1-Bromo-3-Chloro-2-Fluorobenzene

Hongda Chemical

Specifications

HS Code	720304
Chemical Formula	C6H3BrClF
Molar Mass	211.44 g/mol
Appearance	Colorless to light yellow liquid
Boiling Point	Around 195 - 197 °C
Density	Approx. 1.73 g/cm³
Solubility In Water	Insoluble
Solubility In Organic Solvents	Soluble in common organic solvents like ethanol, ether
Vapor Pressure	Low vapor pressure at room temperature

As an accredited 1-Bromo-3-Chloro-2-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	100 g of 1 - bromo - 3 - chloro - 2 - fluorobenzene packaged in a sealed glass bottle.
Storage	1 - bromo - 3 - chloro - 2 - fluorobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and ignition points. Keep it in a tightly closed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents, strong acids, and bases to prevent chemical reactions. Regularly check for any signs of leakage or degradation.
Shipping	1 - bromo - 3 - chloro - 2 - fluorobenzene, a chemical, is shipped in well - sealed, corrosion - resistant containers. They are carefully packed to prevent leakage and damage, following strict hazardous material shipping regulations.

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General Information

Historical Development

1 - Bromo - 3 - Chloro - 2 - Fluorobenzene is a special compound. Its origin can be traced back to the beginning of chemical research in the past. At that time, chemists worked tirelessly to explore the possibility of various combinations of elements.
At first, the research on halogenated benzene compounds was only scratchy. As the years passed, many scholars devoted themselves to research and gradually understood the properties derived from the substitution of halogen atoms at different positions in the benzene ring.
The discovery of 1 - Bromo - 3 - Chloro - 2 - Fluorobenzene is the result of repeated experiments and painstaking research by many chemists. They prepared various reagents in the laboratory, and after countless failures, they finally obtained this compound with a unique structure. Its birth opened up a new frontier for the field of organic chemistry, and then the research on its properties and reactions continued to deepen, promoting the development of chemistry.

Product Overview

1 - Bromo - 3 - Chloro - 2 - Fluorobenzene is also an organic compound. It may be a colorless to pale yellow liquid with a special odor. In this compound, on the benzene ring, bromine atoms, chlorine atoms and fluorine atoms are arranged in one order.
In the field of chemical synthesis, 1 - Bromo - 3 - Chloro - 2 - Fluorobenzene has a wide range of uses. Due to the characteristics of halogen atoms, it can participate in many nucleophilic substitution reactions and is a key raw material for the construction of complex organic structures. Through exquisite reaction design, bromine, chlorine and fluorine atoms can function separately and combine with various reagents to prepare organic molecules with unique functions.
Furthermore, its physicochemical properties also attract attention. Parameters such as melting point and boiling point affect the process of the reaction and the purity of the product under different reaction conditions. The study of this compound is of great significance for deepening the understanding of organic chemistry and expanding the synthesis path. Chemists can explore more efficient and green synthesis methods according to their characteristics to promote the progress of organic synthesis chemistry.

Physical & Chemical Properties

1 - Bromo - 3 - Chloro - 2 - Fluorobenzene is a special organic compound. Its physical and chemical properties are particularly critical.
When it comes to physical properties, this compound is in a liquid state at room temperature and pressure, with a specific color and odor. Its boiling point and melting point are important parameters that characterize the change of its physical state. The boiling point is related to the difficulty of its gasification, and the melting point determines the transition temperature between its solid and liquid states.
As for its chemical properties, the presence of bromine, chlorine and fluorine atoms in its molecules gives it unique reactivity. Bromine, chlorine, and fluorine are all halogen atoms, which can participate in various nucleophilic substitution reactions. If they react with nucleophilic reagents, halogen atoms can be replaced to form new compounds. And its benzene ring structure also affects its chemical behavior. The electron cloud distribution of the benzene ring can make the compound undergo addition and substitution reactions under specific conditions, which is of great significance for its application in the field of organic synthesis.

Technical Specifications & Labeling

1 - Bromo - 3 - Chloro - 2 - Fluorobenzene is a special chemical substance. In terms of process specifications and identification (product parameters), its preparation needs to follow strict methods. The raw materials must be selected in a pure manner, and the reaction conditions, such as temperature, pressure, and catalyst dosage, must be precisely controlled. The reaction device must be clean and well sealed to prevent impurities from mixing.
In terms of identification, its chemical name, molecular formula, molecular weight and other key parameters should be marked in a prominent and standardized way. For its dangerous characteristics, such as toxicity and corrosiveness, it should also be clearly marked to warn users. Storage and transportation requirements should also be fully marked to ensure that the product is safe and compliant in all aspects, so that the relevant personnel can properly dispose of it according to the specifications.

