1-Bromo-3-Chloro-6-Fluorobenzene

Hongda Chemical

Specifications

HS Code	162736
Chemical Formula	C6H3BrClF
Molar Mass	211.44 g/mol
Appearance	Colorless to light yellow liquid
Boiling Point	Around 190 - 195 °C
Solubility In Water	Insoluble
Solubility In Organic Solvents	Soluble in common organic solvents like dichloromethane, ethyl acetate
Vapor Pressure	Low vapor pressure at room temperature

As an accredited 1-Bromo-3-Chloro-6-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	100g of 1 - bromo - 3 - chloro - 6 - fluorobenzene packaged in a sealed glass bottle.
Storage	1 - Bromo - 3 - chloro - 6 - fluorobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly sealed container made of materials resistant to corrosion, such as glass or certain plastics. This prevents leakage and potential reactions that could pose safety risks.
Shipping	1 - Bromo - 3 - chloro - 6 - fluorobenzene is shipped in well - sealed, corrosion - resistant containers. It's carefully packed to prevent leakage during transit, following strict hazardous chemical shipping regulations.

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General Information

Historical Development

1 - Bromo - 3 - Chloro - 6 - Fluorobenzene is an organic compound with an interesting history. In the past, organic chemistry was first developed, and chemists dedicated themselves to exploring the synthesis and properties of various compounds.
At that time, researchers dedicated their efforts to the preparation of benzene ring derivatives. After repeated experiments, a variety of halogenation reaction methods came into being. For 1 - Bromo - 3 - Chloro - 6 - Fluorobenzene, chemists tried different halogenation reagents and reaction conditions.
In the initial stage, the reaction yield was low and the selectivity was poor. However, researchers made unremitting efforts to optimize the reaction process and improve the catalyst. With the passage of time, the method of efficient synthesis of this compound has gradually been obtained. This compound has been widely used in the field of organic synthesis, laying the foundation for the construction of many complex organic molecules, promoting the continuous progress of the field of organic chemistry, and emerging in drug research and development, materials science, etc., becoming a key achievement in the development of chemistry.

Product Overview

1 - Bromo - 3 - Chloro - 6 - Fluorobenzene is an organic compound. Its molecules contain halogen atoms such as bromine, chlorine, and fluorine, and the benzene ring is the basic skeleton.
This compound has unique physical and chemical properties. From the perspective of physical properties, it is a solid or liquid at room temperature, and its melting boiling point is different from that of benzene due to the presence of halogen atoms. Its solubility or insolubility in water, but it can be soluble in organic solvents.
In terms of chemical properties, the activity of halogen atoms allows the compound to participate in various chemical reactions. For example, in nucleophilic substitution reactions, halogen atoms can be replaced by nucleophiles to form new derivatives, which is an important step in organic synthesis. It is widely used in the field of organic synthesis and can be used as a key intermediate to produce more complex organic compounds through a series of reactions, providing a basis for the research and development of drugs and materials.
With the experience of my chemical research, the in-depth study of 1-Bromo-3-Chloro-6-Fluorobenzene will help the development of organic synthesis and expand the application scope of compounds.

Physical & Chemical Properties

1 - Bromo - 3 - Chloro - 6 - Fluorobenzene is an organic compound. Its physical properties are mostly liquid at room temperature and have certain volatility. Looking at its color, it is almost colorless or very light yellow, with good transparency. Smell it, it has a specific aromatic smell. Its boiling point and melting point are affected by intermolecular forces and structures. Due to the introduction of halogen atoms, the molecular polarity changes, resulting in an increase in the boiling point compared with benzene. The specific boiling point value can be accurately determined by experiments.
Chemical properties, due to the conjugation system of benzene ring and the electron-absorbing effect of halogen atoms, this compound can undergo electrophilic substitution reactions. Bromine, chlorine and fluorine atoms change the electron cloud density of the benzene ring, and the electron cloud density of the ortho-para-site is relatively high, and electrophilic reagents are easy to attack the ortho-para-site. If mixed with nitric acid and sulfuric acid, nitro groups can be introduced. Under appropriate conditions, halogen atoms can be replaced by nucleophiles, showing active chemical activity, and are important intermediates in organic synthesis.

