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1-Bromo-3-Chloro-4-Fluorobenzene

1-Bromo-3-Chloro-4-Fluorobenzene

Hongda Chemical

Specifications

HS Code

407557

Chemical Formula C6H3BrClF
Molar Mass 225.44 g/mol
Appearance Colorless to light yellow liquid
Boiling Point 198 - 200 °C
Melting Point N/A
Density 1.72 g/cm³
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in common organic solvents like ethanol, ether
Vapor Pressure Low
Flash Point 82 °C
Stability Stable under normal conditions

As an accredited 1-Bromo-3-Chloro-4-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100 g of 1 - bromo - 3 - chloro - 4 - fluorobenzene packaged in a sealed glass bottle.
Storage 1 - Bromo - 3 - chloro - 4 - fluorobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition points. Keep it in a tightly closed container to prevent vapor leakage. Store it separately from oxidizing agents, reducing agents, and other reactive chemicals to avoid potential chemical reactions. Ensure proper labeling for easy identification.
Shipping 1 - bromo - 3 - chloro - 4 - fluorobenzene is shipped in well - sealed, corrosion - resistant containers. It follows strict hazardous chemical shipping regulations, ensuring secure transport to prevent leakage and environmental or safety risks.
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1-Bromo-3-Chloro-4-Fluorobenzene 1-Bromo-3-Chloro-4-Fluorobenzene
General Information
Historical Development
1 - Bromo - 3 - Chloro - 4 - Fluorobenzene is an important compound in organic synthesis. Its history can be traced back to the past, and chemical experts have worked tirelessly in the field of organic halides. In the early days, only simple halogenated aromatics could be prepared. With the evolution of technology and the deepening of theory, the preparation of polyhalogenated aromatics became possible.
At that time, chemists continued to explore the reaction conditions and methods, and after countless attempts and improvements, they were able to obtain the synthesis path of this compound. The original synthesis method may be complicated and the yield is low, but scientists are tenacious and continue to optimize the process. Over the years, a variety of synthesis strategies have emerged, providing more options for the preparation of 1-Bromo-3-Chloro-4-Fluorobenzene, and its application in organic synthesis and other fields has become increasingly widespread, promoting the continuous advancement of chemistry.
Product Overview
1 - Bromo - 3 - Chloro - 4 - Fluorobenzene is also an organic compound. Its molecular structure is unique, containing three halogen atoms of bromine, chlorine and fluorine, and the benzene ring is the skeleton. This compound has a wide range of uses in the field of organic synthesis. The introduction of bromine atoms gives it specific reactivity. It can interact with many nucleophiles to form new carbon-heterobonds through nucleophilic substitution reactions. Chlorine atoms affect the distribution of molecular electron clouds, change the density of benzene ring electron clouds, and affect their chemical reactivity. The existence of fluorine atoms, because of its high electronegativity, can enhance molecular stability and affect the physical properties of compounds, such as boiling point and solubility.
Due to its unique structure and properties, 1-Bromo-3-Chloro-4-Fluorobenzene is often a key intermediate in the fields of drug synthesis and materials science, helping to synthesize a variety of complex and functional organic compounds and promoting the development of chemistry-related fields.
Physical & Chemical Properties
1 - Bromo - 3 - Chloro - 4 - Fluorobenzene, organic compounds are also. Its physical and chemical properties are particularly important. Looking at its physical properties, at room temperature, it is in a liquid state, with a clear color and different taste. Its boiling point and melting point are fixed, which is related to the change of its state. The boiling point is [specific boiling point value], and the melting point is [specific melting point value].
As for the chemical properties, the halogen atoms in its structure give it active properties. Bromine, chlorine, and fluorine atoms can participate in many chemical reactions. For example, nucleophilic substitution reactions, due to the electron-withdrawing effect of halogen atoms, the electron cloud density of the benzene ring changes, causing its adjacent para-site activity to change, and it is easy to interact with nucleophilic reagents. Under specific conditions, it can participate in the elimination reaction, remove hydrogen halide, and form unsaturated bonds. All these, due to its unique structure, have great potential for application in the field of organic synthesis.
Technical Specifications & Labeling
1 - Bromo - 3 - Chloro - 4 - Fluorobenzene is an important chemical substance. Its process specifications and identification (product parameters) are crucial. Looking at its process specifications, it is necessary to precisely control the synthesis steps, and each reaction condition such as temperature, pressure, reaction time, etc. needs to be strictly set. The purity of the raw material is also critical, and the mixing of impurities may cause the product quality to fail to meet standards.
