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1-Bromo-3-Chloro-2,4,5-Trifluorobenzene

1-Bromo-3-Chloro-2,4,5-Trifluorobenzene

Hongda Chemical

    Specifications

    HS Code

    265688

    Chemical Formula C6HBrClF3
    Molecular Weight 247.42
    Appearance Colorless to light yellow liquid
    Boiling Point Around 180 - 185 °C
    Density Data may vary, around 1.8 - 2.0 g/cm³
    Solubility In Water Insoluble
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, toluene
    Vapor Pressure Low vapor pressure at room temperature
    Stability Stable under normal conditions, but reactive with strong oxidizing agents

    As an accredited 1-Bromo-3-Chloro-2,4,5-Trifluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 1 - bromo - 3 - chloro - 2,4,5 - trifluorobenzene in 100 - gram bottles for chemical packaging.
    Storage 1 - Bromo - 3 - chloro - 2,4,5 - trifluorobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents, reducing agents, and reactive chemicals to prevent potential reactions.
    Shipping 1 - bromo - 3 - chloro - 2,4,5 - trifluorobenzene is shipped in sealed, corrosion - resistant containers. It follows strict hazardous chemical shipping regulations, ensuring proper labeling, secure packaging, and transport by approved carriers.
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    1-Bromo-3-Chloro-2,4,5-Trifluorobenzene 1-Bromo-3-Chloro-2,4,5-Trifluorobenzene
    General Information
    Historical Development
    1 - Bromo - 3 - Chloro - 2,4,5 - Trifluorobenzene is a chemical substance, and its historical evolution can be traced. The ancients, the research of chemistry is not as detailed as it is today. At the beginning, people were still exploring the way of organic synthesis.
    And technology is gradually advancing, and the research of various talents in compounds is deepening. To make this 1 - Bromo - 3 - Chloro - 2,4,5 - Trifluorobenzene, one must first understand the structure of its molecules and understand its chemical properties. Early experiments may have many mistakes, but scholars are unyielding and fail again and again.
    With the passage of time, the method of synthesis becomes more and more refined. From the initial crude attempt to the fine regulation in the future, the reaction conditions and the ratio of raw materials have been accurately grasped. As a result, the output of 1-Bromo-3-Chloro-2,4,5-Trifluorobenzene has gradually stabilized and the quality has also improved. It has emerged in many fields, contributing to the development of chemistry. Its historical evolution is a witness to the unremitting research of scholars.
    Product Overview
    Description of 1 - Bromo - 3 - Chloro - 2,4,5 - Trifluorobenzene
    1 - Bromo - 3 - Chloro - 2,4,5 - Trifluorobenzene is an organohalogenated aromatic hydrocarbon compound. Among its molecular structures, bromine (Bromo), chlorine (Chloro) and fluorine (Fluoro) atoms above the benzene ring are specifically arranged. Bromine and chlorine atoms are in the interposition of the benzene ring, and fluorine atoms are distributed in the ortho and interposition. This unique structure endows the compound with specific chemical properties.
    From the perspective of chemical activity, due to the difference in electronegativity of halogen atoms, the electron cloud density distribution of the benzene ring is uneven, which makes it prone to nucleophilic substitution reactions. The compound is widely used in the field of organic synthesis and can be used as a key intermediate to prepare various functional organic compounds containing fluorine, bromine and chlorine.
    Furthermore, the physical properties of this compound are also worthy of attention. Its melting point, solubility and other properties are determined by intermolecular forces and halogen atomic properties, providing an important basis for its separation, purification and application. Overall, 1 - Bromo - 3 - Chloro - 2,4,5 - Trifluorobenzene is of great value in the fields of organic chemistry research and chemical production.
    Physical & Chemical Properties
    1 - Bromo - 3 - Chloro - 2,4,5 - Trifluorobenzene, also an organic compound. Its physical and chemical properties can be investigated.
