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1-Bromo-2-Fluoro-4-Methoxybenzene

1-Bromo-2-Fluoro-4-Methoxybenzene

Hongda Chemical

Specifications

HS Code

515875

Name 1 - Bromo - 2 - Fluoro - 4 - Methoxybenzene
Molecular Formula C7H6BrFO
Molecular Weight 205.02
Appearance Liquid (usually)
Boiling Point Around 200 - 205 °C
Density Data may vary, around 1.5 - 1.6 g/cm³
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in common organic solvents like ethanol, dichloromethane
Flash Point Data may vary, potentially around 80 - 90 °C
Cas Number Specific number would be needed from official databases

As an accredited 1-Bromo-2-Fluoro-4-Methoxybenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100 g of 1 - bromo - 2 - fluoro - 4 - methoxybenzene packaged in a sealed glass bottle.
Storage 1 - bromo - 2 - fluoro - 4 - methoxybenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents and reactive chemicals. Avoid exposure to moisture which could potentially initiate unwanted reactions.
Shipping 1 - bromo - 2 - fluoro - 4 - methoxybenzene is shipped in well - sealed, corrosion - resistant containers. It follows strict hazardous chemical shipping regulations, ensuring safe transit with proper labeling and handling to prevent leakage and environmental or safety risks.
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1-Bromo-2-Fluoro-4-Methoxybenzene 1-Bromo-2-Fluoro-4-Methoxybenzene
General Information
Historical Development
1 - Bromo - 2 - Fluoro - 4 - Methoxybenzene is also an organic compound. It has been traced back to its origin for a long time. At the beginning, many chemical talents studied the properties and structures of substances. At that time, science and technology were not as prosperous as they are today, and the road to exploration was full of thorns.
After years of trial and error, the public gradually gained something in the art of organic synthesis. In order to make this product, chemists thought hard, adjusted the conditions of various reactions, and selected suitable raw materials. From the initial ignorance and exploration, to the understanding of various reaction mechanisms, it was difficult to describe.
Over the years, chemical techniques have become more and more refined, and the synthesis of 1 - Bromo - 2 - Fluoro - 4 - Methoxybenzene has become more and more mature. From the crude initial attempt to the fine modern process, the development of this compound is a microcosm of the history of chemical exploration, witnessing the unremitting progress and wisdom of human beings in the field of chemistry.
Product Overview
About the description of 1-bromo-2-fluoro-4-methoxybenzene
There is a product called 1-bromo-2-fluoro-4-methoxybenzene. It is an organic compound with a unique structure. Looking at its structure, above the benzene ring, bromine, fluorine and methoxy each occupy a specific position.
This product is very important in the field of organic synthesis. The bromine atom is active and can introduce various functional groups into the benzene ring system to expand its reaction path. The fluorine atom adds its special rationality, which gives the product a unique advantage in specific reactions and applications. The presence of the methoxy group also affects the distribution of its electron cloud, which in turn affects its reactivity and selectivity.
During the synthesis experiment, precise temperature control, selection of reagents and catalysts are the keys to obtaining this substance. And its purity is related to the effectiveness of subsequent applications, so the purification step cannot be ignored. From this point of view, although 1-bromo-2-fluoro-4-methoxybenzene is small, it has a very important position in the field of organic synthesis.
Physical & Chemical Properties
1 - Bromo - 2 - Fluoro - 4 - Methoxybenzene is an organic compound. Its physicochemical properties are crucial. Looking at its physical properties, at room temperature, this substance is often in a liquid state with a specific color and odor. Its boiling point is related to its volatility. After experimental investigation, it is known that under certain pressure conditions, the boiling point is in a certain range, which is extremely important in the process of separation and purification.
In terms of chemical properties, the functional groups such as bromine, fluorine, and methoxy in this compound give it unique reactivity. Bromine atoms are more active and can participate in nucleophilic substitution reactions. Under appropriate reagents and conditions, they can be replaced by other groups. Because of its strong electronegativity, fluorine atoms affect the electron cloud distribution of molecules, which in turn affects the reaction selectivity. Methoxy groups exhibit the electron supply effect, which affects the electron density of benzene rings, making benzene rings more prone to electrophilic substitution reactions. These various physicochemical properties lay the foundation for their application in organic synthesis and other fields.
