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1-Bromo-2-Fluoro-4-(Trifluoromethyl)Benzene

1-Bromo-2-Fluoro-4-(Trifluoromethyl)Benzene

Hongda Chemical

    Specifications

    HS Code

    207544

    Name 1-Bromo-2-fluoro-4-(trifluoromethyl)benzene
    Molecular Formula C7H3BrF4
    Molecular Weight 243.00
    Appearance Colorless to light yellow liquid
    Boiling Point 165 - 167 °C
    Melting Point N/A
    Density 1.707 g/mL at 25 °C
    Flash Point 54 °C
    Solubility Insoluble in water, soluble in organic solvents like ethanol, ether
    Purity Typically high - purity products around 97%+
    Cas Number 124056-46-2

    As an accredited 1-Bromo-2-Fluoro-4-(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100g of 1 - bromo - 2 - fluoro - 4 - (trifluoromethyl)benzene in a sealed, chemical - resistant bottle.
    Storage 1 - Bromo - 2 - fluoro - 4 - (trifluoromethyl)benzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames as it is flammable. Keep it in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents and incompatible substances to avoid potential chemical reactions.
    Shipping 1 - bromo - 2 - fluoro - 4 - (trifluoromethyl)benzene is shipped in specialized, sealed containers to prevent leakage. It follows strict hazardous chemical shipping regulations, ensuring safe transportation.
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    1-Bromo-2-Fluoro-4-(Trifluoromethyl)Benzene 1-Bromo-2-Fluoro-4-(Trifluoromethyl)Benzene
    General Information
    Historical Development
    The chemical industry is changing with each passing day. All kinds of compounds have their own origins and changes. Today, 1 - Bromo - 2 - Fluoro - 4 - (Trifluoromethyl) Benzene is this compound.
    At the beginning, chemists were exploring the mysteries of matter, and occasionally came up with ideas to make this unique product. At that time, the experimental method was still simple, and the use of all kinds of raw materials was not convenient today.
    After generations of craftsmen, the method has gradually refined. From the initial simple attempt, to the ingenious improvement of the reaction conditions later, the ratio of raw materials has also been repeatedly weighed. Everyone worked tirelessly in the laboratory day and night to operate, observe and record, and analyze the results.
    With the passage of time, technology has advanced, and things that were difficult to make in the past can now be produced efficiently. Its application has also become wider, emerging in the fields of medicine and materials, and contributing to the development of the industry. It is a journey of hard work in the history of chemistry.
    Product Overview
    1 - Bromo - 2 - Fluoro - 4 - (Trifluoromethyl) Benzene
    There is now a product named 1 - Bromo - 2 - Fluoro - 4 - (Trifluoromethyl) Benzene. It is a phenomenon of chemical research and has special properties.
    This compound, on benzene, has its own position of bromine atom and fluorine atom Trifluoromethyl. Bromine, the property of the activity, can lead to the reaction of polymers. The fluorine atom gives this material special properties, because of its properties, the molecular properties are changed. The presence of trifluoromethyl also increases its qualitative hydrophobicity.
    In the field of chemical synthesis, 1 - Bromo - 2 - Fluoro - 4 - (Trifluoromethyl) Benzene can be an important raw material. With ingenious reverse methods, it can be used to synthesize multiple derivatives, which are useful in many fields such as engineering, engineering and materials science. Our chemical researchers need to explore their properties and inverse theories in order to explore their further application prospects.
    Physical & Chemical Properties
    1 - Bromo - 2 - Fluoro - 4 - (Trifluoromethyl) Benzene is also an organic compound. Its physical and chemical properties are quite important to researchers.
    Looking at its physical properties, it is mostly liquid at room temperature, with a clear color and a specific taste. The number of boiling points, according to experiments, is about a specific range, which is the key temperature for its gasification. Its density is also fixed, and it is an important parameter for measuring and storing things.
    As for chemical properties, the benzene ring structure gives it unique activity. The substitution of bromine, fluorine and trifluoromethyl makes the molecular reactivity unique. It can react with many reagents by nucleophilic substitution, and has a wide range of uses in the field of organic synthesis. Its stability also changes under specific conditions, influenced by temperature, pH, or biochemical changes, making it the foundation of chemical synthesis and worthy of further investigation.
