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1-Bromo-3-Fluoro-4-Nitrobenzene

1-Bromo-3-Fluoro-4-Nitrobenzene

Hongda Chemical

Specifications

HS Code

948380

Name 1-Bromo-3-fluoro-4-nitrobenzene
Molecular Formula C6H3BrFNO2
Molecular Weight 220.00
Appearance Yellow solid
Melting Point 45 - 49 °C
Boiling Point 233 - 235 °C
Density 1.805 g/cm³
Solubility Insoluble in water, soluble in organic solvents
Flash Point 95.3 °C
Purity Typically high - purity (e.g., 98%+ in commercial products)
Cas Number 1481-57-4

As an accredited 1-Bromo-3-Fluoro-4-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 1 - bromo - 3 - fluoro - 4 - nitrobenzene packaged in a sealed glass bottle.
Storage 1 - Bromo - 3 - fluoro - 4 - nitrobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. Keep it in a tightly closed container to prevent leakage. Store it separately from oxidizing agents, reducing agents, and other reactive chemicals to avoid potential reactions. Use appropriate storage cabinets designed for hazardous chemicals.
Shipping 1 - bromo - 3 - fluoro - 4 - nitrobenzene is shipped in well - sealed, corrosion - resistant containers. It adheres to strict hazardous chemical shipping regulations, ensuring safe transport to prevent spills and environmental or safety risks.
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1-Bromo-3-Fluoro-4-Nitrobenzene 1-Bromo-3-Fluoro-4-Nitrobenzene
General Information
Historical Development
1 - Bromo - 3 - Fluoro - 4 - Nitrobenzene is an organic compound, and its historical development is very interesting. In the past, organic chemistry was just emerging, and many sages dedicated themselves to the research of compounds. The discovery of this compound took several years of research. At that time, scholars used ingenious methods to analyze various reactions in the laboratory. At first, its synthesis was difficult and the yield was quite low. However, the ancestors made unremitting efforts, and after repeated attempts, they improved the synthesis technique. Gradually, the synthesis method became more and more perfect, and the yield also increased. The use of this compound in medicine, materials and other fields gradually became apparent. The exploration of the past has paved the way for the application of the present, and future generations will follow their ambitions, make progress in their research, and hope to develop more potential for the benefit of the world.
Product Overview
1 - Bromo - 3 - Fluoro - 4 - Nitrobenzene is also an organic compound. Its color may be light yellow, and its shape is like a crystalline state. In this compound, bromine (Bromo), fluorine (Fluoro) and nitro (Nitro) are in specific positions according to the benzene ring. Bromine atoms have nucleophilic substitution activity. Fluorine atoms affect the polarity and reactivity of molecules because of their electronegativity. Nitro groups make this compound exhibit unique chemical properties in many reactions.
The process of preparation, or from specific benzene derivatives, is obtained through several steps of halogenation, nitrification, etc. In the reaction, strict control conditions, such as temperature, ratio of reagents, and choice of catalyst, are required to obtain higher yield and purity.
In the field of organic synthesis, 1-Bromo-3-Fluoro-4-Nitrobenzene has a wide range of uses. It can be used as an intermediate to prepare fine chemicals such as medicines, pesticides, and dyes. Due to its special substituent distribution, it can participate in a variety of organic reactions and lay the foundation for the construction of complex organic molecular structures.
Physical & Chemical Properties
1 - Bromo - 3 - Fluoro - 4 - Nitrobenzene is also an organic compound. Its physical and chemical properties are worth studying. Looking at its physical properties, at room temperature, it is a solid with a specific color and shape. The genera of melting point and boiling point have fixed numbers, which are crucial when separating and purifying.
In terms of its chemical properties, it is very active because it contains functional groups such as bromine, fluorine, and nitro. Bromine atoms can be involved in nucleophilic substitution reactions. Fluorine atoms, with their electronegativity, affect the charge distribution of molecules, resulting in different reactivity. Nitro groups are strong electron-absorbing groups, which reduce the electron cloud density of the benzene ring and lead to specific positions in the electrophilic substitution reaction. This compound is widely used in organic synthesis and can be used as an intermediate to produce a variety of organic products. The study of its physicochemical properties has far-reaching significance in the fields of chemical industry, medicine and so on.
