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What are the main uses of 1-Bromo-2-Iodo-4- (Trifluoromethoxy) Benzene?
1-Bromo-2-iodine-4- (trifluoromethoxy) benzene is an organic compound. It has a wide range of uses and has a significant position in the field of organic synthesis.
First, it is often used as a key intermediate in pharmaceutical chemistry. Due to the unique chemical activities and properties of bromine, iodine and trifluoromethoxy in the structure. Bromine and iodine atoms can participate in a variety of nucleophilic substitution reactions, introduce other functional groups, and help to construct complex drug molecular structures. The existence of trifluoromethoxy can significantly change the physical and chemical properties of drug molecules, such as lipophilicity and stability, which in turn affect the biological activity and pharmacokinetic properties of drugs. For example, when developing specific targeted anticancer drugs, this compound can be used as a starting material to introduce specific pharmacoactive groups through multi-step reactions to obtain highly active and selective anticancer drugs.
Second, it also has applications in the field of materials science. Due to its fluorine-containing structure, it can endow materials with special properties. For example, when preparing high-performance fluoropolymer materials, 1-bromo-2-iodine-4 - (trifluoromethoxy) benzene can be used as a monomer or modifier to participate in the polymerization reaction, so that the resulting polymer has excellent corrosion resistance, low surface energy and optical properties. In electronic materials, such fluoropolymers are often used to make special coatings, photoresists, etc., to meet the high performance requirements of electronic devices.
Third, in terms of organic optoelectronic materials, this compound can be chemically modified to become an important part of organic semiconductor materials. By adjusting its molecular structure and changing its optoelectronic properties, it can be used to prepare optoelectronic devices such as organic Light Emitting Diodes (OLEDs) and organic solar cells, providing a broad space for the development of new optoelectronic materials.
What are the synthesis methods of 1-Bromo-2-Iodo-4- (Trifluoromethoxy) Benzene?
There are several common methods for synthesizing 1-bromo-2-iodine-4- (trifluoromethoxy) benzene.
First, the benzene derivative containing trifluoromethoxy is used as the starting material. First, a suitable positioning group is introduced into the benzene ring, and it is halogenated, such as a brominating agent and an iodizing agent in sequence. A suitable brominating reagent can be selected, such as liquid bromine in the presence of a catalyst such as iron powder or iron tribromide, which reacts with benzene derivatives to introduce bromine atoms into the designated position. Then an appropriate iodizing agent, such as potassium iodide, is selected in combination with a suitable oxidizing agent to connect the iodine atom to obtain the target product. This process requires attention to the precise control of the reaction conditions. Temperature, reaction time, etc. have a significant impact on the yield and purity of the product.
Second, you can start from halogenated benzene. First, the halogenated benzene is methoxylated to introduce a methoxy group, and then the methoxy group is modified by trifluoromethylation to obtain a halogenated benzene containing a trifluoromethoxy group. Then through selective halogenation, bromine atoms and iodine atoms are introduced in turn. The key to this path lies in the selectivity of each step of the reaction, ensuring that the halogen atoms are connected at the desired position, and the reagents and conditions of each step of the reaction need to be reasonably selected to achieve the desired reaction effect.
Third, palladium-catalyzed cross-coupling reactions can also be considered. Aromatic halides containing trifluoromethoxy are prepared first, and nucleophiles containing bromine and iodine are prepared at the same time. In the presence of palladium catalysts and ligands, cross-coupling reactions are carried out to promote the breaking of carbon-halogen bonds and coupling with nucleophiles to construct the carbon-halogen bonds of the target products. This method requires high purity of the reaction system, activity of the catalyst and selection of ligands, and appropriate reaction conditions are also the key to successful synthesis.
What are the physical properties of 1-Bromo-2-Iodo-4- (Trifluoromethoxy) Benzene?
1-Bromo-2-iodine-4- (trifluoromethoxy) benzene is one of the organic compounds. Its physical properties are very important and are related to many chemical processes and practical applications.
First of all, its appearance is often colorless to light yellow liquid. This color state is easy to distinguish with the naked eye. In laboratory or industrial operation, the state and purity of the substance can be preliminarily judged according to its appearance. It has a certain degree of volatility. At room temperature and pressure, some molecules will escape into the air. This property needs to be paid attention to when storing and using, and the environment should be well ventilated to prevent danger caused by gas accumulation.
