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1-Bromo-3-Fluoro-2-Iodobenzene

1-Bromo-3-Fluoro-2-Iodobenzene

Hongda Chemical

Specifications

HS Code

651935

Chemical Formula C6H3BrFI
Appearance Solid (Typical organic solid)
Boiling Point Estimated around 220 - 240 °C (under appropriate pressure conditions)
Density Estimated based on similar aromatic halides, around 2.3 - 2.5 g/cm³
Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform, ethyl acetate
Solubility In Water Insoluble
Flash Point Estimated to be relatively high due to high molecular weight and non - volatile nature, >100 °C
Vapor Pressure Low, due to its solid state and high molecular weight

As an accredited 1-Bromo-3-Fluoro-2-Iodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100 g of 1 - bromo - 3 - fluoro - 2 - iodobenzene packaged in a sealed glass bottle.
Storage 1 - Bromo - 3 - fluoro - 2 - iodobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition sources. It should be kept in a tightly - sealed container, preferably made of glass or a suitable plastic that is resistant to chemical reactions. Avoid storing it near oxidizing agents. Proper labeling is crucial to ensure easy identification and safe handling.
Shipping 1 - Bromo - 3 - fluoro - 2 - iodobenzene, a chemical, is shipped in well - sealed, corrosion - resistant containers. Packaging adheres to safety regulations. Shipment is via approved carriers, ensuring proper handling to prevent spills and maintain product integrity.
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1-Bromo-3-Fluoro-2-Iodobenzene 1-Bromo-3-Fluoro-2-Iodobenzene
General Information
Historical Development
Wenfu 1 - Bromo - 3 - Fluoro - 2 - Iodobenzene originated from the research of various sages. In the past, the workers in the field of chemistry exhausted their wisdom to explore the properties of substances and seek synthesis methods.
At the beginning, only a little bit of research on halogenated aromatics was known. However, the public continued to explore and clarify various reaction mechanisms. After years of experiments, the way to prepare 1 - Bromo - 3 - Fluoro - 2 - Iodobenzene was finally obtained.
The initial method was complicated and inefficient, and the yield was meager. However, the heart of a scholar is perseverance. After countless improvements, the reaction conditions are optimized, the reagents are replaced, and the temperature and pressure are adjusted. Gradually, the synthesis method is better, and the yield is also improved.
Looking at its development path, it is like sailing against the current. If you don't advance, you will retreat. The sages forge ahead in the predicament, with wisdom and perseverance, to expand the territory of material research, paving the way for future chemical applications.
Product Overview
1 - Bromo - 3 - Fluoro - 2 - Iodobenzene is also an organic compound. It is a colorless to pale yellow liquid with unique chemical properties. The preparation of this compound often requires fine chemical steps. In the reaction system, a specific halogenating agent interacts with benzene derivatives, and the reaction conditions, such as temperature, pressure, and catalyst dosage, can be obtained through multiple adjustments.
It has a wide range of uses. In the field of drug synthesis, it is often a key intermediary, helping to create new drug molecules to deal with various diseases. In the field of materials science, it can participate in the construction of materials with special properties, such as materials with specific optical and electrical properties. Due to the unique arrangement of bromine, fluorine and iodine atoms in its molecular structure, which endows it with unique reactivity and physical characteristics, it has attracted the attention of chemical research and industrial production, and the prospect is promising.
Physical & Chemical Properties
1 - Bromo - 3 - Fluoro - 2 - Iodobenzene is also an organic compound. It has unique physical and chemical properties. Looking at its physical properties, at room temperature, it is a colorless to light yellow liquid with a special odor. Its boiling point is quite high, which is caused by intermolecular forces. As for chemical properties, due to the presence of halogen atoms such as bromine, fluorine, and iodine, the chemical activity is significant. Bromine atoms are more active and prone to substitution reactions. Under appropriate conditions, they can be replaced by other functional groups. The presence of fluorine atoms enhances the stability of molecules because of their strong electronegativity. Although iodine atoms are relatively inactive, they can also exhibit unique chemical behaviors in specific reactions. This compound has a wide range of uses in the field of organic synthesis and is often a key raw material for the preparation of complex organic molecules. With its unique physical and chemical properties, it has contributed a lot to the development of organic synthetic chemistry.