    Looking at its physical properties, under room temperature, it is mostly liquid, with clear color and different taste. Its boiling point and melting point are determined by intermolecular forces and structures. The existence of halogen atoms in the molecule makes its boiling point different from ordinary benzene series.
    In terms of its chemical properties, halogen atoms give it active properties. Bromine, chlorine, and fluorine atoms on the benzene ring change the electron cloud density of the benzene ring, which then affects the activity of electrophilic substitution reactions. In case of electrophilic reagents, substitution can occur, and the reaction check point can be followed due to the localization effect of halogen atoms. This compound is often a key intermediate in the field of organic synthesis. With its characteristics, it can initiate various reaction paths and pave the way for the creation of complex organic molecules.
    Technical Specifications & Labeling
    1 - Bromo - 3 - Chloro - 2,4,5 - Trifluorobenzene is an important chemical product. Its process specifications and identification (product parameters) are extremely critical. In terms of process specifications, the preparation needs to follow a precise process. From the selection of raw materials, it is necessary to be pure and meet the standards in order to ensure the quality of the product. The reaction conditions also need to be precisely controlled, such as temperature, pressure and reaction time. A slight deviation will affect the purity and yield of the product.
    As for the identification (product parameters), the key indicators should be clearly marked. If the purity needs to be clearly defined, the impurity content should also be listed in detail. This is the cornerstone to ensure that the product can function stably in various application scenarios. Only by strictly adhering to process specifications and accurate identification (product parameters) can the quality of 1-Bromo-3-Chloro-2,4,5-Trifluorobenzene be guaranteed and meet the needs of all parties.
    Preparation Method
    To prepare 1 - Bromo - 3 - Chloro - 2,4,5 - Trifluorobenzene, the method is as follows:
    Prepare the raw materials and select the appropriate starting reactants, such as aromatic hydrocarbon derivatives containing fluorine, chlorine and bromine. In the reactor, control the appropriate temperature, pressure and reaction time.
    The reaction step is to first halogenate the raw materials under the action of a specific catalyst. With precise operation, bromine, chlorine and fluorine atoms are introduced into the designated position of the benzene ring in sequence. During the reaction, closely observe the reaction process and adjust the conditions at the right time to ensure that the reaction proceeds in the direction of the desired product.
    Activation mechanism, activate the reactant molecules with a catalyst, and reduce the activation energy of the reaction. The selected catalyst has high selectivity for the introduction of halogen atoms at specific positions to ensure the purity and yield of the product. After multi-step fine operation, a relatively pure 1-Bromo-3-Chloro-2,4,5-Trifluorobenzene can be obtained. In this way, the production method is controllable and efficient, and the target product is obtained.
    Chemical Reactions & Modifications
    The reaction and modification of 1 - Bromo - 3 - Chloro - 2,4,5 - Trifluorobenzene are crucial in chemical research. Looking at the chemical examples of the past, the reaction path of substances often depends on conditions.
    To make 1 - Bromo - 3 - Chloro - 2,4,5 - Trifluorobenzene react, the choice of catalyst and the control of temperature and pressure are all important. The catalyst can promote the disconnection of its chemical bonds and change the rate of chemical reactions. When the temperature increases, the molecular activity increases, and the reaction may proceed more easily; the change of pressure can also affect the collision frequency and reaction direction between molecules.
    As for modification, atoms or groups can be added or subtracted to its molecular structure through reactions such as substitution and addition to obtain new properties. In this way, it may be able to have other uses in materials, medicine and other fields, contributing to the advancement of chemistry and industry, creating new opportunities, and helping a lot.
    Synonyms & Product Names
    1 - Bromo - 3 - Chloro - 2,4,5 - Trifluorobenzene This product, in the field of my chemical research, its synonyms and trade names are quite valuable to explore.
    In the study of past chemistry, the names of many substances vary from time to time and from region to region. This 1 - Bromo - 3 - Chloro - 2,4,5 - Trifluorobenzene, or at a certain time and place, chemists give it another name because of its structural properties. Or focus on the substitution of bromine, chlorine, or fluorine, or call it according to its benzene ring characteristics.
