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1-Bromo-2-Fluoro-5-Iodobenzene

1-Bromo-2-Fluoro-5-Iodobenzene

Hongda Chemical

Specifications

HS Code

210387

Name 1-Bromo-2-fluoro-5-iodobenzene
Molecular Formula C6H3BrFI
Molecular Weight 300.89
Appearance Off - white to light yellow solid
Cas Number 90297-60-6
Boiling Point 236 - 238 °C
Melting Point 38 - 42 °C
Density 2.326 g/cm³
Flash Point 100.9±23.2 °C
Solubility Soluble in organic solvents like dichloromethane, chloroform

As an accredited 1-Bromo-2-Fluoro-5-Iodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 1 - bromo - 2 - fluoro - 5 - iodobenzene packaged in a sealed glass bottle.
Storage 1 - Bromo - 2 - fluoro - 5 - iodobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials like glass. Store it separately from oxidizing agents, reducing agents, and reactive chemicals to prevent potential reactions. Label the storage clearly for easy identification.
Shipping 1 - bromo - 2 - fluoro - 5 - iodobenzene is shipped in well - sealed, corrosion - resistant containers. Shipment adheres to strict chemical transportation regulations, ensuring proper handling to prevent leakage and maintain safety during transit.
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1-Bromo-2-Fluoro-5-Iodobenzene 1-Bromo-2-Fluoro-5-Iodobenzene
General Information
Historical Development
1 - Bromo - 2 - Fluoro - 5 - Iodobenzene is also a product of transformation. Its development is the result of years of research by the scientific community. In the past, the field of transformation was not as prosperous as it is today, and the research of this compound was like reaching the sky.
At the beginning of the year, many countries suffered from the lack of materials and the thinness of methods. However, his ambition has not changed, and he is eager to explore. The moon has changed, the technology of transformation has been improved, and new materials and new materials have been developed.
The insight and perseverance of the sensitivity of the family, the understanding of the opposite, and the like. For the second time, we have obtained the law, so that 1 - Bromo - 2 - Fluoro - 5 - Iodobenzene will be born. It is a new way of research and development, and it has also laid a good foundation for research and development. Since then, it has added a bright light to the history of transformation.
Product Overview
1 - Bromo - 2 - Fluoro - 5 - Iodobenzene is also an organic compound. Its molecular structure is unique, containing bromine, fluorine, and iodine halogen atoms above the benzene ring. Bromine atoms occupy the first position of the benzene ring, fluorine atoms rank second, and iodine atoms are at the fifth position, with an orderly layout.
This compound has specific properties and has certain reactivity due to the presence of halogen atoms. It can be used for various reactions in organic synthesis, such as nucleophilic substitution, to introduce other functional groups to build complex organic molecules. It may have potential applications in pharmaceutical chemistry, materials science, etc. In drug development, it may become a key intermediate to help form drug molecules with specific activities. In the synthesis of materials, it may affect the electronic and physical properties of materials. The study of this compound is of great significance for expanding organic synthesis methods and discovering new functional materials.
Physical & Chemical Properties
1 - Bromo - 2 - Fluoro - 5 - Iodobenzene is an organic compound, and its physical and chemical properties are very important. Looking at its physical properties, it is liquid at room temperature or has a special odor. The melting point and boiling point are affected by the intermolecular force. Due to the presence of bromine, fluorine and iodine atoms, the molecular polarity is enhanced, and the intermolecular force is increased, and the melting boiling point may change accordingly.
In terms of chemical properties, its benzene ring is aromatic and can undergo electrophilic substitution reaction. Bromine, fluorine and iodine atoms as substituents have an impact on the density distribution of the benzene ring electron cloud. Fluorine atoms are highly electronegative and have an electron-absorbing induction effect, which reduces the density of the benzene ring electron cloud and changes the reactivity. Although the atoms of bromine and iodine are also electronegative, they have lone pairs of electrons, which can be conjugated with the benzene ring, which affects the selectivity of the check point of the electrophilic substitution reaction. This compound has active chemical properties and may have many applications in the field of organic synthesis.
Technical Specifications & Labeling
1 - Bromo - 2 - Fluoro - 5 - Iodobenzene is an important organic compound. Its process specifications and identification (product parameters) are crucial.