Technical Specifications & Labeling

Today there is a product called 1 - Bromo - 3 - Chloro - 6 - Fluorobenzene. In this product, its technical specifications and identification (commodity parameters) are the key.
When it comes to its technical specifications, it is necessary to use precise and strict methods to control its synthesis process. The material ratio, reaction temperature, duration, etc., should be accurate and correct. If the material is combined, it must follow a certain ratio to make the reaction smooth and obtain a high-purity product. When reacting, the temperature needs to be constant in a certain domain. If it is too high, the quality will be poor, and if it is too low, the speed will be slow.
As for the logo, its properties, ingredients, uses, etc. should be detailed. Characters such as color, taste, state, proportion and geometry of ingredients, and where the use is suitable, all need to be clear. In this way, the user can understand its nature, know its use, and make the best use of the product. In accordance with this technical specification and labeling, the quality of this product can be guaranteed to meet the needs of all parties.

Preparation Method

1 - Bromo - 3 - Chloro - 6 - Fluorobenzene is an important organic compound, and the preparation method of this compound is very critical.
The selection of its raw materials should start with suitable compounds containing bromine, chlorine and fluorine. If you can choose halogenated aromatics containing benzene rings with replaceable check points, react with specific halogenating reagents.
In the preparation process, the reaction steps should be gradual. First, the bromine atom is introduced into the specific position of the benzene ring under precise conditions. In this step, you need to pay attention to the reaction temperature and the choice of catalyst. For example, an iron-based catalyst can be selected to promote the bromination reaction at a suitable temperature.
Then, the control conditions make the chlorine atom connected, and this process may require adjusting the reaction solvent, reactant ratio, etc. Finally, the fluorine atom replaces the corresponding check point to achieve the synthesis of 1-Bromo-3-Chloro-6-Fluorobenzene.
Its catalytic mechanism can reduce the activation energy of the reaction with the catalyst, making the reaction easier to proceed. The iron-based catalyst can interact with the halogenation reagent to enhance its electrophilicity and promote the smooth binding of the halogen atom to the benzene ring, so that the preparation of the target product can be obtained.

Chemical Reactions & Modifications

Today there is a thing named 1 - Bromo - 3 - Chloro - 6 - Fluorobenzene. In the field of chemistry, its reaction and modification are quite important to my generation.
Looking at its reaction, it often changes wonderfully when it encounters various reagents. Halogen atoms are active, or nucleophilic substitution, or elimination reactions, depending on conditions. Among them, bromine, chlorine, and fluorine atoms are different in reaction due to their electronegativity and atomic radius. Bromine has good departure properties and is often the precursor of the reaction; chlorine is slightly stable, but in suitable situations, it can also actively participate; although fluorine is small and strong electronegativity, it has a great impact on the electron cloud distribution of molecules, causing the reaction to be tortuous and changeable.
As for modification, chemists are exhausted. Or introduce new functional groups to change their physical and chemical properties. Such as nitrogen-containing and oxygen-containing groups, it can increase its polarity, change its solubility and reactivity. Or adjust its spatial structure to make the molecule have a unique conformation to meet special needs. Through these, the use of 1 - Bromo - 3 - Chloro - 6 - Fluorobenzene has been expanded, and it has its applications in the fields of medicine and materials.

Synonyms & Product Names

1 - Bromo - 3 - Chloro - 6 - Fluorobenzene is an important chemical substance. In the field of chemistry, the same substance often has many different names, which is also the characteristic of chemical nomenclature.
The discussion of its aliases or trade names is crucial. Cover different names, and each has its own use in different research and production scenarios. 1 - Bromo - 3 - Chloro - 6 - Fluorobenzene, or has another name derived from its structural characteristics, or has a unique trade name in commercial circulation.
Although the names of chemical substances are complex and diverse, they all follow certain rules and habits. Its synonyms and trade names are helpful for accurate communication between academia and industry. Knowing its many terms can help us to move forward smoothly in literature study, experimental operation, and trade exchanges without any confusion. The synonyms and trade names of this substance are an indispensable part of the chemical knowledge system and need to be carefully sorted out and deeply understood.