Technical Specifications & Labeling
1 - Bromo - 3 - Fluoro - 4 - Nitrobenzene is an important chemical raw material. Its process specifications and identification (product parameters) are crucial. The process specifications of this product need to clarify its purity, should meet very high standards, and the impurity content must be strictly controlled. The synthesis process, when following the precise process, the raw material ratio is accurate, and the reaction conditions such as temperature and pressure need to be precisely controlled to ensure the quality of the product.
Regarding the identification, the product name and chemical formula should be clearly marked, and its chemical characteristics should be clearly warned to prevent misuse. The packaging label should also be standardized, indicating the storage conditions, and should be placed in a dry, cool place, away from fire sources and oxidants. This way, this product can function safely and efficiently in industrial applications.
Preparation Method
1 - Bromo - 3 - Fluoro - 4 - Nitrobenzene is an important compound in organic synthesis. The preparation method and the selection of raw materials are very important. Usually a specific aromatic hydrocarbon is used as the starting material, and this aromatic hydrocarbon needs to have a suitable substituent to facilitate the subsequent reaction.
In the preparation process, the first step is usually a nitration reaction, in which nitro groups are introduced at specific positions of aromatic hydrocarbons. This step requires precise control of the reaction conditions, such as temperature, reactant ratio, etc., to prevent the growth of side reactions. Then there is a halogenation reaction, in which bromine and fluorine atoms are introduced. When brominating, choose the appropriate brominating agent to control the reaction process; the same is true for fluorination, and choose the appropriate fluorinating agent to ensure the accurate access of fluorine atoms
The reaction steps are rigorous and orderly. After each step, the product needs to be properly separated and purified to remove impurities. The catalytic mechanism is also indispensable. The selection of high-efficiency catalysts can improve the reaction rate and product selectivity, reduce energy consumption and cost, so that 1-Bromo-3-Fluoro-4-Nitrobenzene can be efficiently prepared.
Chemical Reactions & Modifications
Today, there is a substance called 1-Bromo-3-Fluoro-4-Nitrobenzene. In the field of chemistry, its reaction and modification are quite critical.
Looking at the reaction, the characteristics of bromine, fluorine and nitro groups show their respective abilities. Bromine has good activity. In the way of nucleophilic substitution, it can be replaced by other groups and lead new chains into its structure. Although fluorine is small, it has strong electronegativity, which affects the polarity and reactivity of molecules. It often changes the electron cloud distribution of surrounding groups, causing the reaction to be biased in a specific direction. Nitro has strong electron absorption, which reduces the density of the electron cloud of the benzene ring. When electrophilic substitution is used, it prevents the initiation of the reaction, but in specific nucleophilic reactions, it promotes the progress of the reaction.
As for the modification, the physical and chemical properties can be adjusted by substitution reaction, and different functional groups can be replaced. Or change its solubility, or change its stability to meet the needs of diversity. In this way, the reaction and modification of 1-Bromo-3-Fluoro-4-Nitrobenzene can open many new paths for chemical research and application.
Synonyms & Product Names
1 - Bromo - 3 - Fluoro - 4 - Nitrobenzene, its synonymous name and the name of the commodity, are related to the importance of chemical research. In our way of chemical study, knowing its synonymous names can help us understand accurately. This compound, or other names, may be due to academic habits, regional differences, or different synonymous names. The name of the commodity also has its specific reasons. The manufacturer recognizes its characteristics, uses, or assigns it the name of a unique commodity.
Observe this 1 - Bromo - 3 - Fluoro - 4 - Nitrobenzene, or some chemists call it in other terms, but it all refers to this thing. Such as the ancient Fang family, in the refining of medicinal pills, the same thing also has different names, depending on the teacher and region. In today's chemical field, although there are standard names, actual discussions and exchanges, synonymous names often appear. The name of the product may depend on its purity and field of application. If it is specially made for a certain type of reaction, the product name contains relevant information to facilitate user selection.
Safety & Operational Standards
1 - Bromo - 3 - Fluoro - 4 - Nitrobenzene is an important chemical compound in chemical research. Its safety and operation standards are really related to the safety of researchers and endanger the success or failure of experiments.
In terms of safety, this compound is quite dangerous. It contains bromine, fluorine, nitro and other groups. Bromine is active and corrosive. If it touches the skin inadvertently, it can cause burns, pain, redness and ulceration. Therefore, when operating, it is necessary to wear protective clothing, wear thick gloves, and avoid skin exposure. Fluorine is also toxic. The volatile gaseous substances of its compounds, if inhaled into the human body, will damage the respiratory tract, cause coughing, asthma, and even affect the function of the lungs, causing breathing difficulties. The experimental site should be well ventilated and equipped with effective ventilation equipment to expel volatile harmful gases. Nitro is highly oxidizing and potentially explosive. During storage and use, it must be kept away from fire and heat sources to prevent accidental explosion accidents, endangering life and property safety.