Technical Specifications & Labeling
Today there is a product called 1 - Bromo - 3 - Fluoro - 2 - Iodobenzene. In the preparation of the technique, it is necessary to strictly abide by the process specifications and labels. The process specifications, the ratio of materials, the reaction temperature and time, all need to be precisely controlled. If the materials are mixed, they should be orderly and not disordered. When reacting, the temperature should be constant in a certain range, and the duration should not be different, otherwise the product is impure.
As for the label, the label of the product must specify the ingredients, characteristics, hazards and other parameters. Warning words, eye-catching and clear, to prevent misuse. All of these are essential to ensure product quality and safety. Those who are employed must observe and abide by them in order to become a good product, and those who are guaranteed will be safe.
Preparation Method
The raw materials, production process, reaction steps and catalytic mechanism of 1-Bromo-3-Fluoro-2-Iodobenzene are very important. First, an appropriate amount of fluorobenzene is taken as the starting material, mixed with brominating reagents in a specific ratio in a low temperature environment, and the reaction conditions are finely adjusted to make it brominate to obtain bromofluorobenzene-containing intermediates.
Then, this intermediate is co-placed with the iodine-substituted reagent in a specific solvent, and a suitable catalyst is added to control the reaction temperature and duration, so that the iodine atom precisely replaces the target hydrogen atom. After the reaction is completed, the impurities are removed by multi-step separation and purification operations, such as extraction, distillation, recrystallization, etc., to obtain high purity 1-Bromo-3-Fluoro-2-Iodobenzene. Each step needs to be strictly controlled to ensure product quality and yield.
Chemical Reactions & Modifications
1 - Bromo - 3 - Fluoro - 2 - Iodobenzene is an organic compound that has attracted much attention in chemical research. Its chemical reactions and modifications are related to the change of chemical properties and the creation of new substances.
In past studies, chemists have tried to explore the various reactions involved in this compound. For example, nucleophilic substitution reactions, the activity differences of halogen atoms cause their reactivity to be different. Bromine and iodine atoms are relatively easier to leave and can be replaced by nucleophiles, so different functional groups can be introduced to expand the structural diversity of molecules.
However, this reaction also has limitations, and the reaction conditions are often harsh, such as specific solvents, temperatures and catalysts. And the difference in the activity of different halogen atoms also brings the problem of selective control, which is prone to side reactions.
In order to improve this situation, chemists have devised various strategies. Develop highly selective catalysts to make the reaction precisely occur at specific halogen atoms, reducing side reactions. Optimize the reaction conditions and find milder temperature, pressure and solvent combinations to improve the reaction efficiency and economy. This is all the efforts of chemical researchers to optimize the chemical reaction and modification of 1-Bromo-3-Fluoro-2-Iodobenzene.
Synonyms & Product Names
In the field of chemistry, see 1 - Bromo - 3 - Fluoro - 2 - Iodobenzene. Although the name of this substance is a modern chemical term, it is also synonymous with the name of the product.
In the field of chemistry, there are many people who have the same thing but different names. 1 - Bromo - 3 - Fluoro - 2 - Iodobenzene, or have another name to express its properties. Among this substance, bromine, fluorine, and iodine are connected to the benzene ring and have unique characteristics. Or because of their different structures, production methods, and uses, they have synonymous names.
As for the name of a commodity, merchants give it a unique name in recognition of its superiority. This 1 - Bromo - 3 - Fluoro - 2 - Iodobenzene is sold under a special name in the chemical industry, or as a rare product of a certain factory. Its name either expresses its purity or shows its use, hoping to stand out in the market.
Our generation's study of the synonyms and trade names of this thing is beneficial to the knowledge of chemistry and the identification of things in the market. It can be said that there are many substances, and it can also know the wonders of market sales.
Safety & Operational Standards
1 - Bromo - 3 - Fluoro - 2 - Iodobenzene, chemical substances are also. In the field of experiment, safety and operation standards are of paramount importance.
If you want to make this substance, you must first understand its properties. It has the quality of halogenated aromatics and has strong chemical activity. During operation, the first priority is safety protection. Experimenter in front of complete protective equipment, such as protective clothing, gloves and goggles, to avoid contact with the body, skin and eyes. Because of its possible irritation and corrosion, if you accidentally touch it, rinse it with plenty of water and seek medical treatment.
In the operating space, be sure to ventilate well. A fume hood can be set up to allow the harmful gas to be discharged quickly, so as to avoid the danger of poisoning of the experimenter caused by its accumulation. In addition, the use of this agent should be based on the exact amount. Take it with a dropper, a pipette, etc., no more or less, in order to ensure accurate reaction.
