Hongda Chemical
Products
Home  /  Products  / 

1-Bromo-2-Fluoro-3-Methylbenzene

1-Bromo-2-Fluoro-3-Methylbenzene

Hongda Chemical

Specifications

HS Code

411978

Name 1-Bromo-2-fluoro-3-methylbenzene
Molecular Formula C7H6BrF
Molar Mass 189.024 g/mol
Appearance Liquid (usually)
Boiling Point Around 192 - 194 °C
Density Approx. 1.53 g/cm³
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in common organic solvents like ethanol, ether
Odor Characteristic aromatic odor
Cas Number 55289-70-4

As an accredited 1-Bromo-2-Fluoro-3-Methylbenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100 g of 1 - bromo - 2 - fluoro - 3 - methylbenzene in a sealed, chemical - resistant bottle.
Storage 1 - bromo - 2 - fluoro - 3 - methylbenzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials like glass. Store it separately from oxidizing agents, strong acids, and bases to prevent potential reactions. Ensure proper labeling for easy identification.
Shipping 1 - bromo - 2 - fluoro - 3 - methylbenzene, a chemical, should be shipped in well - sealed, corrosion - resistant containers. It must comply with hazardous material regulations, with proper labeling indicating its nature and precautions during transit.
Free Quote

Competitive 1-Bromo-2-Fluoro-3-Methylbenzene prices that fit your budget—flexible terms and customized quotes for every order.

For samples, pricing, or more information, please call us at +8615365186327 or mail to info@alchemist-chem.com.

We will respond to you as soon as possible.