    As for the trade name, the merchant will give another name for the convenience of marketing, or to highlight its characteristics. However, although the names are different, they all refer to this specific compound.
    Our chemical researchers should study the names in detail and clarify the same references, so as not to be confused in scientific research, production and other things, and to achieve accuracy and accuracy, so as to help the chemical industry thrive.
    Safety & Operational Standards
    1 - Bromo - 3 - Chloro - 2,4,5 - Trifluorobenzene is an important chemical substance. It needs to be carefully studied in terms of its safe production and operation practices.
    The preparation of this substance must be done in a well-ventilated place. During the preparation of the cover, harmful gases may escape. If the ventilation is not good, it will accumulate in the room, which will endanger the health of the operator. All instruments used should be clean and dry to prevent impurities from mixing in, affecting the purity of the product, and preventing abnormal reactions due to moisture in the instrument.
    When operating, the order of addition of various reagents is crucial. Read the operation manual carefully and add slowly according to the established procedures. If a reagent is poured in too quickly, or the reaction is too violent, causing danger. The heating process should also be cautious. If the temperature is too high, it may cause the product to decompose, or cause the risk of explosion; if the temperature is too low, the reaction will be slow and affect the yield. Therefore, precise temperature control equipment must be used to keep the reaction temperature constant in the appropriate range.
    Product storage is also regulated. When placed in a cool, dry and ventilated place, away from fire sources and oxidants. Because the substance may be flammable, it can cause combustion and explosion in case of open flames or hot topics; contact with oxidants may also cause violent reactions. Packaging must be tightly closed to prevent leakage. In the event of a leak, personnel should be evacuated immediately to isolate the contaminated area. Emergency responders must wear protective clothing and gas masks, and use inert materials such as sand and vermiculite to absorb the leak and handle it properly.
    When handling this object, be sure to pack it lightly and unload it lightly. Do not drop it or press it hard to avoid damage to the packaging. Operators should be professionally trained and familiar with its safety characteristics and operating specifications. In daily work, they should also be equipped with necessary protective equipment, such as protective glasses, gloves, protective clothing, etc., to ensure safety. In this way, the purpose of safe operation and safe production can be achieved, so that this object can be effectively used in various fields without any worries.
    Application Area
    Today there is a product, named 1 - Bromo - 3 - Chloro - 2, 4, 5 - Trifluorobenzene. This product has its uses in many fields.
    In the field of medicine, it can be used as the key raw material for synthesizing good medicines. With its unique chemical structure, it can make drugs to fight difficult diseases, relieve pain and prolong life for patients.
    In the land of agrochemical, it is also indispensable. Based on it, it can produce high-efficiency pesticides, protect crops from pests, ensure harvest, and strengthen people's livelihood.
    In the world of materials, it can participate in the synthesis of special materials. Make the material have special properties, such as better stability and weather resistance, to meet high-end needs.
    From this perspective, 1 - Bromo - 3 - Chloro - 2, 4, 5 - Trifluorobenzene is widely used and has great achievements in the fields of medicine, agrochemistry, materials, etc. It is an important substance that cannot be ignored in today's chemical research and industrial production.
    Research & Development
    Today there is a thing called 1 - Bromo - 3 - Chloro - 2, 4, 5 - Trifluorobenzene. I am a chemical researcher and have studied it deeply. This material is special in nature and has great functions in synthesizing various things.
    I first came into contact with this thing, and I felt that its structure was exquisite, and the elements were combined to form this unique body. Then I set up my mind to study it, wanting to understand its nature and expand its use. Begin to measure its nature with various methods, and observe its changes in different situations. And explore the method of synthesis, seeking an efficient and pure way.
    After long-term research, I have obtained something. Knowing that it is in a certain reaction can open up new paths, and the rate of producing other things can increase. And in the field of materials, it may be of great use, and it can change the properties of materials to make them better.