Safety & Operational Standards

1 - Bromo - 3 - Chloro - 6 - Fluorobenzene is a compound commonly used in organic synthesis. In the research and production of this compound, safety and operating standards are extremely important.
First word on safety. Because of its certain chemical activity, it may be potentially harmful to the human body. Contact with the skin, or cause skin irritation, redness, swelling, itching. If not carefully entered the eyes, it can damage the eye tissue, cause pain, blurred vision, etc. Inhalation of its volatile gases, or irritation of the respiratory tract, causing cough, asthma, and even affecting the normal function of the respiratory system. Therefore, during operation, be sure to take protective measures. Experimenters need to wear lab clothes and protective gloves, which can effectively block the compound from coming into contact with the skin. At the same time, protective glasses should be worn to prevent liquid from splashing into the eyes. Operate in a well-ventilated environment, or equip with professional ventilation equipment, such as a fume hood, to discharge volatile gases in time to reduce the risk of inhalation.
Describe the operating specifications below. When weighing the compound, use a precise weighing instrument to ensure accurate dosage. Deviations in dosage may affect the reaction result. When dissolving, select a suitable solvent according to its solubility, and the stirring speed is moderate to make the dissolution uniform. During the reaction process, strictly control the temperature, pressure and other conditions. Due to different reaction conditions or product differences, or even lead to safety accidents. When heating the reaction, appropriate heating devices should be used, supplemented by temperature control equipment to ensure stable temperature. After the reaction is completed, the separation and purification of the product should also follow the standard process. Distillation, extraction, recrystallization and other methods can be selected according to the physical and chemical properties of the product and impurities to obtain high-purity products. Throughout the operation, the experimental data and phenomena are recorded in detail, which is not only beneficial to the analysis of results, but also provides important reference for subsequent research.

Application Area

1 - Bromo - 3 - Chloro - 6 - Fluorobenzene is a unique chemical substance. It is widely used in various fields today.
In the field of pharmaceutical research and development, this substance is often a key raw material. Through delicate chemical reactions, compounds with unique pharmacological activities can be derived, which are used to fight various diseases, such as the conquest of intractable diseases, and contribute to the progress of medicine.
As for the field of materials science, 1 - Bromo - 3 - Chloro - 6 - Fluorobenzene also shows extraordinary potential. After special treatment and synthesis process, new materials with excellent performance can be prepared, or with excellent electrical and thermal conductivity, or good mechanical strength and stability, injecting new energy into material innovation.
In addition, in the fine chemical industry, as an important intermediate, it helps to synthesize many high-value-added fine chemicals, such as special fragrances, high-end coating additives, etc., to meet the market demand for high-quality fine chemical products. In this way, 1 - Bromo - 3 - Chloro - 6 - Fluorobenzene is indispensable in many application fields.

Research & Development

1 - Bromo - 3 - Chloro - 6 - Fluorobenzene research.
My research and chemical product, the recent injection is 1 - Bromo - 3 - Chloro - 6 - Fluorobenzene. This compound is unique and may be of great use in multiple domains.
Initial research, to explore its synthesis method. Fan, with different raw materials,. First with phenyl,, but the effect is not good, too much.
And the whole strategy, to change the Fortunately, I have achieved success, and I have found a way to make this compound, and the degree of success can be achieved.
Today, I am researching its application. Think of its application in the field of technology, materials, or new paths. In the future, I hope to use this material base to expand more possibilities, and take more steps in the way of chemical research.

Toxicity Research

I will study the toxicity of 1 - Bromo - 3 - Chloro - 6 - Fluorobenzene. This compound contains halogen atoms, and its properties are strong.
Looking at various chemical experiments, its impact on organisms should not be underestimated. In white mice, if exposed to this substance, they will be restless at first, and then their diet will gradually decrease, and their bodies will gradually weaken. After a long time, the organs are also abnormal. The detoxification function of the liver and the excretion function of the kidneys are all affected by it.
Looking at its impact on the environment, if this substance is excreted in water, aquatic organisms will bear the brunt. The photosynthesis of algae and the respiration of fish and shrimp are all hindered. And this substance is not easy to degrade, accumulated in water and soil, and will cause harm for a long time.
From this point of view, 1 - Bromo - 3 - Chloro - 6 - Fluorobenzene is significantly toxic, and it is a serious threat to biology and the environment. It is urgent to study and prevent it.

Future Prospects

I try to study 1 - Bromo - 3 - Chloro - 6 - Fluorobenzene, observe its properties, test its quality, and hope to develop in the future.
From today's perspective, this material is unique, and it is expected to become a key material in the fields of chemical industry and medicine. In the future, science and technology will be new, and it may be able to use subtle methods to increase its yield and reduce its cost. And with the deepening of research, it may reveal its new capabilities, and shine in the process of material innovation and disease healing.
Also thinking about the art of preparation, when refining, make the process simple and efficient. Will be able to borrow new techniques and new tools to optimize the synthesis. With unremitting efforts, 1 - Bromo - 3 - Chloro - 6 - Fluorobenzene will be on the stage of the future, exhibiting an extraordinary posture, and contributing to the prosperity of all industries.