When reacting, the temperature and time must also be strictly controlled. Different reaction conditions, the product may be different, and it is related to safety. If the temperature is too high, it may cause the reaction to go out of control and cause danger. Therefore, it is necessary to measure it in real time with a thermometer and adjust it accurately with a heating device.
Store this material in a cool, dry and ventilated place. Keep away from fire and heat sources to prevent explosion. Store in a suitable container and seal tightly to prevent volatilization and leakage.
In short, the safety and operating practices of 1-Bromo-3-Fluoro-2-Iodobenzene are essential to the safety of the experimenter and endanger the success of the experiment. It should not be ignored.
Application Area
1 - Bromo - 3 - Fluoro - 2 - Iodobenzene is a unique chemical substance. Its application field is quite wide. In the field of medicinal chemistry, it can be used as a key intermediate to help synthesize compounds with specific pharmacological activities, or to develop drugs for specific diseases. In the field of materials science, due to its own structural characteristics, it may be able to participate in the preparation of new organic optoelectronic materials and contribute to the improvement of material properties. Or in organic synthetic chemistry, with its halogen atom properties, it provides a key node for the construction of complex organic molecules, helps chemists explore novel synthetic paths and strategies, and promotes the progress of organic synthetic chemistry. It is of great value to the development of many scientific fields.
Research & Development
Modern chemistry has been refined, and it has been unremitting in the study of various compounds. Today there is 1-Bromo-3-Fluoro-2-Iodobenzene, which scholars are very interested in.
We have studied its properties in detail and studied its synthesis method. At first, benzene was used as a base, supplemented by various halogenated agents, and this compound was obtained through multiple reactions. During the experiment, the temperature, pressure, and the ratio of reagents are all related to success or failure.
Its unique properties make it a key material for organic synthesis. It can be used as an intermediate to introduce functional groups to produce a variety of derivatives.
Although there are gains today, the road ahead is still far away. If you want to use it widely, you must study its principles and improve your synthesis techniques to ensure higher yield and better purity. Hope that in the future, this compound will shine in the fields of medicine and materials, and be used by the world. This is the wish of our researchers.
Toxicity Research
The toxicity of 1 - Bromo - 3 - Fluoro - 2 - Iodobenzene is investigated. This compound contains bromine, fluorine and iodine elements, and its molecular structure is unique or has special chemical activity.
Considering the experiments, when it comes into contact with biological tissues, or triggers complex biochemical reactions. Its halogen atoms or bond with intracellular molecules, interfering with normal physiological functions.
In vitro cell experiments, it can cause cell morphological changes and inhibit proliferation. And the concentration increases, and the toxic effect becomes more obvious.
Looking at animal experiments, ingestion of this compound can involve multiple organs. Liver or metabolic disorders, kidney or damage, affecting excretion function.
In summary, 1 - Bromo - 3 - Fluoro - 2 - Iodobenzene is significantly toxic, and care should be taken during production and use to prevent it from harming organisms and the environment.
Future Prospects
I have tried to research 1 - Bromo - 3 - Fluoro - 2 - Iodobenzene, which is unique in nature and has a wide range of uses. Looking at the world today, science and technology are improving day by day, and I expect this product to be a great success in the future.
In the field of medicine, it may be able to assist in the research of special new drugs and cure all kinds of diseases. Its delicate structure may be able to accurately act on lesions and reduce the suffering of patients. In materials science, it may be the cornerstone of creating new materials, making materials have extraordinary properties and be used in aerospace, electronics and other industries.
Our scientific researchers should study diligently to explore its more potential. Although the road ahead may be difficult, they are determined to look forward to the future. It is hoped that with the efforts of our generation, 1 - Bromo - 3 - Fluoro - 2 - Iodobenzene will shine in the future, for the well-being of the world, for the advancement of science and technology, and for the prosperity of society.
Where to Buy 1-Bromo-3-Fluoro-2-Iodobenzene in China?
As a trusted 1-Bromo-3-Fluoro-2-Iodobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 1-Bromo-3-Fluoro-2-Iodobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

1 - Bromo - 3 - Fluoro - 2 - What is the main use of Iodobenzene
1 + -Bromo-3-fluoro-2-iodobenzene is also an organic compound. It has a wide range of uses and plays an important role in the field of organic synthesis.
