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1-Bromo-2-Fluoro-4-Iodobenzene

1-Bromo-2-Fluoro-4-Iodobenzene

Hongda Chemical

Specifications

HS Code

202822

Chemical Formula C6H3BrFI
Molecular Weight 300.89
Appearance Typically a colorless to light - colored liquid or solid
Physical State At Room Temperature May be a liquid or solid depending on purity and exact conditions
Density Expected to be relatively high due to heavy halogens
Solubility In Water Low, as it is an organic halogen - containing compound
Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform
Vapor Pressure Low at room temperature due to its relatively high molecular weight and polar nature

As an accredited 1-Bromo-2-Fluoro-4-Iodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 1 - bromo - 2 - fluoro - 4 - iodobenzene: Packed in 100 - gram vials for chemical use.
Storage 1 - Bromo - 2 - fluoro - 4 - iodobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly sealed container, preferably made of glass or a compatible plastic, to prevent leakage and exposure to air and moisture, which could potentially lead to decomposition or reaction.
Shipping 1 - bromo - 2 - fluoro - 4 - iodobenzene is shipped in sealed, corrosion - resistant containers. It follows strict chemical shipping regulations, ensuring proper labeling and secure packaging to prevent leaks during transit.
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1-Bromo-2-Fluoro-4-Iodobenzene 1-Bromo-2-Fluoro-4-Iodobenzene
General Information
Historical Development
In the field of chemistry, 1 - Bromo - 2 - Fluoro - 4 - Iodobenzene, there is also a reason for its popularity. In the past, the chemists have searched up and down the road of organic synthesis. At the beginning, the method of synthesis was not prepared, and it was difficult to obtain this compound.
However, the determination of scholars is unremitting, and the skills are gradually refined over time. From the deep research of basic theory to the innovation of experimental methods, all have devoted their efforts. Or improve the reaction conditions, or explore new reagents, hoping to obtain this exquisite product.
After the efforts of generations, the synthesis method has been perfected day by day. The initial steps are gradually simplified, and the yield is also rising. Therefore, 1-Bromo-2-Fluoro-4-Iodobenzene gradually became useful in the process of chemical synthesis, contributing to the evolution of organic chemistry and becoming a chapter in the development of chemistry.
Product Overview
1 - Bromo - 2 - Fluoro - 4 - Iodobenzene is an important organic compound. It has a unique chemical structure, with bromine, fluorine and iodine atoms in specific positions on the benzene ring. This compound has a wide range of uses in the field of organic synthesis.
Its preparation process often requires delicate chemical reactions. Or by halogenation reaction, bromine, fluorine and iodine atoms are introduced into the benzene ring. This preparation process requires fine regulation of reaction conditions, such as temperature, reaction duration, and ratio of reactants, etc., to obtain ideal yields and purity.
1 - Bromo - 2 - Fluoro - 4 - Iodobenzene can be used as a key intermediate in organic synthesis. With its special structure, it can participate in many nucleophilic substitution, coupling and other reactions to construct more complex organic molecular structures, which has potential application value in pharmaceutical chemistry, materials science and other fields.
Physical & Chemical Properties
1 - Bromo - 2 - Fluoro - 4 - Iodobenzene is an organic compound. Its physical properties are mostly solid at room temperature, with a certain melting point, and the melting range may vary depending on purity. Looking at its appearance, it may be white to light yellow crystalline powder, which is caused by the different photoabsorption and reflection of bromine, fluorine and iodine atoms in the molecular structure.
In terms of its chemical properties, due to the activity of halogen atoms, it can participate in many reactions. For example, nucleophilic substitution reactions, bromine and iodine atoms can be replaced by nucleophiles to form new derivatives. Although fluorine atoms are relatively stable, they can also participate in the reaction under specific conditions, affecting the overall activity and reaction selectivity of the molecule. Due to the difference of electronegativity of halogen atoms, the electron cloud density distribution of benzene ring changes, which affects the reaction check point and activity sequence. This compound has important value in the field of organic synthesis and can be used as a key intermediate to prepare complex organic molecules and promote the development of organic chemistry.
Technical Specifications & Labeling
Today there is a thing called 1 - Bromo - 2 - Fluoro - 4 - Iodobenzene. The technique of its preparation is related to the delicacy of chemistry. To clarify its technical specifications and identification (product parameters), it is necessary to study its process in detail.
