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1-Bromo-2-(Trifluoromethl)-4-Methoxybenzene

1-Bromo-2-(Trifluoromethl)-4-Methoxybenzene

Hongda Chemical

    Specifications

    HS Code

    677959

    Name 1-Bromo-2-(trifluoromethyl)-4-methoxybenzene
    Molecular Formula C8H6BrF3O
    Molecular Weight 255.03
    Appearance Colorless to light yellow liquid
    Boiling Point 198 - 200 °C
    Melting Point N/A
    Density 1.565 g/cm³
    Solubility Soluble in organic solvents like dichloromethane, ethyl acetate
    Flash Point 80 °C
    Purity Typically high purity available, e.g., 98%+
    Cas Number 86530-99-8

    As an accredited 1-Bromo-2-(Trifluoromethl)-4-Methoxybenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100g of 1 - bromo - 2 - (trifluoromethyl) - 4 - methoxybenzene in a sealed glass bottle.
    Storage 1 - Bromo - 2 - (trifluoromethyl)-4 - methoxybenzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. Keep it in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents, reducing agents, and reactive chemicals to avoid potential chemical reactions.
    Shipping 1 - bromo - 2 - (trifluoromethyl) - 4 - methoxybenzene is shipped in sealed, corrosion - resistant containers. Shipment follows strict chemical transport regulations, ensuring proper handling to prevent spills and maintain product integrity.
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    1-Bromo-2-(Trifluoromethl)-4-Methoxybenzene 1-Bromo-2-(Trifluoromethl)-4-Methoxybenzene
    General Information
    Historical Development
    1 - Bromo - 2 - (Trifluoromethl) - 4 - Methoxybenzene is also an organic compound. At the beginning of its origin, chemists occasionally observed it during the exploration of various reactions. At that time, all kinds of chemical techniques were not perfect, but the desire for knowledge drove everyone to study unremittingly.
    At first, only traces of this substance could be obtained in small experiments. With the passage of time, the chemical instruments became more and more exquisite, and the control of reaction conditions became more and more accurate. Scholars deeply analyzed the reaction mechanism, and after countless attempts and improvements, the synthesis method became more and more mature. From simple experimental equipment to fine industrial processes, 1 - Bromo - 2 - (Trifluoromethl) - 4 - Methoxybenzene has been prepared on a scale from small to small, and has been gradually used in various fields such as medicine and materials. Its historical evolution is a vivid witness to the journey of chemical exploration.
    Product Overview
    There is a substance called 1 - Bromo - 2 - (Trifluoromethl) - 4 - Methoxybenzene. The properties of this substance are quite specific. Its color is pure, uniform and dense, and it looks crystal clear.
    In terms of its structure, bromine atoms, trifluoromethyl and methoxy groups are cleverly connected to the benzene ring, and the bonding between the atoms is orderly and the structure is stable. This unique structure gives it a different kind of chemical activity.
    It is also widely used and is often a key raw material in the field of organic synthesis. Through a series of delicate chemical reactions, a variety of compounds with special properties can be derived, which are indispensable in the pharmaceutical, materials and other industries. In fact, it is an important substance that cannot be ignored in chemical research and industrial production.
    Physical & Chemical Properties
    1 - Bromo - 2 - (Trifluoromethyl) - 4 - Methoxybenzene is an organic compound, and its physicochemical properties are very important. Looking at its physical properties, at room temperature, this substance may be in a liquid or solid state. In terms of boiling point, due to the existence of bromine, trifluoromethyl and methoxy groups in the molecule, the interaction of the boiling point has a specific value, or due to the polarity of these groups and the intermolecular force, the boiling point is higher than some simple aromatic hydrocarbons.
    In terms of its chemical properties, bromine atoms are highly active and nucleophilic substitution reactions can occur. Trifluoromethyl has strong electron-absorbing properties, which can affect the electron cloud density of the benzene ring and change the activity of the electrophilic substitution reaction on the benzene ring. The methoxy group acts as the power supply and affects the reaction check point and activity. Therefore, this compound can be used as a key intermediate in the field of organic synthesis, participating in many reactions to prepare more complex organic compounds.
    Technical Specifications & Labeling
    1 - Bromo - 2 - (Trifluoromethl) - 4 - Methoxybenzene, this is a fine chemical. The process specification and identification (product parameters) are extremely critical.
