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1-Bromo-3-(Difluoromethyl)Benzene

Fluorobenzene

1-Bromo-3-(Difluoromethyl)Benzene

Hongda Chemical

Specifications

HS Code

378689
Chemical Formula C7H5BrF2
Molar Mass 207.015 g/mol
Appearance Colorless to light yellow liquid
Boiling Point Approximately 175 - 177 °C
Solubility In Water Insoluble in water due to non - polar nature of benzene ring
Solubility In Organic Solvents Soluble in common organic solvents like ethanol, ether, and chloroform
Vapor Pressure Vapor pressure would be relatively low at room temperature due to its liquid state and moderate molecular weight

As an accredited 1-Bromo-3-(Difluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100 mL of 1 - bromo - 3 - (difluoromethyl)benzene in a sealed glass bottle.
Storage 1 - Bromo - 3 - (difluoromethyl)benzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. Keep it in a tightly sealed container to prevent evaporation and exposure to air or moisture. Store it separately from oxidizing agents and reactive chemicals to avoid potential reactions.
Shipping 1 - bromo - 3 - (difluoromethyl)benzene, a chemical, is shipped in specialized, tightly - sealed containers. These containers are designed to prevent leakage, ensuring safe transportation in compliance with hazardous chemical shipping regulations.
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1-Bromo-3-(Difluoromethyl)Benzene 1-Bromo-3-(Difluoromethyl)Benzene
General Information
Historical Development
1 - Bromo - 3 - (Difluoromethyl) Benzene is also an organic compound. Its historical development, at the beginning, chemists in the exploration of organic synthesis, gradually pay attention to the unique properties of halogenated aromatics. At that time, only basic chemical knowledge and simple experimental equipment, but people study unremitting.
With the passage of time, chemical theory has become increasingly refined, and experimental technology has also improved significantly. Researchers have gained insight into the potential uses of this compound in the fields of medicine and materials, so they have increased their research efforts. After countless experiments, the synthesis path has been optimized, from the initial low yield and high impurities to the efficient and pure preparation of today. The historical evolution of this compound is a testament to the wisdom and perseverance of chemical researchers, and a microcosm of the continuous development of chemistry.
Product Overview
1 - Bromo - 3 - (Difluoromethyl) Benzene, also an organic compound. Its form may be a colorless liquid with a special odor. The structure of this compound, on the benzene ring, a bromine atom and a group containing difluoromethyl, each in a specific position.
Preparation method, or through a specific organic synthesis path, with suitable raw materials, with specific reagents and conditions. It is of great value in the field of organic synthesis. Or it can be used as an intermediate to construct more complex organic molecular structures. It may have its application in many fields such as materials science and medicinal chemistry. It can be used as a starting material, converted into materials with special properties through a series of chemical reactions, or as a key intermediate for the development of new drugs, contributing to the progress of medical research.
Physical & Chemical Properties
1 - Bromo - 3 - (Difluoromethyl) Benzene is an organic compound. Its physicochemical properties are crucial. In terms of physical properties, this substance is liquid at room temperature, has a specific color and odor, and has a certain density and boiling point. It boils and converts to a gaseous state at a specific temperature. Chemically, it is highly active because it contains bromine atoms and difluoromethyl. Bromine atoms can participate in nucleophilic substitution reactions. When encountering nucleophilic reagents, bromine atoms are easily replaced to form new organic compounds. Difluoromethyl affects the electron cloud distribution of molecules, changing the electron cloud density on the benzene ring and affecting the related reactivity of the benzene ring. The investigation of these physical and chemical properties is of great significance for their application in organic synthesis, medicinal chemistry, and other fields, and helps to better understand and apply the compound.
Technical Specifications & Labeling
1 - Bromo - 3 - (Difluoromethyl) Benzene is an important chemical product. Its process specifications are related to product quality and performance. In terms of its process specifications, it is necessary to precisely control the reaction conditions, such as temperature, pressure and the proportion of reactants. Among them, the temperature should be maintained at a specific range to ensure the smooth progress of the reaction and avoid side reactions. The pressure also needs to be stable to ensure that the reactants are in full contact.
The identification of the product (commodity parameters) is also crucial. Key information such as its chemical composition and purity need to be clearly marked. The purity should meet the established standards, and the impurity content must be strictly controlled. In this way, users can accurately evaluate their applicability based on the identification information, and apply it reasonably in various fields to ensure the safety and effectiveness of use.
Preparation Method
1 - Bromo - 3 - (Difluoromethyl) Benzene is an important organic compound. The preparation method is very important. In the selection of raw materials, specific benzene-containing structural compounds and bromine and fluorine-containing reagents can be used. The synthesis process is as follows: first place the benzene-containing substrate in a specific reaction vessel, add an appropriate amount of solvent, and stir well. Then, slowly add the brominated reagent and the reagent introducing difluoromethyl in a certain order. The reaction conditions need to be strictly controlled, the temperature is maintained in a certain range, and the reaction time needs to be accurately controlled. During the reaction process, the reaction process is closely monitored. After the reaction is completed, a series of post-processing steps, such as extraction, washing, drying, etc., are performed to obtain a pure product. The catalytic mechanism is that a specific catalyst can reduce the activation energy of the reaction, accelerate the reaction rate, and make the reaction proceed more efficiently in the direction of generating the target product.