Technical Specifications & Labeling
1 - Bromo - 2 - Fluoro - 4 - Methoxybenzene is also a chemical product. Its technical quality (commodity quality) is essential. Those who are skilled, are the basic requirements of this product, such as the precise ratio of raw materials, the appropriate quality of the reverse parts, the quality and the quality of the product, all need to be refined. And the process steps of the operation must also be clear and orderly, not methodical.
As for the product (commodity quality), the formula and molecular weight of this product must be clearly understood, so that those who know its formation. Its physical rationality, color, shape, melting, etc., also need to be clarified. What's more, it is necessary to be clear. To measure the quality of its product. In this way, the technical specifications (commodity specifications) of this object can be made clear, so as to be suitable for the purpose of chemical research.
Preparation Method
1 - Bromo - 2 - Fluoro - 4 - Methoxybenzene is an important raw material for organic synthesis. The preparation method, raw materials and production process, reaction steps and catalytic mechanism are very important.
Preparation of this compound, usually with specific aromatics as starting materials. First, aromatics and specific halogenating reagents are added to a suitable reaction vessel, and a halogenation reaction is carried out at a precisely controlled temperature and reaction time, and bromine atoms are introduced. Subsequently, bromine-containing intermediates are obtained through separation and purification.
Furthermore, fluorine-containing reagents are added to bromine-containing intermediates to promote fluorine atoms to replace groups at specific positions under the action of specific catalysts. This step requires fine regulation of reaction conditions to ensure accurate substitution of fluorine atoms.
After the reaction is completed, pure 1-Bromo-2-Fluoro-4-Methoxybenzene is obtained by distillation, extraction and other separation methods. The whole preparation process, factors such as raw material purity, reaction temperature, and catalyst dosage all have a significant impact on product quality and yield, and must be strictly controlled.
Chemical Reactions & Modifications
The anti-modification of 1 - Bromo - 2 - Fluoro - 4 - Methoxybenzene is an important issue in the study of annealing. The reaction of this compound often involves the substitution of aromatics. Its bromine, fluorine and methoxy groups have their own activities and can lead to annealing.
In the words of its bromine atom, it can be substituted by the raw nucleus under the appropriate conditions, so that the bromine is placed by other groups, and the properties of the molecule are changed. The fluorine atom has a great effect on the properties of the molecule and the molecular composition of the molecule. Methoxy groups can be used to supply the reaction effect and the density of aromatics, making the reaction easier to be generated at specific locations.
Through the control of reactive components, such as solubility, solubility, and catalysis, it is possible to precisely control the reactive process of 1-Bromo-2-Fluoro-4-Methoxybenzene, and modify it to meet different chemical needs. It is important to synthesize new compounds or improve the performance of existing compounds.
Synonyms & Product Names
1 - Bromo - 2 - Fluoro - 4 - Methoxybenzene has attracted much attention in modern chemical research. Its synonymous names and trade names are also studied in detail by us.
Although the ancient chemical names are simple, they are also precise. Today's 1 - Bromo - 2 - Fluoro - 4 - Methoxybenzene, or similar ancient names. Among its names, "Bromo" is epibromine, "Fluoro" is fluorine, "Methoxy" is nail oxygen, and "benzene" is a benzene ring. Although the ancient chemical vocabulary is not as detailed as it is today, it still has a meaning.
Its synonymous name, or from its structural characteristics, is named after ancient chemical concepts, or by its main functional group combination. The trade name may be related to the manufacturer, use, etc. As in the past, chemical research was all about exploring the nature of matter. The name 1 - Bromo - 2 - Fluoro - 4 - Methoxybenzene also gradually became clear with the deepening of research. Its synonymous name and trade name have also become a part of chemical research, helping us to understand its nature, use and development context.
Safety & Operational Standards
1 - Bromo - 2 - Fluoro - 4 - Methoxybenzene is a chemical substance commonly used in organic synthesis. It is crucial to its safety and operation standards. It is described as follows:
##1. Storage Safety
This substance should be stored in a cool, dry and well-ventilated place, away from fire and heat sources. Because it has certain chemical activity, if the ambient temperature and humidity are too high, or it may cause chemical reactions to cause deterioration. It should be stored separately from oxidants, acids, bases, etc., and must not be mixed to prevent dangerous interactions, such as contact with strong oxidants, or the risk of combustion and explosion. The storage area should be equipped with materials suitable for containing and removing leaks for emergencies.
