1-Bromo-2-Fluorobenzene

Hongda Chemical

Specifications

HS Code	961671
Chemical Formula	C6H4BrF
Molar Mass	175.00 g/mol
Appearance	Colorless to light yellow liquid
Density	1.605 g/cm³ (at 20°C)
Boiling Point	174 - 176°C
Solubility In Water	Insoluble
Solubility In Organic Solvents	Soluble in common organic solvents like ethanol, ether
Flash Point	62°C
Odor	Characteristic aromatic odor
Refractive Index	1.546 (at 20°C)

As an accredited 1-Bromo-2-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	1 - bromo - 2 - fluorobenzene packaged in 500 - mL glass bottles, 10 bottles per carton.
Storage	1 - Bromo - 2 - fluorobenzene should be stored in a cool, well - ventilated area, away from heat sources and open flames. It should be placed in a tightly sealed container to prevent vapor leakage. Since it is a potentially hazardous chemical, store it separately from oxidizing agents, reducing agents, and other reactive substances to avoid dangerous reactions.
Shipping	1 - bromo - 2 - fluorobenzene is a chemical. For shipping, it must be in properly sealed, corrosion - resistant containers. Label packages clearly with relevant hazard warnings. Ship via approved carriers following strict chemical transport regulations.

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General Information

Historical Development

The industry of chemical industry is changing with each passing day, and all kinds of compounds have their own origins and changes. In today's words 1 - Bromo - 2 - Fluorobenzene, in the past, when it first appeared, the workers worked hard to explore its properties and ponder its methods.
In the past, the art of chemical industry was not as skilled as it is today, and it was difficult to obtain this compound. The craftsmen tried it repeatedly, either in simple workshops or in simple environments, with limited materials, seeking unlimited possibilities. The first products, impure and few, are the foundation of the later.
After years of delay, craftsmen have improved their skills day by day, and the quality of 1-Bromo-2-Fluorobenzene has gradually improved, and the output has also increased. From the scarcity of the past to today, it can meet the needs of many parties. During the evolution, it really depends on the unremitting efforts of the ancestors, so that this product can be developed in the field of chemical industry and become the grand view of today.

Product Overview

1 - Bromo - 2 - Fluorobenzene is an organic compound. It may be a colorless liquid with a special odor. In this compound, bromo (Bromo) and fluorine (Fluor) atoms are respectively attached to the benzene ring, giving it unique chemical properties.
In the field of organic synthesis, 1 - Bromo - 2 - Fluorobenzene has a wide range of uses. Because it contains halogen atoms, it can participate in many reactions. For example, in nucleophilic substitution reactions, bromine atoms or fluorine atoms can be replaced by other nucleophiles to form new carbon-heteroatomic bonds to prepare various organic intermediates. It can also be used for coupling reactions, combining with other organometallic reagents to expand the carbon skeleton of molecules and facilitate the synthesis of complex organic molecules.
However, it is also dangerous. Its vapor may irritate the eyes, respiratory tract, etc. When operating, it is necessary to strictly follow safety procedures, conduct it in a well-ventilated place, and take protective measures to avoid harm to the human body. In short, 1-Bromo-2-Fluorobenzene plays an important role in chemical research and industrial production, and should be used with caution.

Physical & Chemical Properties

1 - Bromo - 2 - Fluorobenzene is also an organic compound. Its physical and chemical properties can be studied. Looking at its physical properties, at room temperature, it is mostly liquid, with clear color and taste. Boiling point and melting point are the key markers of physical state transformation. The boiling point is related to the temperature of its gasification, and the melting point determines the boundary between its solid and liquid. Its density is also a characteristic. Under specific conditions, it shows a certain value, which is related to its distribution when mixed with other substances.
As for chemical properties, because its structure contains two atoms of bromine and fluorine, it has unique reactivity. Bromine atoms are more active and can participate in substitution reactions, providing an opportunity to introduce new functional groups. The strong electronegativity of fluorine atoms affects the electron cloud distribution of molecules, which makes the compound exhibit unique behavior in nucleophilic and electrophilic reactions. The synergy between the two makes 1-Bromo-2-Fluorobenzene useful in the field of organic synthesis and an important raw material for many chemical synthesis reactions.

