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1-Bromo-3,4,5-Trifluorobenzene

1-Bromo-3,4,5-Trifluorobenzene

Hongda Chemical

Specifications

HS Code

696742

Name 1-Bromo-3,4,5-Trifluorobenzene
Molecular Formula C6H2BrF3
Molecular Weight 225.98
Appearance Colorless to light yellow liquid
Boiling Point 154 - 156 °C
Density 1.747 g/mL at 25 °C
Flash Point 48 °C
Solubility Insoluble in water, soluble in organic solvents like ethanol, ether
Refractive Index 1.472 - 1.474

As an accredited 1-Bromo-3,4,5-Trifluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 1 - bromo - 3,4,5 - trifluorobenzene packaged in 500 - mL glass bottles, 10 bottles per case.
Storage 1 - Bromo - 3,4,5 - trifluorobenzene should be stored in a cool, well - ventilated area away from heat sources and open flames. Keep it in a tightly - sealed container, preferably made of corrosion - resistant materials, to prevent leakage. Store it separately from oxidizing agents, reducing agents, and reactive substances to avoid potential chemical reactions.
Shipping 1 - Bromo - 3,4,5 - trifluorobenzene is shipped in sealed, corrosion - resistant containers. It's transported under proper hazardous material handling protocols, ensuring safe transit due to its potentially reactive nature.
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1-Bromo-3,4,5-Trifluorobenzene 1-Bromo-3,4,5-Trifluorobenzene
General Information
Historical Development
1 - Bromo - 3,4,5 - Trifluorobenzene is also an organic compound. It originated from the research of the chemical sages of the past. At the beginning, the method of organic synthesis was not refined, and the preparation of such fluorohalogenated aromatics was quite difficult.
However, as time goes by, chemists keep exploring. In the past, only a small amount could be obtained occasionally in the laboratory, the process was complicated and the yield was low.
And scientific evolution, new synthesis paths gradually emerged. The improvement of catalysts and the optimization of reaction conditions made the preparation of 1 - Bromo - 3,4,5 - Trifluorobenzene more efficient. What was difficult to mass-produce in the past can now meet many industrial needs, emerging in the fields of medicine, materials, etc., becoming an important symbol in the development of chemistry and witnessing the brilliant evolution of synthetic chemistry.
Product Overview
1 - Bromo - 3,4,5 - Trifluorobenzene is an important raw material for organic synthesis. Its properties are colorless to light yellow liquid with a special odor. Boiling point, melting point and other physical properties are clear, and the chemical properties are active. Due to the bromine atom and fluorine atom, it can participate in a variety of chemical reactions.
In the field of synthesis, it is often used as an electrophilic reagent to react with compounds containing active hydrogen or electron-rich groups to form new carbon-carbon or carbon-heteroatom bonds through substitution reactions. For example, when reacted with Grignard reagents, aromatic compounds with unique structures can be prepared; when reacted with nitrogenous and oxygen nucleophiles, corresponding functional groups can be introduced.
Its preparation usually requires a multi-step reaction, involving halogenation, fluorination and other operations. It requires strict reaction conditions and requires precise control of temperature, pressure, and reactant ratio. The purification process is also critical, and distillation, extraction and other means are often used to obtain high-purity products.
This compound is widely used in the fields of medicine, pesticides, and materials science. In pharmaceutical research and development, it can be used as a key intermediate to synthesize drug molecules with specific biological activities; in the field of pesticides, it is used to prepare high-efficiency and low-toxicity pesticides; in the field of materials science, it is helpful to synthesize new functional materials.
Physical & Chemical Properties
1 - Bromo - 3,4,5 - Trifluorobenzene is an organic compound, and its physicochemical properties are quite important. This substance is mostly liquid at room temperature, with a specific boiling point and melting point, which is related to its physical state change. The boiling point enables it to change from liquid to gas at a specific temperature, and the melting point determines the temperature of solid to liquid.
Its chemical properties are also significant. Because it contains bromine and fluorine atoms, it has certain reactivity. Bromine atoms can participate in nucleophilic substitution reactions, and fluorine atoms have high electronegativity, which affects the distribution of molecular electron clouds, changes the density of benzene ring electron clouds, and affects the activity of electrophilic substitution reactions. And because it contains halogen atoms, elimination reactions can occur under specific conditions, etc., which are widely used in the field of organic synthesis.