##2. Operating Specifications
When operating, be sure to strictly abide by the operating procedures. Operators need to undergo special training and act strictly according to the rules. It is recommended to wear a self-priming filter gas mask (half mask) during operation to prevent inhalation of harmful substances from damaging the respiratory system; wear chemical safety glasses to protect your eyes from possible splash damage; wear anti-toxic infiltration work clothes to avoid skin contact; wear rubber oil-resistant gloves to enhance protection.
The operating site should be ventilated to reduce the concentration of harmful substances in the air. The handling process should be handled lightly to prevent material leakage caused by damage to packaging and containers. Tools and equipment after use should be cleaned in time to avoid residual substances affecting the next use or causing other problems.
If a leak occurs accidentally, personnel from the contaminated area of the leak should be quickly evacuated to the safe area, and quarantined to strictly limit access. Emergency personnel need to wear self-contained positive pressure breathing apparatus and anti-virus clothing to cut off the source of the leak as much as possible. In the case of a small leak, it can be absorbed by sand, vermiculite or other inert materials; in the case of a large leak, build a dike or dig a pit for containment, cover it with foam to reduce steam disasters, and then transfer it to a tanker or special collector with an explosion-proof pump for recycling or transportation to a waste treatment site for disposal.
Only by strictly following the above safety and operating practices can the safety of 1-Bromo-2-Fluoro-4-Methoxybenzene be ensured during storage and use, and accidents can be avoided.
Application Area
1 - Bromo - 2 - Fluoro - 4 - Methoxybenzene is also an organic compound. Its application field is quite wide. In the field of pharmaceutical chemistry, it can be used as a key intermediate. Due to its unique chemical structure, it can derive many bioactive molecules through various chemical reactions, helping to create new drugs.
In the field of materials science, it also has its uses. Or can participate in the synthesis of polymer materials, endowing materials with specific properties, such as improved material stability, electrical properties, etc.
In fine chemistry, it can be used to prepare special dyes, fragrances and other fine chemicals. With its structural characteristics, it adds unique quality to the product. Therefore, 1 - Bromo - 2 - Fluoro - 4 - Methoxybenzene is of great value in many application fields and is a substance that cannot be ignored in chemical research and industrial production.
Research & Development
Today there is a substance named 1 - Bromo - 2 - Fluoro - 4 - Methoxybenzene. As a chemical researcher, I have worked hard on the research and development of this substance.
Begin to investigate its structure, analyze its atomic arrangement and bond characteristics in detail. Know the chemical activities of bromine, fluorine and methoxy groups, which affect the overall properties of this substance. Then think about how to optimize its synthesis. After repeated experiments, adjust the temperature and pressure of the reaction, and change the ratio of the reactants, in order to obtain better yield and purity.
It also examines its application field, considering that it can be used as an intermediate to assist in the creation of new drugs; in material science, it can give materials specificity. Therefore, pushing its development, hoping to contribute to the progress of various fields, so as to promote the research and application of this chemical, and make great progress.
Toxicity Research
Taste the things in the world, their properties are good and evil, and it is especially important to study the toxicity of chemical products. Today there is 1 - Bromo - 2 - Fluoro - 4 - Methoxybenzene, its toxicity should be carefully observed.
Look at its structure, the genus of bromine and fluorine, strong and active. Such atoms in compounds often change their physical properties and chemical properties. According to common sense, this product may have a certain toxicity. Bromine atoms are active, easy to react with other substances, or enter the organism, causing chaos in its biochemical order. Fluorine, although beneficial to some agents, is also harmful in excess. As for the methoxyl group, although slightly stable, it may be suspected of auxiliary toxicity to the whole molecule.
During the experiment, be cautious. Add protective gear to avoid its gas and liquid contact. If it is accidentally stained, it can be solved quickly. Exploring its toxicity can provide essential evidence for the chemical industry, pharmaceutical research, and environmental protection, ensuring everyone's well-being and protecting the balance of ecology.
Future Prospects
Wuguanfu 1 - Bromo - 2 - Fluoro - 4 - Methoxybenzene has extraordinary potential and is full of promising future development. Its structure is unique, and the combination of bromine, fluorine and methoxy groups must give it different chemical properties.
In today's world, chemical research is changing with each passing day, and this compound may emerge in the research and development of new materials. With its unique properties, it may be applied to electronic materials to improve the performance of electronic components and make devices more delicate and efficient.
Furthermore, in the field of medicine, it is also expected to become a key intermediate for innovative drugs. With its structural properties, it will help to synthesize special new drugs and contribute to human health and well-being.