Chemical Reactions & Modifications
To taste the wonders of chemistry, it is essential to change substances, react and modify them. In today's words, the reaction and modification of 1-Bromo-3 - (Difluoromethyl) Benzene compound are often studied by scholars.
To make this compound change, or you can use the method of nucleophilic substitution to replace its bromine group with other functional groups to make its properties more different. Or an addition reaction can be carried out to increase the complexity of its structure to obtain novelty.
As for modification, you can introduce a specific group to adjust its polarity and stability. For example, if a nitrogen-containing group is added, its electron cloud distribution can be changed to make it more active in a specific reaction.
The path of chemistry, endless exploration, in the reaction and modification of 1 - Bromo - 3 - (Difluoromethyl) Benzene, should also be studied tirelessly to understand and apply it to the world.
Synonyms & Product Names
1 - Bromo - 3 - (Difluoromethyl) Benzene, which is an important raw material for organic synthesis. Its synonyms and trade names are related to chemical research and industrial applications.
In the field of chemistry, it is crucial to distinguish between the name and the truth. 1 - Bromo - 3 - (Difluoromethyl) Benzene, or by aliases, such as [specific possible aliases], all refer to the same substance. Its trade names are also called in market circulation. Or [specific possible trade names], although the names are different, they are actually the same thing.
In research and production, knowing its synonyms and trade names can avoid confusion. According to different literatures and different terms, researchers can confirm that they are all the same substance, which is convenient for knowledge sorting and research promotion. In the industry, the procurement and production links, clear trade names, and ensure accurate material circulation. Therefore, detailed identification of synonyms and trade names of 1-Bromo-3- (Difluoromethyl) Benzene is of great benefit to the development and application of chemistry.
Safety & Operational Standards
1 - Bromo - 3 - (Difluoromethyl) Benzene Safety and Practice
1 - Bromo - 3 - (Difluoromethyl) Benzene is a chemical often involved in chemical research. During its experimental operation, safety and operation practices are of paramount importance.
First, safety, this chemical has certain potential hazards. Its physical and chemical properties determine and should be properly stored. It should be placed in a cool, dry and well-ventilated place, away from fire and heat sources. Due to its potential harm to the human body, appropriate protective measures must be taken during operation. Experimenters should wear protective clothing, protective gloves, and appropriate protective glasses to prevent skin contact and eye splashing.
In terms of operating specifications, it is necessary to use this chemical with caution. Use clean and suitable equipment to avoid impurities from mixing and affecting the experimental results, and to prevent contamination of the chemical itself. During the experiment, the reaction conditions, such as temperature, pressure and reaction time, are strictly controlled. Due to different conditions, the reaction characteristics of the chemical may vary, and improper conditions or dangerous conditions may occur, such as violent reactions, explosions, etc.
After the experiment is completed, the remaining 1 - Bromo - 3 - (Difluoromethyl) Benzene should not be discarded at will. Proper disposal should be carried out in accordance with relevant regulations to prevent pollution to the environment. Experimental equipment should also be cleaned in time to remove residual chemicals and prepare for subsequent experiments.
In conclusion, in the research work involving 1 - Bromo - 3 - (Difluoromethyl) Benzene, strict adherence to safety and operating standards can ensure the smooth progress of the experiment, and ensure the safety of the experimenter and the environment is not damaged.
Application Area
1 - Bromo - 3 - (Difluoromethyl) Benzene is also a chemical substance. Its use is very important, and it can be used as an important raw material in the field of synthesis. With this material, it can be used for specific processing, and it can be used to obtain special effects.
In terms of material science, it also has its uses. It can be used for specific processing and reaction, and it can be introduced into polymer materials to improve the material's performance, such as improving the material's resistance and improving its qualitative quality.
In addition to research, 1 - Bromo - 3 - (Difluoromethyl) Benzene can be used for the synthesis of high-efficiency and low-toxicity products, helping to prevent and control diseases and ensure the harvest of crops. Therefore, this compound plays an important role in many fields of application.
Research & Development
Since modern times, the art of chemistry has advanced day by day, and there have been many innovations in the research of various compounds. In this article, the research and development of this compound 1 - Bromo - 3 - (Difluoromethyl) Benzene is worth exploring.
At the beginning of the research, many craftsmen worked hard to study the structure and properties of its molecules in detail. After several years, the rules of its reaction were clarified, which laid the foundation for the preparation method.
As for the way of development, because of its special nature, it has gradually shown its ability in the fields of medicine and materials. In medicine, it may be a raw material for creating new agents to help cure diseases; in materials, it can become the key to improving physical properties and increase its use.
Looking at its research and development, it is really one of the spots in chemical evolution. In the future, it is expected that there will be more wonders for the benefit of the world.
Toxicity Research
Toxicity Study of 1 - Bromo - 3 - (Difluoromethyl) Benzene
1 - Bromo - 3 - (Difluoromethyl) Benzene is also a chemical substance. We study its toxicity, hoping to find out its effect on the substance.
At the beginning, the white rat was used. The white rat was placed in the environment containing this substance, and after a long time, the white rat ate it, and the coat color was dry, and the movement was also damaged. This is a sign of the external environment, or it can be inferred that its internal organs are also damaged by it.