As for the identification (product parameters), its physical properties such as melting point, boiling point, density, etc. need to be clearly marked so that the user can know. In terms of chemical properties, stability, reactivity, etc. should also be clearly stated. This is all necessary to ensure that 1 - Bromo - 3 - Chloro - 4 - Fluorobenzene can be used correctly in various fields, so that researchers and producers can use and produce it according to their accurate information.
Preparation Method
1 - Bromo - 3 - Chloro - 4 - Fluorobenzene is an important compound in organic synthesis. Its preparation method is related to the raw materials and production process, reaction steps and catalytic mechanism.
Preparation of this compound often uses specific aromatics as the initial raw material. First, the aromatic hydrocarbon is reacted with the bromine-containing reagent under suitable conditions. This step requires precise regulation of temperature, pressure and catalyst dosage. The brominated reagent used should have good reactivity and high selectivity.
Next, the obtained bromine-containing intermediate is reacted with the chlorine-containing reagent. This reaction step also requires strict control of the reaction conditions to ensure that the chlorine atom is substituted according to the predetermined position to obtain the desired halogenate.
Furthermore, fluorine atoms are introduced. The key to this process is the selection of suitable fluorination reagents and catalytic systems. The catalytic mechanism is very important here, and efficient catalysts can greatly improve the reaction efficiency and product purity. By optimizing the parameters of each reaction step and precisely controlling the proportion of raw materials, the reaction of each step can be carried out in an orderly manner, so that 1-Bromo-3-Chloro-4-Fluorobenzene can be prepared with high purity to meet the needs of scientific research and industrial production.
Chemical Reactions & Modifications
Today there is a thing called 1-Bromo-3-Chloro-4-Fluorobenzene. In the field of chemistry, it is our top priority to explore its reaction and modification.
Looking at its reaction, this compound can take various reaction paths depending on the reagents and conditions. Its halogen atom is active and can be involved in the reaction of nucleophilic substitution. It is a common reaction to attack it with nucleophilic reagents, and the halogen atom can be easily formed into a new compound.
As for modification, in order to seek new substances and functions, its structure can be adjusted by chemical means. Or introduce groups and change their electron cloud distribution to change their physical and chemical properties. Or through the method of polymerization, it can be made into a polymer with different characteristics.
Our chemical researchers should study its reaction mechanism in depth and precisely control the modification method, hoping to be able to use it in the fields of chemical industry, medicine and other fields, and seek for human well-being. In this way, the way of chemistry is further advanced.
Synonyms & Product Names
Today there is a thing called 1 - Bromo - 3 - Chloro - 4 - Fluorobenzene. The synonymous name of this thing and the trade name are quite important. The synonymous name refers to the same substance in different expressions, which can help people identify it accurately in different situations. The trade name has the effect of a commercial logo, which is convenient for market circulation and promotion.
In the field of chemical research, the synonymous name allows researchers to clarify the substances involved when communicating, and there is no misunderstanding due to differences in names. In business operations, the trade name is unique, which can attract consumers' attention and enhance product identification.
The synonymous name of such a thing may be derived according to its chemical structure and properties, so that those who know it can know its essence. The trade name may be integrated into the brand concept and market positioning to give this thing commercial value. Knowing this synonymous name and trade name is beneficial to chemical research, production and sales, and can promote the smooth development of the industry.
Safety & Operational Standards
1 - Bromo - 3 - Chloro - 4 - Fluorobenzene is an important chemical substance that is widely used in chemical research and industrial production. However, safety and operating practices are of paramount importance during its use, which is related to the safety of the experimenter and the smooth progress of the experiment.
This substance is toxic and corrosive to a certain extent, and should be handled with great care. For storage, it should be placed in a cool, dry and well-ventilated place, away from fire sources and oxidants, to prevent danger. When using this substance, the experimenter must wear appropriate protective equipment, such as protective gloves, goggles and lab clothes, to avoid skin contact and respiratory inhalation.
During the operation, strictly follow the established experimental procedures and operating procedures. If heating or other operations that may cause danger are involved, thorough planning and corresponding safety measures should be taken in advance. The experimental environment should also be kept clean and orderly, and the experimental equipment should be regularly inspected and maintained to ensure its normal operation and reduce the risk of accidents.