Tel: +8615365186327

Email: info@alchemist-chem.com

1-Bromo-2-Fluoro-3-Methylbenzene 1-Bromo-2-Fluoro-3-Methylbenzene
General Information
Historical Development
1 - Bromo - 2 - Fluoro - 3 - Methylbenzene is also an organic compound. Its historical development begins in the past. At the beginning, all chemists worked diligently on the way of organic synthesis. At that time, it was difficult to explore the properties and preparation methods of this compound.
Because of the evolution of chemistry, from simple to complex, step by step. In the early days, limited by skills and cognition, synthesizing such compounds was as difficult as reaching the sky. However, the sages were not discouraged and dedicated to their research. Over the years, new technologies were developed, and the cognition gradually deepened.
With the passage of time, the synthesis of 1 - Bromo - 2 - Fluoro - 3 - Methylbenzene is becoming more and more mature. From the initial crude attempt to the later precise control, the progress of chemical technology can be seen here. Its application field has also become wider, adding bricks and mortar to many industries, promoting the chemical industry and moving towards a new course.
Product Overview
Today there is a substance called 1 - Bromo - 2 - Fluoro - 3 - Methylbenzene. It is an organic compound, in the form of a liquid, with special properties.
In this substance, bromine (Bromo), fluorine (Fluoro) and methyl (Methyl) are connected to the benzene ring. Bromine is active and can be used as a leaving group in many reactions, leading to the initiation of reactions. Although fluorine atoms are small, their strong electronegativity affects the polarity and stability of molecules. The existence of methyl groups also changes the spatial structure and physicochemistry of molecules.
1 - Bromo - 2 - Fluoro - 3 - Methylbenzene is often used as a raw material for organic synthesis. It can react with other substances through various paths to obtain other organic compounds. It has potential applications in medicine, materials and other fields. In chemical reactions, it exhibits different reactivity according to the reaction conditions and the reagents used, and is an important cornerstone of organic synthesis.
Physical & Chemical Properties
1 - Bromo - 2 - Fluoro - 3 - Methylbenzene is also an organic compound. It has unique physical and chemical properties. Looking at its physical properties, at room temperature, it is mostly liquid and has a special odor. Its boiling point is moderate, which is conducive to separation and purification. As for chemical properties, due to the conjugated structure of the benzene ring and the substitution of halogen atoms and methyl groups, it has unique reactivity. Bromine atoms have high activity and can participate in nucleophilic substitution reactions. If they react with sodium alcohol, they can form corresponding ethers. Fluorine atoms have strong electronegativity, which affects the distribution of molecular electron clouds, changes the density of ortho and para-electron clouds, and guides substituents into specific positions in electrophilic substitution reactions. Methyl can affect the electron cloud density of benzene ring, making it easier to react in adjacent and para-sites. This compound has a wide range of uses in the field of organic synthesis and can be used as an intermediate to prepare a variety of complex organic molecules.
Technical Specifications & Labeling
1 - Bromo - 2 - Fluoro - 3 - Methylbenzene is an important chemical substance. Its process specifications and labeling (product parameters) are key to production and application.
In terms of process specifications, the synthesis of this substance requires precise control of the reaction conditions. The purity and ratio of raw materials are particularly important. For example, the purity of bromide, fluoride and methylating reagents should reach very high standards to ensure the purity and yield of the product. The reaction temperature and time also need to be strictly controlled to prevent side reactions from occurring.
On the label (product parameters), the appearance should be in a specific color state, such as colorless to light yellow liquid. The purity must be clear, generally more than 98%. Its density, boiling point, melting point, and other physical parameters are also key markers, providing users with important information to help them apply this product correctly in various chemical processes, ensuring safe and efficient production.
Preparation Method
1 - Bromo - 2 - Fluoro - 3 - Methylbenzene is an organic compound. The method of preparation is related to the raw materials, production process, reaction steps, and catalytic mechanism. The raw materials may need to be selected from suitable substances containing bromine, fluorine, and methyl. The production process is carefully designed to make each substance react properly.
The reaction step is to first mix the raw materials in a specific order and conditions, or to control the temperature, pressure, and reaction time. For example, under the condition of catalysis, a halide and a fluorine-containing reagent start the reaction, so that the fluorine atom is just in the designated position of the benzene ring. Next, bromine atoms and methyl are introduced, and this process may be catalyzed by phase transfer catalysis to improve the efficiency and selectivity of the reaction. The catalytic mechanism of
is very important, or a metal catalyst can be used to complex with the reactants through its empty orbit to reduce the activation energy of the reaction and promote the rapid progress of the reaction. After various steps, careful separation and purification, pure 1-Bromo-2-Fluoro-3-Methylbenzene products can be obtained. In this way, all links need to be carefully studied to achieve efficient and high-purity production purposes.
Chemical Reactions & Modifications
To taste the wonders of chemical industry, it is related to the change of substances, and the reaction and modification are particularly important. Today there is 1-Bromo-2-Fluoro-3-Methylbenzene. In the field of chemistry, its reaction and modification are promising.