Discussing the process specifications, when synthesizing this compound, the reaction conditions need to be precisely controlled. For example, the reaction temperature should be maintained in a specific range to ensure the efficiency of the reaction and the purity of the product. The ratio of reactants cannot be ignored, and precise formulation can achieve the best reaction effect.
In terms of identification (product parameters), the purity index needs to be clarified, which is related to the performance of the product in various application scenarios. Its appearance characteristics should also be recorded in detail, such as color, morphology, etc., to facilitate accurate identification. In this way, the quality of 1 - Bromo - 2 - Fluoro - 5 - Iodobenzene products can be guaranteed to meet the needs of different fields.
Preparation Method
To prepare 1 - Bromo - 2 - Fluoro - 5 - Iodobenzene, prepare raw materials. Take fluorobenzene as the starting material, and under the catalysis of bromine and iron, through electrophilic substitution, bromine enters the ortho position to obtain 2 - fluorobenzene. In this step, the temperature control is moderate, so that the reaction is sufficient and the by-product is less.
Next, 2 - fluorobenzene interacts with iodine in a specific reagent. After substitution reaction, iodine enters the counter position to form 1 - Bromo - 2 - Fluoro - 5 - Iodobenzene. Pay attention to the proportion of each substance during the reaction process and monitor it in a timely manner.
The product is separated and purified, and impurities are removed by distillation and recrystallization to obtain pure products. In this process, the raw materials are easy to obtain, the reaction steps are clear, and the control is proper. The optimum yield of 1-Bromo-2-Fluoro-5-Iodobenzene can be obtained.
Chemical Reactions & Modifications
To taste the wonders of chemical industry, it is related to the change of substances, and the reaction and modification are particularly important. In today's words, 1 - Bromo - 2 - Fluoro - 5 - Iodobenzene. In the field of organic synthesis, it is often the starting material. To change its properties, consider various reactions.
If the method of nucleophilic substitution is used, it may be possible to ease its halogen atoms to obtain other derivatives to increase its activity and use. On aromatic rings, bromine, fluorine, and iodine have their own characteristics, which can trigger different changes according to different reaction conditions.
Or the reaction of coupling makes it connect with other organic fragments, expand the molecular structure, and derive new substances. And in its structure, the resistance of the halogen atom and the electronic effect all affect the reaction path and rate.
Making good use of various reaction conditions, such as temperature, solvent, catalyst, adjusting its reactivity, and precise modification can open up new ways for chemical synthesis and produce more useful substances to meet various needs.
Synonyms & Product Names
Today there is a thing called 1 - Bromo - 2 - Fluoro - 5 - Iodobenzene. Although its name is complex, it is crucial for our chemical research.
The synonymous name of this thing also needs to be carefully examined. A synonymous name is like a wrong road in a forest. Although it appears to be different, it actually points to one place. In the field of chemistry, a synonymous name can help us better understand its essence and broaden the realm of cognition.
As for the trade name, it should not be underestimated. The trade name is the logo of this thing circulating in the market, which is well known to everyone. Different markets, different uses, or different trade names. This is all about the operation of business, and it is also related to our research.
Our chemical researchers must delve into the synonyms and trade names of this thing, and strive to gain insight into the true meaning of its chemistry in the name of complexity, so as to help the progress of research and contribute to the development of chemistry.
Safety & Operational Standards
1 - Bromo - 2 - Fluoro - 5 - Iodobenzene is an important chemical substance that is often used in our chemical research. Its safety and operating standards are of paramount importance to the smooth progress of our research and the safety of personnel.
Store this substance in a cool, dry and well-ventilated place. Keep away from fire and heat sources to prevent accidents. Because of its certain chemical activity, improper storage or deterioration will affect the accuracy of subsequent experiments. And it needs to be stored in isolation from oxidizing agents, reducing agents, etc., to avoid dangerous chemical reactions.
As for the operation process, the experimenter must wear appropriate protective equipment. Wear protective gloves to prevent skin contact, as it may irritate and corrode the skin. Wear protective glasses to protect your eyes from possible splashing damage. The operation should be carried out in a fume hood, which can effectively eliminate volatile gaseous substances, reduce their concentration in the experimental environment, and ensure the safety of the experimenter's breathing.