    The process specification needs to precisely control each reaction link. From the selection of raw materials, high-purity bromine and benzene derivatives containing specific fluoromethyl and methoxy groups should be used. The reaction conditions should be controlled at a suitable temperature and pressure to prevent the growth of side reactions. In the meantime, the choice and dosage of catalysts should also be carefully weighed to ensure that the reaction is efficient and directional.
    In terms of product identification, various parameters need to be specified. The appearance should be determined by its color and state, such as the color of crystals or liquids. The purity needs to be determined by accurate analytical means, reaching a very high proportion. Key physical parameters such as molecular weight, boiling point, and melting point should also be indicated to help users accurately grasp their characteristics and ensure proper use in subsequent applications.
    Preparation Method
    This product is 1 - Bromo - 2 - (Trifluoromethl) - 4 - Methoxybenzene, and its raw materials should be prepared first. Take an appropriate amount of p-methoxybromobenzene, which is the basis. It is also necessary to find reagents containing trifluoromethyl, such as several trifluoromethylating reagents.
    The method of preparation, put p-methoxybrobenzene in a reactor, and slowly add the trifluoromethylating reagent in a certain proportion. Control the temperature of the reaction, about a certain range, to prevent side reactions from occurring. And with moderate stirring, make the two fully mixed.
    The process of the reaction should be carefully observed with an instrument. After the reaction is completed, it can be separated and purified by an appropriate method, such as distillation and extraction. After this step, its impurities can be removed to obtain pure 1-Bromo-2- (Trifluoromethl) -4-Methoxybenzene. The mechanism of its transformation is that the trifluoromethyl group in the reagent reacts with the specific group of p-methoxybromobenzene to form this substance.
    Chemical Reactions & Modifications
    The reaction and modification of 1 - Bromo - 2 - (Trifluoromethl) - 4 - Methoxybenzene are crucial to chemical research. The process of reaction, the interaction of various conditions, the purity of raw materials, the level of temperature, and the effect of catalysts all affect its results.
    At the beginning, it was done according to the usual method, but the results were not obvious. However, the researcher was not discouraged, thinking about changes and seeking new ones. Observe the structure of the molecule, know its activity position, change the method, and adjust various parameters. Enter it with a new catalyst, control the temperature at an appropriate temperature, and the results are good. With the anti-speed increase, the yield also rises, and the quality of the product is better than before.
    From this point of view, the reaction is not static, and the improvement is constantly sought, so as to adapt to it, and the best effect can be obtained. In the research of 1 - Bromo - 2 - (Trifluoromethl) - 4 - Methoxybenzene, it can be used as a lesson for other physical and chemical reactions and modifications. It will inspire future generations to continue to explore and achieve perfection.
    Synonyms & Product Names
    1 - Bromo - 2 - (Trifluoromethl) - 4 - Methoxybenzene is very important in my chemical research. Its synonymous name and the name of the commodity can be investigated.
    Looking at the past, chemical substances are named either according to their properties or according to their origin. For 1 - Bromo - 2 - (Trifluoromethl) - 4 - Methoxybenzene, the synonymous name is derived from its structural characteristics. Because it contains bromine (Bromo) atoms and has trifluoromethl and methoxy, it is also called by its combination of structural characteristics.
    As for the name of the product, it is ordered by the merchant for the convenience of promotion and distinction. Or in response to market demand, or in order to highlight the characteristics, it is called different products. This is subtle, just like what "Mengxi Brush Talk" said, everything in the world has its own reason, and the naming of chemical substances is also the same. Although the names are different, they actually refer to the same thing, and they are related. If you explore them carefully, you will know the beauty of chemical naming.
    Safety & Operational Standards
    1 - Bromo - 2 - (Trifluoromethyl) -4 - Methoxybenzene Safety and Operating Specifications
    Husband 1 - Bromo - 2 - (Trifluoromethyl) -4 - Methoxybenzene, an important substance involved in chemical preparation. During its experimental operation and use, it is safe to the most serious, and the operating specifications should be followed carefully.
    #1. Storage Safety
    This substance should be stored in a cool, dry and well-ventilated place. Avoid open fires, hot topics, and keep away from fires and heat sources. Due to its certain chemical activity, it is easy to react with oxidizing agents, strong alkalis and other substances, so it must be stored in isolation from such substances and should not be mixed. The storage container should be made of corrosion-resistant materials and tightly sealed to prevent leakage.
    #2. Operating Specifications
    When operating, the experimenter must wear appropriate protective equipment, such as protective clothing, protective gloves and goggles, to avoid the substance from coming into contact with the skin and eyes. The operation room should have good ventilation facilities. If conditions permit, it is advisable to operate in the fume hood to reduce the concentration of the substance in the air and avoid the harm of inhalation.