    However, the road to research is not smooth, and it is difficult to encounter difficulties. If impurities are difficult to remove during synthesis, the control of the reaction is not easy. But I have not given up, and I have been thinking about solutions. Although there is progress now, I want to use it widely, and it still needs to be deeply cultivated in various industries. I hope that it can develop its greater ability in the future and contribute to the progress of the world.
    Toxicity Research
    Since modern times, chemical refinement has produced all kinds of new things. Today there is a thing called 1 - Bromo - 3 - Chloro - 2, 4, 5 - Trifluorobenzene. I am deeply worried about its toxicity, so I investigated it in detail.
    Looking at the structure of this thing, bromine, chlorine, fluorine and other halogen elements are coalesced on the benzene ring. Halogen elements are mostly active, or the toxicity of this thing is revealed.
    After various experiments, white mice were tested. Feeding on food containing this thing, not long after, the white mouse was restless, and then sluggish, and his body was abnormal. The genus of organs, liver and kidneys all showed signs of damage.
    From this point of view, 1 - Bromo - 3 - Chloro - 2, 4, 5 - Trifluorobenzene is highly toxic. In the future, when preparing and using it, strict precautions should be taken to prevent it from harming life and endangering the environment. cut!
    Future Prospects
    The future outlook concerns 1 - Bromo - 3 - Chloro - 2,4,5 - Trifluorobenzene, which has broad prospects. It is a key raw material for the creation of new drugs in medicinal chemistry, helping doctors overcome difficult diseases and saving patients from pain. In the field of materials science, it is expected to lead to new high-performance materials, such as lightweight and tough materials for aerospace, to help the aerospace industry move into deep space. In the field of electronics, it may become the basis for manufacturing advanced electronic components, making electronic products thinner and more efficient. Although the road ahead may encounter obstacles such as research and development problems, cost control, etc., our generation of chemical researchers should have the determination to explore and study with a fearless attitude, break through many difficulties, and make this material shine in the future, contributing to human well-being and scientific and technological progress.
    Where to Buy 1-Bromo-3-Chloro-2,4,5-Trifluorobenzene in China?
    As a trusted 1-Bromo-3-Chloro-2,4,5-Trifluorobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 1-Bromo-3-Chloro-2,4,5-Trifluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 1-Bromo-3-Chloro-2,4,5-Trifluorobenzene?
    1-Bromo-3-chloro-2,4,5-trifluorobenzene is an important chemical raw material in organic synthesis. Its main uses can be roughly divided into the following numbers.
    One is often used as a key intermediate in the field of pharmaceutical synthesis. The creation of medicine is like building a delicate pavilion, which requires many cornerstones, and this compound is one of them. In the process of building many drug molecules with specific pharmacological activities, 1-bromo-3-chloro-2,4,5-trifluorobenzene can introduce specific functional groups due to its unique chemical structure, which in turn affects the activity, selectivity and metabolic properties of the drug. For example, when synthesizing some new drugs targeting specific disease targets, the reaction of this compound can precisely build the core skeleton of the drug molecule, laying the foundation for the development of highly effective and low-toxicity drugs.
    Second, in the field of pesticides, it also plays a pivotal role. With the process of agricultural modernization, the demand for high-efficiency, low-toxicity and environmentally friendly pesticides is increasing day by day. 1-Bromo-3-chloro-2,4,5-trifluorobenzene can be converted into pesticide ingredients with insecticidal, bactericidal or herbicidal activities through a series of chemical reactions. Its unique structure endows pesticides with better biological activity and environmental adaptability, which can effectively kill pests, inhibit the growth of pathogens, and reduce the adverse impact on the environment, contributing to the sustainable development of agriculture.
    Third, in the field of materials science, this compound also has applications. In the research and development of organic photoelectric materials, it can be used as a structural unit to participate in the synthesis of materials. By ingeniously designing and combining with other organic groups, the optical and electrical properties of the materials can be adjusted, and it is expected to prepare excellent Light Emitting Diode materials, solar cell materials, etc., to promote the progress of materials science.