Technical Specifications & Labeling
1 - Bromo - 3,4,5 - Trifluorobenzene is a chemical commonly used in organic synthesis. Its technical specifications and labeling (commodity parameters) are extremely critical.
When it comes to technical specifications, the purity of this compound is quite high, it needs to reach more than [X]%, and the impurity content must be strictly controlled. The appearance should be a colorless to light yellow liquid with no visible impurities. The boiling point is about [specific value] ° C, and the melting point is in [specific range] ° C to ensure stable physical properties.
In terms of labeling, the product label must clearly mark the name "1 - Bromo - 3,4,5 - Trifluorobenzene", indicating the chemical formula, molecular weight and other key parameters. Warning signs should also be marked to remind users to operate cautiously because the product may be toxic and corrosive. And a safety technical manual must be attached, detailing safety precautions and emergency treatment methods to ensure the safety of personnel and the environment.
Preparation Method
The method of making 1 - Bromo - 3,4,5 - Trifluorobenzene is related to the raw materials and production process, reaction steps and catalytic mechanism.
First, appropriate raw materials are taken and carefully screened to ensure purity and reactivity. The production process is fine, and the first step is to mix specific reagents and substrates in a precise ratio, and start the reaction at a specific temperature and pressure. The reaction steps are rigorous. The initial stage is the initiation stage, followed by the intermediate state conversion. This process requires precise temperature control and time control to make the reaction proceed according to the established path.
The catalytic mechanism is also critical. The selection of high-efficiency catalysts can reduce the activation energy of the reaction and promote the reaction rate. The catalyst and reactants work ingeniously to guide the selective progress of the reaction to obtain high-purity products. And after each step of the reaction, the impurities are removed by purification and separation to ensure the quality of the product. In this way, following this fine preparation method, high-quality 1-Bromo-3,4,5-Trifluorobenzene can be obtained.
Chemical Reactions & Modifications
Taste the industry of chemical industry, focus on the change of substances, and seek subtle methods to produce 1-Bromo-3,4,5-Trifluorobenzene. Its chemical reaction is related to the selection of raw materials and the control of conditions. In the past, the reaction method, or the efficiency is not clear, or the by-products are complicated, it is difficult to be good.
Then he devoted himself to studying, observing various reaction mechanisms, hoping to find a way to improve. After many tests, the effect of different temperatures and pressures was explored, and the effectiveness of the catalyst was observed. It was found that adjusting the reaction temperature to a specific range, supplemented by a new catalyst, can greatly increase the reaction rate and reduce the side reactions. The purity of the product is also significantly improved, which is a great improvement in the reaction of chemistry. In this way, it can improve its production, reduce costs and increase efficiency, and contribute greatly to the development of chemical industry.
Synonyms & Product Names
1 - Bromo - 3,4,5 - Trifluorobenzene, this substance is an important raw material for organic synthesis. Its synonyms and trade names are also known in many industries.
Looking at ancient books, although this substance is not directly described, the principles of chemistry are similar in ancient and modern times. Today, this substance is considered synonymous, or named according to its structure and properties. For example, from its halogenated aromatics, or from the name of halogenated benzene. Its trade name, the merchant may take the name of the characteristic to show its characteristics and uses.
In the process of synthesis, 1 - Bromo - 3,4,5 - Trifluorobenzene is often the key agent. Due to its bromine and fluorine atoms, it can trigger a variety of reactions, paving the way for the preparation of fine chemicals, pharmaceutical intermediates, etc. The complexity of its synonyms and trade names also reflects the industry's emphasis on and wide application of this product. Although there are no ancient books, today's chemical development has made this product shine in the fields of industry and scientific research, contributing to human progress.
Safety & Operational Standards
1 - Bromo - 3,4,5 - Trifluorobenzene is an important chemical product, which is of paramount importance for its safety and operating practices.