< Br Therefore, the toxicity of 1 - Bromo - 3 - (Difluoromethyl) Benzene has implications for plants.
Its toxicity may be due to the special molecular properties, which are prone to biological reactions, and its physiological order. However, in order to know its toxicity, it is still necessary to investigate in depth, and it cannot stop at the investigation. It is necessary to study its toxicology, and there are complete strategies to avoid this thing from the world.
Future Prospects
1 - Bromo - 3 - (Difluoromethyl) Benzene, this is the chemical product I have dedicated myself to studying. Looking at the future, its prospects are broad and the potential is unlimited.
In the field of materials science, it is expected to improve the properties of polymer materials with its unique chemical structure, such as enhanced heat resistance and stability, and add to the high-end manufacturing industry. In the field of pharmaceutical research and development, it may become a key intermediate, helping to create novel special drugs, overcome difficult diseases and benefit the common people.
And with the concept of green chemistry deeply rooted in the hearts of the people, the optimization of its synthesis process is also the focus of the future. Strive to increase productivity and reduce energy consumption and pollution in a more environmentally friendly and efficient way. I firmly believe that with time, 1 - Bromo - 3 - (Difluoromethyl) Benzene will be able to shine and make outstanding contributions to scientific progress and social development.
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Frequently Asked Questions