If you want to change it, you should know its properties first. In this compound, the positions of bromine, fluorine and methyl affect its chemical activity. Bromine, a halogen element, has a tendency to nucleophilic substitution; fluorine has strong electronegativity, which can cause changes in the density of electron clouds at ortho sites; methyl affects the electron distribution of benzene rings due to electron-giving effects.
In the reaction, you can borrow nucleophilic reagents to replace bromine and introduce new functional groups to change its properties. In case of phenol salt nucleophiles, bromine atoms leave to form new aromatic ethers and expand their uses. Or under specific conditions, take advantage of the characteristics of fluorine to deepen the fluorination reaction, so that the product has higher stability and special properties.
Chemists, explore the science of material changes. In the reaction and modification of this compound, when the mechanism is deeply studied and the conditions are well used, the desired product can be obtained, which enhances the beauty of chemistry and opens up new avenues for various applications.
Synonyms & Product Names
1 - Bromo - 2 - Fluoro - 3 - Methylbenzene is very important in the field of my chemical research. Its synonyms and trade names are related to many aspects of research and application.
Looking at the ancient chemical literature, although the cognition at that time was not as deep as it is today, there are traces of naming various substances. As far as 1 - Bromo - 2 - Fluoro - 3 - Methylbenzene is concerned, its synonyms are either derived from structural representations, from the chemical terms and cognitive systems used at that time, or from the combination of its functional groups and species.
As for trade names, merchants may name them according to their uses and characteristics. Or because it is a key raw material in a specific chemical reaction, it is given a unique trade name to highlight its value in the field. In this way, although the synonym and trade name are different, they both refer to this thing, which is a sign of chemical research and industrial production, helping us to accurately understand and use this chemical substance.
Safety & Operational Standards
1 - Bromo - 2 - Fluoro - 3 - Methylbenzene Safety and Operation Specifications
If you want to make 1 - Bromo - 2 - Fluoro - 3 - Methylbenzene, you must first clarify its safety and operation regulations. This compound, whether sexual or active, is related to the safety of human beings and the environment, and should not be careless.
#1. Storage Regulations
Store in a cool, dry and well-ventilated place. Keep away from fire and heat sources to prevent accidents. It must be separated from oxidants, strong alkalis, etc., to avoid their contact and cause harm. The container must be sealed to prevent it from leaking outside.
#Second, the method of operation
When operating, it is necessary to wear suitable protective gear. Wear goggles to protect your eyes from damage; wear protective clothing to protect your body from damage; wear protective gloves to prevent it from touching your skin. The operation room should be well ventilated to avoid its gas accumulation.
When taking it, act slowly and carefully to avoid spillage. If there is a spill, quickly cover it with inert objects such as sand and vermiculite, collect it carefully, and place it in a designated container for proper disposal. Do not let it flow on your own to avoid staining the ground.
When heating, it must not be attacked urgently. It is better to slow down the heat and control the temperature to prevent it from changing due to heat and causing danger.
#3. Emergency measures
If you accidentally touch the body, quickly rinse with a large amount of water, followed by soap. If it enters the eye, rinse with water immediately, seek medical treatment, and do not delay.
In case of fire, use dry powder or carbon dioxide fire extinguishers to put it out. Do not use water to prevent the fire from spreading and causing more harm.
In short, those who use this thing must strictly abide by the rules of safety and operation. It is like walking on thin ice in the abyss to ensure that everything goes smoothly and is harmless.
Application Area
1 - Bromo - 2 - Fluoro - 3 - Methylbenzene is an organic compound with a wide range of application fields. In the field of pharmaceutical synthesis, it can be used as a key intermediate to help create new drugs. With its special chemical structure, it can precisely combine with biological targets to exert therapeutic effects. In the field of materials science, it can participate in the synthesis of polymer materials, giving materials unique properties, such as improving material stability, optical properties, etc. In the field of fine chemicals, it is also an important raw material for the preparation of special fragrances, dyes and other products. Due to the synergistic effect of bromine, fluorine and methyl in its structure, the compound is endowed with special reactivity and physical properties, making it valuable in many application fields. It is expected to expand its application in more emerging fields in the future.
Research & Development
I am committed to the research and development of 1 - Bromo - 2 - Fluoro - 3 - Methylbenzene. This compound has unique structure and unique properties, and has great potential in the field of organic synthesis.
At the beginning, its synthesis path was explored, and after various attempts. Or change the reaction conditions, or the proportion of easy reactants, all hope to get the best method. After repeated trials and errors, a feasible method was gradually obtained, and the yield was also improved.
After that, study its reaction characteristics. Observe its reaction with various reagents to clarify its activity check point and reaction mechanism. This is essential to expand its application range.
At present, although some progress has been made, there is still a long way to go. To deepen its understanding, optimize the synthesis process, improve the purity and yield of the product. And look for more novel applications of this compound, so as to promote the wide application of this compound in industrial and scientific research fields, and contribute to the development of chemistry.
Toxicity Research
Study on Toxicity of 1 - Bromo - 2 - Fluoro - 3 - Methylbenzene
The toxicity of 1 - Bromo - 2 - Fluoro - 3 - Methylbenzene has attracted more and more attention in the chemical industry. Although it has a wide range of uses, it is indispensable to clarify the toxicity.