In terms of operating specifications, when taking 1 - Bromo - 3 - Fluoro - 4 - Nitrobenzene, be sure to use a precise measuring tool, and take it accurately according to the experimental requirements. Do not take more or take it by mistake to avoid waste and experimental errors. Weighing is carried out in a fume hood to prevent the spread of harmful gases. During the reaction process, temperature, pressure and other conditions are strictly controlled. Due to its active chemical properties, high temperature or abnormal pressure, it is easy to cause side reactions, affect the purity and yield of the product, and may also cause danger. The stirring speed also needs to be moderate. Too fast or too slow is not conducive to the reaction. After the reaction, the product treatment must also be cautious. According to its chemical characteristics, appropriate separation and purification methods are used, and the waste generated is properly disposed of according to environmental protection requirements, and cannot be discarded at will to avoid polluting the environment.
In conclusion, when studying 1 - Bromo - 3 - Fluoro - 4 - Nitrobenzene, always keep safety and operating standards in mind to ensure the smooth operation of the experiment, ensure the safety of yourself and surrounding personnel, and maintain the cleanliness of the environment.
Application Area
1 - Bromo - 3 - Fluoro - 4 - Nitrobenzene is an important chemical substance. Its application field is quite wide. In the field of medicinal chemistry, it can be used as a key intermediate to help synthesize compounds with specific pharmacological activities. Due to its unique chemical structure, it can be ingeniously reacted to introduce key functional groups to construct complex drug molecular structures, opening up paths for new drug research and development.
In the field of materials science, it also plays a significant role. It can participate in the synthesis of functional materials with special properties, such as materials with specific optoelectronic properties, in the manufacture of optoelectronic devices, which can optimize device performance, improve its stability and efficiency.
In the field of organic synthesis, it is often used as a starting material. By virtue of the activity of bromine, fluorine, nitro and other functional groups, various organic reactions can be used to construct various organic compounds, expanding the boundaries of organic synthesis, and contributing to the development of organic chemistry.
Research & Development
The rise of modern chemistry, studying the properties of substances, and seeking the production of new materials are the top priorities for scholars. 1 - Bromo - 3 - Fluoro - 4 - Nitrobenzene, a special compound is also.
Our generation studied this compound, observed its structure, and explored its reaction. At first, analyze its chemical bonds, and clarify the connection of atoms. Experiment to find its properties, and observe its changes in different contexts.
Then think about its preparation method, improve the process, and seek high-efficiency and pure products. This compound is available in the fields of medicine and materials. We hope to advance our skills to promote mass production and increase its quality, so that it can thrive in industry and academia, so as to benefit everyone, contribute to the development of chemistry, and become the ambition of our generation's scientific research.
Toxicity Research
Today there is a substance, named 1 - Bromo - 3 - Fluoro - 4 - Nitrobenzene. I am a chemical researcher, and I am concerned about its toxicity, which is related to everyone's health.
The study of the toxicity of this substance is the first to emphasize its chemical properties. Bromine, fluorine, and nitro are attached to the benzene ring, or make the physical properties active and easy to react with other substances. And the benzene ring is toxic, and with the addition of various groups, the toxicity may increase.
Animal test is also the key. Feed it to a white rat and observe its appearance. If the behavior of the white rat is abnormal, or the feeding and activity are poor, it is a sign of toxicity.
Human contact should also be considered. If the skin touches it, it may sensitize or burn; if it inhales its qi, it may damage the respiratory system, or even enter the blood, harming the whole body.
In summary, the toxicity of 1-Bromo-3-Fluoro-4-Nitrobenzene should be further studied. The protection strategy should not be slack, and everyone should be safe.
Future Prospects
Husband 1 - Bromo - 3 - Fluoro - 4 - Nitrobenzene, the thing that transforms. I am a person who transforms things, and I have high expectations for the future of this thing. Its unique nature can be the foundation of multiplication and opposition, or it can be used to explore new frontiers.
Undeveloped, or it can be used to make more beautiful things, saving people from illness and pain. Or in the field of materials, develop its capabilities and create extraordinary things. The road ahead is uncertain, but we believe that our wisdom and diligence will surely enable 1 - Bromo - 3 - Fluoro - 4 - Nitrobenzene to develop its capabilities in the field of transformation, and it will become the cornerstone of the undeveloped world, for the benefit of the world.