Preparation Method

1 - Bromo - 3 - Chloro - 2 - Fluorobenzene is an important organic compound, and its preparation method is related to the raw materials, production process, reaction steps and catalytic mechanism.
To prepare this compound, specific aromatics can be selected as the initial raw materials. First, bromine, chlorine and fluorine atoms are introduced in an orderly manner with suitable halogenated reagents through delicate reaction steps. The control of reaction conditions is extremely critical, such as temperature, pressure, reaction time, etc., all need to be precisely grasped.
In terms of production process, the characteristics of the reaction equipment should be considered to ensure uniform mixing and sufficient reaction of the materials. During the reaction process, the choice of catalyst can greatly improve the reaction rate and product purity. Efficient production can be achieved by carefully designing the reaction process and optimizing the connection of each link.
Furthermore, the catalytic mechanism cannot be underestimated. Appropriate catalysts can reduce the activation energy of the reaction and promote the reaction to proceed along the desired path. By regulating the catalytic activity check point, the position and selectivity of substituents can be precisely controlled, so that 1-Bromo-3-Chloro-2-Fluorobenzene can be prepared with high quality. In this way, a good method for preparing this compound can be obtained.

Chemical Reactions & Modifications

F 1 - Bromo - 3 - Chloro - 2 - Fluorobenzene, organic halogenated aromatic hydrocarbons and the like. In the field of chemical synthesis, its reaction and modification are of great importance to scholars.
Looking at its chemical properties, the existence of halogen atoms makes this compound have unique reactivity. Bromine, chlorine, and fluorine atoms each have their own properties, which affect the distribution of molecular electron clouds, causing their nucleophilic substitution, electrophilic substitution, and other reactions to be heterogeneous.
The reaction of nucleophilic substitution, due to the different activities of halogen atoms, can choose specific conditions to make nucleophilic reagents choose sites to attack. For example, using a strong base as an agent, appropriate temperature, or can introduce specific groups into the molecule to modify it.
And it can be catalyzed, electrophilic substitution. According to the change of electron cloud density of benzene ring, the reaction check point is controlled, and the selectivity of yield is increased. This is the way to modify this compound, and the product with better performance is expected to be used in the fields of medicine and materials for the benefit of the world.

Synonyms & Product Names

1 - Bromo - 3 - Chloro - 2 - Fluorobenzene, its synonymous name and the name of the commodity are quite important. In the course of my chemical research, I have carefully examined its name, and it can be seen that the synonymous name precisely expresses its molecular composition from the perspective of chemical structure. For example, according to the chemical naming rules, this name highlights the specific positions and combinations of bromine, chlorine and fluorine atoms on its benzene ring.
The name of the commodity, or according to its use and characteristics, has different names in commercial circulation. Although the two expressions are different, they both refer to the same chemical substance. Just like ancient utensils, they have both scientific names and common names, each has its own use. The scientific name helps researchers to clarify its essence, and the trade name is easy to trade. The synonyms and trade names of 1 - Bromo - 3 - Chloro - 2 - Fluorobenzene complement each other and are indispensable in the research and application of chemistry and industry. It is a key guide for our generation to explore this chemical substance.

Safety & Operational Standards

1 - Bromo - 3 - Chloro - 2 - Fluorobenzene Safety and Operation Specifications
Husband 1 - Bromo - 3 - Chloro - 2 - Fluorobenzene is a compound commonly used in organic synthesis. Its unique properties are related to safety and operation standards, and cannot be ignored.
When storing, choose a cool, dry and well-ventilated place. This compound is afraid of moisture, and it may deteriorate in case of moisture, which affects its quality. It should be stored in a sealed container to prevent volatilization and escape, and to avoid co-storage with strong oxidants, strong bases, etc., to avoid violent reactions and endanger safety.
When operating, the experimenter must wear strict protective gear. Wear experimental clothes and protective gloves, and the material is better to resist the erosion of this compound. Goggles are also required to prevent splashing into the eyes and causing damage to the eyes. If operated in a fume hood, it can effectively remove volatile gas, reduce toxicity to the environment, and ensure the health of the experimenter.
During use, be sure to exercise caution. When measuring, use a precise instrument to take the amount required for the experiment, not more or less. When transferring, beware of spills. If there is any spill, clean it up immediately with appropriate methods. If it is spilled on the desktop, cover it with a material with good adsorption immediately, and handle it properly after collection.
The reaction conditions must also be strictly controlled. 1 - Bromo - 3 - Chloro - 2 - Fluorobenzene participates in the reaction, temperature, pressure, catalyst and other factors have a great impact on the reaction. Be sure to operate according to the established procedures and parameters, and must not change it without authorization, so as not to lose control of the reaction and cause safety.
If you are unlucky enough to come into contact with this compound, you should also have emergency measures. If the skin touches it, rinse it with plenty of water immediately, followed by soap. If it enters the eye, rinse it with running water immediately, for not less than 15 minutes, and seek medical attention immediately.
In short, although 1 - Bromo - 3 - Chloro - 2 - Fluorobenzene is useful for scientific research, its safety and operation standards are the guarantee of smooth experiment and personnel safety, and cannot be ignored.