In the synthesis method, specific procedures should be followed. The choice of raw materials must be pure and the proportion must be accurate. The temperature and timing of the reaction are all key. If the temperature is not properly controlled, or the product is impure; if the time is not good, the reaction is not complete.
In terms of marking, in addition to its name, its physicochemical properties need to be listed. Such as melting point and boiling point, this is essential for identification. The purity geometry must also be marked in detail, which is related to the quality of the product. On its packaging, its technical specifications and key parameters should be written in clear text, so that the user can understand its characteristics and use it correctly. In this way, the essence of the technical specifications and identification (product parameters) of this object should be met.
Preparation Method
The method of making 1 - Bromo - 2 - Fluoro - 4 - Iodobenzene is related to the raw materials and production process, reaction steps and catalytic mechanism. First, benzene is taken as the base, and brominated at temperature with a brominating agent to obtain bromobenzene. Then, after fluorination, fluorine atoms are introduced to form 1 - bromo - 2 - fluorobenzene. At this time, a good iodine agent is selected, the temperature is controlled, and the speed is reacted in sequence. By means of catalytic effect, the iodine atoms are just in the designated check point, and then 1 - Bromo - 2 - Fluoro - 4 - Iodobenzene is obtained. In the meantime, the purity of raw materials, the stability of temperature and pressure, and the activity of catalysis are all related to the quality and quantity of products, which must be carefully inspected and strictly controlled to make a good product.
Chemical Reactions & Modifications
Taste the wonders of chemistry, related to the change of substances, reaction and modification is the gist. In this sentence, 1 - Bromo - 2 - Fluoro - 4 - Iodobenzene is a substance that has infinite variables in the way of reaction.
The reaction of the observer's chemistry may produce different results due to different reagents and different conditions. This compound encounters active reagents, or can be replaced by substitution, translocation of halogen atoms, and structural renewal. Its bromine, fluorine, and iodine atoms each have their own properties, and each shows its own energy in the reaction, or first or later, depending on the conditions.
As for modification, the method of reaction can be used to add its functional group and change its properties. To increase the hydrophilicity of this substance or to change its stability depends on the ingenuity of the reaction. If an appropriate method is used to introduce the genera of hydroxyl and carboxyl groups, it will have a wider range of uses and can be used in the fields of medicine and materials.
Therefore, chemical reactions and modifications are really powerful tools for shaping substances, and the same is true for 1-Bromo-2-Fluoro-4-Iodobenzene. Its future changes can be expected.
Synonyms & Product Names
1 - Bromo - 2 - Fluoro - 4 - Iodobenzene This substance is quite important in today's chemical research. Its synonymous name and the name of the commodity cannot be ignored by scholars.
The name of the husband is synonymous, either because of the different naming methods in the past, or according to the characteristics of the structure. For example, according to the naming convention of halogenated benzene, because of its benzene ring, the bromine, fluorine, and iodine trihalogen atoms are called according to their positions, or they are called by their positional relationships.
As for the name of the commodity, there are often unique names between markets for the purpose of identification and trade. Merchants give names according to their uses, purity, or specific fields they are suitable for.
This chemical thing, its synonymous name and the name of the commodity, are both chemical learners and practitioners who must not know it when they communicate and use it. Only by looking at its name can we know its substance, which is beneficial to chemical experiments and production.
Safety & Operational Standards
1 - Bromo - 2 - Fluoro - 4 - Iodobenzene Safety and Operation Code
Husband 1 - Bromo - 2 - Fluoro - 4 - Iodobenzene, chemical substances are also very useful in our chemical research. However, its nature is risky, so when operating, we must strictly abide by safety and operation standards to ensure safety.
This substance is toxic, or can penetrate through the skin, breathe and inhale, or accidentally take it and cause harm to the person. When operating, wear protective clothing, such as lab clothes, gloves, and choose those that are resistant to its corrosion. Wear protective goggles to prevent it from splashing into the eyes. Operate in a well-ventilated place. If conditions permit, it is advisable to use a fume hood to allow the volatile gas to drain quickly and avoid aggregation in the room.
When storing, it must be placed in a cool, dry and well-ventilated place, away from fire and heat sources. Because it is sensitive to light and heat, it needs to be stored in a dark place, and it can be stored in a brown bottle. It should also be placed separately from oxidants, strong alkalis, etc., to avoid the risk of reaction.