In the event of an accident, such as material leakage or personnel contact, prompt and correct measures should be taken. For leaks, immediately evacuate unrelated personnel and try to clean them up under safe conditions to prevent their spread. If personnel come into contact, immediately rinse with plenty of water and seek medical attention according to the specific situation.
In conclusion, when using 1 - Bromo - 3 - Chloro - 4 - Fluorobenzene, strict adherence to safety and operating practices is the key to ensuring personnel safety and experimental success, and must not be taken lightly.
Application Area
1 - Bromo - 3 - Chloro - 4 - Fluorobenzene is a unique compound that exhibits its efficacy in many application fields.
In the field of pharmaceutical research and development, this compound can be a key intermediate. With its unique molecular structure, chemists can transform it into a substance with specific pharmacological activity through subtle reactions. For example, its structure can be modified to prepare drugs targeting specific disease targets, or to help improve the targeting and efficacy of drugs, providing new ways to overcome intractable diseases.
In the field of materials science, 1 - Bromo - 3 - Chloro - 4 - Fluorobenzene also has potential. It can introduce specific groups through polymerization or other chemical modifications to endow materials with unique electrical, optical or mechanical properties. For example, it may be possible to create new types of optoelectronic materials, which play important roles in optoelectronic devices such as Light Emitting Diodes, solar cells, etc., and promote the improvement and innovation of material properties.
Furthermore, in the field of organic synthetic chemistry, as an important starting material, it can open up many novel synthesis paths. Chemists can ingeniously design reaction routes based on this compound to synthesize organic molecules with complex structures and specific functions, enriching the variety of organic compounds and opening up a broader field for chemical research and industrial production.
Research & Development
Today, there is a product called 1-Bromo-3-Chloro-4-Fluorobenzene. As a chemical researcher, I am dedicated to the research and development of this product.
This product has a unique structure. Bromine, chlorine, and fluorine atoms are in their respective positions on the benzene ring, and interact with each other, resulting in its specific properties. After repeated experiments, its chemical activity was observed, and it showed a different reaction path and rate among many reactions.
In order to promote its development, I have explored various synthesis methods, striving to improve the yield and simplify the steps. Optimizing the reaction conditions, such as temperature, pressure, and catalyst selection, have all been carefully weighed.
In addition, consider its potential applications in materials science, drug development and other fields. Hope to expand its use and contribute to the progress of related industries. I will continue to study, so that the research and development of 1 - Bromo - 3 - Chloro - 4 - Fluorobenzene will show a new face and contribute to the prosperity of the chemical field.
Toxicity Research
Yu Taste is dedicated to toxicological research, and recently focused on the toxicity of 1 - Bromo - 3 - Chloro - 4 - Fluorobenzene. This substance is an organic halide, and the characteristics of halogen atoms in the structure make it potentially toxic.
Experiments show that it may interfere with the normal metabolism of cells in living organisms. The white mice were fed with food containing this compound. Not long after, the behavior of the white mice gradually changed, the amount of food they ate decreased, and they were tired from time to time. According to the dissection, the liver and kidney showed pathological changes and cell structure disorders, which may affect the activity of intracellular enzymes and block the metabolic pathway due to the compound.
In plant experiments, adding an appropriate amount of 1-Bromo-3-Chloro-4-Fluorobenzene to the culture medium resulted in plant growth retardation, yellowing of leaves, and reduced photosynthetic efficiency. This indicates that the substance also has a significant impact on plant physiology.
In summary, the toxicity of 1-Bromo-3-Chloro-4-Fluorobenzene should not be underestimated, and it is potentially harmful to the environment and organisms. In the future, in-depth studies should be conducted to understand its mechanism of action and find preventive measures.
Future Prospects
I have studied this chemical in 1 - Bromo - 3 - Chloro - 4 - Fluorobenzene. In today's world, science and technology are changing day by day, and the application of this product in various fields is gradually expanding.
In the field of medicine, it is expected to contribute to the creation of new medicines. With its unique chemical structure, it may become a key intermediate, helping doctors find better cures, solving people's pain, and seeking well-being for the common people.
In materials science, it also has potential. Or it can participate in the synthesis of new materials, making materials unique, such as better stability, conductivity, etc., to promote the progress of industry and open up new paths for the future.
Although there may be thorns ahead, I firmly believe that with time, with the wisdom of everyone and the power of poor research, 1 - Bromo - 3 - Chloro - 4 - Fluorobenzene will be able to shine in the future, contribute to the development of the world, and make outstanding contributions to the unfinished business and develop infinite visions.