It is first used in the creation of medicine. Chemists borrow 1 + -bromo-3-fluoro-2-iodobenzene as a raw material and can make special drugs through complex reactions. The cover has a unique structure, which can introduce specific functional groups, make the drug targeted, accurately act on the focus, improve the curative effect, and reduce the side effects.
Furthermore, it is also indispensable in materials science. With this compound as a starting material, special functional materials can be synthesized, such as photoelectric materials. After ingenious design and reaction, the material can be given excellent photoelectric properties, which can be used in Light Emitting Diode, solar cells and other devices to promote the progress of energy and display technology.
In the field of pesticide research and development, 1 + -bromo-3-fluoro-2-iodobenzene also contributes. Based on it, high-efficiency and low-toxicity pesticides can be prepared. With its structural characteristics, pesticides can precisely act on pests, reducing environmental harm while ensuring crop yield and quality, and meeting the needs of today's green agriculture development.
In conclusion, 1 + -bromo-3-fluoro-2-iodobenzene has important uses in many fields such as medicine, materials, and pesticides due to its unique structure, promoting the development and progress of related industries.
What are the physical properties of 1 - Bromo - 3 - Fluoro - 2 - Iodobenzene
1-Bromo-3-fluoro-2-iodobenzene is also an organic compound. Its physical properties are particularly important, which is related to the use and characteristics of this compound.
First of all, under normal temperature and pressure, 1-bromo-3-fluoro-2-iodobenzene is often in a liquid state, and the view is clear and transparent. This is due to the attractive force and arrangement between molecules.
As for the boiling point, it is about a specific temperature range. The presence of bromine, fluorine and iodine atoms in the cover molecule increases the intermolecular force, resulting in a higher boiling point. Bromine atoms have a large atomic radius and an electron cloud. Fluorine and iodine also have their own characteristics. The synergy of the three makes the intermolecular attractive force strong. To vaporize it, more energy is required, so the boiling point rises.
Melting point is also an important physical property. Due to the regularity of molecular structure and the interaction between atoms, 1-bromo-3-fluoro-2-iodobenzene has a specific melting point. The arrangement of atoms in the molecule affects the lattice energy, which is also related to the melting point. The specific structure of the molecule of this compound determines its melting point.
In terms of solubility, 1-bromo-3-fluoro-2-iodobenzene has good solubility in organic solvents, such as common ether, chloroform, etc. Because it is an organic molecule, it has certain non-polarity. According to the principle of "similar phase solubility", it can be well miscible with organic solvents. However, the solubility in water is not good. Water is a polar molecule, and the force between it and 1-bromo-3-fluoro-2-iodobenzene is weak, so it is difficult to dissolve.
Density is also one of its physical properties. The density of 1-bromo-3-fluoro-2-iodobenzene is higher than that of water due to the relatively large atomic masses of bromine, fluorine and iodine atoms. Heavier atoms increase the mass of the substance per unit volume, resulting in higher density.
In summary, the physical properties of 1-bromo-3-fluoro-2-iodobenzene, such as appearance, boiling point, melting point, solubility and density, are determined by its molecular structure and atomic properties, and are of great significance in organic synthesis, chemical research and other fields.
What are the synthesis methods of 1 - Bromo - 3 - Fluoro - 2 - Iodobenzene
The synthesis method of 1 + -bromo-3-fluoro-2-iodobenzene is particularly crucial. One method is to use benzene as the starting material. First, the benzene is brominated. Bromine and a suitable catalyst, such as iron filings, can be used to obtain bromobenzene at an appropriate temperature. This step requires temperature control and does not cause side reactions to multiply.
Then, p-bromobenzene is nitrified and treated with mixed acid (concentrated sulfuric acid and concentrated nitric acid) to obtain a mixture of o-nitrobromobenzene and p-nitrobromobenzene. After separation, such as rectifying or recrystallizing, o-nitrobromobenzene is obtained. Subsequently, the reduction reaction of o-nitrobromobenzene can be used with iron powder and hydrochloric acid, or catalytic hydrogenation, etc., to convert the nitro group into an amino group to obtain o-aminobromobenzene.
After that, it is prepared by diazotization reaction. Sodium nitrite and hydrochloric acid are used at low temperature (0-5 ° C) to change the amino group into a diazonium salt. Then fluoroboronic acid is added to obtain the diazonium salt of fluoroboronic acid, which is decomposed by heating, and then fluorine atoms are introduced to obtain 1-bromo-3-fluorobenzene.