During operation, use it with precision and use clean and dry utensils. If it accidentally splashes on the skin, rinse quickly with plenty of water, followed by soap. If it enters the eye, rinse immediately with flowing water and seek medical treatment. If it is sprinkled on the countertop or ground, clean it up immediately. First cover it with adsorbents, such as vermiculite and sand, carefully collect it, and then dispose of it in accordance with relevant regulations.
After the experiment is completed, the utensils used must be washed and dried to remove residues. The waste should not be discarded at will. It needs to be collected in accordance with chemical waste treatment specifications and handed over to professional institutions for disposal.
In short, the operation of 1 - Bromo - 2 - Fluoro - 4 - Iodobenzene must be done with caution, and follow safety and operation specifications to protect your own safety and ensure the smooth operation of the experiment.
Application Area
1 - Bromo - 2 - Fluoro - 4 - Iodobenzene is also an organic compound. Its application field is quite wide, and it can be used as a key intermediate for the synthesis of specific drugs in the field of medicinal chemistry. With its unique structure, it can react ingeniously with many reagents, and the well-designed synthesis path can prepare a good medicine for specific diseases.
In the field of materials science, it also has important functions. It can participate in the preparation of materials with special photoelectric properties, such as materials used in new display technologies. Through its participation in polymerization reactions, etc., it can endow materials with unique electron transport and optical properties, so that materials can exhibit excellent performance in the display field.
Furthermore, in organic synthesis chemistry, it is an important building block for building complex organic molecular structures. Chemists selectively trigger various reactions by virtue of the activity differences of bromine, fluorine and iodine atoms, expanding the structural diversity of organic molecules, thus promoting the continuous development of organic synthesis chemistry.
Research & Development
There is a substance called 1 - Bromo - 2 - Fluoro - 4 - Iodobenzene. As a chemical researcher, I observe this substance, observe its characteristics, explore its causes, and hope to gain something to help its research and development.
The structure of this substance is unique, with bromine, fluorine, and iodine atoms on the benzene ring. The properties of each atom affect each other, resulting in its unique chemical properties. In the reaction, it is either active or stable, depending on its environment and reaction.
We have conducted various experiments to investigate the reaction of this substance under different conditions. Or heat up, or add additives, and watch the traces of its changes. Hope to be able to understand the law of its reaction, control the process of its reaction, so that it can be used in the fields of medicine and materials, and develop its capabilities to promote the progress of science and industry. This is what our generation has studied, and it is also an important task to promote the development of this material.
Toxicity Research
Recently, in the field of chemistry, the study of highly toxic properties, especially 1 - Bromo - 2 - Fluoro - 4 - Iodobenzene, is extremely important. It is an organic halide with a unique structure and atomic arrangement, but the toxicity is unknown, so the study is urgent.
At the beginning, looking at its chemistry, it is very active in response to other things, and can initiate various reactions. However, it may also increase toxicity. Or enter the organism, interact with biochemical molecules, disrupt its metabolism and cause dysfunction.
times, in the environment, its stability is high, difficult to decompose, accumulated in water and soil, or into the food chain, starting from micro-matter, gradually accumulating in high-trophic organisms, and eventually endangering human beings.
Furthermore, during the actual research, the operator must be strictly protected. Although the strength of its poison has not been determined, halogenated aromatics are many toxic and cannot be prevented. Only by knowing its toxicity can it be used for chemical safety and environmental protection, paving the way.
Future Prospects
The future prospects of the husband are related to 1 - Bromo - 2 - Fluoro - 4 - Iodobenzene. We dedicate ourselves to research it, hoping that it will shine in various fields. Looking at the field of chemical industry today, new materials have emerged one after another, and this compound has unique properties, which may be the key to opening up a new path.
It is expected that it can be created in medicine, which can help doctors make special drugs and save patients from pain. In the field of electronic materials, it may become a key component and promote the performance of devices. Although there may be thorns in the road ahead, we scientific researchers must uphold the determination and explore its infinite potential. In time, 1 - Bromo - 2 - Fluoro - 4 - Iodobenzene will surely be used by the world, showing a brilliant scene, adding bricks and mortar to human well-being, demonstrating the power of science, and developing the future.
Where to Buy 1-Bromo-2-Fluoro-4-Iodobenzene in China?
