add to material innovation. In the field of fine chemicals, it can be used as a basic raw material to derive a series of high-value-added fine chemicals to improve the quality and diversity of chemical products. With its unique chemical structure, it shows potential in many application fields and promotes the development of related industries.
Research & Development
Taste the industry of chemical industry, study substances in order to open up new paths. Today there is 1 - Bromo - 3 - Fluoro - 5 - Chloro Benzene, which is also a key quality in our scientific research.
We observe its properties in detail and explore its rationale. Analyze its structure and observe its reaction characteristics. In the laboratory, through various experiments, observe the change of its phase combination with other things, and measure its physical properties, such as the point of melting and the dissolution.
And think about the future development of this thing, if we can make good use of its properties, or in the field of medicine, we can make special drugs; in the field of materials, create novel materials. However, there are many obstacles in the road of scientific research. Only with a rigorous heart and unremitting efforts can we make achievements in the research and development of 1-Bromo-3-Fluoro-5-Chloro Benzene and contribute to the chemical industry.
Toxicity Research
The judgment of material nature is related to the safety of the people. There is a substance today, named 1 - Bromo - 3 - Fluoro - 5 - Chloro Benzene. The poison of its nature should be investigated in detail by our generation.
The poison of this substance may involve living things. If you accidentally touch it, the skin may feel uncomfortable, and the disease of erythema, swelling and pain may arise. And if its qi enters the lungs, it may cause respiratory stagnation, cough and boredom, and even damage the organs, endangering life.
And consider its impact on the environment, the dissipation of poison, or sewage and soil, harming plants, trees, insects and fish. Therefore, we who are students must be very careful when we study this poison. Study its control methods and find a way to avoid it, hoping to protect the health of the people and protect the tranquility of the environment. Make this poison not a threat to the world, and it is the aspiration of our generation.
Future Prospects
In the future, in 1 - Bromo - 3 - Fluoro - 5 - Chloro Benzene, this compound has great potential. This compound, which combines bromine, fluorine, and chlorotriphenol, is unique and has extraordinary properties.
Not yet, it may be able to make a big impact in the field of research. With its high-quality properties, it may be able to precisely control the role of biological targets of molecules and biological targets, giving birth to many new special effects. In terms of material science, its special properties are expected to produce high-performance functional materials, such as materials with excellent resistance, resistance or light properties.
Furthermore, in the process of synthesis, 1 - Bromo - 3 - Fluoro - 5 - Chloro Benzene must be an important step to introduce new synthetic methods and expand the capabilities of compounds. Our researchers are committed to exploring, in order to explore more of its capabilities, and to make this compound an extraordinary force for human well-being.
Where to Buy 1-Bromo-3-Fluoro-5-Chloro Benzene in China?
As a trusted 1-Bromo-3-Fluoro-5-Chloro Benzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 1-Bromo-3-Fluoro-5-Chloro Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-bromo-3-fluoro-5-chlorobenzene?
Mercury, lead, arsenic, and cadmium are highly toxic elements. They have different uses in many fields, but they also pose potential hazards and cannot be ignored.
Mercury, a liquid metal, has unique physical and chemical properties. In ancient times, it was often used in alchemy, and alchemists wanted to use it to refine longevity pills. Although it was ineffective, it preserved experience for later chemical research. In the field of medicine, mercury compounds were used as disinfectants and preservatives in the past, but due to toxicity, they are now rarely used. In industry, mercury is used to make thermometers and sphygmomanometers, because its thermal expansion and contraction properties accurately reflect temperature and pressure changes. However, mercury evaporates to form mercury vapor, which can damage the nervous system and kidneys when inhaled into the human body, causing tremors, insomnia, memory loss and other symptoms.
Lead is soft and resistant to corrosion. In ancient times, it was often cast as currency and utensils because it was easy to process and form. In the field of construction, it was used to make water pipes, but lead would dissolve in water and endanger human health. In modern times, lead is widely used to make lead-acid batteries, which supply energy for cars, electric vehicles, etc. However, when lead enters the human body, it will affect the development of the nervous system, especially in children. It can cause mental decline and abnormal behavior. It can also affect the hematopoietic system and cardiovascular system.
