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What are the main uses of 1-Bromo-3-Fluoro-4-Iodobenzene?
1-Bromo-3-fluoro-4-iodobenzene is also an organic compound. It has a wide range of uses and is often used as a key intermediate in the field of organic synthesis.
First, when creating new drugs, this compound can participate in the construction of the core structure of drug molecules. Due to the unique properties of bromine, fluorine, iodine and other halogen atoms, it can significantly change the physical, chemical and biological activities of compounds. Through organic reactions, 1-bromo-3-fluoro-4-iodobenzene can be combined with other reagents, and then compounds with specific pharmacological activities can be derived, laying the foundation for the development of new drugs.
Second, in the field of materials science, it also has important applications. It can be integrated into the structure of polymer materials through specific reactions, giving the materials unique properties such as good solubility, thermal stability, and electrical properties. For example, when preparing materials with special photoelectric properties, 1-bromo-3-fluoro-4-iodobenzene can become a key starting material for building functional structural units, helping to prepare high-performance materials suitable for organic Light Emitting Diodes, solar cells, and other devices.
Furthermore, in the field of fine chemicals, it can be used to synthesize special fragrances, dyes, and other fine chemicals. With the reactivity of halogen atoms, it can precisely introduce the required functional groups through a series of chemical transformations, and achieve fine regulation of product structure and properties to meet the special needs of fine chemicals in different industries.
In summary, although 1-bromo-3-fluoro-4-iodobenzene is a small organic molecule, it plays an indispensable role in many important fields such as organic synthesis, drug research and development, materials science and fine chemicals, and is of great significance to promote technological progress and industrial development in related fields.
What are the physical properties of 1-Bromo-3-Fluoro-4-Iodobenzene?
1-Bromo-3-fluoro-4-iodobenzene is one of the organic halogenated aromatic hydrocarbons. Looking at its physical properties, it is mostly liquid or solid under normal conditions, and the color state is often colorless to light yellow. Due to the existence of halogen atoms such as bromine, fluorine, and iodine in the molecule, the distribution of electron clouds is different, and the absorption and reflection of light are also different.
Its melting boiling point is relatively high due to the influence of halogen atoms. Due to the high electronegativity of halogen atoms, the intermolecular force is enhanced, especially iodine atoms, which have a large atomic weight and a large van der Waals force. In general, the melting point range is between -10 ° C and 50 ° C, and the boiling point is between 200 ° C and 300 ° C, but the exact value varies depending on the purity and test conditions.
1-Bromo-3-fluoro-4-iodobenzene has a density greater than that of water, about 2.0-2.5 g/cm ³. The weight of the halogen atom increases the weight of the molecule and increases the density. Its solubility is difficult to dissolve in polar solvents such as water. Due to the weak polarity of the molecule, the force between the molecule and the water molecule is small. However, it is easily soluble in most organic solvents, such as ether, dichloromethane, chloroform, etc. Due to the "similar miscibility", the organic solvent is compatible with the intermolecular force of the compound.
In addition, 1-bromo-3-fluoro-4-iodobenzene has a certain volatility. Although the volatility caused by halogen atoms is weakened, some molecules will still escape to the gas phase with the increase of temperature, causing it to have an odor, odor or pungent, with a certain degree of irritation. Use with caution and operate with good ventilation.
What is the chemical synthesis method of 1-Bromo-3-Fluoro-4-Iodobenzene?
To prepare 1-bromo-3-fluoro-4-iodobenzene, the following method can be followed.
First take benzene as the starting material, and introduce the acetyl group by acylation reaction. This can be obtained by means of acid halide or anhydride, catalyzed by Lewis acid such as anhydrous aluminum trichloride. After obtaining acetylbenzene, the nitro group is introduced into the intermediate position of the acetyl group through nitrification reaction. This step requires a mixed acid of nitric acid and sulfuric acid. Because the acetyl group is an intermediate position group, the nitro group is mostly included in the intermediate position.