Application Area

1 - Bromo - 3 - Chloro - 2 - Fluorobenzene is a unique chemical with a wide range of application fields. In the field of medicinal chemistry, this compound is often a key intermediary. With its unique structure, chemists can follow an ingenious reaction path to convert it into molecules with specific pharmacological activities, thus paving the way for the development of new drugs.
In the field of materials science, 1 - Bromo - 3 - Chloro - 2 - Fluorobenzene also shows its extraordinary value. With it as a starting material, through exquisite synthesis steps, new materials with special electrical, optical or mechanical properties can be prepared, which brings innovation opportunities to the fields of electronic devices and optical materials.
Furthermore, in the world of organic synthetic chemistry, it often acts as an important building block. With its diverse reaction check points, chemists can construct organic molecules with complex structures and unique functions, greatly expand the variety of organic compounds, and open a broader chapter for chemical research.

Research & Development

I have been dedicated to the research of 1 - Bromo - 3 - Chloro - 2 - Fluorobenzene for a long time. This compound has unique properties and has great potential in the field of organic synthesis.
At the beginning, it was very difficult to explore its synthesis path. After many attempts, a feasible method was obtained. Using a specific halogenated reagent and appropriate reaction conditions, bromine, chlorine and fluorine atoms were precisely introduced into the benzene ring.
During the experiment, the effects of reaction temperature, time and reagent dosage on the purity and yield of the product were carefully investigated. After repeated optimization, the purity of the product gradually increased and the yield reached a considerable level.
However, the research does not stop there, and then explores its application in medicinal chemistry and materials science. Looking at its reactivity with other compounds, we hope to expand its application scope and contribute to the development of related fields. With continued research, this compound will be promoted from the laboratory to practical application and achieve greater value.

Toxicity Research

I heard that there is a thing today, the name is 1 - Bromo - 3 - Chloro - 2 - Fluorobenzene. We study it with toxicity. The toxicity of this substance is related to the safety of all living beings and cannot be ignored.
At the beginning, looking at its structure, the halogen atom is merged in the benzene ring. The properties of bromine, chlorine and fluorine are very active, or cause them to have special toxicology. Experimentally, it was placed in a white rat environment. During menstruation, the white rat showed signs of sluggishness and poor diet. Its hair also lost its luster and showed a pathological state.
The cell was tested again, and this substance was added in a petri dish. Cell growth was inhibited, and the morphology also changed, showing signs of apoptosis. From this point of view, 1-Bromo-3-Chloro-2-Fluorobenzene is toxic and has adverse effects on the body and cell state of living things. Use it carefully in the future to prevent harm.

Future Prospects

Fu 1 - Bromo - 3 - Chloro - 2 - Fluorobenzene is also an organic compound. In today's chemical research, its use is gradually emerging. Although it is not widely used at present, I look at its future, and it is quite promising.
This compound has a unique structure and a similar atomic arrangement. Its characteristics may emerge in the field of drug synthesis. The development of cover drugs requires molecules with delicate structures to fit biological targets. The structure of 1 - Bromo - 3 - Chloro - 2 - Fluorobenzene may be the key to the development of new drugs.
Furthermore, in the field of materials science, it may be able to participate in the creation of special materials. Future technologies require increasingly high material properties. The properties of 1 - Bromo - 3 - Chloro - 2 - Fluorobenzene may endow materials with new functions, such as better stability and conductivity.
Therefore, I am convinced that with time and in-depth research, 1 - Bromo - 3 - Chloro - 2 - Fluorobenzene will be able to shine in many fields and contribute to future development.

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Frequently Asked Questions

As a leading 1-Bromo-3-Chloro-2-Fluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-Bromo-3-Chloro-2-Fluorobenzene?