Technical Specifications & Labeling

1 - Bromo - 2 - Fluorobenzene is an important compound in organic synthesis. Its preparation process needs to be strictly controlled. The selection of raw materials is crucial. When benzene derivatives are used as starting materials, bromine and fluorine atoms are introduced through halogenation. When preparing
, the reaction conditions must be precisely regulated. Temperature, pressure and reaction time all affect the purity and yield of the product. The reaction temperature should be maintained at a certain range. If it is too high or causes more side reactions, if it is too low, the reaction rate will be delayed.
Quality testing is also indispensable. Spectroscopic analysis methods such as nuclear magnetic resonance (NMR) and infrared spectroscopy (IR) can be used to determine the structure and purity of the product. The quality of 1-Bromo-2-Fluorobenzene can be ensured by precise measurement of chemical shifts and absorption peaks to clarify the molecular structure and identify impurities.

Preparation Method

1 - Bromo - 2 - Fluorobenzene is an organic compound, and the selection of raw materials is very important for the preparation of this compound. O-fluoroaniline can be selected as the initial raw material, and the preparation goal can be achieved by the diazotization reaction and Sandmeier reaction.
The preparation process is as follows: First, o-fluoroaniline is diazotized with hydrochloric acid and sodium nitrite in a low temperature environment to generate a diazonium salt. This step requires strict temperature control to prevent the decomposition of the diazonium salt. Then, the generated diazoic salt is reacted with cuprous bromide and undergone the Sandmeier reaction to obtain 1 - Bromo - 2 - Fluorobenzene.
The reaction steps are as follows: In the first step, under the condition of 0-5 ℃, the o-fluoroaniline is slowly dropped into the mixed solution containing hydrochloric acid and sodium nitrite, and stirred evenly to ensure that the reaction is sufficient. In the second step, the above-mentioned diazonium salt solution is slowly added to the solution containing cuprous bromide, and stirred continuously to promote the smooth progress of the reaction.
In terms of catalytic mechanism, cuprous bromide acts as a catalyst in the Sandmeier reaction, which can effectively reduce the activation energy of the reaction, accelerate the reaction rate, and enable the diazonium group to be replaced by bromine atoms smoothly, achieving the preparation of 1-Bromo-2-Fluorobenzene.

Chemical Reactions & Modifications

1 - Bromo - 2 - Fluorobenzene is an important raw material for organic synthesis, and its chemical reaction and modification are extremely critical. In the field of organic synthesis, it is often modified by nucleophilic substitution reactions.
In the past, nucleophilic substitution reactions were mostly carried out with conventional reagents and conditions. However, conventional methods have the drawbacks of low reaction efficiency and many side reactions. Therefore, the reaction conditions need to be improved.
Some scholars have tried to intervene in the reaction with a new catalyst, which can significantly improve the reaction rate and reduce side reactions. In addition, in the choice of reaction solvent, after many experiments, the selection of a solvent with a specific polarity can make the reaction easier to proceed and the purity of the product can be improved. The chemical reaction of 1-Bromo-2-Fluorobenzene is optimized and modified in this way, which makes it more applicable in the organic synthesis industry, and can prepare more high-purity target products, which promotes the development of the field of organic synthesis.

Synonyms & Product Names

1 - Bromo - 2 - Fluorobenzene, this thing is also, its synonymous name and the name of the commodity, there is quite a bit to investigate. There are many names for chemical things, or according to their structure, or according to their actual use, each has its own name.
This 1 - Bromo - 2 - Fluorobenzene, from its structure, is above the benzene ring, one bromide and one fluorine, the position is established, and the name follows. However, among the shops, the merchants are for the convenience of trade, or another name for the commodity.
In the past, Fang family studied, in order to clarify its nature, scrutinized its quality, and often called it in the name of synonymy. Due to the convenience of experimentation or academic tradition, although the names are different, they actually refer to the same thing.
Looking at the classics, the names of synonyms help scholars understand their essence, while the names of commodities have the effect of identification in the field of industry and commerce. Although the two are different, they are both related to the cognition and application of 1-Bromo-2-Fluorobenzene, and cannot be ignored in the field of chemistry.