At the end, the iodization reaction of 1-bromo-3-fluor 1 + -Bromo-3-fluoro-2-iodobenzene can be obtained by reacting iodine with a suitable oxidant, such as hydrogen peroxide, in a suitable solvent.
Another method, or from other benzene-containing cyclic compounds. If m-fluoroaniline is used as the starting material, the target molecular structure can also be gradually constructed through a series of reactions such as diazotization and halogenation. During each step of the reaction, the reaction conditions, such as temperature, reagent ratio, reaction time, etc., need to be carefully regulated to achieve the purpose of high-efficiency and high-selectivity synthesis of 1 + -bromo-3-fluoro-2-iodobenzene.
1 - Bromo - 3 - Fluoro - 2 - Iodobenzene What to watch out for when storing and shipping
1 + -Bromo-3 + -fluoro-2 + -iodobenzene is an organic compound. When storing and transporting, many key points should be paid attention to in order to ensure safety and quality.
Let's talk about storage first. First, because of its many chemical activities, it should be placed in a cool, dry and well-ventilated place. If this compound is heated or causes a chemical reaction, it will deteriorate, and even pose a safety hazard. Humid environment may also cause reactions such as hydrolysis, so a dry environment is necessary. Second, it needs to be stored separately from oxidants, reducing agents, strong bases, strong acids, etc. This compound may react violently with the above substances, such as oxidizing agents or oxidizing them, strong acids and strong bases or promoting their substitution and elimination. Third, choose the appropriate material for the storage container, generally use glass bottles or specific plastic bottles. Glass bottles have good chemical stability, but if the compound is corrosive to the glass, you need to choose a special material plastic bottle, and the container must be well sealed to prevent it from evaporating or reacting with air components. Fourth, it should be clearly marked, indicating the name of the compound, molecular formula, danger and other information for access and management, and the warehouse should have emergency treatment equipment and plans, such as fire extinguishing equipment, eye washers, etc.
Let's talk about transportation. First, make sure that the packaging is in good condition before transportation, and choose suitable packaging materials according to their characteristics. For example, use shockproof and leak-proof packaging to prevent packaging damage due to bumps and collisions during transportation. Second, the means of transportation should be clean and dry, without residual substances that may react with the compound, and temperature and humidity should be controlled to avoid high temperature and high humidity environments. Third, transportation personnel should be professionally trained to be familiar with the characteristics of the compound and emergency treatment methods, and always check whether the packaging is in good condition during transportation. Fourth, transportation should follow relevant regulations and standards, and handle necessary transportation licenses and procedures to ensure legal compliance with transportation.
In this way, when storing and transporting 1 + -bromo-3 + -fluoro-2 + -iodobenzene, strict compliance with the above points can effectively avoid risks and ensure its quality and transportation and storage safety.
1 - Bromo - 3 - Fluoro - 2 - What effect does Iodobenzene have on the environment and the human body?
1 + -Bromo-3 + -fluoro-2 + -iodobenzene is also an organic compound. Its impact on the environment and the human body cannot be ignored.
In terms of the environment, such halogenated aromatics may be relatively stable in nature and difficult to degrade naturally. If released in the environment, or retained in soil or water for a long time. It is in the soil, or affects the soil, hindering the uptake of nutrients and moisture by plant roots, causing plant growth to be trapped and even withered. In water bodies, or ingested by aquatic organisms, accumulated and amplified through the food chain. If small fish accidentally eat plankton containing this compound, large fish eat small fish, the concentration gradually rises, endangering the aquatic ecological balance.
As for the human body, 1 + -bromo-3 + -fluoro-2 + -iodobenzene may be ingested into the human body through breathing, skin contact, or diet. It enters the body through the respiratory tract, or irritates the mucosa of the respiratory tract, causing cough, asthma, etc. Through skin contact, it may cause allergies and inflammation. If ingested by mistake, it may cause adverse reactions in the digestive system, such as nausea, vomiting, and abdominal pain. And this compound may have potential carcinogenic, teratogenic, and mutagenic risks. Long-term exposure to this environment may damage the genetic material of human cells, increasing the risk of cancer; exposure to pregnant women may affect the normal development of the fetus and cause deformities.
In summary, 1 + -bromo-3 + -fluoro-2 + -iodobenzene has potential harm to the environment and human beings. It should be treated with caution to prevent its release into the environment and reduce human contact with the substance, so as to ensure ecological and personal safety.