    Technical Specifications & Labeling
    1 - Bromo - 2 - Fluoro - 4 - (Trifluoromethyl) Benzene, chemical substances are also. Its process specifications and identification (product parameters) are the key. Process specifications are related to the preparation method, and must be based on precise steps, the proportion of raw materials is appropriate, and the reaction conditions such as temperature, pressure, and duration are carefully controlled to obtain a pure product. In terms of identification, product parameters should be clearly stated, such as purity should reach a very high standard, and impurity content should be strictly limited to meet the quality requirements. Appearance, odor, etc. should also be accurately described for identification. In this way, in chemical research and production, it can ensure that this product is properly applied, play its due effect, and help scientific research and industrial processes.
    Preparation Method
    The method of making 1 - Bromo - 2 - Fluoro - 4 - (Trifluoromethyl) Benzene is the first raw material. The fluorobenzene is taken as the base, supplemented by a brominating agent and a trifluoromethylating agent. This is the foundation.
    The preparation process is first to use fluorobenzene and a brominating agent at a specific temperature and pressure. The temperature control is precise, so that the bromine atom fits into the benzene ring at a specific position, and the bromofluorobenzene intermediate is obtained. This step requires strict observation of the reaction process to achieve efficient conversion.
    Next, trifluoromethyl is introduced. With the selected trifluoromethylating agent, according to the appropriate ratio, it is co-placed in the reaction kettle with the intermediate. The reaction conditions were adjusted so that trifluoromethyl was successfully connected to the benzene ring. This process requires strict reaction equipment and operation to ensure a smooth reaction and excellent yield.
    Furthermore, the regulation of the reaction steps is crucial. Parameters such as reaction time, temperature and pressure of each step need to be carefully set to obtain high-quality products. And between reactions, a purification mechanism needs to be set up. By distillation, extraction, column chromatography and other methods, impurities are removed and the purity of the product is improved to achieve high-quality 1-Bromo-2-Fluoro-4 - (Trifluoromethyl) Benzene output.
    Chemical Reactions & Modifications
    A chemical researcher tried to study the chemical changes of 1 - Bromo - 2 - Fluoro - 4 - (Trifluoromethyl) Benzene. The initial reaction was carried out according to the conventional method and common reagents and conditions, but the resulting product was impure and the yield was not as expected.
    I think, this reaction may not be accurate due to the conditions. Then I carefully investigated various reaction parameters, temperature, pressure, and reactant ratio. After many debugging, the temperature was changed to nanometers, and the proportion was adjusted to size.
    The influence of the catalyst was also considered, and different activities and selectivity were replaced. After many attempts, the final method was exquisite. The purity of the reaction is greatly improved, and the yield is also significantly increased. During this process, it is well understood that changes in chemistry and subtle adjustments can lead to very different results. Although it has gone through twists and turns, it is also gratifying to have this improvement method.
    Synonyms & Product Names
    1 - Bromo - 2 - Fluoro - 4 - (Trifluoromethyl) Benzene is an important substance in chemistry. There are many opinions on the synonymous name of this substance. Or it is named after its structural characteristics. It has bromine atoms, fluorine atoms and trifluoromethyl atoms attached to the benzene ring, so it is also known as its element combination. As for the trade name, it also varies according to the manufacturer and use.
    Although ancient chemistry was not as precise as it is today, there are also methods for identifying and naming substances. Although there was no system naming rule at that time, it was also named according to its properties and sources. Today's 1 - Bromo - 2 - Fluoro - 4 - (Trifluoromethyl) Benzene has a unique name in the past or because of its appearance and reaction characteristics. Although it is difficult to study in detail, it must be related to today's synonymous names and trade names, and it is also a witness to the development of chemistry.
    Safety & Operational Standards
    1 - Bromo - 2 - Fluoro - 4 - (Trifluoromethyl) Benzene is an important chemical substance that is of great value in chemical research and industrial production. However, safety and operating standards are of paramount importance during its production and use.
    This substance has certain chemical activity and may pose potential hazards to the human body and the environment. Therefore, during operation, the first priority is to ensure the safety of personnel. Experimenters or producers must wear complete protective equipment, such as protective clothing, gloves, goggles, etc., to prevent skin contact and eye splashing. And the operation should be carried out in a well-ventilated environment, preferably in a fume hood to avoid inhalation of volatile gaseous substances.
    Furthermore, its storage also needs to follow specific specifications. It should be stored in a cool, dry and ventilated place, away from fire, heat and oxidants. The storage container must be well sealed to prevent leakage.