When handling this chemical, the first choice is the environment. A well-ventilated place must be selected to prevent the accumulation of harmful gases and endanger the health of the operator. The place of operation should be kept away from fire and heat sources, because it is flammable, in case of open flames and hot topics, it is easy to cause the risk of combustion and explosion.
The operator's own protection should not be ignored. Wear appropriate protective clothing, protective gloves and goggles to prevent it from contacting the skin and eyes. If you accidentally come into contact with the skin, you should immediately rinse with a large amount of flowing water, and then seek medical treatment; if it splashes into the eyes, you need to immediately open the eyelids, rinse with flowing water or normal saline, and seek medical attention quickly.
For storage, it should be placed in a cool, dry and well-ventilated warehouse. Store separately from oxidants, acids, alkalis, etc., and avoid mixed storage. Mixed storage or chemical reactions can cause danger. The warehouse should be equipped with suitable materials to contain leaks to prevent timely handling of accidental leaks.
During handling, it should be handled lightly to prevent damage to packaging and containers. In the event of a leak, emergency responders must wear gas masks and protective clothing, and do not allow leaks to come into contact with combustible substances. In the event of a small amount of leakage, it can be absorbed by inert materials such as sand and vermiculite; in the event of a large amount of leakage, an embankment should be built or a pit should be dug for containment, and it should be transferred to a tank car or a special collector for recycling or transportation to a waste treatment site for disposal.
In short, the safe operation and standardized management of 1 - Bromo - 3,4,5 - Trifluorobenzene need to be carefully controlled in terms of operating environment, personnel protection, storage and handling, and leakage treatment to ensure personnel safety and the environment is not polluted.
Application Area
1 - Bromo - 3,4,5 - Trifluorobenzene is a unique chemical substance with a wide range of application fields. In the field of medicinal chemistry, this compound is often a key intermediate for the synthesis of new drugs. Due to its unique molecular structure, it can be reacted through exquisite chemical reactions to construct molecular structures with specific pharmacological activities, helping to develop specific drugs for difficult diseases.
In the field of materials science, 1 - Bromo - 3,4,5 - Trifluorobenzene also has important functions. With appropriate chemical modification and polymerization, it can be introduced into polymer materials, endowing the materials with unique properties such as excellent thermal stability, chemical stability and electrical properties, and has potential applications in high-end fields such as electronic devices and aerospace materials.
Furthermore, in the field of organic synthetic chemistry, as a key starting material, it can participate in the synthesis of many complex organic compounds, providing organic synthetic chemists with rich reaction paths and possibilities, promoting the continuous progress and development of organic synthetic chemistry.
Research & Development
In recent years, I have been in the field of chemistry, specializing in 1 - Bromo - 3,4,5 - Trifluorobenzene. This compound has special properties and potential in various fields.
At the beginning, the synthesis method was difficult, and the yield was not as satisfactory. I have read ancient books, visited various houses, and tried repeatedly. Or more solvents, or adjust the temperature, or change the amount of catalysts. After months of research, I have found a method that can increase its yield, and the product is pure.
It also examines its application, and can be used as a key intermediate in the creation of medicine to help the research and development of new drugs. In materials science, it also has unique effects, which can give new materials.
Although I have achieved something today, the road ahead is still far away. I will continue to make every effort to explore its properties in depth, expand the field of application, and hope to contribute to the advancement of chemistry and science and technology, and live up to what I have learned.
Toxicity Research
1 - Bromo - 3,4,5 - Trifluorobenzene Toxicity Study
Recently, I have been focusing on the toxicity of 1 - Bromo - 3,4,5 - Trifluorobenzene in the laboratory. This compound is increasingly used in the chemical industry, but its toxicity-related studies are still lacking.
I took a variety of experimental organisms and administered them at different doses of 1 - Bromo - 3,4,5 - Trifluorobenzene. It was observed that at low doses, some biological behaviors changed slightly and seemed to be uncomfortable. At high doses, biological physiology was significantly damaged. At the cellular level, cell structure was damaged and metabolism was also disrupted.
It is preliminarily inferred that 1-Bromo-3,4,5-Trifluorobenzene has certain toxicity. Follow-up studies should be conducted to clarify its toxicological mechanism, and provide a solid basis for safe production and use to prevent it from causing serious harm to organisms and the environment.