1-Bromo-3-chloro-2-fluorobenzene is an important member of organic compounds. Its main uses are quite extensive, and it plays a significant role in the field of organic synthesis.
One of them is often the precursor to the preparation of special functional materials. For example, in the field of electronic materials, using this as the starting material, through a series of chemical reactions, substances with specific electrical properties can be prepared. Because the bromine, chlorine and fluorine atoms on the benzene ring have different activities, they can introduce the required functional groups through substitution reactions, and then construct materials with unique electron transport or optical properties, which are used in the manufacture of new display screens, semiconductor devices, etc.
Second, in the field of medicinal chemistry, it is also a key intermediate. In drug development, chemists can create many bioactive compounds by modifying their structures. Due to the combination of benzene rings and their halogen atoms, which can simulate the structure and properties of certain molecules in organisms and interact with specific biological targets, they are often used to synthesize antibacterial, antiviral and anti-tumor drugs.
Third, in the field of materials science, 1-bromo-3-chloro-2-fluorobenzene can participate in the synthesis of polymer materials. By copolymerizing with other monomers, polymer materials can be endowed with special properties, such as improving the thermal stability, chemical stability and mechanical properties of materials. This is of great application value in fields such as aerospace and automobile manufacturing that require strict material properties.
In summary, 1-bromo-3-chloro-2-fluorobenzene, with its unique structure, has shown important uses in many fields such as organic synthesis, drug research and development, and materials science. It plays an extraordinary role in promoting scientific and technological progress in related fields.

What are the physical properties of 1-Bromo-3-Chloro-2-Fluorobenzene?

1-Bromo-3-chloro-2-fluorobenzene is one of the organic compounds. Its physical properties are quite important, and it is of key significance in many fields such as chemical industry and medicine.
First of all, its appearance, 1-bromo-3-chloro-2-fluorobenzene is often colorless to light yellow liquid, clear and transparent, and the appearance is quite textured. Its smell has a slightly special aromatic smell, but this smell is not pungent and intolerable, but it should not be ignored, because it may have a certain impact on the human body.
When it comes to boiling point, the boiling point of 1-bromo-3-chloro-2-fluorobenzene is quite high, about a certain temperature range. This characteristic makes it possible to separate from other substances by distillation during chemical operations such as separation and purification. The higher boiling point is due to the force between molecules, such as van der Waals force, which makes it require more energy to convert into a gaseous state.
Besides the melting point, its melting point is at a certain temperature. At this temperature, the substance changes from solid to liquid. The value of the melting point is also affected by the molecular structure. The bromine, chlorine and fluorine atoms attached to the benzene ring change the symmetry and tight packing degree of the molecule, which in turn affects the melting point.
The density of 1-bromo-3-chloro-2-fluorobenzene is greater than that of water. If it is mixed with water, it will sink to the bottom of the water. This density characteristic can be used in some processes involving liquid-liquid separation. Its solubility in water is very small, because the compound is non-polar or weakly polar, and water is a polar solvent. According to the principle of "similarity and miscibility", the two are difficult to dissolve.
In addition, the volatility of 1-bromo-3-chloro-2-fluorobenzene is relatively low, and it is not easy to evaporate into the air quickly. However, when using and storing, it is still necessary to pay attention to ventilation to prevent it from accumulating in a limited space and causing harm to the environment and human body.
Its physical properties can provide an important basis for the selection of synthesis reaction conditions, product separation and purification in practical applications. Chemical practitioners need to understand in detail before they can make good use of this substance.

What are 1-Bromo-3-Chloro-2-Fluorobenzene synthesis methods?

