1-Bromo-3,4-difluoro-2-methoxybenzene, which has a wide range of uses. In the field of pharmaceutical synthesis, it is often a key intermediate. Due to the specific layout of halogen atoms and methoxy groups on the benzene ring, the molecule is endowed with unique reactivity and spatial structure. It can be connected with other organic fragments through nucleophilic substitution, coupling and other reactions to build complex pharmaceutically active molecules. For example, in the development of some antibacterial and antiviral drugs, it is often relied on to participate in reactions to build a core skeleton with biological activity.
In the field of materials science, it also has extraordinary performance. Due to its fluorine content, fluorine atoms have high electronegativity, which can improve the physical and chemical properties of materials. If used in the synthesis of polymer materials with special properties, it can improve the thermal stability, chemical stability and weather resistance of the material. In the preparation of high-performance coatings, plastics and other materials, the introduction of this compound can make the material have unique surface properties, such as low surface energy, water and oil repellency.
In addition, in the field of fine chemicals, 1-bromo-3,4-difluoro-2-methoxybenzene is also used as an important raw material for the synthesis of special fragrances and additives. With its unique chemical structure and appropriate chemical modification, fragrance ingredients with novel odors can be created, or additives with specific functions for chemical products can be created to meet different industrial and consumer needs.

1-Bromo-3,4-difluoro-2-methoxybenzene is one of the organic compounds. Its physical properties are quite explainable.
First of all, its appearance, at room temperature, is mostly colorless to light yellow liquid, and the appearance is clear, like clear water in a mirror, with a special smell. However, this smell is neither fragrant nor odorous, unique, and the smell can be distinguished from its uniqueness.
When it comes to the melting point, it is between -10 ° C and -5 ° C. If the ambient temperature drops to this area, this substance will gradually condense into solidification, just like the formation of ice in water, and the physical properties will also vary between the morphological changes. The number of boiling points is roughly in the range of 190 ° C to 200 ° C. When heated to this temperature range, the liquid boils and turns into steam, which is the key temperature for its gas-liquid phase transition.
As for the density, it is about 1.6 g/cm ³ or so, which is heavier than water. If it is co-placed with water, it will sink underwater, just like the falling water of a stone, and it is distinct. Its solubility also has characteristics. It can be well miscible in organic solvents such as ethanol and ether, just like the water of a fish, which blends seamlessly. However, in water, the solubility is poor, and the two meet, such as oil and water, and separate from each other.
The physical properties of 1-bromo-3,4-difluoro-2-methoxybenzene are of great significance in organic synthesis and other fields. Because of its morphology, melting boiling point, density and solubility characteristics, it determines its behavior in the reaction. It is also an important basis for related chemical operations and research.

The synthesis of 1-bromo-3,4-difluoro-2-methoxybenzene has attracted much attention in the field of organic synthesis. The following are common methods for synthesizing this compound.
First, 3,4-difluoro-2-methoxyaniline is used as the starting material. The diazonium salt is reacted with sodium nitrite and hydrochloric acid at low temperature to form a diazonium salt. The diazonium salt is abnormally active, and then reacts with cuprous bromide. After the Sandmeier reaction, the diazonium group is replaced by a bromine atom, and then 1-bromo-3,4-difluoro-2-methoxybenzene is obtained. The key to this approach is to control the conditions of the diazotization reaction. Low temperature is the key to ensuring the stability of the diazonium salt, and the amount of cuprous bromide and the reaction time also have a great influence on the yield of the product.
Second, you can start from 3,4-difluorophenol. First, the phenolic hydroxyl group of dimethyl sulfate is methylated to obtain 3,4-difluoroanisole. Then, in the presence of a suitable catalyst such as iron powder or iron tribromide, the electrophilic substitution reaction of 3,4-difluoroanisole with bromine occurs. Due to the fact that the methoxy group is an ortho-para-site group and the influence of factors such as steric hindrance, bromine atoms can be selectively introduced at the ortho-site to obtain 1-bromo-3,4-difluoro-2-methoxybenzene. During this process, the methylation reaction needs to pay attention to the toxicity of dimethyl sulfate, and the operation must be cautious. In the electrophilic substitution reaction, the activity and dosage of the catalyst and the reaction temperature are all related to the purity and yield of the product.
Third, 1-bromo-3,4-difluorobenzene is used as the raw material and reacts with sodium methoxide under alkaline conditions. The nucleophilic anion of sodium methoxide attacks the halogen atom on the benzene ring, and a nucleophilic substitution reaction occurs. The halogen atom is replaced by methoxy group, and the final product is 1-bromo-3,4-difluoro-2-methoxybenzene. This method requires attention to the strength of alkaline conditions. Too strong or too weak may lead to side reactions and affect the formation of products.

1-Bromo-3,4-difluoro-2-methoxybenzene is also an organic compound. When storing it, many matters should be paid attention to.
Bear the brunt, the storage place must be cool and dry. If it is in a warm and humid place, this compound may have a chemical reaction due to changes in humidity and temperature, resulting in damage to its quality. For example, under high temperature, its molecular activity may increase or cause decomposition reactions; in a high-humidity environment, moisture may interact with the compound, resulting in deterioration.
Furthermore, it should be stored in a well-ventilated place. If this compound evaporates gas, the ventilation can allow the gas to escape in time without accumulation. Once the gas accumulates, one may cause the indoor air to be polluted, and the other may cause safety risks due to excessive concentration, such as explosion, poisoning, etc.
In addition, the compound should be kept away from fire sources and oxidants. It has certain chemical activity, and it can cause fire in case of fire, or due to flammability; in case of oxidants, or trigger a violent oxidation reaction, which is unthinkable.
And storage containers are also exquisite, and a well-sealed container is required. If the seal is not good, the compound or in contact with the air, the oxygen, carbon dioxide and other components in the air can react with it, which will damage its purity and properties.
In addition, the storage area should be clearly marked, indicating the name, characteristics and precautions of this thing. In this way, the person who uses or maintains it is clear at a glance, and it can be operated in accordance with regulations to avoid danger.

1 - 溴 - 3,4 - 二氟 - 2 - 甲氧基苯之市场价格，实难确言。此乃因市场价格常随诸多因素变动不居，犹如风云变幻。

其一，供需之势，左右价格甚巨。若此物需求如日中天，求者如过江之鲫，而供给却如凤毛麟角，稀缺非常，则其价必如扶摇直上之风筝，节节攀升。反之，若市场供过于求，堆积如山，无人问津，则价格难免一落千丈，如坠深渊。

其二，生产成本，亦为关键。从原料采买，至生产过程中诸般耗材、人力之投入，皆影响成本。若原料难得，价高且难觅，生产工艺又繁复异常，需众多巧匠精工细作，耗费大量财力物力，则其成本必高，价格自也不菲。

其三，行业竞争，同样不可小觑。若市场之上，生产此物者寥寥无几，如孤星高悬，几近垄断之态，则定价权操于其手，价格或可随心所欲。然若竞争者如繁星密布，各施手段，竞相争夺市场，则为吸引买家，价格或会有所让步，以争一席之地。

其四，宏观经济之形势，亦如无形之手，暗中推动价格变化。经济繁荣之时，百业兴旺，资金充裕，对于此类化工产品需求旺盛，价格或能坚挺上扬。反之，经济衰退之际，百业凋零，需求锐减，价格亦难独善其身，恐将随之下滑。

至于具体之价格，或需亲赴化工产品交易市场，详询各商家；或可于专业化工资讯平台，细查近期报价，方能得较准确之数，然此数亦不过一时之象，非恒常不变者也。