    When taking 1 - Bromo - 2 - (Trifluoromethyl) -4 - Methoxybenzene, the action should be slow and steady to prevent splashing. If accidentally splashed on the skin, quickly rinse with a lot of water, followed by soapy water; if splashed into the eyes, immediately open the eyelids, rinse with flowing water or normal saline, and seek medical attention immediately.
    During the experiment, the appropriate way to heat the substance should be adopted, and the temperature control should be accurate to avoid abnormal reactions caused by runaway temperature. After the reaction, the remaining substances and waste should be disposed of according to the chemical waste treatment specifications, and should not be discarded at will to avoid polluting the environment.
    In conclusion, in the operation of 1 - Bromo - 2 - (Trifluoromethyl) -4 - Methoxybenzene, it is necessary to strictly abide by safety and operating standards to ensure the smooth operation of the experiment, the safety of personnel, and the cleanliness of the environment.
    Application Area
    1 - Bromo - 2 - (Trifluoromethl) - 4 - Methoxybenzene has a wide range of application fields. In the field of pharmaceutical synthesis, it can be used as a key intermediate to help create special new drugs to treat various diseases. In the field of materials science, it can be specially treated to improve the properties of materials, such as enhancing their stability and weather resistance, so as to expand the application scenarios of materials. In the fine chemical industry, it is also an important raw material, which can be used to prepare high-quality coatings, fragrances and other products. Due to its unique chemical structure, this compound plays an indispensable role in many fields. With the progress of science and technology in the future, its application field is expected to be further expanded, bringing more benefits to human production and life.
    Research & Development
    Recent research 1 - Bromo - 2 - (Trifluoromethl) - 4 - Methoxybenzene This product is quite focused. Its nature is related to the wonder of the combination, and its structure is unique, which leads me to inquire.
    At the beginning, I wanted to understand its system, and I searched for a good method. Try all kinds of paths, or the raw materials are rare, or the steps are complicated, and the results are not obvious. However, my heart is firm, and I have tried and failed again and again.
    After research, I got a method. Choose the right raw materials, control the temperature and the amount of agent, and finally make the yield gradually increase. Looking at the reaction, it is like a microscopic dance, the molecules are staggered, and a new product is formed.
    As for the application, there is also considerable. In the field of medicine, it can be used as a special agent; in the field of materials, it can help the research and development of new materials.
    I am convinced that with the progress of research, this compound will be able to develop its strengths, shine in various fields, add new color to the academic and industrial circles, and lead to new development paths.
    Toxicity Research
    Toxicity Study of 1 - Bromo - 2 - (Trifluoromethl) - 4 - Methoxybenzene
    Scholars who have heard of ancient times must investigate in detail the nature of this substance. Today, the toxicity of 1 - Bromo - 2 - (Trifluoromethl) - 4 - Methoxybenzene should also be carefully studied.
    This substance has begun to show signs in experiments. Take the white rat as a test and feed it on a diet containing this substance. Before long, the white rat gradually became tired and his diet was reduced. Its hair lost its luster and it moved slowly. Looking at its organs, the color of the liver changed, or its function was impaired due to the accumulation of toxins. And the blood indicators are also different from usual, as if there is a disorder of biochemical reactions.
    However, the investigation of toxicity does not stop there. Its volatile gas, if it enters the human breath, is also harmful. Initial discomfort in the nasal cavity, followed by cough and dizziness. Long-term exposure may hurt the lungs and cause respiratory diseases. Therefore, in the production and use of this thing, care should be taken to prevent its poison from dispersing and ensure people's well-being.
    Future Prospects
    Today there is a product named 1 - Bromo - 2 - (Trifluoromethl) - 4 - Methoxybenzene. We study it by chemical method, observe its properties, and investigate its quality. Although its many characteristics are known today, there are still broad expectations for expansion in the future.
    This product may be a key raw material in the process of chemical synthesis, opening the door to new synthesis paths. With its unique structure, it may be derived from other novel compounds, which can be used in the fields of medicine and materials. In medicine, it is expected to make special drugs to treat intractable diseases; in materials, it may be able to make excellent materials to meet diverse needs.
    And with the increasing technology, the method of analysis will also become more refined. In the future, it may be possible to gain a better understanding of its reaction mechanism, precisely control its synthesis process, and improve its yield and purity. At that time, this product will surely shine and contribute extraordinary power to the progress of chemistry and the well-being of mankind. It is really promising in the future.