    The operation process also needs to be rigorous. When accessing this substance, a precise measuring tool should be used, and it should be measured accurately according to the needs of the experiment or production. If there is a leak, emergency measures need to be initiated immediately. A small amount of leakage can be absorbed by inert materials such as sand and vermiculite; if there is a large amount of leakage, it is necessary to evacuate personnel, seal the scene, and notify professional cleanup personnel to deal with it.
    In conclusion, for 1 - Bromo - 2 - Fluoro - 4 - (Trifluoromethyl) Benzene, we must adhere to strict safety and operating practices to ensure the safety of personnel and the environment is not compromised, and to ensure the smooth conduct of related work.
    Application Area
    1 - Bromo - 2 - Fluoro - 4 - (Trifluoromethyl) Benzene This compound is valuable in many application fields. In the field of pharmaceutical research and development, its unique chemical structure can be used as a key intermediate to help synthesize specific drugs or target specific diseases. In the field of materials science, it can participate in the preparation of materials with special properties, such as those with excellent optical or electrical properties, which are expected to be used in high-end electronic devices. In the field of agricultural chemistry, it may become an important starting material for the development of new pesticides to synthesize highly efficient and low-toxic pesticides and protect crops from pests and diseases. It can be seen that this compound has great application potential in many fields, and it is a chemical substance worthy of further investigation and development.
    Research & Development
    In recent years, Yu has dedicated himself to the research of 1 - Bromo - 2 - Fluoro - 4 - (Trifluoromethyl) Benzene. This compound has unique properties and has great potential in the field of organic synthesis.
    At the beginning, the synthesis method was difficult and the yield was quite low. Yu and his colleagues studied day and night, researched classics, learned from ancient methods, and participated in today's new techniques. After months of trial and error improvement, the method was finally optimized. The yield gradually increased and the quality was also good.
    Looking at its application, it can be used as a key intermediate in pharmaceutical research and development, paving the way for the creation of new agents; in materials science, it may endow materials with specific properties.
    Although today has made progress, there is still a long way to go. In the future, we will continue to improve, expand its application, and tap its potential. We hope to contribute to the development of the industry, so that this compound can be widely used and benefit many parties.
    Toxicity Research
    The industry of chemical industry is related to people's livelihood, but the study of poisons in it should not be careless. Today there is a thing called 1 - Bromo - 2 - Fluoro - 4 - (Trifluoromethyl) Benzene, and the study of its toxicity is a top priority.
    The chemical properties of this thing may involve poison. Between experiments, observe its response to other things, and observe its effect on living beings. Small animals try it, and see that it has discomfort, hair or withered, slow down, and even endangers life.
    And explore its shadow in the environment. Scattered in water and soil, fear sewage sources, damage soil fertilizer, harm grass and trees. And if its qi is vented in the air, people will smell it, or cause respiratory diseases, and the mind will be dizzy.
    Therefore, the study of the toxicity of this substance requires rigorous and comprehensive protection. Records are detailed to clarify its harm, to stop the chemical industry, to establish safety regulations, to ensure the well-being of all beings, and to protect the peace of the world.
    Future Prospects
    Wuguanfu 1 - Bromo - 2 - Fluoro - 4 - (Trifluoromethyl) Benzene is an important product in the chemical industry. In today's world, science and technology are advancing day by day, and the field of chemical industry is also booming. This product has great potential for future development.
    It may be used to create new materials to meet the needs of many fields. For example, in the field of electronics, it may help electronic devices to be more delicate and efficient; in the field of medicine, it may pave a new path for the research and development of new drugs, saving patients from suffering.
    Furthermore, with the gradual rise of the concept of green chemistry, the preparation process of this product is also expected to move towards a more environmentally friendly and efficient direction. In order to achieve the good use of resources and the protection of the environment. In the future, this product will definitely shine on the stage of chemical industry, become the focus of attention, add bricks and tiles to the well-being of mankind, and display endless brilliance.
    Where to Buy 1-Bromo-2-Fluoro-4-(Trifluoromethyl)Benzene in China?
    As a trusted 1-Bromo-2-Fluoro-4-(Trifluoromethyl)Benzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 1-Bromo-2-Fluoro-4-(Trifluoromethyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What is the main use of 1 - Bromo - 2 - Fluoro - 4 - (Trifluoromethyl) Benzene?