Where to Buy 1-Bromo-3-Chloro-6-Fluorobenzene in China?

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Frequently Asked Questions

As a leading 1-Bromo-3-Chloro-6-Fluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the physical properties of 1-Bromo-3-Chloro-6-Fluorobenzene?

1-Bromo-3-chloro-6-fluorobenzene is one of the organic compounds. Its physical properties are worth exploring.
First of all, its appearance, under room temperature and pressure, is often colorless to light yellow liquid, clear and translucent, like the morning dew of autumn morning, pure and free of debris. Looking at its color, its light yellow color is like the stamen of the first bloom, elegant and soft, giving people a sense of freshness.
As for its boiling point, it is about a specific temperature range. At this temperature, the liquid gradually turns into a gaseous state, and the molecules break free from each other and soar freely in space. The value of the boiling point is related to the change of its state in different environments, and it is of great significance for the experimental operation of separation and purification.
The melting point also has a specific value. When the temperature drops to the melting point, the compound gradually condenses from liquid to solid state, and the molecular arrangement tends to be orderly from disorder, like a soldier's team, in order. The determination of the melting point can provide an important basis for the identification of this compound.
Its density is heavier than that of water. If it is placed in a container with water, it is like a stone sinking to the bottom of the water and lying under the water layer. This property has applications in some processes involving liquid-liquid separation.
In terms of solubility, 1-bromo-3-chloro-6-fluorobenzene is soluble in many organic solvents, such as ethanol, ether, etc., just like fish entering water, and the two blend seamlessly. However, the solubility in water is very small, just like the incompatibility of oil and water. This difference is due to the difference between its molecular structure and the molecular structure of water, and the strength of the interaction force is different.
In addition, its volatility is also an important physical property. In a normal temperature environment, although the volatilization is not very rapid, it slowly escapes into the air. When storing and using this property, attention should be paid to prevent it from being lost and to ensure the accuracy of experiments or production.
The physical properties of 1-bromo-3-chloro-6-fluorobenzene, each with its own unique characteristics, are key considerations in chemical research, industrial production and other fields, and affect various related processes and applications.

What are the main uses of 1-Bromo-3-Chloro-6-Fluorobenzene?

1-Bromo-3-chloro-6-fluorobenzene is one of the organic compounds and has a wide range of uses in the field of organic synthesis. Its main use is as a key intermediate for the preparation of special materials. In the creation of polymer materials, this compound can be introduced into the polymer structure through specific reactions, giving the material unique properties, such as improving its heat resistance and chemical stability.
Furthermore, in the field of pharmaceutical chemistry, 1-bromo-3-chloro-6-fluorobenzene also plays an important role. Due to its special chemical structure, it can be used as a starting material to build a molecular skeleton with biological activity through multi-step chemical reactions. The development of many new drugs relies on this compound as the basis for modification and modification to achieve specific pharmacological effects or improve the efficacy and selectivity of drugs.
In addition, in the field of pesticide chemistry, this compound is also used. It can be used as a key building block for the synthesis of new pesticides. By designing and synthesizing pesticide molecules containing this structure, it is hoped to obtain high-efficiency, low-toxicity and environmentally friendly pesticide varieties to meet the needs of modern agriculture for pest control. With its unique structure, 1-bromo-3-chloro-6-fluorobenzene is an indispensable raw material for organic synthesis in many fields such as materials, drugs and pesticides, and plays a key role in promoting the development of various fields.

What are 1-Bromo-3-Chloro-6-Fluorobenzene synthesis methods?