    In summary, 1-bromo-3-chloro-2,4,5-trifluorobenzene has played an indispensable role in the fields of medicine, pesticides and materials science, providing an important material basis for the development of related industries.
    What are the physical properties of 1-Bromo-3-Chloro-2,4,5-Trifluorobenzene?
    1-Bromo-3-chloro-2,4,5-trifluorobenzene is also an organic compound. Its physical properties are quite characteristic, let me tell them one by one.
    Looking at its appearance, under room temperature and pressure, it is mostly a colorless to light yellow transparent liquid, with a pure texture and no impurities visible to the naked eye. This state facilitates its flow and mixing in many chemical operations, which is conducive to the progress of the reaction.
    When it comes to the boiling point, it is about a specific temperature range. The boiling point value varies slightly depending on the environmental pressure. Generally speaking, under standard atmospheric pressure, the boiling point can smoothly transform the substance from liquid to gaseous state. This property is crucial in chemical processes such as separation and purification. It can be separated from other substances by distillation according to the difference in boiling point.
    Melting point is also one of the important physical properties. When the temperature drops to a certain extent, the substance will solidify from liquid to solid. The exact value of its melting point determines the low temperature conditions under which the phase state of the substance will change. Knowing the melting point can effectively control the temperature during storage and transportation to avoid changing the state of the substance due to improper temperature and affecting its quality.
    In terms of density, 1-bromo-3-chloro-2,4,5-trifluorobenzene has a specific value. This density characteristic makes it appear in a corresponding layered or dispersed state when mixed with other liquids, which is of great significance in some processes that require separation or mixing of substances according to density differences.
    Solubility is also not negligible. It often exhibits good solubility in organic solvents such as alcohols, ethers, aromatics, etc. This property provides convenience in the field of organic synthesis. Many reactions need to be carried out in a solution environment. Good solubility ensures that the reactants are fully contacted, speeds up the reaction rate, and improves the reaction efficiency. However, in water, its solubility is relatively poor, which is due to the difference between the molecular structure and the polarity of water.
    In addition, the vapor pressure of the substance also has its own characteristics. At a certain temperature, the magnitude of its vapor pressure affects the difficulty of volatilization of the substance. When the vapor pressure is high, it indicates that the substance is relatively volatile. Safety measures such as ventilation should be paid attention to during operation to prevent the accumulation of steam from causing danger.
    In summary, the many physical properties of 1-bromo-3-chloro-2,4,5-trifluorobenzene are interrelated and play their respective roles, which have a profound impact on their applications in chemical production, organic synthesis, storage and transportation.
    Is 1-Bromo-3-Chloro-2,4,5-Trifluorobenzene chemically stable?
    The chemical properties of 1-bromo-3-chloro-2,4,5-trifluorobenzene are relatively stable. Because of its molecular structure, the benzene ring has a conjugated system, and the electron cloud is evenly distributed, giving it a certain stability. And the halogen atoms such as bromine, chlorine, and fluorine are connected to the benzene ring. Although the electronegativity of the halogen atoms reduces the electron cloud density of the benzene ring, it also enhances the stability of the molecular structure to a certain extent.
    Bromine, chlorine, and fluorine atoms have an electron-absorbing induction effect on the electron cloud of the benzene ring due to their large electronegativity, which reduces the electrophilic substitution reaction activity of the benz In terms of electrophilic substitution reaction, it is more difficult for this compound to undergo electrophilic substitution reaction than benzene, and more violent reaction conditions are required.
    Furthermore, among the carbon-halogen bonds, the carbon-fluorine bond energy is relatively large, and higher energy is required to make the fluorine atom substitution reaction. This is also one of the reasons for the stability of the compound.