    1-Bromo-2-fluoro-4- (trifluoromethyl) benzene, this compound has a wide range of uses. In the field of medicinal chemistry, it is often used as a key intermediate in drug synthesis. Due to its unique chemical structure, various chemical reactions can be used to construct drug molecules with specific biological activities. For example, when developing antibacterial and antiviral drugs, it can provide a basis for the design of novel drug structures, which can help to develop drugs with better efficacy and less side effects.
    In the field of materials science, it also has important uses. It can be used to prepare organic materials with special properties, such as fluorine-containing functional materials. Due to the presence of fluorine atoms in the molecule, the material exhibits excellent chemical stability, weather resistance and low surface energy. These materials can be used in coatings, plastics and other fields to improve material properties and expand the application range.
    In organic synthesis chemistry, as an important raw material, it participates in many organic reactions, such as nucleophilic substitution reactions, metal catalytic coupling reactions, etc., to synthesize a series of complex organic compounds, providing a powerful tool for organic synthesis chemists to explore new reaction paths and compound structures, and promoting the continuous development of organic synthesis chemistry.
    What are the physical properties of 1 - Bromo - 2 - Fluoro - 4 - (Trifluoromethyl) Benzene
    1-Bromo-2-fluoro-4- (trifluoromethyl) benzene, also an organic compound. Its physical properties have various characteristics.
    First of all, its appearance, at room temperature, this substance is mostly colorless to light yellow transparent liquid, clear and clear, like the dew of autumn morning, pure and free of variegated colors, no suspended particles, the view is clear to the mind.
    Second time and its smell, there is a special aromatic smell, but this fragrance is not as rich and sweet as ordinary flowers. It is a unique chemical aroma. It is slightly irritating to smell, but different from the pungent odor. In the chemical environment, this smell is quite significant, and the smell can be recognized by this.
    Furthermore, its boiling point is about a certain temperature range, which is determined by factors such as intermolecular forces. Due to the presence of bromine, fluorine and other atoms in the molecule, its boiling point is different from that of ordinary benzene series. When the external temperature reaches its boiling point, the substance gradually changes from liquid to gaseous state, just like sublimation. In distillation and other operations, this property is very important, and can be separated and purified according to the different boiling points.
    As for the melting point, there is also a specific value. When the temperature drops below the melting point, 1-bromo-2-fluoro-4- (trifluoromethyl) benzene condenses from a liquid state to a solid state, like ice crystals, with regular crystal forms and hard texture.
    In addition, its density is also an inherent physical property. Compared with water, the density is higher. If it is co-placed with water in a vessel, it can be seen that it sinks to the bottom of the water, like a pearl falling in a deep pool, with clear boundaries. This property is widely used in experimental operations such as extraction and in liquid-liquid separation steps in industrial production.
    In terms of solubility, this substance is insoluble in water. Due to the existence of many halogen atoms in its molecular structure, its polarity is quite different from that of water, so it is insoluble. However, in organic solvents such as ethanol and ether, it has good solubility and can be miscible with organic solvents, just like water emulsion, which facilitates its application in organic synthesis and other fields. It is often used as a reaction solvent or to dissolve other organic compounds.
    1 - Bromo - 2 - Fluoro - 4 - (Trifluoromethyl) Benzene
    1-Bromo-2-fluoro-4- (trifluoromethyl) benzene is one of the organic compounds. Its chemical properties are of great interest and are of great importance in the field of organic synthesis.
    Regarding its nucleophilic substitution reaction, the bromine atom activity of this compound is quite high. The electron cloud density distribution on its aromatic ring is affected by fluorine atoms and trifluoromethyl, so that the electron cloud density of the carbon site connected to the bromine atom decreases, and it is more vulnerable to attack by nucleophilic reagents. If sodium alcohol is used as a nucleophilic reagent, under suitable reaction conditions, the bromine atom can be replaced by an alkoxy group to form corresponding ether compounds. The smooth progress of this reaction really depends on the regulation of the activity of the substituents on the aromatic ring to the bromine atom.
    As for the electrophilic substitution reaction, because trifluoromethyl is a strong electron-withdrawing group, the fluorine atom also has an electron-withdrawing effect, and the electron cloud density of the aromatic ring is reduced. Therefore, the electrophilic substitution activity of this compound is lower than that of benzene. And the localization effect of such electron-withdrawing groups causes electrophilic reagents to attack its intermediate sites more often. For example, when mixed acids (mixtures of sulfuric acid and nitric acid) are used as nitrifying reagents, nitro groups are introduced into the positions between bromine atoms to obtain the corresponding nitro-substituted products.