Safety & Operational Standards

1 - Bromo - 2 - Fluorobenzene is an important chemical substance that is widely used in many fields of chemical research and industrial production. However, the safety and operating standards of this substance are of paramount importance.
Its properties have certain chemical activity. During operation, the first thing to do is to ensure that the environment is well ventilated. If placed in a closed space, volatile gas accumulates, or accidents may occur. As the ancients said: "Ventilation is smooth, and hidden dangers can be eliminated." The operator must wear appropriate protective equipment, such as protective clothing, gloves and goggles, to prevent it from coming into contact with the skin and eyes. Because of contact with this substance, it may cause skin irritation and burns, and if it enters the eyes, it is even more harmful.
When storing, it should be placed in a cool, dry place away from fire sources and oxidants. If stored improperly, it may cause a violent reaction or even an explosion when exposed to heat or strong oxidants. Ancient books also say: "The hiding of things, according to the nature of the choice, can keep safe."
During the process of taking and transferring 1-Bromo-2-Fluorobenzene, the action must be precise and gentle to prevent it from spilling. In the event of spilling, it should be dealt with immediately according to the established emergency procedures. Cover it with adsorption material first to avoid diffusion, and then collect and dispose of it carefully. Do not rinse and discharge it into the sewer at will to avoid polluting the environment.
In addition, the relevant operators should be professionally trained to be familiar with the characteristics, safety precautions and emergency treatment methods of this product. Only in this way can 1-Bromo-2-Fluorobenzene be ensured to be safe during use, and the operation is orderly, so that the research and production can be carried out smoothly, so as not to cause disasters due to negligence.

Application Area

1 - Bromo - 2 - Fluorobenzene is an organic compound with a wide range of application fields. In the field of medicinal chemistry, it is often used as a key intermediate for the synthesis of drug molecules with specific biological activities. Due to its unique chemical structure, it can participate in a variety of chemical reactions, help to build complex drug frameworks, or introduce specific functional groups, thereby enhancing drug efficacy and selectivity.
In the field of materials science, this compound can lay the foundation for the synthesis of new functional materials. For example, after a specific chemical reaction, it can be introduced into polymer structures to give materials special photoelectric properties, or improve the thermal stability and mechanical properties of materials, and is used in electronic devices, optical materials and other fields.
Furthermore, in organic synthesis chemistry, 1-Bromo-2-Fluorobenzene is an important starting material for the construction of many complex organic molecules. Chemists use ingenious design of reaction routes to take advantage of the activity differences between bromine and fluorine functional groups to carry out nucleophilic substitution, coupling and other reactions to expand the structural diversity of organic compounds, contributing to the development of organic synthesis chemistry.

Research & Development

I have been studying chemical products for a long time, and recently I focused on 1-Bromo-2-Fluorobenzene. This compound has great potential for research and development.
Its unique structure, the substitution of bromine and fluorine atoms, endows it with specific chemical properties. After many experiments, it was found that it can be used as a key intermediate in the field of organic synthesis. Under specific reaction conditions, it can be cleverly combined with a variety of reagents to derive a series of compounds with special properties.
However, there are still challenges to its wide application. Such as precise control of reaction selectivity and effective control of cost in the preparation process. We, the researchers, should make unremitting efforts to find ways to optimize, improve its preparation efficiency and application value, and hope to contribute to the development of the chemical field, so that its potential can be fully realized.

Toxicity Research

Yu Su is dedicated to the research of poisons, and recently focused on 1-Bromo-2-Fluorobenzene. Although this substance is a commonly used reagent in organic synthesis, its toxicity cannot be underestimated.
Looking at its chemical structure, the characteristics of bromine and fluorine atoms give it special activity. Experiments have shown that it can disturb the metabolism of cells in organisms. Taking small animals as an experiment, it can be seen that they are slow to move and seem to be mentally tired.
Investigate its toxicology, or due to the affinity of bromine and fluorine atoms with the activity checking points of proteins and enzymes in the body, the function of proteins and enzymes is abnormal. Although the whole leopard is not yet known, its toxicity has been revealed. In order to prevent its harm, during production and use, it is necessary to strictly abide by the procedures and prepare proper protective equipment to avoid poisons hurting people. And continue to conduct in-depth research to clarify the details and protect people from being invisible.

Future Prospects

1 - Bromo - 2 - Fluorobenzene is an important raw material for organic synthesis and has broad prospects. Although the current preparation technology has been achieved, there is still room for improvement. In the future, we are expected to borrow new technologies and new methods to optimize the synthesis path and improve the yield and purity.
This compound may have a major breakthrough in the field of medicine, or it may help to develop new specific drugs and contribute to human health and well-being. In the field of materials science, it may also lead to novel high-performance materials, which are widely used in many fields such as electronics and optics.
Furthermore, with the concept of green chemistry deeply rooted in the hearts of the people, the green synthesis of 1 - Bromo - 2 - Fluorobenzene will become a key development direction. Strive to reduce energy consumption, reduce pollution and achieve sustainable development. In this way, 1 - Bromo - 2 - Fluorobenzene will surely shine in the future and lead the innovation and development in related fields.

Where to Buy 1-Bromo-2-Fluorobenzene in China?

As a trusted 1-Bromo-2-Fluorobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.