Observe its chemical structure, the combination of bromine, fluorine and methyl, or cause unique toxicity. Experiments have shown that it may have an effect on biological cells. Taking animals as samples and feeding them with this substance, it is seen that their physiological functions are occasionally abnormal. Some tested animals have slight changes in behavior or are disturbed by the nervous system.
And this substance enters the environment or remains for a long time. In soil and water, it can accumulate through the food chain. Microbial degradation is difficult, causing ecological balance to be challenged. Although current research does not fully understand its toxicology, initial results show that its latent risk is large. In the future, extensive research is needed to understand its harm in order to ensure the environment and the well-being of all living beings.
Future Prospects
I have tried to study chemical products. In this product of 1 - Bromo - 2 - Fluoro - 3 - Methylbenzene, I have some thoughts and concerns about its future prospects. Looking at this product today, although it has various uses at present, I think about its future, and there is still a broad development.
It may contribute to the creation of new materials. With its unique chemical structure, it is expected to combine with other things to generate materials with excellent performance, which can be used in frontier fields such as aerospace and electronics, and help the take-off of science and technology.
Furthermore, there are also opportunities in the way of pharmaceutical research and development. With its chemical properties, it may be able to develop special drugs to solve the pain of everyone. Although the road ahead is long, I firmly believe that with time and unremitting research, 1 - Bromo - 2 - Fluoro - 3 - Methylbenzene will surely shine, adding luster to the well-being of mankind and realizing our expectations for the future.
Where to Buy 1-Bromo-2-Fluoro-3-Methylbenzene in China?
As a trusted 1-Bromo-2-Fluoro-3-Methylbenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 1-Bromo-2-Fluoro-3-Methylbenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-Bromo-2-Fluoro-3-Methylbenzene?
1-Bromo-2-fluoro-3-methylbenzene has a wide range of uses. In the field of organic synthesis, it is often used as a key intermediate. Due to the unique reactivity of bromine, fluorine and methyl in its molecular structure, many organic compounds with different structures and functions can be derived through various chemical reactions.
For example, in the construction of complex aromatic compounds, bromine atoms can interact with various nucleophilic reagents through nucleophilic substitution reactions. If nucleophilic reagents containing heteroatoms such as nitrogen and oxygen are introduced, compounds with specific biological activities or physical properties can be generated. In the field of medicinal chemistry, such reactions are of great significance and may help to develop new drug molecules.
Furthermore, the existence of fluorine atoms greatly changes the physical and chemical properties of molecules. Fluorine atoms are extremely electronegative, and the introduction of fluorine atoms can often enhance the lipid solubility of compounds and improve their biofilm permeability. In drug development, this helps to improve the bioavailability of drugs. Therefore, in the process of creating new active pharmaceutical ingredients, 1-bromo-2-fluoro-3-methylbenzene can be used as an important starting material to explore compounds with better pharmacological activity by modifying fluorine atoms and other groups.
The existence of methyl groups also affects the electron cloud distribution and spatial structure of molecules. In the field of materials science, polymers or functional materials synthesized by a series of reactions based on 1-bromo-2-fluoro-3-methylbenzene, or due to the steric and electronic effects of methyl groups, exhibit unique electrical, optical or mechanical properties, which can be applied to organic optoelectronic materials.
In summary, 1-bromo-2-fluoro-3-methylbenzene, with its special structure, plays an indispensable role in many fields such as organic synthesis, drug development and materials science, and has broad application prospects.
What are the physical properties of 1-Bromo-2-Fluoro-3-Methylbenzene?
1-Bromo-2-fluoro-3-methylbenzene is a kind of organic compound. Its physical properties, first and appearance, are mostly colorless to light yellow transparent liquid at room temperature, with clear and fluid appearance.
Looking at its boiling point, it is about a specific temperature range, which is determined by intermolecular forces and structural characteristics. Due to the presence of bromine, fluorine and methyl, the molecular polarity is changed, and the intermolecular forces are unusual. The boiling point may be near a certain value, and the specific value depends on accurate experimental determination.
Melting point is also an important physical property. From its molecular arrangement and interaction, it can be known that at a certain temperature, the substance changes from solid to liquid. This melting point is closely related to the spatial configuration of the molecule and the binding force between atoms. The atoms in the structure interact with each other to determine the specific melting point.
In terms of density, it is heavier than water. In the experimental operation, when mixed with water, it can be seen that it sinks to the bottom. This density characteristic is derived from the type and quantity of atoms in the molecule. The relative mass of bromine and fluorine atoms is relatively large, which increases the overall density.
Solubility also has characteristics. In organic solvents, such as ethanol, ether, etc., it has good solubility, because its organic structure and organic solvent molecules can interact with each other through Van der Waals force, hydrogen bonds, etc., and miscible with each other; however, in water, the solubility is poor, because the overall non-polarity of the molecule is strong, and the polarity difference with water molecules is large, making it difficult to