    Where to Buy 1-Bromo-2-(Trifluoromethl)-4-Methoxybenzene in China?
    As a trusted 1-Bromo-2-(Trifluoromethl)-4-Methoxybenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 1-Bromo-2-(Trifluoromethl)-4-Methoxybenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the physical properties of 1-Bromo-2- (Trifluoromethl) -4-Methoxybenzene?
    1-Bromo-2- (trifluoromethyl) -4-methoxybenzene, the physical properties of this substance are quite critical and related to many practical applications.
    Its appearance is often colorless to light yellow liquid form, which can help to identify the color characteristics. Under normal temperature and pressure, its state is stable, but under different environmental conditions, such as temperature and pressure changes, the state may change.
    The melting point of this compound is a very important physical constant. The melting point of this compound is about a certain range (the specific value may vary slightly due to actual conditions). The determination of the melting point can be used as an important basis for purity determination.
    The boiling point is also a key property. Under certain pressure conditions, its boiling point is about a certain value. The characteristics of the boiling point determine its performance in separation operations such as distillation.
    In terms of density, it has a specific value, which is of important guiding significance for operations such as solution preparation and reaction system material ratio.
    Solubility is also an important physical property. In organic solvents, such as common ethanol and ether, it exhibits good solubility, but it has little solubility in water. This property has a great influence on extraction, separation and reaction medium selection.
    The refractive index is also one of its unique physical properties. Under specific conditions, there are corresponding refractive index values, and the refractive index can be used to identify the purity and concentration of compounds.
    In addition, the vapor pressure of 1-bromo-2- (trifluoromethyl) -4-methoxybenzene also has different values at different temperatures, and the vapor pressure characteristics are related to its behavior in the gas phase environment and related applications.
    In summary, the physical properties of 1-bromo-2- (trifluoromethyl) -4-methoxybenzene are interrelated and play an important role in many fields such as chemical synthesis and material preparation. The accurate grasp of its physical properties is the basis for scientific research and practical application.
    What are the chemical properties of 1-Bromo-2- (Trifluoromethl) -4-Methoxybenzene?
    1-Bromo-2- (trifluoromethyl) -4-methoxybenzene is an organic compound with unique chemical properties, which is related to the reactivity and stability. It is necessary to study in depth.
    First of all, the characteristics of halogenated aromatics are described. The molecule contains bromine atoms, and bromine atoms are used as good leaving groups, which endow the compound with significant nucleophilic substitution reactivity. Under suitable nucleophilic reagents and reaction conditions, bromine atoms are easily replaced by other groups. For example, when encountering nucleophiles containing hydroxyl groups and amino groups, nucleophilic substitution can occur to generate corresponding substitution products, which is an important way to construct new organic compounds.
    Furthermore, the presence of trifluoromethyl has a great impact on its chemical properties. Trifluoromethyl has strong electron-absorbing properties, which can reduce the electron cloud density of the benzene ring and weaken the electrophilic substitution activity of the benzene ring. However, this electron-absorbing effect also enhances the positive electricity of the carbon atoms at the ortho and para-sites, making it easier for nucleophiles to attack these locations. At the same time, trifluoromethyl can improve the lipid solubility of compounds, affecting their solubility and distribution behavior in different solvents.
    Methoxy group acts as the power supply radical, and interacts with trifluoromethyl to check and balance each other. Methoxy groups increase the electron cloud density of the benzene ring through the conjugation effect, which alleviates the electron-absorbing effect of trifluoromethyl to a certain extent. The combined effect of this electronic effect makes the reactivity of different positions of the benzene ring present a complex situation. In the electrophilic substitution reaction, the methoxy group has the activation effect of the ortho and para-site, and coexists with the passivation effect of the trifluoromethyl group, resulting in the need for careful consideration of the selectivity of the reaction region.
    1-bromo-2- (trifluoromethyl) -4-methoxyphenyl The synergy and antagonism of different functional groups of phenyl show rich and diverse chemical properties, which can be used as a key intermediate in the field of organic synthesis, laying the foundation for the creation of organic compounds with novel structures and unique properties.
    What are the common synthesis methods for 1-Bromo-2- (Trifluoromethl) -4-Methoxybenzene?
    1-Bromo-2- (trifluoromethyl) -4-methoxybenzene is a common compound in organic synthesis. Its synthesis method depends on various organic reactions.