When taking the substance, the action should be steady and accurate. Use clean, dry appliances to avoid impurities from mixing. Measure the required amount accurately, and do not take more at will to prevent waste and subsequent processing troubles. If it is accidentally spilled, do not panic, and should be handled immediately according to the established cleaning procedures. Cover it with appropriate adsorption material to prevent its spread, and then collect it carefully and dispose of it properly.
Furthermore, after the experiment is completed, the remaining 1 - Bromo - 2 - Fluoro - 5 - Iodobenzene should not be discarded at will. Recycling or harmless treatment should be carried out in accordance with relevant regulations. In this way, the safety of the entire research process can be ensured, so that our chemical research can be carried out in an orderly and smooth manner.
Application Area
1 - Bromo - 2 - Fluoro - 5 - Iodobenzene is a special chemical substance. Its application field is quite wide. In the field of organic synthesis, it is often used as a key intermediate. In ancient Chinese, this substance can be used to prepare other complex organic compounds.
The exquisite organic synthesis of man, 1 - Bromo - 2 - Fluoro - 5 - Iodobenzene can participate in a variety of chemical reactions due to its unique structure. Its bromine, fluorine and iodine atomic properties enable it to react with many reagents such as substitution and addition. For example, when preparing certain compounds with specific pharmacological activities, this substance can skillfully guide the reaction direction and help synthesize the target product.
In the field of materials science, it may be used to create new functional materials. Through chemical reactions, it is introduced into the material structure, giving the material unique electrical, optical and other properties. It is an important substance that cannot be ignored in chemical research and application, and plays a key role in many fields, promoting the progress and development of related science and technology.
Research & Development
Today there is a substance called 1 - Bromo - 2 - Fluoro - 5 - Iodobenzene. As a chemical researcher, I often study the properties of this substance.
Looking at its structure, bromine, fluorine and iodine atoms are attached to the benzene ring. This unique structure makes it have different chemical activities. I often use various experiments to explore its reaction mechanism.
In the field of organic synthesis, this substance can be a key intermediate. Through a specific reaction path, a variety of compounds may be derived, which can be used in medicine, materials and other industries.
Our scientific researchers study day and night, hoping to expand the breadth and depth of its application. Drawing on the foundation of ancient methods and using current techniques, I hope to achieve something, and promote this object to shine in industrial production and academic research, so as to help the advancement of science and technology and the benefit of people's livelihood.
Toxicity Research
Recently, I have focused on the toxicity study of 1 - Bromo - 2 - Fluoro - 5 - Iodobenzene. Looking at its molecular structure, bromine, fluorine, and iodine atoms are connected to the benzene ring. This structure may cause it to have unique chemical activity and toxicity characteristics.
From an experimental point of view, it is applied to the test organism at an increasing dose. At the beginning, the behavior of the test organism is slightly different, and there is no serious pathology. And the dose reaches a certain value, it can be seen that the test organism is slow to move, eats less, and its physiological function gradually decays.
After analysis, this substance enters the organism or interacts with biological macromolecules such as proteins and nucleic acids to disrupt its normal physiological function. The characteristics of its halogen atoms may enhance the reactivity, making it easier to chemically react with substances in the body of organisms, causing cell damage, and then affecting the overall health of organisms.
In summary, 1-Bromo-2-Fluoro-5-Iodobenzene has certain toxicity. Follow-up studies need to explore its toxicological mechanism and preventive measures to avoid its harm to organisms and the environment.
Future Prospects
1 - Bromo - 2 - Fluoro - 5 - Iodobenzene is also a material for chemical processing. The future prospects of this product can be improved.
This product has the field of synthesis, or can open up new avenues. Its special properties, including bromine, fluorine, and iodine atoms, must be reduced. Not yet, or it can be used as a new way to synthesize rare compounds, to meet the needs of manufacturing, materials, etc.
In terms of production, it may be based on its performance, develop special effects, and cure diseases. In the field of materials, it may be possible to obtain new materials with excellent performance, which can be used in manufacturing and aviation.
However, if you want to achieve this state, you also need to be diverse and exhaustive, study its characteristics in depth, and break it down. In the future, 1 - Bromo - 2 - Fluoro - 5 - Iodobenzene can expand the color, become the cornerstone of the first step, and push forward to make a difference to the world.