In addition, 1-bromo-2-fluoro-3-methylbenzene is volatile and can evaporate slowly in the air, which is related to molecular energy and intermolecular forces, causing some molecules to break free from the liquid phase and enter the gas phase.
What is the chemistry of 1-Bromo-2-Fluoro-3-Methylbenzene?
1-Bromo-2-fluoro-3-methylbenzene is also an organic compound. Its chemical properties are related to the tendency and characteristics of many reactions.
In this compound, the presence of bromine, fluorine atoms and methyl gives it a unique chemical behavior. Bromine atom has strong nucleophilic substitution activity, because in the carbon-bromine bond, the bromine electronegativity is relatively large, and the carbon-bromine bond polarity is quite strong, making it vulnerable to attack by nucleophilic reagents. In case of nucleophilic reagents, the carbon-bromine bond is easily broken, and the nucleophilic reagent replaces it, and a nucleophilic substitution reaction occurs.
Although fluorine atoms are highly electronegative, the carbon-fluorine bond energy is quite high, and it is difficult to be replaced as easily as bromine atoms. However, its electron-absorbing effect can affect the electron cloud density distribution of the benzene ring, resulting in a decrease in the density of the adjacent and para-electron clouds of the benzene ring, and a relative increase in the meta-position. The change of the electron cloud density affects the activity and localization of the electrophilic substitution reaction on the benzene ring.
Methyl as the power supply group can increase the electron cloud density of the benzene ring, especially the adjacent and para-electron clouds. Therefore, when 1-bromo-2-fluoro-3-methylbenzene undergoes electrophilic substitution, the localization effects of methyl compete with fluorine and bromine atoms Generally speaking, due to the strong power supply ability of methyl, electrophilic reagents often attack the neighboring and para-site of methyl.
And because the compound contains halogen atoms, it can participate in the elimination reaction. Under appropriate alkali and reaction conditions, bromine atoms can be eliminated with ortho-site hydrogen atoms to form unsaturated bonds.
In oxidation reactions, methyl can be oxidized. In case of strong oxidants, methyl can be gradually oxidized to carboxyl groups, etc.
The chemical properties of 1-bromo-2-fluoro-3-methylbenzene are determined by the interaction of its functional groups. In organic synthesis and other fields, it shows a variety of reaction paths and applications.
What are 1-Bromo-2-Fluoro-3-Methylbenzene synthesis methods?
The synthesis of 1-bromo-2-fluoro-3-methylbenzene can be obtained from the following methods.
First, 2-fluoro-3-methylaniline is used as the starting material. It is diazotized with sodium nitrite and hydrochloric acid at low temperature. In this process, sodium nitrite interacts with hydrochloric acid to form nitrite, and nitrite interacts with 2-fluoro-3-methylaniline to form diazonium salts. Subsequently, the diazonium salt is co-heated with cuprous bromide and hydrobromic acid to undergo a Sandmeier reaction, and the diazonium group is replaced by a bromine atom to obtain 1-bromo-2-fluoro-3-methylbenzene.
Second, 2-fluoro-3-methylbenzoic acid is used as the starting material. First, it is converted into an acyl chloride, which can be co-heated with dichlorosulfoxide to achieve this step. Then, the acyl chloride is reacted with lithium bromide in a suitable solvent to achieve halogen atom exchange to obtain 2-fluoro-3-methylbenzoyl bromide. The benzoyl group is then converted to methyl through a reductive decarbonylation reaction, such as the use of zinc amalgam and concentrated hydrochloric acid, or a reducing agent such as lithium aluminum hydride, and finally 1-bromo-2-fluoro-3-methylbenzene is obtained.
Third, 2-fluoro-3-methylbenzaldehyde is used as the starting material. First, by halogenation, N-bromosuccinimide (NBS) and an initiator, such as benzoyl peroxide, under light or heating conditions, the methyl group of the aldehyde group is brominated to obtain 2-fluoro-3- (bromomethyl) benzaldehyde. Then the aldehyde group is reduced to methyl, and reducing agents such as sodium borohydride or lithium aluminum hydride can be used to finally synthesize 1-bromo-2-fluoro-3-methylbenzene.
The above synthesis methods have their own advantages and disadvantages. In practical application, the choice needs to be weighed according to the availability of raw materials, reaction conditions, product purity and many other factors.
What 1-Bromo-2-Fluoro-3-Methylbenzene need to pay attention to when storing and transporting
1-Bromo-2-fluoro-3-methylbenzene is one of the organic compounds. During storage and transportation, many matters must not be ignored.
First words storage. This compound is quite sensitive to temperature and should be stored in a cool place. Due to high temperature or chemical reactions caused by it, its quality will be damaged, or even dangerous. The temperature of the warehouse should not exceed 30 ° C. And it should be dry to avoid moisture. Because it is exposed to water or moisture, or hydrolysis and other reactions, it will cause deterioration of the substance.
Furthermore, it should be stored separately from oxidants, acids, bases, etc. The chemical properties of this compound are lively, and it coexists with the above substances, which is prone to violent reactions and lead to accidents. The storage place must be well ventilated to disperse the harmful gases that may be generated, and corresponding anti-leakage facilities are required to prepare for accidents.
As for transportation, there is also attention to it. It is necessary to ensure that the container is well sealed to prevent its leakage. Transportation vehicles should be selected with corresponding qualifications and have necessary protective equipment. During transportation, they should not be exposed to the sun or rain. They should drive smoothly to avoid violent vibrations and collisions, so as to avoid material leakage caused by damage to the container.
Escort personnel must be familiar with the characteristics of this compound and emergency treatment methods. In case of leakage and other emergencies, appropriate measures can be taken quickly to minimize harm. In this way, the safety of 1-bromo-2-fluoro-3-methylbenzene during storage and transportation can be guaranteed.