Melting point and boiling point are also key physical properties. Its melting point is low, causing it to be mostly liquid at room temperature, while the boiling point varies depending on the influence of bromine, iodine and trifluoromethoxy groups in the molecular structure. The halogen atom and special methoxy group enhance the intermolecular force, resulting in a relatively high boiling point. The exact value of the boiling point helps to separate and purify it by distillation and other means.
In terms of solubility, this compound is difficult to dissolve in water due to the strong hydrogen bonding between water molecules, and the organic substance is a non-polar or weakly polar molecule with weak interaction with water. However, it is soluble in many organic solvents, such as dichloromethane, chloroform, ether, etc. This property is often used in organic synthesis for extraction, reaction medium selection and other links.
Density is also an important physical property. Its density is greater than that of water. When it comes to liquid-liquid separation operations, depending on the density difference, the compound can be stratified with the aqueous phase to achieve preliminary separation.
The physical properties of 1-bromo-2-iodine-4 - (trifluoromethoxy) benzene, from appearance, volatility, melting point, solubility to density, all play a decisive role in its treatment, reaction and application in the chemical field. Scientists and industrial practitioners need to know in detail before they can make good use of this compound.
What are the chemical properties of 1-Bromo-2-Iodo-4- (Trifluoromethoxy) Benzene
1-Bromo-2-iodine-4- (trifluoromethoxy) benzene, this is an organohalogenated aromatic hydrocarbon compound containing bromine, iodine and trifluoromethoxy groups, which give it unique chemical properties.
Its bromine atom has high activity and is easy to participate in nucleophilic substitution reactions. When encountering nucleophilic reagents, such as alkoxides and amines, bromine atoms can be replaced by nucleophilic groups to generate new organic compounds. For example, when reacted with sodium alcohol, corresponding ether products can be formed; when reacted with ammonia or amines, nitrogen-containing derivatives can be obtained.
Iodine atoms are also reactive, although sometimes slightly slower than bromine atoms, but under certain conditions, nucleophilic substitution can also occur. Because the carbon-iodine bond energy is relatively small, it is easier to break. In some organic synthesis, iodine atoms can be used as leaving groups to achieve specific structural transformation.
Trifluoromethoxy is a strong electron-absorbing group, which significantly affects the electron cloud density of the benzene ring, causing the electron cloud density of the benzene ring to decrease. This makes the electrophilic substitution reaction activity on the benzene ring decrease, and the difficulty of the electrophilic reagent to attack the benzene ring increases. However, this group can enhance the molecular fat solubility, affect the physical properties and biological activities of compounds, and is of great significance in the fields of medicinal chemistry and materials science.
In addition, the spatial arrangement of atoms in 1-bromo-2-iodine-4- (trifluoromethoxy) benzene molecules determines its spatial structure, affects the interaction between molecules, and then affects its physical properties such as melting point and boiling point. And because of its halogen atoms and electron-withdrawing groups, it is also worthy of attention in the environment or the way it interacts with other substances. It has potential applications in many fields such as organic synthesis, pharmaceutical research and development, and material preparation.
What is the price range of 1-Bromo-2-Iodo-4- (Trifluoromethoxy) Benzene in the market?
The price of 1-bromo-2-iodine-4- (trifluoromethoxy) benzene in the market is difficult to determine due to different market conditions and changing supply and demand. Looking at the market conditions in the past, its price was determined by many factors.
First, the price of raw materials is heavily tied. In the production of this compound, the abundance of raw materials used and the rise and fall of the price will cause its cost to fluctuate, which in turn will affect the selling price. If the raw materials are rare and expensive, the price of this product should be high.
Second, the simplicity of the process is also the key. If the production requires exquisite and complicated methods, it will take a long time and cost a lot of labor, and the price will also increase. If the reaction conditions used are harsh, or special catalysts are required, the cost will rise.
Third, the supply and demand of the market is related to the rise and fall of prices. If there are many applicants and few suppliers, the price will rise; on the contrary, if the supply exceeds the demand, the price will decline. If this product is mostly used in the preparation of special pharmaceutical and electronic materials, when these industries prosper, the demand surges, and the price will also rise.
Fourth, changes in the current situation also have an impact. Trade policies and tariff adjustments can cause fluctuations in the market. If trade barriers are added, the road to imports is blocked, and the supply of local products changes, the price will also change.
Roughly speaking, in the past, the price of this product in the market ranged from tens to hundreds of yuan per gram. However, this is only an approximation. Today, the price determination still needs to be carefully considered in the current market conditions, and the price can only be obtained by consulting the commercial of chemical materials or the institution of market research.