Where to Buy 1-Bromo-2-Fluoro-5-Iodobenzene in China?
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Frequently Asked Questions

As a leading 1-Bromo-2-Fluoro-5-Iodobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What is the chemistry of 1-Bromo-2-Fluoro-5-Iodobenzene?
1-Bromo-2-fluoro-5-iodobenzene is also an organic compound. Its chemical properties are particularly important and affect many chemical reactions and applications.
In this compound, the presence of halogen atoms such as bromine (Br), fluorine (F) and iodine (I) endows it with unique chemical activities. Halogen atoms have electron-absorbing properties, which can affect the electron cloud density of benzene rings. When the benzene ring undergoes electrophilic substitution reactions, the regioselectivity is different. Usually, halogen atoms are ortho and para-sites, but because of their electron-absorbing properties, the electron cloud density of benzene rings is reduced, so the electrophilic substitution reaction activity is slightly less than that of benzene.
For nucleophilic substitution reactions, halogen atoms can be used as leaving groups. The large volume of iodine atoms and weak carbon-halogen bonds make them have a high tendency to leave and are more likely to be replaced by nucleophiles. Bromine atoms are second, and fluorine atoms are more difficult to leave due to high carbon-fluorine bond energy.
In addition, 1-bromo-2-fluoro-5-iodobenzene can participate in metal-catalyzed coupling reactions, such as Suzuki coupling, Stille coupling, etc. In these reactions, halogen atoms interact with metal catalysts to form active intermediates, which are then coupled with other organic reagents to form carbon-carbon bonds. They are widely used in the field of organic synthesis and can produce complex organic molecules. They have potential applications in medicinal chemistry, materials science and other fields.
Its physical properties also affect chemical behavior, such as solubility, melting point, boiling point, etc. Such properties are related to its reactivity in different solvents and the choice of separation and purification methods. Overall, 1-bromo-2-fluoro-5-iodobenzene is rich in chemical properties and occupies an important position in the field of organic synthesis chemistry. It is a key raw material and intermediate for the creation of novel organic compounds.
What are the main uses of 1-Bromo-2-Fluoro-5-Iodobenzene?
1-Bromo-2-fluoro-5-iodobenzene is also an organic compound. It has a wide range of uses and is often a key raw material and intermediate in the field of organic synthesis.
In the field of medicinal chemistry, based on this, many biologically active molecules can be prepared. With its structural properties, it may interact with specific targets in organisms to help the research and development of new drugs.
In the path of materials science, it may participate in the synthesis of functional materials. Due to its halogen atom properties, it may affect the electronic structure and optical properties of materials, such as the preparation of materials with special optoelectronic properties, used in optoelectronic devices, such as organic Light Emitting Diodes, solar cells, etc.
It is also useful in the field of pesticide chemistry. After chemical modification, pesticide active ingredients with insecticidal, bactericidal, herbicide and other effects can be obtained, which can contribute to the control of pests and diseases in agricultural production.
In addition, in the field of academic research, chemists often use this compound to explore novel chemical reaction paths and mechanisms, expand the knowledge boundary of organic chemistry, and lay the foundation for the development of organic synthesis methodologies. It has important uses in organic synthesis, medicine, materials, pesticides, and scientific research, promoting progress and development in related fields.
What is 1-Bromo-2-Fluoro-5-Iodobenzene synthesis method?
The synthesis of 1-bromo-2-fluoro-5-iodobenzene is an important topic in organic synthetic chemistry. To synthesize this substance, many methods are often followed, among which halogenation is the common method.
First, benzene is used as the starting material because of its stable structure and wide source. First, benzene is halogenated, and suitable halogenating reagents can be selected. If you want to introduce fluorine atoms, you can use an electrophilic substitution reaction to use fluorine-containing reagents. Under appropriate reaction conditions, such as specific temperatures and catalysts, fluorine atoms are substituted for hydrogen atoms on the benzene ring to obtain fluorobenzene derivatives.
Then bromine atoms are introduced, and the method of electrophilic substitution reaction is also adopted. Choose a suitable brominating reagent to replace the hydrogen atom at a specific position on the benzene ring under specific reaction conditions. At this time, attention should be paid to the precise control of the reaction conditions, because different conditions will affect the selectivity of the substitution position.