Although the current research may still be in its infancy, I firmly believe that with time and unremitting research, 1 - Bromo - 2 - Fluoro - 4 - Methoxybenzene will bloom, create new trends in various fields, and achieve a brilliant vision for the future.
Where to Buy 1-Bromo-2-Fluoro-4-Methoxybenzene in China?
As a trusted 1-Bromo-2-Fluoro-4-Methoxybenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 1-Bromo-2-Fluoro-4-Methoxybenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-Bromo-2-Fluoro-4-Methoxybenzene?
1-Bromo-2-fluoro-4-methoxybenzene, which has a wide range of uses. In the field of organic synthesis, it is often used as a key intermediate. It can be derived from a variety of organic compounds through various chemical reactions. For example, when building complex aromatic structures, it can carry out nucleophilic substitution, coupling and other reactions by virtue of its activity check points of bromine, fluorine and methoxy, laying the foundation for the creation of new drugs and functional materials.
In the field of pharmaceutical chemistry, this is used as a starting material. Through clever chemical modification, molecules with specific biological activities can be synthesized. For example, with the help of methoxy to enhance the lipophilicity of compounds and improve their absorption and distribution in vivo; bromine and fluorine atoms can adjust the density of molecular electron clouds, affecting their interaction with biological targets, and then develop antibacterial, anti-tumor and other drugs.
In the field of materials science, 1-bromo-2-fluoro-4-methoxybenzene also has important value. After specific polymerization reactions or functionalization modifications, materials with special optical and electrical properties can be prepared, such as for organic Light Emitting Diodes (OLEDs), solar cells and other optoelectronic devices, to improve device performance and efficiency.
Furthermore, in the manufacturing of fine chemical products, such as fragrance and dye synthesis, 1-bromo-2-fluoro-4-methoxybenzene is used as a raw material to endow the product with unique structure and performance, adding product characteristics and application advantages. In short, it plays an important role in many fields, promoting the development of related industries and technological innovation.
What are the physical properties of 1-Bromo-2-Fluoro-4-Methoxybenzene?
1-Bromo-2-fluoro-4-methoxybenzene is one of the organic compounds. Its physical properties are quite critical and it is widely used in chemical and scientific research fields.
First of all, its properties are mostly colorless to light yellow liquids at room temperature, with a clear and translucent appearance. This state is easy to observe and operate. In practical applications, researchers can preliminarily judge its purity and state by its appearance.
Second discussion on its boiling point. The boiling point of 1-bromo-2-fluoro-4-methoxybenzene is about a specific temperature range. The value of the boiling point is extremely important for the separation and purification of compounds. By means of distillation, according to its boiling point characteristics, the substance can be accurately separated from the mixture to ensure its purity and meet the needs of scientific research and production.
In addition, its melting point also has characteristics. The determination of melting point is an important means to identify the compound. The melting point of 1-bromo-2-fluoro-4-methoxybenzene with different purity is slightly different. By accurately measuring the melting point, its purity can be judged, providing a key basis for quality control.
Repeat its solubility. This compound has good solubility in organic solvents such as ethanol, ether, etc. This property makes it able to fully mix with various reactants in organic synthesis reactions, promoting the smooth progress of the reaction. In water, its solubility is poor, and this difference helps to separate and enrich it by solvent extraction.
In addition, the density of 1-bromo-2-fluoro-4-methoxybenzene is also an important physical property. The value of density is related to its stratification in solution, and is of great significance to the separation operation and the construction of related reaction systems. Accurately grasping its density can optimize the experimental process and improve the experimental efficiency and accuracy.
In summary, the physical properties of 1-bromo-2-fluoro-4-methoxybenzene, such as their properties, boiling point, melting point, solubility, and density, are interrelated and affect their application in scientific research and production practice. Only by deeply understanding and accurately grasping these properties can we better control this compound and maximize its effectiveness.
What is the chemical synthesis method of 1-Bromo-2-Fluoro-4-Methoxybenzene?
There are various ways to synthesize 1-bromo-2-fluoro-4-methoxybenzene, which are described in detail here.
First, p-methoxyphenol is used as the starting material, because its phenolic hydroxyl group has high reactivity. Shilling p-methoxyphenol interacts with bases (such as sodium hydroxide), and the hydrogen of the phenolic hydroxyl group is replaced by sodium ions to form sodium phenol salts. This is because the acidic nature of the phenolic hydroxyl group can neutralize with the base, and the formation of sodium phenol salt increases the density of electron clouds on the aromatic ring, which is conducive to the subsequent electrophilic substitution reaction.