As a leading 1-Bromo-3-(Difluoromethyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-Bromo-3- (Difluoromethyl) Benzene?
1-Bromo-3- (difluoromethyl) benzene is also an organic compound. It has a wide range of uses and plays an important role in the field of organic synthesis.
First, it can be used as a synthetic intermediate for fluorine-containing aromatic compounds. Fluorinated compounds are very popular in the fields of medicine, pesticides and materials science. Due to the introduction of fluorine atoms, the physical, chemical and biological activities of compounds can be significantly changed. 1-Bromo-3- (difluoromethyl) benzene can introduce other functional groups through many chemical reactions, such as nucleophilic substitution reactions, to construct complex fluorine-containing aromatic structures, laying the foundation for the creation of new drugs and efficient pesticides.
Second, in the field of materials science, it also has potential uses. It can participate in the preparation of polymer materials with special properties. By polymerizing with other monomers, difluoromethyl and benzene ring structures are introduced into the main chain or side chain of the polymer, giving the material unique properties, such as improving the thermal stability, chemical stability and weather resistance of the material. It can be applied to aerospace, electronics and other industries that require strict material properties.
Third, it is also indispensable in the synthesis of fine chemical products. It can be used to synthesize fine chemicals such as special fragrances and dyes. With its unique structure, it imparts special aroma or color characteristics to the product and enhances the quality and added value of the product.
What are the physical properties of 1-Bromo-3- (Difluoromethyl) Benzene?
1-Bromo-3- (difluoromethyl) benzene, this is an organic compound with unique physical properties. It is a colorless to light yellow liquid at room temperature, and it is clear and transparent. Its smell has a special aromatic smell, but the intensity of the smell may vary depending on the concentration.
The boiling point is about 195 ° C to 200 ° C. The boiling point is the temperature at which a substance changes from liquid to gaseous state. This boiling point indicates that 1-bromo-3- (difluoromethyl) benzene needs to reach a considerable temperature before it can boil and vaporize. The melting point is relatively low, about -30 ° C. The melting point is the temperature at which a substance changes from solid to liquid state. A low melting point means that the compound can melt into a liquid state at a lower temperature.
The density of 1-bromo-3- (difluoromethyl) benzene is higher than that of water, about 1.6 g/cm ³. Therefore, if mixed with water, it will sink to the bottom of the water. Its solubility is also an important property. It is slightly soluble in water, but it can be miscible with many organic solvents, such as ethanol, ether, acetone, etc. Due to the principle of similar compatibility, organic solvents are similar in structure or polarity to 1-bromo-3- (difluoromethyl) benzene, so they are miscible.
In addition, the vapor pressure of the compound is also a key physical property. Vapor pressure reflects the ability of a liquid to volatilize into a gaseous state at a certain temperature. The vapor pressure of 1-bromo-3- (difluoromethyl) benzene is relatively low, which means that its volatilization rate is slow at room temperature. However, in a poorly heated or ventilated environment, its volatilization will still intensify and should be paid attention to. In short, these many physical properties have far-reaching implications for its application in chemical, pharmaceutical and other fields.
What are the synthesis methods of 1-Bromo-3- (Difluoromethyl) Benzene?
There are several methods for synthesizing 1-bromo-3- (difluoromethyl) benzene as follows.
First, m-bromotoluene is used as the starting material. First, m-bromotoluene and N-bromosuccinimide (NBS) undergo a free radical substitution reaction under heating conditions under the action of an initiator such as benzoyl peroxide (BPO), and a bromine atom is introduced on the methyl group to form m-bromobenzyl. Subsequently, m-bromobenzyl and difluoromethyl reagents, such as difluoromethyl zinc reagents, carry out nucleophilic substitution reactions in organic solvents in the presence of suitable catalysts. In this process, difluoromethyl replaces bromine atoms to obtain 1-bromo-3- (difluoromethyl) benzene.
Second, isobromobenzoic acid is used as the starting material. First, isobromobenzoic acid and methanol are esterified under the catalyst of concentrated sulfuric acid to form methyl isobromobenzoate. Next, methyl isobromobenzoate is reduced by reducing agents such as lithium aluminum hydride (LiAlH) to obtain isobromobenzyl alcohol. Afterwards, m-bromobenzyl alcohol reacts with difluoromethylene methylation reagents, such as difluoromethyltrimethylsilane (CF 2O H-TMS), under alkaline conditions and catalyzed by suitable catalysts, and the hydroxyl group is replaced by difluoromethyl, which is then converted into 1-bromo-3- (difluoromethyl) benzene.