As for the introduction of iodine atoms, the iodization reaction can be used. Select a suitable iodizing reagent and in the appropriate reaction system, urge the iodine atom to replace the hydrogen atom at a specific position on the benzene ring, so as to achieve the synthesis of 1-bromo-2-fluoro-5-iodobenzene.
Another strategy can also start with a halogen atom and gradually introduce the remaining halogen atoms through a multi-step reaction. In the meantime, a protective group strategy may be used to ensure that each halogenation reaction occurs at the expected position and avoid unnecessary side reactions. In short, the synthesis of 1-bromo-2-fluoro-5-iodobenzene requires careful design of the synthesis route and precise control of the reaction conditions according to the specific experimental conditions, availability of raw materials and the difficulty of the reaction, in order to effectively achieve the synthesis of the target product.
1-Bromo-2-Fluoro-5-Iodobenzene What are the precautions in storage and transportation?
1-Bromo-2-fluoro-5-iodobenzene is also an organic compound. During storage and transportation, many important items must not be ignored.
First word storage. This compound has a certain chemical activity and should be stored in a cool, dry and well-ventilated place. Cover a cool environment to reduce the rate of chemical reaction caused by temperature; dry conditions can avoid changes such as moisture hydrolysis; good ventilation can disperse harmful gases that may escape and ensure the safety of the storage environment. And it needs to be kept away from fire and heat sources to prevent the risk of explosion caused by heat.
Furthermore, it should be stored separately from oxidants and strong alkalis. Due to the encounter of 1-bromo-2-fluoro-5-iodobenzene with oxidants, or severe oxidation reaction; coexistence with strong bases may also trigger uncontrollable chemical changes, endangering safety. At the same time, the storage container must be sealed to prevent it from volatilizing or reacting with external substances.
As for transportation, caution is also required. Transportation vehicles should ensure that they are clean and dry, and there are no residual substances that may react with them. On the way, they must be protected from sun exposure, rain exposure, and high temperature. When loading and unloading, the operator should handle it lightly, and do not drop it or put heavy pressure on it to avoid damage to the container and leakage of compounds.
If leakage unfortunately occurs, emergency response must be done quickly. First evacuate the surrounding people, isolate the leaking area, and strictly prohibit the fire from approaching. Small leaks can be absorbed by inert materials such as sand and vermiculite; large leaks need to be built or dug for containment, and then properly disposed of. In this way, 1-bromo-2-fluoro-5-iodobenzene is safe for storage and transportation.
1-Bromo-2-Fluoro-5-Iodobenzene impact on the environment and people
1-Bromo-2-fluoro-5-iodobenzene is one of the organic compounds. It has many effects on the environment and human body.
First of all, its impact on the environment. This substance has a certain chemical stability. If it flows into the natural environment, it is not easy to degrade. In the soil, or adsorbed on soil particles, it causes gradual changes in soil properties, which affects the uptake of nutrients by plant roots, thereby hindering plant growth and development, or causing plant physiological disorders and affecting their reproduction. If it enters the water body, it will harm aquatic organisms. It may interfere with the nervous system and endocrine system of aquatic organisms, causing abnormal fish behavior, such as disordered swimming posture and reduced foraging ability. And through the bioaccumulation of the food chain, the concentration in high-trophic organisms gradually increases, endangering the balance of the entire aquatic ecosystem.
As for the impact on the human body, 1-bromo-2-fluoro-5-iodobenzene can enter the body through respiratory tract, skin contact, accidental ingestion, etc. Inhalation through the respiratory tract can irritate the mucosa of the respiratory tract, causing cough, asthma, breathing difficulties, etc. Contact with the skin, or cause skin allergic reactions, such as erythema, itching, blisters, etc. If eaten by mistake, it will damage the digestive system, causing nausea, vomiting, abdominal pain, diarrhea, etc. In particular, this substance may be potentially carcinogenic and teratogenic. Long-term exposure to this substance may cause genetic mutations in human cells, increasing the risk of cancer; in pregnant women, or affect the normal development of the fetus, causing fetal malformation.
Therefore, for 1-bromo-2-fluoro-5-iodobenzene compounds, when handled with caution, its production, use and discharge should be strictly controlled to protect the environment and human health.