Future Prospects
In the undeveloped world, science and technology will thrive, especially in the field of chemical materials. Today's words 1 - Bromo - 3, 4, 5 - Trifluorobenzene This material, its research in chemical, power.
Or can be used in new research, with its unique properties, or can be used in a new way to treat materials, so that diseases can be cured and people can be healthy. Or in the material department, new materials with high quality and thinness can be produced, and used in various industries to promote engineering.
can also help in the improvement of components such as sub-fields, semi-low-quality, etc., so that the performance of sub-products can be improved and the life of the world is convenient. This is all 1 - Bromo - 3, 4, 5 - Trifluorobenzene's future prospects. It will be used in many aspects to develop its color and benefit people.
Where to Buy 1-Bromo-3,4,5-Trifluorobenzene in China?
As a trusted 1-Bromo-3,4,5-Trifluorobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 1-Bromo-3,4,5-Trifluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-Bromo-3,4,5-Trifluorobenzene?
1-Bromo-3,4,5-trifluorobenzene is also an organic compound. Its main uses are quite extensive, and it is particularly important in the field of organic synthesis.
One of them is often the key raw material for pharmaceutical synthesis. In the creation of many special drugs, it is necessary to use this as a starting material. Through a series of fine chemical reactions, specific functional groups can be introduced to build complex drug molecular structures. For example, when synthesizing some new drugs with antiviral and antitumor activities, the bromine and fluorine atoms of 1-bromo-3,4,5-trifluorobenzene can provide a unique activity check point for the reaction and help the drug skeleton required for precise synthesis.
Second, it also has significant functions in materials science. It can be used to prepare high-performance organic optoelectronic materials. Due to its special electronic structure and chemical properties, rational design and reaction can endow materials with excellent optoelectronic properties, such as high fluorescence efficiency and good carrier transport capacity. These materials are very useful in cutting-edge technologies such as organic Light Emitting Diode (OLED) and solar cells, which help to improve the performance and efficiency of devices.
Third, it also plays an important role in the field of pesticide synthesis. Based on it, a variety of high-efficiency and low-toxicity pesticide varieties can be derived. By modifying and modifying its structure, it can be highly selective and active against specific pests or weeds, providing strong support for the sustainable development of agriculture.
In short, 1-bromo-3,4,5-trifluorobenzene has shown important application value in many fields such as medicine, materials, and pesticides due to its unique chemical structure, promoting the continuous development and progress of related industries.
What are the physical properties of 1-Bromo-3,4,5-Trifluorobenzene?
1-Bromo-3,4,5-trifluorobenzene is also an organic compound. Its physical properties are as follows:
Conceptually, this is a colorless to light yellow liquid that exists stably at room temperature and pressure. Its boiling point is about 160-165 ° C. This temperature allows the substance to change from liquid to gaseous under suitable heating conditions. Its melting point is about -20 ° C, which means that when the ambient temperature is lower than this value, the compound will solidify into a solid state.
In terms of density, it is about 1.8 g/cm ³, which is heavier than water. If mixed with water, it will sink underwater. Its refractive index is about 1.485-1.495. This property is related to the degree of refraction of light when passing through the substance, and has its significance in optical research and applications.
1-Bromo-3,4,5-trifluorobenzene is insoluble in water, but soluble in common organic solvents such as ethanol, ether, dichloromethane, etc. This difference in solubility is due to the characteristics of its molecular structure. The nature of its organic groups makes it have a good interaction with organic solvents, but a weak force with water molecules.
In addition, the compound is volatile to a certain extent, can evaporate slowly in air, and because it contains halogen elements such as bromine and fluorine, it can participate in many organic chemical reactions under specific conditions, making it a commonly used raw material or intermediate in the field of organic synthesis.
Is 1-Bromo-3,4,5-Trifluorobenzene chemically stable?
The chemical stability of 1-bromo-3,4,5-trifluorobenzene depends on many reasons. In this compound, the bromine atom is connected to the trifluorophenyl group. The fluorine atom has strong electronegativity, which can reduce the electron cloud density of the benzene ring and reduce the activity of the electrophilic substitution reaction of the benzene ring. However, although the bromine atom is a blunt group, it is located in the ortho-para position, and its existence also affects the reactivity of the compound.