When reacting with brominated reagents (such as bromine or N-bromosuccinimide), the hydrogen atom in the ortho or para-position of the aromatic ring of sodium phenol salt is more easily replaced by the bromine atom due to the localization effect of the phenolic hydroxyl group. In this reaction system, due to the combined effect of steric hindrance and electronic effect, the bromine atom mainly replaces the ortho-hydrogen of the phenolic hydroxyl group to obtain 2-bromo-4-methoxyphenol. This reaction requires controlling the reaction conditions, such as temperature, reactant ratio and reaction time, to ensure the selectivity and yield of the reaction.
Then 2-bromo-4-methoxyphenol is fluorinated. Fluorinated reagents, such as potassium fluoride, are usually used to react in specific solvents (such as polar aprotic solvents such as dimethyl sulfoxide). Fluoride ions in potassium fluoride are used as nucleophiles to replace bromine atoms in 2-bromo-4-methoxyphenol to obtain the target product 1-bromo-2-fluoro-4-methoxybenzene. This fluorination reaction also needs to pay attention to the reaction conditions. Polar aprotic solvents can improve the activity of fluoride ions and promote the smooth occurrence of nucleophilic substitution reactions. In the
synthesis process, separation and purification operations are often required after each step of the reaction, such as extraction, distillation, recrystallization, etc., to remove impurities and obtain a purified product to ensure the purity of each step, in order to ensure the quality and yield of the final target product.
What 1-Bromo-2-Fluoro-4-Methoxybenzene need to pay attention to when storing and transporting
1-Bromo-2-fluoro-4-methoxybenzene should be stored and transported with caution. This is because of its special chemical properties, slightly careless, or dangerous.
When storing, the first choice of environment. It should be placed in a cool, dry and well-ventilated place. If it is in a high temperature and humid place, the substance may react with moisture and hot air, causing quality deterioration and even causing safety risks. The warehouse temperature should be controlled within a specific range to prevent thermal decomposition.
Furthermore, the packaging must be tight. Choose suitable packaging materials, such as corrosion-resistant glass bottles or special plastic containers, tightly sealed to prevent leakage. Because the compound may be toxic and corrosive, once leaked, it will not only damage the environment, but also endanger personal safety.
When transporting, there are also many considerations. Relevant regulations and standards should be followed, and compliant transportation means should be selected. During transportation, vibration and impact must be prevented to avoid package damage. Escorts should be familiar with the characteristics of the substance and emergency treatment methods to prepare for accidents.
And the transportation environment should also be paid attention to, avoid direct sunlight, and prevent mixing with other chemicals to prevent chemical reactions. Therefore, when storing and transporting 1-bromo-2-fluoro-4-methoxybenzene, care must be taken to ensure safety and proper disposal and circulation of the substance.
1-Bromo-2-Fluoro-4-Methoxybenzene impact on the environment and human health
1-Bromo-2-fluoro-4-methoxybenzene is one of the organic compounds. Its impact on the environment and human health can be particularly investigated.
In the environment, if this compound is released, it may cause multiple effects. It has certain chemical stability, is difficult to degrade naturally, or persists in the environment for a long time. Once it enters the water body, it may disturb the aquatic ecosystem. Aquatic organisms, such as fish, shrimp and shellfish, may absorb this substance. At first, it may cause abnormal behavior, change in swimming and foraging. Over time, it may damage its reproductive and developmental functions, and reduce the population. And this substance may be transmitted and enriched through the food chain layer by layer, endangering higher trophic organisms.
In the soil, it may affect the community structure and function of soil microorganisms. Soil microorganisms are essential for soil fertility and material circulation. If they are disturbed, soil ecological balance may be damaged, affecting plant growth.
As for human health, if people ingest this compound through breathing, diet or skin contact, it may be harmful. When exposed to the respiratory tract, it may irritate the mucosa of the respiratory tract, causing cough, asthma and other diseases. If ingested orally, it may be absorbed into the blood through the digestive system, which may interfere with the normal physiological functions of the human body. Or it may affect the nervous system, causing dizziness, fatigue, and inattention. Long-term exposure may cause damage to important organs such as the liver and kidneys, affect their metabolism and detoxification functions, accumulate over time, or cause serious diseases.
From this perspective, 1-bromo-2-fluoro-4-methoxybenzene poses a latent risk to the environment and human health. When it is produced, used and disposed of, extra caution should be taken to prevent it from causing harm to the environment and human body.