As a trusted 1-Bromo-2-Fluoro-4-Iodobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 1-Bromo-2-Fluoro-4-Iodobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

1 - Bromo - 2 - Fluoro - 4 - What is the main use of Iodobenzene
1-Bromo-2-fluoro-4-iodobenzene is also an organic compound. It has a wide range of uses and is often a key raw material and intermediate in the field of organic synthesis.
First, it plays a significant role in the synthesis of medicine. It can be converted into molecules with specific pharmacological activities through a series of chemical reactions to create new drugs. For example, it can be used to build specific chemical structures for the development of antibacterial, anti-cancer and other drugs. Due to the characteristics of halogen atoms, it can affect the activity, solubility and bioavailability of molecules, so it is indispensable in the research of medicinal chemistry and the process of new drug creation.
Second, in the field of materials science, it also has important functions. It can participate in the preparation of special functional materials, such as optoelectronic materials. Due to the presence of halogen atoms in its molecular structure, it can endow materials with unique electrical and optical properties, such as adjusting the energy band structure of materials, which in turn affects their luminescence, conductivity and other properties. It may play a key role in the development of organic Light Emitting Diodes (OLEDs), solar cells and other materials.
Third, it is also a commonly used starting material in the synthesis of fine chemical products. It can synthesize various fine chemicals, such as special dyes and fragrances, by reacting with different reagents. By precisely adjusting the reaction conditions and the proportion of reactants, fine chemical products with diverse structures and unique properties can be prepared to meet the needs of different industries for special chemicals.
What are the physical properties of 1 - Bromo - 2 - Fluoro - 4 - Iodobenzene
1-Bromo-2-fluoro-4-iodobenzene is one of the organic compounds. Its physical properties are quite unique.
Looking at its properties, under normal temperature and pressure, it is mostly in a liquid state, which is due to the state of intermolecular forces. Its color may be colorless to light yellow. This color state originates from the electronic transition characteristics of the atoms in the molecular structure.
When it comes to boiling points, it is about a relatively high range. Due to the existence of halogen atoms such as bromine, fluorine, and iodine in the molecule, the intermolecular forces are enhanced, and the energy required for the molecules to break free from the liquid phase is increased, so the boiling point rises. The specific value varies according to the experimental conditions, but it is roughly within a certain range. The melting point of
also has its own specific value. Due to the arrangement and interaction of molecules, the lattice energy is fixed, so the melting point is relatively stable.
The density is greater than that of water. Due to the large atomic weight of halogen atoms in the molecule, the unit volume mass is increased. Placing it in water will sink to the bottom.
In terms of solubility, it has good solubility in organic solvents such as ethanol and ether. This is due to the principle of "similar compatibility". The compound is an organic molecule, and the force between it and the organic solvent molecules is similar, so it can be miscible. However, it has poor solubility in water, because its molecular polarity is different from that of water molecules, and the interaction force is weak.
The vapor pressure is low. Due to the strong intermolecular force, it is more difficult for molecules to escape from the liquid phase and enter the gas phase. Therefore, at a certain temperature, the number of molecules evaporated to the gas phase per unit time is small, and the vapor pressure is low.
These physical properties are of great significance in the fields of organic synthesis and chemical production, providing a basis for the design of related operations and reactions.
Is 1 - Bromo - 2 - Fluoro - 4 - Iodobenzene chemically stable?
1 + -Bromo-2-fluoro-4-iodobenzene is an organic compound, and the stability of its chemical properties is very important. From the structural point of view, there are bromine, fluorine and iodine halogen atoms attached to the benzene ring.
Halogen atoms on the benzene ring will exert influence through induction effect and conjugation effect. Fluorine atoms are extremely electronegative and have strong electron-sucking induction effect, which can reduce the electron cloud density of the benzene ring. Although the electronegativity of bromine and iodine is inferior to that of fluorine, they also have electron-sucking induction effect, and their atomic radius is larger, and the performance of conjugation effect is also different.
In terms of stability, on the one hand, the electron-withdrawing properties of halogen atoms reduce the electron cloud density of the benzene ring, which weakens the electrophilic substitution activity of the benzene ring, which improves the stability to a certain extent. For example, compared with benzene, electrophilic reagents attack the benzene ring of 1 + -bromo-2-fluoro-4-iodobenzene more difficult.