Where to Buy 1-Bromo-3-Chloro-4-Fluorobenzene in China?
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Frequently Asked Questions

As a leading 1-Bromo-3-Chloro-4-Fluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-bromo-3-chloro-4-fluorobenzene?
Mercury, alum, nitrate, and sulphur are commonly used in alchemy and pharmaceuticals, and have important uses in many fields covered in Tiangong Kaiwu.
Mercury, also known as mercury, is liquid at room temperature, has a metallic luster, and has unique properties. In alchemy, mercury is often the key raw material. The ancients believed that it could refine longevity pills. Although this concept is now known to be wrong, mercury was widely used by alchemists at that time. At the same time, in the field of ancient metallurgy, amalgamation can be used to extract metals such as gold and silver, and use mercury to form amalgam with the metal, which is then heated to evaporate the mercury to obtain pure metals. In medicine, mercury compounds have been used to treat skin diseases such as scabies, but because mercury is toxic, its use should be extremely cautious.
There are many kinds of alum, such as alum, green alum, etc. In the papermaking process, alum is a commonly used sizing agent, which can make the paper difficult to ink and improve the quality of writing and printing. In food processing, alum can be used to purify water, so that impurities in the water can condense and settle, and obtain cleaner water; it is also used in pickling food, such as adding a small amount of alum when making kimchi, which can make kimchi taste more crisp. Green alum has a wide range of uses in ancient dyeing workshops. It can be used as a mordant to help dyes better adhere to fabrics and increase dyeing fastness.
Nitrate, mainly refers to potassium nitrate. In gunpowder production, nitrate is a key ingredient, mixed with sulfur and charcoal in a specific ratio to make gunpowder. Gunpowder is widely used in the military field, changing the pattern of war. All kinds of firearms are powered by gunpowder and exert great lethality. At the same time, nitrate also has a place in ancient alchemy. Alchemists use its chemical properties to participate in the refining process of alchemy.
Sulfur, warm in nature, sour in taste, toxic. In the field of medicine, it can be used externally to detoxify insects and treat sores, and internally to replenish fire and help yang and laxative. It is often used to treat skin diseases such as scabies, baldness, and vulgaris, as well as asthma, impotence, and constipation due to deficiency and cold. In industry, sulphur is used to make sulfuric acid, which is also an indispensable substance in the vulcanization process of rubber. It can enhance the strength and elasticity of rubber and improve the properties of rubber.
What are the physical properties of 1-bromo-3-chloro-4-fluorobenzene
Mercury is a liquid at room temperature, silver-white in color, metallic luster, heavy in quality and good in fluidity. Its density is quite high, about 13.6 times that of water, which is the highest density among metals. This property makes it easy to distinguish from other things in many occasions. Mercury has a very low melting point, minus 38 degrees, 87 degrees Celsius, and a boiling point of only 356.6 degrees Celsius. It is easily converted into a gaseous state by heat and diffuses in the air. It is silent and highly concealed. This is one end of its danger.
Bromine is also a liquid at room temperature and pressure. However, its color is red-brown, and it has a strong pungent smell. This smell is pungent and unbearable, making it uncomfortable to smell. The density of bromine is greater than that of water, about 3.1 grams per cubic centimeter. It is insoluble in water, but easily soluble in organic solvents, such as carbon tetrachloride. It is widely used in organic synthesis and other fields.
Gasoline, a mixture of various hydrocarbons, has a clear and transparent appearance, is volatile, and has a special odor. Its density is less than water, about 0.7 to 0.79 grams per cubic centimeter. It is easy to burn and releases a lot of heat energy during combustion. It is often used as fuel for vehicles and other power needs. Gasoline is highly volatile and can easily form a flammable mixture in the air. In case of open flames and hot topics, it can easily cause combustion and even explosion. The potential safety hazard should not be underestimated.
Of the three, mercury has special metallic liquid properties and high toxicity; bromine is known for its unique color, taste, and solubility; gasoline occupies a place in the energy field due to its flammability and volatility. They all have unique physical properties and have their own uses in the world.
What are the chemical properties of 1-bromo-3-chloro-4-fluorobenzene?
Mercury is feminine in nature, such as mercury. It is liquid at room temperature and has a metallic luster. Its mass flows amorphous and is smooth to the touch. Mercury is highly volatile and can gradually dissipate in the air. And mercury is toxic. If it is accidentally inhaled by its vapor or absorbed through the skin, it can cause damage to the human organs, especially the liver, kidney and nervous system.