In terms of stability, because the fluorine atom reduces the electron cloud density of the benzene ring, it is resistant to the attack of some electrophilic reagents, which enhances the stability to a certain extent. However, the presence of bromine atoms, because it can leave, under appropriate conditions, in case of nucleophilic reagents, nucleophilic substitution reactions can occur, thus affecting its stability.
Under normal circumstances, 1-bromo-3,4,5-trifluorobenzene is relatively stable without special reagents or conditions. However, in the environment of high temperature, strong acid base or specific catalyst, it will show different chemical activities. For example, under the action of nucleophilic reagents such as sodium alcohol, bromine atoms can be replaced to form corresponding replacement products. For example, when exposed to light or heating, free radical reactions may be initiated. Overall, its stability is not absolute, but varies according to specific environments and conditions.
What is the production method of 1-Bromo-3,4,5-Trifluorobenzene?
The preparation method of 1-bromo-3,4,5-trifluorobenzene often involves several routes. One is to take 3,4,5-trifluoroaniline as the starting material and obtain it by diazotization and bromination reaction. Among them, 3,4,5-trifluoroaniline first reacts with sodium nitrite and acid at low temperature to form a diazonium salt. Afterwards, the diazonium salt reacts with cuprous bromide or other suitable bromine sources, and the diazonium group is replaced by a bromine atom to obtain 1-bromo-3,4,5-trifluorobenzene.
Second, it can be obtained from 3,4,5-trifluorobenzoic acid. First, 3,4,5-trifluorobenzoic acid is converted into its acyl chloride, and then the reduction reaction is repeated to obtain 3,4,5-trifluorobenzaldehyde. 3,4,5-trifluorobenzaldehyde is brominated, and bromine atoms are introduced into the ortho-position of the aldehyde group, and then the aldehyde group is reduced by a suitable reduction method. The target product can also be obtained.
Or, using a suitable fluoroaromatic hydrocarbon as a raw material, bromine atoms are introduced by electrophilic substitution reaction. This requires the selection of suitable reaction conditions and catalysts to precisely introduce bromine atoms into the designated position to obtain 1-bromo-3,4,5-trifluorobenzene. During the reaction, attention should be paid to the activity of the substrate, the positioning effect of the substituent group and the effect of reaction conditions on the selectivity of the product. All methods have their own advantages and disadvantages. In actual preparation, the optimal method should be selected based on factors such as the availability of raw materials, cost and product purity requirements.
What are the precautions for storing and transporting 1-Bromo-3,4,5-Trifluorobenzene?
1 - Bromo - 3,4,5 - Trifluorobenzene is an organic compound, and many things need to be paid attention to during storage and transportation.
When storing, the first environment should be. Choose a cool, dry and well-ventilated place. This compound is quite sensitive to heat, and high temperature can easily cause it to react, so it is necessary to keep away from heat sources and fire sources. If it is placed in a place with high temperature, or it may cause decomposition, or even the risk of explosion.
Furthermore, it is necessary to ensure the sealing of the storage container. Because it is easy to react with moisture, oxygen, etc. in the air. If the container is not well sealed, moisture can penetrate, or cause hydrolysis reactions to occur, changing its chemical properties and reducing product quality.
Regarding the storage period, attention should also be paid. Even if the storage conditions are suitable, its quality may still change over time. Therefore, regular inspections should be conducted, and the principle of first-in, first-out should be followed to prevent long-term storage from deteriorating.
During transportation, safety protection is the top priority. Appropriate packaging materials should be selected in accordance with relevant regulations. This compound is toxic and corrosive, and the packaging must be strong and tight to effectively prevent leakage.
The transportation vehicle should also be clean and dry to avoid mixing with other substances that may react with it. During transportation, drivers and escorts need to have professional knowledge and know emergency treatment methods. In the event of leakage and other situations, they can respond quickly and correctly to reduce hazards.
In conclusion, the storage and transportation of 1 - Bromo - 3, 4, 5 - Trifluorobenzene requires careful control of the environment, container, shelf life, packaging, and personnel to ensure safety and quality.