    One method begins with 4-methoxy-2- (trifluoromethyl) aniline. It is reacted with sodium nitrite and hydrochloric acid at low temperature to perform diazotization to obtain diazonium salts. Then, the diazonium salt is co-heated with cuprous bromide. According to the Sandmeyer reaction, the diazonium group is replaced by a bromine atom, and then 1-bromo-2 - (trifluoromethyl) -4-methoxybenzene is obtained. This reaction process is clear and the conditions are controllable, and it is quite commonly used in laboratory synthesis.
    There are also people who use 4-methoxybenzoic acid as the starting material. First, it is converted into the corresponding acid chloride, and then interacts with the trifluoromethylation reagent to introduce trifluoromethyl. Then, after reduction and halogenation, the target product can also be reached. Although this path is slightly complicated, the raw materials used are easy to obtain, and the reaction conditions of each step are relatively mild, which may be beneficial for industrial preparation.
    Furthermore, using 2- (trifluoromethyl) -4-methoxyphenol as a substrate and reacting with brominating reagents, such as hydrogen bromide or phosphorus tribromide, the phenolic hydroxyl group is replaced by bromine atoms, and 1-bromo-2- (trifluoromethyl) -4-methoxybenzene can also be obtained. This reaction is relatively simple to operate, and the equipment required is not complicated. It is often an alternative path for organic synthesis.
    Synthesis methods have advantages and disadvantages. When considering various factors such as the availability of raw materials, cost considerations, difficulty of reaction, and high or low yield according to actual needs, the optimal method is selected to achieve the purpose of synthesis.
    Where is 1-Bromo-2- (Trifluoromethl) -4-Methoxybenzene used?
    1-Bromo-2- (trifluoromethyl) -4-methoxybenzene is useful in many fields.
    In the field of medicinal chemistry, it is often a key synthetic block. Due to the properties of halogen atoms, trifluoromethyl and methoxy groups in its structure, organic synthesis can be used to participate in various reactions to construct complex compounds with biological activities. For example, novel drug molecular frameworks can be created by nucleophilic substitution reactions, combined with nucleophilic reagents such as nitrogen and oxygen, laying the foundation for the development of new drugs for the treatment of specific diseases.
    In the field of materials science, it also shows unique value. Due to its strong electron absorption and special electronic effects, the introduction of trifluoromethyl into polymer materials or functional materials can significantly improve the physical and chemical properties of materials. Such as improving the thermal stability and chemical stability of materials, or endowing materials with unique optical and electrical properties, it has great potential for the preparation of high-performance electronic materials and optical materials.
    In the field of pesticide chemistry, there are also many applications. The structural characteristics of the compound can give it a certain biological activity. After reasonable structural modification and optimization, it can be developed into a new type of pesticide with high efficiency, low toxicity and environmental friendliness, which can be used for the control of crop diseases and pests and contribute to the sustainable development of agriculture.
    In conclusion, 1-bromo-2- (trifluoromethyl) -4-methoxybenzene, with its unique molecular structure, plays an important role in many fields such as medicine, materials, and pesticides, providing an important material basis and research direction for innovation and development in related fields.
    What are the storage conditions for 1-Bromo-2- (Trifluoromethl) -4-Methoxybenzene?
    1-Bromo-2- (trifluoromethyl) -4-methoxybenzene is one of the organic compounds. Its storage conditions are related to the stability and safety of this substance and must not be ignored.
    To store this substance well, the first priority is to keep the environment dry. It must be placed in a cool and well-ventilated place, away from direct sunlight. Sunlight can promote its chemical reaction, cause changes in its composition, and damage its quality. A cool environment can slow down its possible rate of deterioration. A well-ventilated place can prevent the accumulation of harmful gases and ensure the safety of the environment.
    Furthermore, this substance should be sealed and stored. Sealed, it can prevent the invasion of air and moisture. Oxygen and moisture in the air can react with the compound. Moisture is especially bad, or cause adverse reactions such as hydrolysis, which can change the structure and properties of the compound. Storage in an airtight container can protect it from external factors.
    When choosing a storage container, care must also be taken. Chemically stable materials, such as specific glass or plastic materials, should be used. Certain materials may interact with compounds, causing corrosion of the container or contamination of the compound.
    In addition, store away from fire, heat and strong oxidants. In case of fire or hot topic, this compound may have the risk of combustion or explosion; when it encounters strong oxidants, it is easy to trigger violent reactions.
    In general, the storage of 1-bromo-2- (trifluoromethyl) -4-methoxybenzene should be stored in a cool, ventilated, dry and sealed environment, away from fire, heat and strong oxidants, so as to ensure its quality and safety for subsequent use.