Arsenic, a variety of compounds. Ancient arsenic (arsenic trioxide) was often used as a poison. However, a small amount of arsenic compounds were used as drugs in the field of medicine, such as the treatment of certain blood In agriculture, arsenic-containing pesticides have been used to prevent insects, but their residues can pollute soil and water sources. Arsenic enters the human body and can damage the skin, liver, kidneys and other organs. Long-term exposure can cause skin cancer, lung cancer, etc.
Cadmium has good corrosion resistance and electroplating properties. It is often plated on metal surfaces to prevent corrosion in industry and is also used in the manufacture of nickel-cadmium batteries. Cadmium enters the human body and can accumulate in the kidneys and bones, causing renal insufficiency and osteoporosis. "Pain disease" is a typical disease caused by cadmium pollution. Patients have severe bone pain and are prone to fractures.
Although mercury, lead, arsenic, and cadmium have certain uses in human development, due to toxicity, caution must be taken when using them, and protection and pollution prevention and control must be done to ensure human health and ecological environment safety.
What are the physical properties of 1-bromo-3-fluoro-5-chlorobenzene?
Mercury, bromine, gallium, and cesium all have wonderful physical properties.
Mercury is a liquid metal at room temperature, and silver optical flows like a spiritual liquid. Its melting point is as low as -38.87 ° C, and its boiling point is 356.6 ° C. The density of mercury is quite large, about 13.59 grams/cubic centimeter, which is heavier than normal matter. Its fluidity is very good, like silver beads rolling, which is elusive. And mercury has a certain evaporation, which can be slowly volatilized in the air, and its vapor is toxic. Be careful.
Bromine is the only non-metallic element that is liquid at room temperature and pressure. It is red-brown in color and has a strong pungent smell, which is unbearable. Bromine has a melting point of -7.2 ° C and a boiling point of 58.76 ° C. Its density is 3.119 grams per cubic centimeter, which is heavier than water. Bromine is volatile, and its reddish-brown mist can be seen rising in the air, and bromine is highly corrosive, touching the skin.
Gallium, seemingly ordinary, but its melting point is extremely low, only 29.78 ° C, slightly higher than normal temperature, placed in the palm of your hand, melts when heated, and turns into a liquid, like magic. Its boiling point is extremely high, reaching 2403 ° C. The density of gallium is about 5.904 grams per cubic centimeter. Solid gallium is soft, can be easily cut, and has good electrical conductivity.
Cesium, silver-white in color, soft as wax, deforms when touched. Its melting point is extremely low, 28.44 ° C, and it melts into a liquid when it is slightly hot. The chemical properties of cesium are extremely active, and it reacts violently when exposed to water. It explodes and ignites, releasing hydrogen. Its density is 1.879 g/cm3. Among alkali metals, cesium has the strongest metallic properties and is extremely sensitive to light. It is often used in optoelectronic devices.
These four things are either hidden in deep mountain veins or hidden in the field of chemistry. With their unique physical properties, they are all used in scientific research and industry. They are treasures that nature has bestowed on our generation. We should make good use of them.
Is 1-Bromo-3-fluoro-5-chlorobenzene chemically stable?
1. Mercury is active, liquid at room temperature, and has a metallic luster. Although it appears to be relatively stable under common conditions, its chemical properties are quite unique. Mercury can form amalgam with a variety of metals, which is relatively easy to occur, indicating that mercury is more active in metal interactions. And mercury is easy to react with oxygen. When heated, it can quickly combine with oxygen to form mercury oxide.
2. Bromine is the only non-metallic element that is liquid at room temperature and pressure, and its chemical properties are active. Bromine has strong oxidizing properties and can react with many metals and non-metals. For example, it can react violently with sodium metal to form sodium bromide. In the field of organic chemistry, bromine is often used as an important reagent, participating in various reactions such as substitution and addition, which shows that its chemical properties are active and not stable.
3. Astatine is a halogen element and is radioactive. Due to its short half-life and minimal content in nature, the study of its chemical properties is limited. However, based on the law of gradual changes in the properties of halogen elements, astatine should have a certain degree of oxidation and can react with metals to form corresponding compounds. It is inferred from theory and limited experiments that astatine is not a chemically stable substance.
In summary, mercury, bromine, and astatine are all non-chemically stable substances, and each exhibits relatively active chemical properties under different conditions.
What are the synthesis methods of 1-bromo-3-fluoro-5-chlorobenzene?
To prepare 1-ether, 3-alkyne, and 5-bromobenzene, the following methods can be used.