On the other hand, the stability of carbon-halogen bonds is also related to the overall stability. The bond energy of carbon-fluorine bonds is relatively large and quite stable; the bond energy of carbon-bromine bonds and carbon-iodine bonds is relatively small. Under certain conditions, the carbon-bromo bond and the carbon-iodine bond may break more easily, causing chemical reactions, which in turn impairs their stability.
Under common conditions, the chemical properties of 1 + -bromo-2-fluoro-4-iodobenzene are relatively stable without the action of specific reagents. However, at high temperatures, light or in the presence of specific catalysts, the carbon-halogen bond may activate, triggering reactions such as substitution and elimination, and the stability will also change accordingly.
What are the synthesis methods of 1 - Bromo - 2 - Fluoro - 4 - Iodobenzene
The synthesis of 1 + -bromo-2-fluoro-4-iodobenzene involves many delicate methods.
First, it can be obtained from benzene through a multi-step substitution reaction. First, benzene and bromine are electrophilically substituted under the catalysis of iron tribromide to obtain bromobenzene. Then, bromobenzene is used as a substrate and fluorine atoms are introduced under specific conditions. This process requires the selection of suitable fluorination reagents, such as anhydrous potassium fluoride, etc., and can proceed smoothly with the help of a phase transfer catalyst. After 1-bromo-2-fluorobenzene is obtained, it is then iodinated. The use of iodine and 1-bromo-2-fluorobenzene in the presence of oxidants, electrophilic substitution, such as hydrogen peroxide and other oxidants, prompts the iodine atom to replace the hydrogen at a specific position on the benzene ring, resulting in 1 + -bromo-2-fluoro-4-iodobenzene.
Second, it can also start from phenolic compounds. Phenols are converted into diazonium salts by diazotization reaction. Subsequently, under the action of different halogenating reagents, bromine, fluorine and iodine atoms are introduced step by step. First, with a suitable brominating reagent, the diazonium salt is converted into a bromine-containing intermediate, and then the fluorination reaction is carried out, and finally This path requires precise control of the reaction conditions. The temperature of the diazotization reaction, the amount of halogenated reagent and the reaction time all have a great impact on the yield and purity of the product.
Third, arylboronic acid or its esters are used as raw materials, with the help of coupling reaction strategies such as Suzuki coupling reaction. First, arylboronic acid or its esters containing different halogen atoms are prepared, and then each aryl fragment is coupled in the presence of a base through a suitable catalyst, such as palladium catalyst. This method has good selectivity and relatively mild conditions, but the catalyst cost is high, which requires strict anhydrous and anaerobic reaction system.
All kinds of synthetic methods have their own advantages and disadvantages, and they need to be carefully selected according to actual needs, considering factors such as raw material availability, cost, yield and purity.
1 - Bromo - 2 - Fluoro - 4 - What are the precautions for Iodobenzene in storage and transportation
1 + -Bromo-2-fluoro-4-iodobenzene is an organic compound. When storing and transporting, many matters need to be paid careful attention.
Safety first. This compound is toxic and irritating to a certain extent, and contact or inhalation may endanger human health. When storing, be sure to keep it in a cool, well-ventilated place, away from fire and heat sources, and avoid mixing with oxidants, strong alkalis and other substances to prevent violent chemical reactions and the risk of fire or explosion. Operators need to wear appropriate protective equipment, such as protective gloves, goggles and protective clothing, to prevent skin-to-eye contact; the operating environment should be well ventilated or operated in a fume hood to avoid inhalation of volatile gases.
The second is packaging. The packaging material must be solid and durable, which can effectively prevent leakage. Common packaging such as glass bottles, the mouth of the bottle must be tightly sealed; if plastic packaging is used, it is necessary to ensure that the material has good compatibility with the compound and will not be corroded. The name, nature, hazard warning and other information should be clearly marked on the outside of the package for easy identification and handling.
During transportation, ensure that the packaging is complete to avoid package damage caused by collision and vibration. Transportation vehicles need to be equipped with corresponding fire and emergency treatment equipment for emergencies. Follow relevant transportation regulations and standards, properly choose transportation methods and routes, and keep away from densely populated areas and important facilities.
Storage temperature should not be ignored. Generally, it is recommended to store in a low temperature environment to slow down its volatilization and chemical reaction rate. Regularly check the storage container for signs of leakage and deterioration, and deal with abnormal situations in time. In this way, the safety of 1 + -bromo-2-fluoro-4-iodobenzene during storage and transportation can be guaranteed, and accidents and hazards can be avoided.