1-Bromo-3,5-bis (trifluoromethyl) benzene, an important raw material for organic synthesis, is widely used in many fields.
First, in the field of medicinal chemistry, it is often a key intermediate. Organic compounds containing trifluoromethyl often have unique physical, chemical and biological activities. Using it as a starting material, through multiple steps of exquisite chemical reactions, molecules with complex structures and specific pharmacological activities can be constructed. For example, it can be used to synthesize antibacterial and antiviral drugs, because the introduction of trifluoromethyl can significantly change the lipophilicity and metabolic stability of the compound, thereby enhancing the affinity between the drug and the target and enhancing the efficacy.
Second, in the field of materials science, it also plays an important role. It can be used to prepare functional polymer materials. By polymerizing with other monomers, trifluoromethyl and bromine atoms are introduced into the polymer chain, which can endow the material with special properties. Such as the preparation of materials with excellent weather resistance, chemical stability and low surface energy, such materials are of great application value in industries that require strict material properties such as aerospace and automobile manufacturing.
Third, in the field of pesticide chemistry, 1-bromo-3,5-bis (trifluoromethyl) benzene can be used as an important building block for the synthesis of new pesticides. With the help of rational molecular design and chemical modification, the synthesized pesticides may have the characteristics of high efficiency, low toxicity, and environmental friendliness, which is of great benefit to pest control and crop protection.
In short, 1-bromo-3,5-bis (trifluoromethyl) benzene has shown important application value in many fields such as medicine, materials, and pesticides due to its unique chemical structure, promoting technological innovation and development in various fields.

1-Bromo-3,5-bis (trifluoromethyl) benzene is one of the organic compounds. It has unique physical properties, let me tell you one by one.
Looking at its properties, under room temperature, 1-bromo-3,5-bis (trifluoromethyl) benzene is often colorless to light yellow transparent liquid. This state is convenient for it to flow and mix in many chemical reaction systems, and it can participate in various reaction steps smoothly in the chemical synthesis process.
When it comes to the melting point, it is about -19 ° C. The lower melting point indicates that the substance is easy to change from solid to liquid in a relatively low temperature environment. This property makes it easier to achieve uniform dispersion and contact of the material at a specific initial stage of the reaction, which is of great significance for some reactions that need to be opened in the low temperature molten state. The boiling point of
is about 172-174 ° C. This boiling point value reveals that it will change from liquid to gaseous when heated to this temperature range at atmospheric pressure. This boiling point characteristic determines its application in chemical operations such as separation and purification. For example, it can be separated from other substances with different boiling points by distillation according to the difference in boiling points.
Its density is about 1.83 g/cm ³, which is heavier than water. If mixed with water, it will sink at the bottom of the water. This density characteristic provides an important basis for discrimination and separation in operations involving liquid-liquid separation.
1-Bromo-3,5-bis (trifluoromethyl) benzene is insoluble in water, but soluble in common organic solvents such as ether, dichloromethane, tetrahydrofuran, etc. This solubility characteristic allows it to flexibly select suitable organic solvents according to the reaction requirements in the field of organic synthesis, build a reaction environment, and promote the reaction.
In addition, its vapor pressure has a specific value at a certain temperature. The existence of vapor pressure indicates that some molecules will escape from the liquid surface to form steam in a confined space. This property is closely related to the volatilization characteristics of the substance. It has important reference value for the setting of environmental ventilation and other conditions in storage and use.

The chemical stability of 1-bromo-3,5-bis (trifluoromethyl) benzene depends on many factors and cannot be generalized.
In this substance, the bromine atom is connected to the benzene ring, which is a conjugated system and has certain stability. However, the bromine atom can participate in reactions such as nucleophilic substitution because it can be used as a leaving group. If there is a nucleophilic reagent attack, the bromine atom may be replaced. The difficulty of this reaction depends on the activity of the nucleophilic reagent and the reaction conditions.
Looking at the trifluoromethyl on its benzene ring, this is a strong electron-absorbing group, which can reduce the electron cloud density of the benzene ring, reduce the electrophilic substitution activity of the benzene ring, and make it difficult to occur electrophilic substitution. On the other hand, the existence of trifluoromethyl may affect the molecular space structure and electron distribution, and also have an effect on the activity of bromine atoms.
In common organic solvents, 1-bromo-3,5-bis (trifluoromethyl) benzene may have a certain solubility, and this solubility also affects its chemical behavior. In case of high temperature, light and other conditions, or cause free radical reactions, etc., its chemical properties change.
Overall, the chemical properties of 1-bromo-3,5-bis (trifluoromethyl) benzene are relatively stable under specific conditions. However, under suitable reaction conditions and reagents, various chemical reactions can still occur, which is not absolutely stable.