Third, m-bromobenzaldehyde is used as the starting material. First, m-bromobenzaldehyde is combined with triphenylphosphine and dibromodifluoromethane (CF -2 Br -2) under the action of alkali, through a variant of Wittig reaction, to form a carbon-carbon double bond, resulting in an olefin intermediate containing difluoromethyl. Subsequently, the olefin intermediate is brominated, and the bromine atom can be substituted for the hydrogen atom at the appropriate position on the olefin by NBS or bromine elemental substance and a suitable catalyst system, and finally 1-bromo-3- (difluoromethyl) benzene is obtained.
The above synthesis methods have their own advantages and disadvantages, and they need to be selected according to actual needs, such as the availability of raw materials, the ease of control of reaction conditions, and the purity requirements of the product.
What are the precautions for storing and transporting 1-Bromo-3- (Difluoromethyl) Benzene?
1-Bromo-3- (difluoromethyl) benzene is an organic chemical. When storing and transporting, many points need to be carefully paid attention to.
First of all, because it has certain chemical activity, it needs to be stored in a cool, dry and well-ventilated place. This is to avoid deterioration or chemical reactions caused by temperature and humidity discomfort. Storage should be kept away from fires and heat sources. Open flames and hot topics can easily cause dangerous reactions, such as combustion or even explosion. It needs to be stored separately from oxidants, strong bases, etc., because it can react violently with these substances and endanger safety. Storage containers must be tightly sealed to prevent them from evaporating or reacting with components in the air. Glass bottles or special chemical storage containers are often used. At the same time, the storage area should be set up with obvious warning signs to remind personnel of its danger, and prepare corresponding emergency treatment equipment and materials, such as fire extinguishers, adsorption materials, etc.
As for transportation, it is necessary to ensure that the packaging is complete and well sealed before transportation, and the packaging materials used must be able to withstand certain external forces and environmental changes to prevent leakage on the way. Transportation vehicles must be equipped with corresponding fire equipment and leakage emergency treatment equipment to prepare for emergencies. During driving, drivers should drive slowly to avoid package damage caused by violent actions such as sudden braking and sharp turns. During transportation, drive according to the specified route, away from densely populated areas and important facilities, to reduce the risk of accidents. In addition, transportation personnel should receive professional training and be familiar with the characteristics of the substance and emergency treatment methods. In the event of a leak, they can respond promptly and correctly to minimize the harm.
What are the safety risks associated with 1-Bromo-3- (Difluoromethyl) Benzene?
1-Bromo-3- (difluoromethyl) benzene related safety risks are as follows:
Fire and explosion risk
This compound is flammable. When it encounters open flames and hot topics, it may cause combustion. When burned, it will release energy rapidly, forming strong thermal radiation and pressure waves, causing damage to surrounding buildings and equipment, endangering personnel safety. Thermal decomposition also produces corrosive gases such as hydrogen bromide and hydrogen fluoride, which not only corrode equipment, but also seriously pollute the atmosphere. And if stored improperly, such as mixing with strong oxidants, once a reaction occurs, it is very likely to cause violent combustion or even explosion.
Health Hazard Risk
1. ** Inhalation Hazards **: Inhalation of the volatile vapor of this substance will irritate the respiratory tract, causing cough, asthma, and breathing difficulties. Long-term or large-scale inhalation will damage lung function and cause chemical pneumonia and other diseases. In addition, the bromine and fluorine compounds it contains will interfere with the normal physiological functions of the human body, causing adverse effects on the nervous system, cardiovascular system, etc., causing dizziness, headache, palpitations and other symptoms.
2. ** Skin Contact Hazards **: Contact with the skin can cause skin irritation, tingling, burning, redness, swelling, itching, and even chemical burns. If absorbed through the skin into the human body, it will further damage internal organs.
3. ** Eye Contact Hazards **: Accidentally entering the eyes can strongly irritate the eyes, causing pain, tears, and blurred vision. In severe cases, it can damage the cornea and conjunctiva, causing vision loss or even blindness.
4. ** Hazards of Accidental Eating **: After ingestion, it will corrode the mucosa of the mouth, throat, and gastrointestinal tract, causing severe pain, vomiting, and diarrhea. After absorption, it will circulate to the whole body with the blood, damage multiple organ functions, and threaten life safety.
Risk of Environmental Hazards
1-Bromo-3- (difluoromethyl) benzene enters the environment and is difficult to degrade. Residues in the soil will affect the activity and structure of soil microorganisms, cause soil fertility to decrease, and affect plant growth. Entering the water body will poison aquatic organisms, destroy the balance of aquatic ecosystems, and enrich through the food chain, ultimately endangering human health. Volatile into the atmosphere, it will participate in photochemical reactions, form photochemical smog, reduce atmospheric visibility, and endanger human respiratory health.