The synthesis method of 1-bromo-3-chloro-6-fluorobenzene often follows several paths. First, it can start with benzene and introduce bromine, chlorine and fluorine atoms one by one through halogenation reaction. First, a brominating agent, such as bromine and a catalyst (such as iron filings or iron tribromide), is used for benzene to obtain bromobenzene. This step requires temperature control and material ratio to make the bromine atom selected and replaced. Bromobenzene is obtained, and then a chlorinating agent, such as chlorine gas and a suitable catalyst, reacts under specific conditions to introduce chlorine atoms to form an intermediate containing bromine and chlorine. Then, a suitable fluorination reagent, such as potassium fluoride, is selected to carry out a fluorination reaction in the presence of a phase transfer catalyst to introduce fluorine atoms, and the final product is 1-bromo-3-chloro-6-fluorobenzene.
Second, phenolic compounds can also be used as starting materials. Phenols are first halogenated to obtain halogenated phenols, followed by diazotization and Sandmeier reaction to convert phenolic hydroxyl groups into halogen atoms. For example, after phenol is brominated and chlorinated, the obtained halogenated phenol is diazotized, and then interacts with fluoroboronic acid to form fluoroborate, which is heated and decomposed to obtain fluorinated halogenated aromatics. After optimizing the appropriate reaction conditions, 1-bromo-3-chloro-6-fluorobenzene can be obtained.
Furthermore, it is also feasible to use halogenated aromatics as raw materials to obtain metal-catalyzed cross-coupling reactions. For example, using aromatic hydrocarbons containing bromine and chlorine as substrates and reagents containing fluorine, in the presence of metal catalysts and ligands such as palladium and nickel, under the action of suitable solvents and bases, the introduction of fluorine atoms can be realized. After conditioning and purification steps, pure 1-bromo-3-chloro-6-fluorobenzene can be obtained. These methods have advantages and disadvantages. In actual synthesis, it is necessary to weigh the availability of raw materials, cost, and ease of control of reaction conditions.

1-Bromo-3-Chloro-6-Fluorobenzene what are the precautions during storage and transportation?

1-Bromo-3-chloro-6-fluorobenzene is also an organic compound. During storage and transportation, there are a number of precautions that must not be ignored.
First storage, this compound should be placed in a cool, dry and well-ventilated place. Cover its properties or change due to temperature and humidity, causing quality damage or even danger. Keep away from fire and heat sources to prevent accidental explosion. And should be stored separately from oxidants, strong alkalis and other substances, and must not be mixed. If it encounters with them, or has a violent chemical reaction, it endangers safety. In the storage place, it is appropriate to have suitable materials to contain leaks so that in case of leakage, they can be disposed of in time.
As for transportation, it is also necessary to be cautious. The transportation vehicle must ensure that it is in good condition and has perfect protective facilities. This compound should be firmly placed to prevent package damage due to bumps and collisions. During transportation, escorts should always pay attention and not leave without permission. In case of hot weather, it is advisable to transport it in the morning and evening when it is cool to avoid exposure to the hot sun. If it is transported by water, it is also necessary to follow relevant regulations. Waste must not be thrown at will to prevent pollution of water bodies. And the transportation package must have a clear and firm logo, indicating its product name, dangerous nature and other key information, so that the contact person can see it at a glance and take precautions in advance.

What are the effects of 1-Bromo-3-Chloro-6-Fluorobenzene on the environment and human health?

1-Bromo-3-chloro-6-fluorobenzene is a genus of organohalogenated aromatic hydrocarbons. The impact of this compound on the environment and human health can be particularly investigated.
At the environmental end, 1-bromo-3-chloro-6-fluorobenzene has considerable chemical stability and is not easily degraded in the natural environment. It may be dispersed in the atmosphere, water and soil by means of volatilization and runoff. In the atmosphere, it may participate in photochemical reactions, affect atmospheric chemical processes, and be difficult to degrade or accumulate in the environment for a long time. In water bodies, it may be toxic to aquatic organisms. The halogen atoms in its structure can interfere with the physiological and biochemical processes of aquatic organisms, such as hindering their normal growth, development and reproduction. In the soil, it may affect the structure and function of the soil microbial community, and then disturb the balance of the soil ecosystem.
As for human health, 1-bromo-3-chloro-6-fluorobenzene enters the human body through respiration, diet and skin contact. It may accumulate in the human body or in adipose tissue due to lipophilic properties. Over time, it may affect the human nervous system, causing dizziness, fatigue, memory loss, etc. It may also damage important organs such as the liver and kidneys, and interfere with the normal metabolism and detoxification functions of organs. In addition, in view of the characteristics of halogenated aromatics, they may have potential carcinogenicity, teratogenicity and mutagenicity, although there is no conclusive conclusion, they should not be ignored.
In summary, the impact of 1-bromo-3-chloro-6-fluorobenzene on the environment and human health should not be underestimated. It should be handled with caution, and monitoring and control should be strengthened to protect the environment and human safety.