Where to Buy 1-Bromo-3-Fluoro-4-Nitrobenzene in China?
As a trusted 1-Bromo-3-Fluoro-4-Nitrobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 1-Bromo-3-Fluoro-4-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-Bromo-3-Fluoro-4-Nitrobenzene?
1-Bromo-3-fluoro-4-nitrobenzene is an important chemical raw material in the field of organic synthesis. Its main use is in the synthesis of medicine. The functional groups of bromine, fluorine and nitro in the genine molecule all have unique chemical activities, which can be introduced into the molecular structure of the target drug through various chemical reactions, such as nucleophilic substitution reactions, and then endow the drug with specific biological activities and pharmacological properties.
Furthermore, in the field of pesticide creation, 1-bromo-3-fluoro-4-nitrobenzene also plays a role. Through ingenious synthesis methods, it can be converted into pesticide ingredients with high insecticidal, bactericidal or herbicidal effects. Because of its special structure, it can play a role in specific pests, bacteria or weeds, and can reduce the adverse impact on the environment to a certain extent, it is very popular in the field of modern agricultural chemistry.
In addition, in the field of materials science, this compound also shows potential use. Using it as a starting material, through chemical modification and polymerization reactions, etc., it may be able to prepare functional materials with special properties, such as organic semiconductor materials with good photoelectric properties, etc., which are expected to be applied to electronic devices, optical materials and many other fields, injecting new vitality into the development of materials science.
In conclusion, 1-bromo-3-fluoro-4-nitrobenzene, with its unique molecular structure and chemical activity, plays an indispensable role in many fields such as medicine, pesticides, and materials science, and is of great significance to the development of related industries.
What are the physical properties of 1-Bromo-3-Fluoro-4-Nitrobenzene?
1-Bromo-3-fluoro-4-nitrobenzene, which is colorless to light yellow liquid or solid. Its melting point is about 26-28 ° C, and its boiling point is 254-256 ° C. Due to the special groups such as bromine, fluorine, and nitro, it has certain chemical activity.
In terms of its solubility, it is quite soluble in organic solvents such as ethanol, ether, and dichloromethane, but it is very soluble in water. Due to its molecular polarity, the polarity of the cover is quite different from that of water, and it follows the principle of similar compatibility.
In terms of stability, it can exist stably at room temperature and pressure without special chemical action. In case of hot topics, open flames, or contact with strong oxidants, it may be dangerous. Due to the existence of nitro groups, it has potential oxidation, and the reaction may be out of control at high temperatures.
Its density is greater than that of water, about 1.85g/cm ³. The vapor pressure is low, and the volatilization is not very significant at room temperature. However, when heated, the vapor volatilization accelerates, and attention should be paid to prevention.
In chemical reactions, bromine atoms have high activity and are prone to nucleophilic substitution reactions. Fluorine atoms affect the selectivity of the reaction area. Nitro groups are strong electron-absorbing groups, which reduce the density of electron clouds in the benzene ring and increase the difficulty of electrophilic substitution reactions. These are all important physical properties, which are crucial in the fields of chemical synthesis, analysis and testing, and require careful consideration during experimental operations.
What is the chemical synthesis method of 1-Bromo-3-Fluoro-4-Nitrobenzene?
The chemical synthesis of 1-bromo-3-fluoro-4-nitrobenzene is an important topic in the field of organic synthesis. Its synthesis route depends on many reaction principles and skills of organic chemistry.
The first one can be started from benzene derivatives. With benzene as the raw material, the nitration reaction is carried out first. In the environment where sulfuric acid and nitric acid are mixed, benzene can be converted into nitrobenzene. In this reaction, nitric acid is catalyzed by sulfuric acid to generate nitroyl cation (NO 2), which attacks the benzene ring as an electrophilic reagent. After the electrophilic substitution reaction, one of the hydrogen atoms on the benzene ring is replaced by nitro (-NO 2) to obtain nitrobenzene.
The second one is halogenated to nitrobenzene. Because the nitro group is the meta-localization group, the bromination or fluorination should introduce the halogen atom at the meta-site. Take the bromination reaction as an example. In the presence of an appropriate catalyst such as iron filings or iron tribromide, nitrobenzene reacts with bromine, and the bromine atom can selectively enter the nitro interposition to obtain m-bromonitrobenzene.