The preparation methods of 1-bromo-3,5-bis (trifluoromethyl) benzene are ancient and diverse. The details are as follows:
First, 3,5-bis (trifluoromethyl) aniline is used as the starting material. The aniline is first diazotized with sodium nitrite and hydrobromic acid in a low temperature environment. This reaction needs to be carefully controlled to ensure that the temperature of the reaction system is maintained in a suitable range, generally at 0-5 ° C. After the diazotization reaction, the resulting diazonium salt is then replaced by a reducing agent such as hypophosphoric acid, so that the diazonium group is replaced by a bromine atom, and finally 1-bromo-3,5-bis (trifluoromethyl) benzene is obtained. The key to this method lies in the precise control of the temperature during the diazotization reaction. If the temperature is too high, the diazonium salt is easy to decompose, resulting in impure products and reduced yield.
Second, 3,5-bis (trifluoromethyl) benzoic acid is used as the starting material. First, it is converted into the corresponding acid chloride. Commonly used chlorinating reagents such as dichlorosulfoxide are used. The two are heated and refluxed in an appropriate solvent such as toluene to obtain the acid chloride. The acid chloride is then reacted with halogenated reagents such as cuprous bromide under specific conditions to convert the carboxyl group into a bromine atom, thereby obtaining the target product. In this process, the preparation of the acid chloride needs to pay attention to the sealing of the reaction device to prevent the escape of chlorinated reagents, and the excess chlorinated reagents and solvents need to be
Third, m-bis (trifluoromethyl) benzene is used as raw material. In the presence of suitable catalysts such as iron or ferric chloride, it undergoes an electrophilic substitution reaction with bromine. In this reaction, the amount of catalyst and reaction temperature have a great influence on the selectivity of the product. Generally speaking, an appropriate amount of catalyst can speed up the reaction rate, but too much may lead to the formation of polybrominated by-products. The reaction temperature also needs to be strictly controlled. Usually within a certain temperature range, increasing the temperature can speed up the reaction, but too high temperature can easily lead to side reactions, resulting in a decrease in the purity of the product. By carefully adjusting the reaction conditions, bromine atoms can selectively replace hydrogen atoms at specific positions on the benzene ring to obtain 1-bromo-3,5-bis (trifluoromethyl) benzene.

The market price of 1-bromo-3,5-bis (trifluoromethyl) benzene varies depending on the quality, source, purchase quantity and market supply and demand.
In the chemical raw material market, if it is an ordinary industrial grade with a purity of about 95%, when the bulk purchase volume is 100-500 kg, the price per kilogram may be in the range of 500-800 yuan. This is because the industrial grade product has slightly more impurities, it can meet most general industrial synthesis needs, and the price is relatively close to the people.
If it is of high purity, up to 98% or more, it is mostly used in pharmaceutical research and development or high-end electronic chemicals. When the purchase volume is 10-50 kg, the price per kilogram may rise to 1000-1500 yuan. Because of its strict requirements on purity and complex preparation process, the price is high.
In addition, if the purchase quantity is very small, only a few grams to hundreds of grams, used in laboratory research and development stage, often sold in bottles, the price of each bottle (such as 25 grams) may be 500-1000 yuan, and the average price per kilogram is as high as 20,000-40,000 yuan. This is due to the high cost of packaging and sales in small quantities.
Market supply and demand also have a significant impact on prices. If demand surges at a certain time and supply is limited, such as when the demand for fluorinated fine chemicals in the electronics industry increases sharply, prices may increase by 10% to 30%. Conversely, if there is a surplus of supply, prices may be lowered accordingly.