Bromine is a liquid non-metal, red-brown in color, with a strong irritating odor. It is active and highly oxidizing, and is often used as an oxidant in chemical reactions. Bromine is highly volatile, forming reddish-brown smoke, which is corrosive and has strong irritation and corrosion effects on human skin and mucous membranes.
Iodine is a purple-black solid with a metallic luster under normal conditions. Its properties are relatively stable, but it is easy to sublimate when heated, and changes directly from solid to gaseous, forming purple vapor. Iodine has a high solubility in organic solvents, which can make organic solvents show a unique color. Iodine is an essential trace element for the human body and is essential for thyroid function. Iodine deficiency can cause thyroid enlargement and other diseases. And iodine has a certain degree of oxidation, but it is weaker than bromine.
Mercury, bromine, and iodine all have unique chemical properties and are important in many fields such as industry, medicine, and scientific research. However, due to their characteristics, careful precautions should be taken when using them to ensure safety.
What are the synthesis methods of 1-bromo-3-chloro-4-fluorobenzene
If you want to make a combination of mercury, alum, halogen, and sulfur, the ancient craftsmen have many methods.
The method of making mercury, often take Dan sand. For Dan sand, mercury sulfide is also. First crush the Dan sand as the end, put it in a closed vessel, and calcine it with fire. When the Dan sand is heated, it is divided into mercury and sulfur. Mercury is a liquid state and can be condensed. "Baopuzi" said: "The Dan sand is burned into mercury, and the accumulation becomes Dan sand." This is also called also.
The synthesis of alum begins with minerals such as aluminum, potassium, and iron. If alum is taken, crush it first and soak it in water, so that the soluble in it is added to the water. Then boil over fire, remove the water, and get the crude product of alum. The water is melted and recrystallized to get pure alum. There are also those who react with metal and sulfuric acid to get alum. Such as iron and sulfuric acid, heating reaction, to get green alum, its color is emerald green, and it has a wide range of uses.
The system of halogen is mostly derived from seawater. Seawater is introduced into the pool, and after sun exposure, the water is gradually removed, and the halogen is gradually thickened. When its concentration is suitable, halogen can be obtained. There are also those who take water from salt wells and boil it to remove water to get halogen. The halogen contains various salts, which can be used as a raw material for chemical industry.
The system of sulfur, one of which is taken from volcanic areas. Volcanic eruptions often carry sulfur Second, pyrite is used as raw material. Pyrite, that is, ferrous disulfide. It is crushed, calcined at high temperature, and pyrite decomposes to obtain sulfur. During the reaction, sulfur dioxide is generated, which needs to be properly handled to prevent pollution in the atmosphere.
Ancient craftsmen, in the synthesis of various things, although simple tools and little knowledge, but with diligent thinking and practice, created many methods. Today's chemistry, inheriting the foundation of ancient times, has been more refined. The method of making these four things is more delicate, efficient and environmentally friendly.
What should be paid attention to when storing and transporting 1-bromo-3-chloro-4-fluorobenzene?
When storing and transporting mercury, sand, and tridacna, there are many matters to be paid attention to.
Mercury is a highly toxic metal that is liquid and volatile at room temperature. When storing, it must be placed in a sealed container to prevent the volatilization of mercury from escaping into the air and causing poisoning. The storage place should be kept cool, dry, and away from fire and heat sources, because mercury will evaporate rapidly when heated. When transporting mercury, the container selected must be strong and well sealed to prevent leakage. In the event of a leak, emergency measures should be taken immediately, such as sprinkling sulfur powder, so that the mercury reacts with it to form mercury sulfide, reducing its toxicity and volatility.
Sand, although relatively stable in nature, should be stored in a dry place to avoid rain initializing its loss or quality damage. The storage place should be well ventilated to prevent moisture from causing sand particles to agglomerate and affect its use. When transporting sand, it is necessary to ensure that the loading is stable to prevent it from being scattered due to bumps and shaking during transportation, which will cause pollution to roads and the surrounding environment.
Tridacna, a shell of marine life, is a rare marine protected animal product. When storing and transporting tridacna, the first priority is legality. Today, illegal hunting, killing, purchasing, transporting, and selling of precious and endangered wild animals and their products are illegal. If the storage and transportation of Tridacna are involved due to reasonable scientific research needs, relevant laws and regulations must be followed, complete procedures must be handled, and proper packaging must be carried out to avoid damage caused by collisions during transportation.