Frequently Asked Questions

As a leading 1-Bromo-2-Fluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-Bromo-2-Fluorobenzene?

1-Bromo-2-fluorobenzene is also an organic compound. It has a wide range of uses and has many important applications in the field of chemical synthesis.
First, it is often a key intermediate in organic synthesis. Chemists can use various chemical reactions to involve bromine atoms or fluorine atoms of 1-bromo-2-fluorobenzene to construct complex and delicate organic molecular structures. For example, in the construction of fluorine-containing aromatic compounds, this compound can be used as a starting material, and other functional groups can replace bromine atoms through substitution reactions to prepare organic materials with specific properties and functions.
Furthermore, it also has significant uses in the field of medicinal chemistry. Due to the unique properties of fluorine atoms, the introduction of fluorine-containing groups can often change the physicochemical properties, biological activities and metabolic stability of drug molecules. 1-Bromo-2-fluorobenzene can be used as an important building block to provide a structural basis for the development of new drugs, helping to create drugs with better efficacy and fewer side effects.
In addition, in the field of materials science, 1-bromo-2-fluorobenzene participates in the synthesis of organic materials, or has special photoelectric properties. Such materials can be applied in the fields of organic Light Emitting Diodes (OLEDs), solar cells, etc., contributing to the improvement of materials' performance and functional expansion. Due to the presence of bromine and fluorine atoms in the structure, the material is endowed with a unique electron cloud distribution and spatial configuration, which in turn affects the electrical and optical properties of the material.
In short, although 1-bromo-2-fluorobenzene is a small organic molecule, it plays an indispensable role in many fields such as chemical industry, medicine, and materials, and is of great significance to promote the development of related fields.

What are the physical properties of 1-Bromo-2-Fluorobenzene?

1-Bromo-2-fluorobenzene is one of the organic compounds. It has many physical properties, which are described as follows:
Under normal temperature and pressure, 1-bromo-2-fluorobenzene is a colorless to light yellow transparent liquid. When left in sunlight or for a long time, or due to slow oxidation, the color may become slightly darker.
The boiling point is about 173-174 ° C. The value of this boiling point is determined by the intermolecular force. The existence of van der Waals forces between its molecules, and the presence of bromine and fluorine atoms changes the polarity of the molecule, which in turn affects the intermolecular forces, causing its boiling point to be at the S value.
As for the melting point, it is about -13 ° C. The melting point depends on the lattice energy and the intermolecular forces. In this compound, the molecular arrangement and interaction make the melting point fall within this range.
The density of 1-bromo-2-fluorobenzene is about 1.71 g/mL. The size of the density depends on the mass of the molecule and the degree of compactness between the molecules. The relative atomic mass of bromine and fluorine atoms is larger, and the molecular structure is specific, resulting in higher densities.
Its solubility is also an important physical property. 1-Bromo-2-fluorobenzene is insoluble in water, because water is a polar solvent, and although the compound contains polar bromine and fluorine atoms, the whole molecule is not strongly polar, and it is "similarly soluble", so it is difficult to dissolve in water. However, it is soluble in many organic solvents, such as ethanol, ether, dichloromethane, etc. Because the force between organic solvents and 1-bromo-2-fluorobenzene molecules is similar, it is mutually soluble.
In addition, 1-bromo-2-fluorobenzene has a certain volatility and will gradually evaporate in an open environment. Its volatilization rate is related to factors such as temperature, surface area, and air circulation. The higher the temperature, the larger the surface area, and the smoother the air circulation, the faster the volatilization.

Is 1-Bromo-2-Fluorobenzene chemically stable?