The method of making ethers is commonly used in the Williamson synthesis method. The reaction of halogenated hydrocarbons with sodium alcohols, such as the reaction of halogenated alkanes with sodium alcohols in an appropriate solvent, the halogen atoms are replaced by alkoxy groups to form ethers. For example, bromoethane is co-heated with sodium ethanol to form ethyl ether. The reaction mechanism is that the alkoxy negative ion of sodium alcohols acts as a nucleophilic reagent to attack the α-carbon atom of halogenated hydrocarbons, and the halogen ions leave. This is a nucleophilic substitution reaction. There is also an intermolecular dehydration method of alcohols. Under the action of dehydrating agents such as sulfuric acid, two-molecule alcohols can remove a molecule of water to form ethers. However, this method is more suitable for primary alcohols, and secondary alcohols and tertiary alcohols are prone to side reactions, such as elimination of the reaction to form olefins.
As for the synthesis of ethylene, the nucleophilic substitution reaction of acetylene is commonly used. Acetylene reacts with sodium metal to obtain sodium acetylene, which reacts with halogenated hydrocarbons and can introduce alkyl groups to obtain corresponding alkynes. To synthesize 3-alkynes, sodium acetylene can be obtained first, and then reacted with suitable halogenated hydrocarbons. For example, reacted with 1-bromopropane, 1-pentyne In this reaction, the carbon anion of sodium acetylene has strong nucleophilicity, attacking the α-carbon atom of the halogenated hydrocarbon, and the halogen ion leaves to realize the growth of the carbon chain and generate alkynes. In addition, the dehalogenation method of o-dihalogenated alkanes can also be used. Under the action of strong bases such as potassium hydroxide alcohol solution, the elimination reaction of o-dihalogenated alkanes occurs to form alkynes.
Synthesis of 5-bromobenzene can be achieved through the bromination reaction of benzene. Using benzene as a raw material, under the action of catalysts such as iron bromide, benzene and bromine undergo an electrophilic substitution reaction, and bromine atoms replace hydrogen atoms on the benzene ring to obtain bromobenzene. To introduce If there are some groups on the benzene ring, it can affect the position of the subsequent substitution reaction. If there is a power supply group connected to the benzene ring, it is an ortho-and para-position group, which can make the subsequent substituents mainly enter the ortho-and para-position; if there is an electron-absorbing group, it is an meso-position group, so that the subsequent substituents mainly enter the meso-position. To obtain 5-bromobenzene, a suitable positioning group can be introduced into the benzene ring to guide the bromine atom into the desired position, and then the positioning group can be removed by an appropriate reaction.
What are the precautions for storing and transporting 1-bromo-3-fluoro-5-chlorobenzene?
Oil, pulp, lacquer, wax, etc., should be paid attention to in the way of storage and transportation.
First, the storage place must be dry, cool and well ventilated. Oil is flammable, and if it is placed in a high temperature or unventilated place, it is prone to fire risk. The same is true for pulp. In a high temperature and humid place, it may deteriorate and rot, and lose its original properties. Paint contains many chemicals, which can change in adverse environments or cause changes in composition, affecting its effectiveness. Wax is easy to melt when heated, so it should be placed in a cool place to maintain its shape and quality.
Second, the method of packaging is crucial. Oil should be stored in a tightly sealed container to prevent it from evaporating, and to avoid contact with air and moisture, causing it to oxidize and deteriorate. The packaging of pulp should be able to resist external shocks and collisions to prevent it from leaking. The container of paint should be corrosion-resistant, because the ingredients in the paint or chemical reaction with ordinary materials. The packaging of wax should be able to maintain its shape stable and prevent extrusion deformation.
Third, when transporting, the bumps of the road cannot be ignored. Oil, pulp, paint and wax should be properly fixed to prevent them from being damaged due to shaking and collision during transportation. And the temperature and humidity in the means of transportation should also be adjusted appropriately. If the oil is transported at high temperature, it is not only easy to evaporate and lose, but also increases the risk of safety; if the wax is heated, it may melt and adhere, which will affect its quality and use.
Fourth, when handling, the action should be gentle. Oil drums, pulp drums, paint drums, wax blocks, etc., should not be thrown or collided to prevent the container from breaking and material leakage. And the person handling, when he knows the characteristics of various materials and follows the corresponding operating specifications, can keep the storage and transportation safe and smooth, so that the oil, pulp, paint and wax do not lose their use.