Then, fluorination is performed. A specific fluorinating reagent, such as a fluorine-containing nucleophile, can be used to react with m-bromonitrobenzene under suitable conditions, so that the fluorine atom replaces the hydrogen atom at a specific position on the benzene ring, and finally obtains 1-bromo-3-fluoro-4-nitrobenzene.
For example, a fluorinated benzene derivative can be used as the starting material, and the synthesis goal can be achieved through similar electrophilic substitution reaction steps such as nitrification and bromination. However, no matter what method, the reaction conditions, such as temperature, ratio of reactants, reaction time, etc., need to be carefully controlled to ensure the reaction selectivity and yield. In this way, the target product 1-bromo-3-fluoro-4-nitrobenzene can be obtained.
1-Bromo-3-Fluoro-4-Nitrobenzene What are the precautions during storage and transportation?
1-Bromo-3-fluoro-4-nitrobenzene is a commonly used raw material for organic synthesis. However, it is toxic and corrosive. During storage and transportation, many matters need to be paid attention to.
When storing, the first environment. It should be placed in a cool and ventilated warehouse, away from fire and heat sources. Due to high temperature, or the chemical reaction of this substance, it may cause danger. The temperature of the warehouse should be controlled within a specific range to prevent its properties from changing.
Furthermore, it must be stored in separate stores with oxidants and food chemicals, and must not be mixed. Because it encounters with oxidants, or reacts violently, or even explodes; if it is mixed with edible chemicals, if it leaks, it may contaminate food and endanger everyone's health.
Packaging is also crucial. Packaging must be sealed to prevent the intrusion of water vapor and air. If the package is damaged, it will come into contact with water vapor or air, or deteriorate, or evaporate harmful gases.
During transportation, it is also necessary not to slack off. Transport vehicles must ensure that they are in good condition and have corresponding fire and emergency equipment. Escort personnel must be familiar with the characteristics of this object and emergency disposal methods. When driving, bumps and vibrations should be avoided to prevent damage to the package.
The loading and unloading process must also be cautious. The operator should wear appropriate protective equipment, such as protective clothing, gloves and goggles, to prevent contact with this object. Loading and unloading should be handled lightly, without touching or heavy pressure, so as not to break the package.
The storage and transportation of 1-bromo-3-fluoro-4-nitrobenzene are all related to safety and must be operated in strict accordance with regulations.
1-Bromo-3-Fluoro-4-Nitrobenzene impact on the environment and human health
1-Bromo-3-fluoro-4-nitrobenzene is one of the organic compounds. Its impact on the environment and human health cannot be ignored.
First of all, its impact on the environment. If this substance is released in the environment, it migrates and transforms between water bodies, soil and atmosphere. In water bodies, or diffuses with water currents, affecting aquatic organisms. Because it has certain toxicity, or causes damage to the physiological functions of aquatic organisms, growth and reproduction are blocked. Such as fish or abnormal behavior, developmental deformities, shellfish and other filter-feeding organisms, or ingestion of water containing this substance, the accumulation of toxins in the body, and then affects the balance of the entire aquatic ecosystem. In the soil, or adsorbed by soil particles, affecting the activity and community structure of soil microorganisms. Soil microorganisms are of great significance in maintaining soil fertility and material circulation. If they are affected, soil ecological functions may be damaged. In the atmosphere, this substance may enter through volatilization or participate in photochemical reactions to generate other harmful substances, which affect air quality.
Describe its impact on human health. If people ingest this substance through breathing, diet or skin contact, it may cause various hazards. By breathing into the body, this substance may irritate the respiratory tract, causing cough, asthma, breathing difficulties and other diseases. Long-term exposure may damage lung function and increase the risk of respiratory diseases. Ingestion through diet, such as eating contaminated food, this substance may accumulate in the body. It may interfere with the normal physiological metabolism of the human body, damaging important organs such as the liver and kidneys. The liver is responsible for detoxification and the kidneys excrete. If the two are damaged, the body's detoxification function will be weakened, harmful substances will remain in the body, or cause systemic lesions. Contact with the skin may cause skin allergies, redness, swelling, itching, etc., or penetrate the body through the skin, endangering the health of the whole body.
In summary, 1-bromo-3-fluoro-4-nitrobenzene is potentially harmful to the environment and human health. During its production, use and disposal, it should be treated with caution and effective protective and control measures should be taken to reduce its adverse effects on the environment and human body.