    And its reduction reaction, bromine atoms can be reduced and removed by suitable reducing agents. For example, the reduction system composed of metal zinc and acid can gradually replace bromine atoms with hydrogen atoms to form fluorinated (trifluoromethyl) benzene derivatives.
    1-bromo-2-fluoro-4 - (trifluoromethyl) benzene has rich and diverse chemical properties, and nucleophilic substitution, electrophilic substitution and reduction are all key properties that organic synthesis chemists rely on when constructing complex organic molecular structures.
    What is the preparation method of 1 - Bromo - 2 - Fluoro - 4 - (Trifluoromethyl) Benzene
    The preparation method of 1-bromo-2-fluoro-4- (trifluoromethyl) benzene is a key issue in the field of organic synthesis. To prepare this substance, common methods include benzene derivatives containing corresponding substituents as starting materials, which are obtained by halogenation and other series of reactions.
    One method can first take benzene compounds containing fluorine and trifluoromethyl, and use appropriate brominating reagents, such as bromine (Br ²), to carry out bromination reaction under specific reaction conditions. In this case, the reaction requires a suitable catalyst, such as iron powder (Fe) or iron tribromide (FeBr 🥰), etc. Because there are both fluorine atoms and trifluoromethyl on the benzene ring, both of which are electron-withdrawing groups, which will reduce the electron cloud density of the benzene ring, the bromination reaction conditions may need to be adjusted appropriately to ensure the smooth progress of the reaction. The reaction temperature and reaction time also need to be precisely controlled. If the temperature is too high, it may cause the formation of polybrominated products, and if the temperature is too low, the reaction rate will be too slow.
    Another method can be used to introduce fluorine atoms through selective fluorination from benzene derivatives containing bromine and trifluoromethyl. Commonly used fluorination reagents include potassium fluoride (KF), which reacts in aprotic polar solvents such as dimethyl sulfoxide (DMSO) in the presence of heating and phase transfer catalysts. In this process, the phase transfer catalyst can promote the ionic fluorination reagent to enter the organic phase and improve the reaction efficiency. However, the selective fluorination reaction needs to pay attention to avoid the side reactions of fluorine substitution in other positions. By reasonably selecting the reaction substrate structure and controlling the reaction conditions, such as temperature and fluorination reagent dosage, the purpose of highly selective introduction of fluorine atoms can be achieved.
    Preparation of 1-bromo-2-fluoro-4- (trifluoromethyl) benzene requires careful selection of the appropriate preparation path according to the actual situation, considering the availability of raw materials, the difficulty of reaction conditions, and the purity of the product.
    1 - Bromo - 2 - Fluoro - 4 - (Trifluoromethyl) Benzene Storage and Transportation
    1 + -Bromo-2-fluoro-4- (trifluoromethyl) benzene is also an organic compound. During storage and transportation, many matters must not be ignored.
    First storage, this compound needs to be placed in a cool and ventilated warehouse. Because of its certain chemical activity, high temperature is easy to react, and good ventilation can avoid gas accumulation and prevent danger. The temperature of the warehouse should be controlled within a specific range, not too high, to avoid decomposition or deterioration. And it must be kept away from fires and heat sources. Open flames and hot topics can cause danger, so smoking and fire should be strictly prohibited in the storage area.
    Furthermore, it should be stored separately from oxidants, acids, bases, etc., and must not be mixed. Due to its chemical properties, it encounters with such substances, or reacts violently, causing the risk of fire and explosion. At the same time, the storage area should be equipped with suitable materials to contain leaks, so as to prevent accidental leakage and deal with them in time to minimize harm.
    As for transportation, caution is also required. Transportation vehicles should ensure that they are in good condition and have corresponding safety facilities. During transportation, they should be protected from exposure to the sun, rain, and high temperature. Summer transportation should be selected when it is cool in the morning and evening to avoid high temperatures during the day. Containers used during transportation must be firm, sealed, and leak-proof. When loading and unloading, the operator must pack and unload lightly, and it is strictly forbidden to drop and pressure, so as not to damage the container and cause material leakage.
    In conclusion, the storage and transportation of 1 + -bromo-2-fluoro-4- (trifluoromethyl) benzene are all related to safety, and the precautions in all aspects must be strictly followed to ensure safety.