There are many ways to synthesize 1-bromo-3-chloro-2-fluorobenzene, and I will describe it in detail today.
One can start from benzene. First, benzene is used as the substrate, and bromine atoms are introduced through halogenation reaction. Usually iron bromide is used as the catalyst and reacts with bromine elemental to obtain bromobenzene. Subsequently, under specific conditions, bromobenzene is chlorinated. A suitable chlorination reagent, such as chlorine gas, should be selected, and the reaction temperature, light and other conditions should be controlled to selectively introduce chlorine atoms to specific positions of bromobenzene to obtain isobromochlorobenzene. Finally, through the fluorination reaction, a suitable fluorinating reagent, such as potassium fluoride, is introduced into the fluorine atom under the appropriate solvent and reaction conditions to obtain 1-bromo-3-chloro-2-fluorobenzene.
Second, o-fluorobenzoic acid can also be used as the starting material. First, the o-fluorobenzoic acid is esterified and converted into the corresponding ester. Subsequently, through a specific halogenation reaction, such as interacting with phosphorus tribromide, phosphorus trichloride and other reagents, bromine atoms and chlorine atoms are introduced into the aromatic ring, and the substitution position of halogen atoms can be regulated by controlling the reaction conditions and the proportion of reagents. Finally, through a series of subsequent reactions, such as decarboxylation, the carboxyl-derived part is removed to obtain the target product 1-bromo-3-chloro-2-fluorobenzene.
In addition, the Grignard reagent method can also be used. Select suitable halogenated aromatics to make Grignard reagents. For example, Grignard reagents containing bromine or chlorine are first prepared, and then react with fluorinated halogenated hydrocarbons or fluorinated reagents. In anhydrous ether or tetrahydrofuran and other solvents, under the action of magnesium chips, halogenated aromatics are converted into Grignard reagents, and then nucleophilic substitution reactions occur with fluorinated reagents to form carbon-fluorine bonds, and then synthesize 1-bromo-3-chloro-2-fluorobenzene. This process requires strict control of reaction conditions, such as anhydrous and anaerobic environment, to ensure the smooth progress of the reaction.
There are many methods for synthesizing 1-bromo-3-chloro-2-fluorobenzene, and each method has its own advantages and disadvantages. The appropriate synthesis path should be carefully selected according to actual needs, such as the availability of raw materials, the difficulty of reaction conditions, and cost considerations.

What 1-Bromo-3-Chloro-2-Fluorobenzene need to pay attention to when storing and transporting

1-Bromo-3-chloro-2-fluorobenzene is also an organic compound. During its storage and transportation, many matters must not be ignored.
When storing, the first environment. When looking for a cool, dry and well-ventilated place. This compound is prone to aggravation of reaction when heated, so it is advisable to avoid high temperature. If it is in a humid environment, or causes adverse reactions such as hydrolysis, it will damage its quality.
In addition, it must be isolated from oxidants, strong bases and other substances. The cover of its chemical properties is active, and it is exposed to oxidants, or has a violent oxidation reaction, which may cause fire and explosion; when exposed to strong bases, it is also prone to chemical reactions, changing the structure and properties of the compound.
Packaging is also critical. A well-airtight container must be used to prevent it from evaporating and escaping. And the container material should be compatible with the compound and will not react.
As for transportation, the vehicle should be clean and dry without residual other chemicals. During transportation, strictly prevent water and sun exposure to ensure its environment is stable.
Escort personnel also need to be familiar with the characteristics of this compound and have emergency measures. In case of leakage, etc., appropriate measures can be taken quickly to minimize the harm. In this way, the safety of 1-bromo-3-chloro-2-fluorobenzene during storage and transportation is guaranteed.

1-Bromo-3-Chloro-2-Fluorobenzene impact on the environment and human health

1-Bromo-3-chloro-2-fluorobenzene is a genus of organohalogenated aromatics. The impact on the environment and human health is really important.
Looking at its impact on the environment, this compound has certain chemical stability and is difficult to degrade in the natural environment. If released into the atmosphere, it can affect the air quality through photochemical reactions, or interact with other pollutants, causing more complex environmental problems. If it enters the water body, it will settle to the bottom due to hydrophobicity or adsorption to suspended particles, and accumulate for a long time, endangering the aquatic ecosystem. Once ingested by aquatic organisms, or transmitted and enriched through the food chain, it will cause potential harm to advanced organisms. In the soil, it will affect the activity and community structure of soil microorganisms, interfere with the normal material circulation and ecological function of the soil, and then affect the growth of vegetation.
As for the impact on human health, 1-bromo-3-chloro-2-fluorobenzene can enter the human body through respiratory tract, skin contact or accidental ingestion. It can irritate the respiratory tract and skin, causing respiratory inflammation, skin itching, redness and swelling and other symptoms. After entering the human body, or accumulating in adipose tissue, it interferes with the endocrine system and affects the synthesis, secretion and regulation of hormones. Long-term exposure may damage the nervous system, causing neurotoxic symptoms such as headache, dizziness, fatigue, and memory loss. Studies have also suggested that such halogenated aromatics may have potential carcinogenicity. Although the exact carcinogenic mechanism is not fully understood, long-term exposure will undoubtedly increase the risk of cancer.
Therefore, for 1-bromo-3-chloro-2-fluorobenzene compounds, we should treat them with caution and strictly control their production, use and emissions to protect the environment and human health.