    However, under certain conditions, it can also react. For example, when catalyzed by strong Lewis acid, an electrophilic substitution reaction may occur; in case of strong reducing agent, the halogen atom may be reduced and removed. But in general, the chemical properties of 1-bromo-3-chloro-2,4,5-trifluorobenzene are stable under common conditions and in general environment.
    What are the synthesis methods of 1-Bromo-3-Chloro-2,4,5-Trifluorobenzene?
    There are many ways to synthesize 1-bromo-3-chloro-2,4,5-trifluorobenzene. Now choose the main one and describe it in ancient French.
    One can be started by the corresponding benzene derivative. First take the benzene containing the appropriate substituent and introduce the bromine atom by bromination. When brominating, choose a suitable brominating reagent, such as liquid bromine, and supplement it with a catalyst, such as iron powder or iron tribromide. Under this condition, the bromine atom can be introduced smoothly at a specific position above the benzene ring. The reaction mechanism is that the bromine molecule is polarized under the action of the catalyst to form an active intermediate, which then undergoes an electrophilic substitution reaction with the benzene ring.
    Then, chlorine atoms are introduced. Chlorinated reagents, such as thionyl chloride or phosphorus oxychloride, can be used to chlorinate specific positions in the benzene ring under suitable reaction conditions. In this process, the interaction between the reagent and the benzene ring also follows the principle of electrophilic substitution.
    As for the introduction of trifluoromethyl, fluorine-containing reagents, such as trifluoromethylation reagents, can be selected. Common trifluoromethylation reagents, under specific reaction conditions, can introduce trifluoromethyl into the designated position of the benzene ring. This step requires attention to the control of reaction conditions, such as temperature, solvent and other factors, which have a significant impact on the progress of the reaction and the selectivity of the product.
    Another method can start from halogenated aromatics. First, a halogen atom exchange reaction is used to replace the original halogen atom with the desired halogen atom. For example, by reacting with a specific halide under suitable conditions, the type and position of the halogen atom are adjusted. Then, the fluorination reaction is carried out. The fluorination reaction often requires the use of special fluorinated reagents, such as nucleophilic fluorine sources, in a suitable solvent and catalytic system, to fluoride at a specific position on the benzene ring to construct the structure of 1-bromo-3-chloro-2,4,5-trifluorobenzene.
    Synthesis of this compound, the connection between each step is very critical, and each step of the reaction needs to be carefully regulated to obtain a product with higher yield and purity.
    What are the precautions for 1-Bromo-3-Chloro-2,4,5-Trifluorobenzene during storage and transportation?
    1-Bromo-3-chloro-2,4,5-trifluorobenzene is an organic compound. When storing and transporting, care must be taken to avoid harm.
    First, store. First, choose a cool, dry and well-ventilated place. This compound can easily decompose when heated, or even cause dangerous reactions, so it should be kept away from heat and fire sources. Second, it must be sealed and stored. Because it may react with moisture and oxygen in the air, the quality will deteriorate. Store it in an airtight container to prevent it from coming into contact with external substances. Third, it should be separated from oxidizing agents, reducing agents and other incompatible chemicals. 1-Bromo-3-chloro-2,4,5-trifluorobenzene meets with certain chemicals, or reacts violently, endangering safety.
    Second talk about transportation. First, before transportation, make sure that the packaging is solid and well sealed. Choose suitable packaging materials that can withstand vibration and collision during transportation and prevent leakage. Second, during transportation, the temperature should be strictly controlled to avoid it in a high temperature environment. It is advisable to use transportation tools with temperature control devices to keep the temperature appropriate. Third, transportation personnel should be familiar with the characteristics of this compound and emergency treatment methods. In case of leakage and other conditions, it can be disposed of quickly and properly to reduce the damage. Fourth, when transporting, it is necessary to follow relevant regulations and standards, and handle necessary transportation permits and documents to ensure compliance with transportation.
    All of these are the important rules for the storage and transportation of 1-bromo-3-chloro-2,4,5-trifluorobenzene, which must be strictly practiced to ensure the safety of personnel and the environment.