The obtained m-nitroacetylbenzene is reduced to an amino group by iron powder and hydrochloric acid or catalytic hydrogenation to form m-aminoacetylbenzene. Then, sodium nitrite and hydrochloric acid are used at low temperature to transform the amino group into a diazonium salt, that is, m-diazoacetylbenzene salt. Next, fluoroboronic acid is added to obtain the precipitation of m-fluoroborondiazoacetylbenzene, which is decomposed by heating to obtain m-fluoroacetylbenzene.
m-fluoroacetylbenzene is oxidized in a basic potassium permanganate solution to convert the acetyl group into a carboxyl group to obtain m-fluorobenzoic acid. Then, in a system of cuprous bromide and hydrobromic acid, the carboxyl group is exchanged for a bromine atom under heating to obtain m-bromofluorobenzene.
M-bromofluorobenzene reacts with iodine in the presence of appropriate oxidants such as nitric acid or periodic acid, and iodine atomic energy is selectively introduced into the ortho-position of the bromine atom to obtain 1-bromo-3-fluoro-4-iodobenzene. The whole process requires attention to the control of reaction conditions at each step, such as temperature, reagent dosage and reaction time, in order to achieve higher yield and purity.
What are the precautions in storage and transportation of 1-Bromo-3-Fluoro-4-Iodobenzene?
1-Bromo-3-fluoro-4-iodobenzene is also an organic compound. During storage and transportation, many matters must not be ignored.
First word storage. This material should be placed in a cool, dry and well-ventilated place. Because of the cool environment, it can reduce the risk of chemical properties changing due to excessive temperature. If it is exposed to high temperature, it may cause reactions such as decomposition and polymerization, which will damage its quality. A dry place is also critical to cover its contact with water, or cause adverse reactions such as hydrolysis, resulting in impure ingredients. Good ventilation can avoid the accumulation of its volatile gases and avoid potential safety hazards. And it must be kept away from fire and heat sources to prevent fire and explosion. These are all important rules for safeguarding its chemical stability and safety.
Then transport. When handling, be sure to handle it with care and do not damage the container. Because it is fragile, if the container breaks, the compound will leak, or cause environmental pollution, and pose a threat to personnel safety. The transportation vehicle is also selected as suitable, with anti-leakage, fire prevention and other facilities. And during transportation, environmental factors such as temperature and humidity should be closely monitored to ensure its stability. If you pass through densely populated areas, you need to be more careful to avoid accidents.
In conclusion, the storage and transportation of 1-bromo-3-fluoro-4-iodobenzene is related to safety and quality, and all details need to be carefully handled to ensure safety.
What is the market price of 1-Bromo-3-Fluoro-4-Iodobenzene?
1-Bromo-3-fluoro-4-iodobenzene is also an organic compound. It is difficult to determine the price of its market. This price varies due to many reasons, such as the trend of supply and demand, the cost of production, the purity of the product, and the differences in the area and time of sale.
Looking at the market of chemical raw materials, generally speaking, if the demand for this product is wide and the supply is thin, the price will be high; if the supply is abundant and the demand is small, the price may drop. And the cost of making this product is also greatly related to the price. The price of its raw materials, the method of making it, and the amount of energy consumption are all factors of cost. If the method of preparation is simple and the raw materials are easy to obtain and the consumption is small, the cost will decrease, and the price will also decrease; otherwise, the price will increase.
In addition, the purity of the product has a huge impact on the price. The higher the purity, the more difficult it is to make, and the more expensive the price will often be. For example, high-purity 1-bromo-3-fluoro-4-iodobenzene is used in fine chemical industry, pharmaceutical research and development, etc., and its price must be higher than that of ordinary purity.
As for the area of sale, it is also related. Where transportation is convenient and industry is concentrated, the supply and transportation are smooth, and the price may be easy; in remote places, it is difficult to lose, and the price may The change of seasons sometimes causes the price to change, but it is often not the main reason for such chemicals.
To know its exact price, you should carefully study the market of chemical raw materials, consult suppliers, traders, or watch professional market newspapers, and get a close price.