1-Bromo-2-fluorobenzene is also an organic compound. The stability of its chemical properties is related to various factors and cannot be generalized.
From the perspective of chemical bonds, carbon-bromine bonds and carbon-fluorine bonds have their own characteristics. In the carbon-bromine bond, the bromine atom has a larger radius and the carbon-bromine bond has a longer length. This bond is relatively easy to break, so that the bromine atom of the compound is easily replaced under certain conditions. For example, in the nucleophilic substitution reaction, if there are suitable nucleophiles, such as sodium alcohol, amines, etc., the carbon-bromine bond can be broken, and the bromine atom is replaced by a nucleophilic group.
The carbon-fluorine bond is not the case. The fluorine atom is extremely electronegative, and the carbon-fluorine bond energy is quite high and very stable. The existence of this bond affects the overall stability of the molecule to a certain extent, and also affects its reactivity, so that the reaction is mostly carried out in the direction of retaining the carbon-fluorine bond.
Furthermore, the conjugate system of the benzene ring has a great influence on the stability of 1-bromo-2-fluorobenzene. The benzene ring has a large pi bond conjugate system, and the electron cloud can be delocalized, which reduces the molecular energy and enhances the stability. However, the substitution of bromine and fluorine on the benzene ring will change the electron cloud density distribution of the Fluorine atoms have strong electron-absorbing induction effect. Bromine atoms have both electron-absorbing induction effect and electron-giving conjugation effect. The combined effect of the two causes the change of electron cloud density of benzene ring, which affects its reactivity and stability.
In common chemical environments, 1-bromo-2-fluorobenzene can remain relatively stable without special conditions. However, under conditions such as high temperature, strong acid-base or specific catalyst, various reactions can occur, such as substitution, addition, etc., and the stability also changes.
To sum up, the stability of 1-bromo-2-fluorobenzene is not static and depends on the specific chemical environment and reaction conditions.

What are 1-Bromo-2-Fluorobenzene synthesis methods?

The synthesis methods of 1-bromo-2-fluorobenzene are ancient and various. The following are several common methods described in detail.
First, o-fluoroaniline is used as the starting material. The diazotization reaction of o-fluoroaniline with sodium nitrite and hydrobromic acid is carried out at low temperature. This step requires careful temperature control to prevent the reaction from being too violent. The resulting diazonium salt is unstable, followed by the addition of cuprous bromide, a Sandmeier reaction occurs, and the diazonium group is replaced by a bromine atom to obtain 1-bromo-2-fluorobenzene. The reaction conditions of this method are relatively mild, but the preparation process of diazonium salt needs to be handled with caution to prevent the danger of explosion.
Second, take o-fluorobenzoic acid as the starting material. First, it is converted into o-fluorobenzoyl chloride, which can be achieved by co-heating with sulfoxide chloride. Then o-fluorobenzoyl chloride is reduced to o-fluorobenzyl alcohol under the action of a reducing agent such as lithium aluminum hydride. Then o-fluorobenzyl alcohol reacts with phosphorus tribromide, and the hydroxyl group is replaced by a bromine atom, and the target product can be obtained through a series of reactions. There are many steps in this route, but the reaction of each step is relatively classic and easy to control.
Third, o-difluorobenzene is used as the raw material. Under the action of a specific catalyst, such as a palladium-containing catalyst system, an electrophilic By selecting suitable reaction conditions and catalysts, bromine atoms can selectively replace hydrogen atoms in the ortho-position of one fluorine atom to generate 1-bromo-2-fluorobenzene. This method has high selectivity, but the cost of catalysts may be high, and the requirements for reaction equipment are not low.
All synthesis methods have advantages and disadvantages. In practical application, it is necessary to comprehensively weigh factors such as raw material availability, cost, and reaction conditions, and choose the most suitable method to prepare 1-bromo-2-fluorobenzene.

1-Bromo-2-Fluorobenzene What are the precautions in storage and transportation?

1-Bromo-2-fluorobenzene is also an organic compound. During storage and transportation, many matters must be observed.
First words storage. This compound has a certain chemical activity and should be stored in a cool and ventilated warehouse. Due to excessive temperature, it may cause chemical reactions, damage its quality, or even cause danger. The temperature of the warehouse should be controlled within a specific range to ensure its stability. And it should be kept away from fire, heat sources, open flames and hot topics, which can make it uneasy and cause accidents.
Furthermore, it must be stored separately from oxidants, acids, bases, etc. 1-Bromo-2-fluorobenzene and other substances have different chemical properties. When mixed, it is easy to cause chemical reactions, or produce harmful gases, or cause explosions and other disasters. At the same time, the storage area should be equipped with suitable materials to contain the substances that may leak, so as to prevent the leakage from spreading around, polluting the environment and endangering safety.
As for transportation, also need to be cautious. Before transportation, make sure that the packaging is complete. The packaging is not good, the bumps and vibrations during transportation are easy to cause leakage. The packaging materials used should be able to withstand certain external forces and have the ability to prevent leakage. During transportation, the driving should be stable, avoid violent actions such as sudden braking and sharp turning, and prevent the packaging from being damaged. Transport vehicles should also follow the prescribed route, away from sensitive areas such as densely populated areas and water sources. Escorts must be familiar with their characteristics and emergency treatment methods. In case of emergencies, they can respond in time to reduce the harm. In short, the storage and transportation of 1-bromo-2-fluorobenzene must comply with relevant regulations and be careful to ensure that security is not at risk.